Research Explorer

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Researcher

Rudi Beyaert

Publications & Research Data

Awards & Distinctions

390 Results

2026

Development and validation of a flow cytometry-based ISG15 induction assay to monitor the type I interferon response

Birthe MichielsRudi BeyaertJens StaalDoreen DillaertsMaaike CockxGlynis FransBirgit TimmermansNatalie LorentIsabelle MeytsXavier Bossuyt

A1 Journal Article in CLINICAL IMMUNOLOGY

2025

A tale of two barriers: CARD14 in skin and gut

Aigerim AidarovaRudi BeyaertInna Afonina

CARD14 signaling in intestinal epithelial cells induces intestinal inflammation and intestinal transit delay

Aigerim AidarovaMarieke CarelsMira HaegmanYasmine DriegeSteven TimmermansEline Van DammeJavier Aguilera-LizarragaMaria Francesca ViolaRita de Cassia de Oliveira CollacoJoan Manils et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

CREB regulates Foxp3+ST-2+ TREGS with enhanced IL-10 production

Sudheendra Hebbar SubramanyamJudit Turyne HriczkoSaskia SchulzThomas LookTannaz GoodarziTim ClarnerMiriam ScheldMarkus KippEva VerjansSvenja Boell et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Multi-step pathway engineering in probiotic Saccharomyces boulardii for abscisic acid production in the gut

Femke Van GaeverPaul VandecruysYasmine DriegeSeo Woo KimJohan M. TheveleinRudi BeyaertJens Staal

A2 Journal Article in METABOLIC ENGINEERING COMMUNICATIONS

NF-κB regulated expression of A20 controls IKK dependent repression of RIPK1 induced cell death in activated T cells

By Scott LayzellAlessandro BarbaruloGeert van LooRudi BeyaertBenedict Seddon

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Role of MALT1 substrate cleavage in immune regulation : insights from a mouse gene targeting approach

Ioannis SkordosRudi BeyaertAnnelies DemeyerJens Staal

2024

CARD14 signalosome formation is associated with its endosomal relocation and mTORC1-induced keratinocyte proliferation

Paul A O'SullivanAigerim AidarovaInna AfoninaJoan ManilsTeresa L M ThurstonRachel InstrellMichael HowellStefan BoeingSashini RanawanaMelanie Herpels et al.

A1 Journal Article in BIOCHEMICAL JOURNAL

Chimeric and mutant CARD9 constructs enable analyses of conserved and diverged autoinhibition mechanisms in the CARD-CC protein family

Jens StaalYasmine DriegeFemke Van GaeverJill SteelsRudi Beyaert

A1 Journal Article in FEBS JOURNAL

Engineering of an abscisic acid-producing saccharomyces boulardii strain and analysis of its therapeutic potential in preclinical models of inflammation

Femke Van GaeverRudi BeyaertJens Staal

Interleukin-33-activated basophils promote asthma by regulating Th2 cell entry into lung tissue

Martijn SchuijsClaudia Mariela Brenis GómezFabian BickJustine Van MoorleghemManon VanheerswynghelsGeert van LooRudi BeyaertDavid VoehringerRichard M. LocksleyHamida Hammad et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Polo-like kinase 1 (PLK1) is a novel CARD14-binding protein in keratinocytes

Stella IliakiMarja KreikeNatalia Ferreras MorenoFemke De MeyerAigerim AidarovaHarald BraunClaude LibertInna AfoninaRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis

Femke Van GaeverFleur MingneauSam VanherleYasmine DriegeMira HaegmanElien Van WonterghemJunhua XieRoosmarijn VandenbrouckeJerome J. A. HendriksRudi Beyaert et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2023

A20 is a master switch of IL-33 signalling in macrophages and determines IL-33-induced lung immunity

Aurora Holgado MuñozZhuangzhuang LiuAigerim AidarovaChristina MüllerMira HaegmanYasmine DriegeMarja KreikeCharlotte ScottInna AfoninaRudi Beyaert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Exploring species-specificity in TLR4/MD-2 inhibition with amphiphilic lipid a mimicking glycolipids

Alessio BorioAurora Holgado MuñozChristina PasseggerHerbert StroblRudi BeyaertHolger HeineAlla Zamyatina

A1 Journal Article in MOLECULES

IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer

Olga S. BlombergLorenzo SpagnuoloHannah GarnerLeonie VoorwerkOlga I. IsaevaEwald van DykNoor BakkerMyriam ChalabiChris KlaverMaxime Duijst et al.

A1 Journal Article in CANCER CELL

Laboratory mice with a wild microbiota generate strong allergic immune responses

Junjie MaEgon UrgardSolveig RungeCajsa H. ClassonLaura MathäJulian M. StarkLiqin ChengJaviera A. ÁlvarezSilvia Von ZedtwitzAusteja Baleviciute et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

Normal lymphocyte homeostasis and function in MALT1 protease-resistant HOIL-1 knock-in mice

Ioannis SkordosYasmine DriegeMira HaegmanMarja KreikeJens StaalAnnelies DemeyerRudi Beyaert

A1 Journal Article in FEBS JOURNAL

Proteolytic activity of the paracaspase MALT1 is involved in epithelial restitution and mucosal healing

Leonie WittnerLukas WagenerJakob J. WieseIris StolzerSusanne M. KrugElisabeth NaschbergerRene JackstadtRudi BeyaertRaja AtreyaAnja A. Kühl et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The impact of hepatocyte-specific deletion of hypoxia-inducible factors on the development of polymicrobial sepsis with focus on GR and PPARα function

Tineke VanderhaeghenSteven TimmermansMelanie EggermontDeepika WattsJolien VandewalleCharlotte WallaeysLouise NuyttensJoyca De TemmermanTino HochepiedSylviane Dewaele et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2022

CARD14 signalling ensures cell survival and cancer associated gene expression in prostate cancer cells

Domien VannesteJens StaalMira HaegmanYasmine DriegeMarieke CarelsElien Van NuffelPieter De BleserYvan SaeysRudi BeyaertInna Afonina

A1 Journal Article in BIOMEDICINES

Editor profile : Rudi Beyaert

FEBS Journal Editorial TeamRudi Beyaert

Editorial material

Engineering a highly sensitive biosensor for abscisic acid in mammalian cells

Seo Woo KimKûbra AlciFemke Van GaeverYasmine DriegeKeylla BicalhoGeert GoeminneClaude LibertAlain GoossensRudi BeyaertJens Staal

A1 Journal Article in FEBS LETTERS

GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141

Leslie NaesensSantoshi MuppalaDhiraj AcharyaJosephine NemegeerDelfien BogaertJung-Hyun LeeKatrien StaesVeronique DebackerPieter De BleserMarieke De Bruyne et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

Identification and functional characterization of CARD14 protein-protein interactions

Stella IliakiRudi BeyaertInna Afonina

Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism

Xiaoting SunXingkang HeYin ZhangKayoko HosakaPatrik AnderssonJing WuJieyu WuXu JingQiqiao DuXiaoli Hui et al.

A1 Journal Article in GUT

Mutations in RNU7-1 weaken secondary RNA structure, induce MCP-1 and CXCL10 in CSF, and result in Aicardi-Goutières syndrome with severe end-organ involvement

Leslie NaesensJosephine NemegeerFilip RoelensLore VallaeysMarije MeuwissenKatrien JanssensPATRICK VERLOOBenson OgunjimiDimitri HemelsoetLevi Hoste et al.

A1 Journal Article in JOURNAL OF CLINICAL IMMUNOLOGY

Reprogramming of glucocorticoid receptor function by hypoxia

Tineke VanderhaeghenSteven TimmermansDeepika WattsVille PaakinahoMelanie EggermontJolien VandewalleCharlotte WallaeysLise Van WyngeneKelly Van LooverenLouise Nuyttens et al.

A1 Journal Article in EMBO REPORTS

Targeting and regulation of interleukin-33 signalling in lung inflammation

Aurora Holgado MuñozRudi BeyaertInna Afonina

TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C

Levi HosteLisa RoelsLeslie NaesensVictor BosteelsStijn VanheeSam DupontCedric BosteelsRobin BrowaeysNiels VandammeKevin Verstaen et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Tumor-educated T-regs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche

Kevin KosMuhammad A. AslamRieneke van de VenMax D. WellensteinWietske PietersAntoinette van WeverwijkDanique E. M. DuitsKim van PulCheei-Sing Hau Cheei-Sing HauKim Vrijland et al.

A1 Journal Article in CELL REPORTS

Unraveling the functional roles of endogenous phytohormones in mammals

Seo Woo KimRudi BeyaertAlain GoossensJens Staal

2021

Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry

Ioannis SkordosAnnelies DemeyerRudi Beyaert

A2 Journal Article in STAR PROTOCOLS

Aspergillus fumigatus recognition by dendritic cells negatively regulates allergic lung inflammation through a TLR2/MyD88 pathway

Pauline PercierSofie De PrinsGiresse TimaRudi BeyaertJohan GrootenMarta RomanoOlivier Denis

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Bidirectional crosstalk between hypoxia inducible factors and glucocorticoid signalling in health and disease

Tineke VanderhaeghenRudi BeyaertClaude Libert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Clinical, genetic and immunological evaluation of the type I interferonopathy Aicardi-Goutieres syndrome caused by mutations in RNU7-1

Leslie NaesensJosephine NemegeerTessa KerreRudi BeyaertSimon TavernierJonathan MaelfaitFilomeen Haerynck

Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice

Tim PietersSara T'SasStijn VanheeAndré Pedro Pinto De AlmeidaYasmine DriegeJuliette RoelsWouter Van LoockeWillem DaneelsMathijs BaensArnaud Marchand et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Defining the combinatorial space of PKC::CARD-CC signal transduction nodes

Jens StaalYasmine DriegeMira HaegmanMarja KreikeStella IliakiDomien VannesteMarie LorkInna AfoninaHarald BraunRudi Beyaert

A1 Journal Article in FEBS JOURNAL

GTF3A mutations in a patient with herpes simplex encephalitis reveals a novel role in viral immunity by transcribing 5S rRNA pseudogenes serving as RIG-I ligands

Leslie NaesensSantoshi MuppalaJung-Hyun LeeJosephine NemegeerDhiraj AcharyaDelfien BogaertMichiel van GentJens StaalKatrien StaesVeronique Debacker et al.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. KlionskyAmal Kamal Abdel-AzizSara AbdelfatahMahmoud AbdellatifAsghar AbdoliSteffen AbelHagai AbeliovichMarie H. AbildgaardYakubu Princely AbuduAbraham Acevedo-Arozena et al.

A1 Journal Article in AUTOPHAGY

IL-33trap-mediated IL-33 neutralization does not exacerbate choroidal neovascularization, but fails to protect against retinal degeneration in a dry age-related macular degeneration model

Inge Van HoveTine Van BergenIsabelle EtienneAurora Holgado MuñozInna AfoninaRudi BeyaertJean HM. FeyenTjing-Tjing Hu

A1 Journal Article in EXPERIMENTAL EYE RESEARCH

Immune responses and therapeutic options in psoriasis

Inna AfoninaElien Van NuffelRudi Beyaert

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Novel mutations in RNU7-1 weaken secondary RNA structure, induce MCP-1 and CXCL10 in CSF and result in Aicardi-Goutières syndrome with severe end-organ involvement

Leslie NaesensJosephine NemegeerFilip RoelensLore VallaeysMarije MeuwissenKatrien JanssensPATRICK VERLOOBenson OgunjimiDimitri HemelsoetProgram for Undiagnosed Rare Diseases (UD-PrOZA) et al.

Polo-like kinase 1 (PLK1) signaling in cancer and beyond

Stella IliakiRudi BeyaertInna Afonina

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Tailored modulation of cellular pro-inflammatory responses with disaccharide lipid A mimetics

Holger HeineFlorian AdanitschTina Tinkara PeterneljMira HaegmanChristoph KasperSimon IttigRudi BeyaertRoman JeralaAlla Zamyatina

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

The effect of hypoxia and hypoxia inducible factors on the glucocorticoid receptor function and their role during sepsis

Tineke VanderhaeghenClaude LibertRudi Beyaert

ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation

Lise Van WyngeneTineke VanderhaeghenIoanna PettaSteven TimmermansKatrien CorbeelsBart Van der SchuerenJolien VandewalleKelly Van LooverenCharlotte WallaeysMelanie Eggermont et al.

A1 Journal Article in ISCIENCE

2020

Classification and nomenclature of metacaspases and paracaspases : no more confusion with caspases

Elena A. MininaJens StaalVanina E. AlvarezJohn A. BergesIlana Berman-FrankRudi BeyaertKay D. BidleFrédéric BornancinMagali CasanovaJuan J. Cazzulo et al.

A1 Journal Article in MOLECULAR CELL

Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome

Vivien BéziatSimon TavernierYin-Huai ChenCindy S. MaMarie MaternaArian LaurenceJens StaalDominik AschenbrennerLisa RoelsLisa Worley et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Fragility can be a good thing in cancer

Annelies DemeyerRudi Beyaert

Editorial material

Long-term MALT1 inhibition in adult mice without severe systemic autoimmunity

Annelies DemeyerYasmine DriegeIoannis SkordosJulie CoudenysKelly LemeireDirk ElewautJens StaalRudi Beyaert

A1 Journal Article in ISCIENCE

MALT1 targeting suppresses CARD14‐induced psoriatic dermatitis in mice

Elien Van NuffelJens StaalGriet BaudeletMira HaegmanYasmine DriegeTino HochepiedInna AfoninaRudi Beyaert

A1 Journal Article in EMBO REPORTS

Phytohormones : multifunctional nutraceuticals against metabolic syndrome and comorbid diseases

Seo Woo KimAlain GoossensClaude LibertFilip Van ImmerseelJens StaalRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Single-chain soluble receptor fusion proteins as versatile cytokine inhibitors

Aurora Holgado MuñozHarald BraunKenneth VerstraeteDomien VannesteNico CallewaertSavvas SavvidesInna AfoninaRudi Beyaert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

ST2 as checkpoint target for colorectal cancer immunotherapy

Kevin Van der JeughtYifan SunYuanzhang FangZhuolong ZhouHua JiangTao YuJinfeng YangMalgorzata M. KamockaKa Man SoYujing Li et al.

A1 Journal Article in JCI INSIGHT

Taking the STING out of sepsis?

Jolien VandewalleTineke VanderhaeghenRudi BeyaertClaude Libert

Editorial material

Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities

Arne MartensDario PriemEsther HosteJessica VettersSofie RennenLeen CatrysseSofie VoetLaura DeelenMozes SzeHanna-Kaisa Vikkula et al.

A1 Journal Article in NATURE IMMUNOLOGY

Zinc inhibits lethal inflammatory shock by preventing microbe-induced interferon signature in intestinal epithelium

Jolien SouffriauSteven TimmermansTineke VanderhaeghenCharlotte WallaeysKelly Van LooverenLindsy AelbrechtSylviane DewaeleJolien VandewalleEvy GoossensSerge Verbanck et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

2019

A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation

Simon TavernierV AthanasopoulosPATRICK VERLOOG BehrensJens StaalDelfien BogaertLeslie NaesensMarieke De BruyneSofie Van GassenEef Parthoens et al.

A1 Journal Article in NATURE COMMUNICATIONS

CARD14/MALT1 signaling in skin homeostasis and disease

Elien Van NuffelRudi BeyaertInna Afonina

Deletion of mucosa-associated lymphoid tissue lymphoma translocation protein 1 in mouse T cells protects against development of autoimmune arthritis but leads to spontaneous osteoporosis

Elisabeth GilisDjoere GaublommeJens StaalKoen VenkenMaarten DhaenensStijn LambrechtJulie CoudenysTine DecruyNadia SchryversYasmine Driege et al.

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

Engineering a minimal cloning vector from a pUC18 plasmid backbone with an extended multiple cloning site

Jens StaalKûbra AlciWouter De SchamphelaireMartine VanhouckeRudi Beyaert

A1 Journal Article in BIOTECHNIQUES

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Andrea CossarizzaHyun-Dong ChangAndreas RadbruchAndreas AcsDieter AdamSabine Adam-KlagesWilliam W AgaceNima AghaeepourMuebeccel AkdisMatthieu Allez et al.

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

IL-33trap is a novel IL-33-neutralizing biologic that inhibits allergic airway inflammation

Aurora Holgado MuñozHarald BraunElien Van NuffelSammy DetryMartijn SchuijsKim DeswarteKarl VergoteMira HaegmanGriet BaudeletJurgen Haustraete et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Impact of TLR4 engagement on the phagosomal proteome in dendritic cells and consequences for antigen degradation and presentation

Anne-Marie PauwelsRudi BeyaertEik Hoffmann

MALT1 proteolytic activity suppresses autoimmunity in a T cell intrinsic manner

Annelies DemeyerIoannis SkordosYasmine DriegeMarja KreikeTino HochepiedMathijs BaensJens StaalRudi Beyaert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

MALT1-deficient mice develop atopic-like dermatitis upon aging

Annelies DemeyerElien Van NuffelGriet BaudeletYasmine DriegeMarja KreikeDavid MuyllaertJens StaalRudi Beyaert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Molecular regulation of T cell receptor signaling

Marie LorkRudi BeyaertJens Staal

Novel carboxylate-based glycolipids : TLR4 antagonism, MD-2 binding and self-assembly properties

Florent CochetFabio A FacchiniLenny ZaffaroniJean-Marc BillodHelena CoelhoAurora Holgado MuñozHarald BraunRudi BeyaertRoman JeralaJesus Jimenez-Barbero et al.

A1 Journal Article in SCIENTIFIC REPORTS

Spatiotemporal changes of the phagosomal proteome in dendritic cells in response to LPS stimulation

Anne-Marie PauwelsAnetta HartlovaJulien PeltierYasmine DriegeGriet BaudeletPriscille BrodinMatthias TrostRudi BeyaertEik Hoffmann

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile

Karen DendonckerSteven TimmermansJolien VandewalleMelanie EggermontJoanna LempiäinenVille PaakinahoEvelien Van HammeSylviane DewaeleSofie VandevyverMarlies Ballegeer et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitination and phosphorylation of the CARD11-BCL10-MALT1 signalosome in T cells

Marie LorkJens StaalRudi Beyaert

A1 Journal Article in CELLULAR IMMUNOLOGY

2018

A CARD9 founder mutation disrupts NF-κB signaling by inhibiting BCL10 and MALT1 recruitment and signalosome formation

Marieke De BruyneLevi HosteDelfien BogaertLien Van den BosscheSimon TavernierEef ParthoensMélanie MigaudDeborah KonopnickiJean Cyr YombiBart Lambrecht et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

A screening assay for Selective Dimerizing Glucocorticoid Receptor Agonists and Modulators (SEDIGRAM) that are effective against acute inflammation

Jolien SouffriauMelanie EggermontSara Van RyckeghemKelly Van LooverenLise Van WyngeneEvelien Van HammeMarnik VuylstekeRudi BeyaertKarolien De BosscherClaude Libert

A1 Journal Article in SCIENTIFIC REPORTS

Ancient origin of the CARD-coiled coil/Bcl10/MALT1-like paracaspase signaling complex indicates unknown critical functions

Jens StaalYasmine DriegeMira HaegmanAlice BorghiPaco HulpiauLaurens LievensIsmail Sahin GülSrividhya Sundararaman IyerAmanda GonçalvesIneke Dhondt et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Bradyrhizobium lipid A : immunological properties and molecular basis of its binding to the myeloid differentiation protein-2/toll-like receptor 4 complex

Luigi Lembo-FazioJean-Marc BillodFlaviana Di LorenzoIda PacielloMateusz PallachSara Vaz-FranciscoAurora Holgado MuñozRudi BeyaertManuel FresnoAtsushi Shimoyama et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Dichotomous function of IL-33 in health and disease : from biology to clinical implications

Harald BraunInna AfoninaChristina MuellerRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Disaccharide-based anionic amphiphiles as potent inhibitors of lipopolysaccharide-induced inflammation

Alessio BorioAurora Holgado MuñozJose Antonio GarateRudi BeyaertHolger HeineAlla Zamyatina

A1 Journal Article in CHEMMEDCHEM

Engineering a minimal cloning vector from a pUC18 plasmid backbone with an extended multiple cloning site

Jens StaalWouter De SchamphelaireRudi Beyaert

GC content of Early Metazoan genes and its impact on gene expression levels in mammalian cell lines

Ismail Sahin GülJens StaalPaco HulpiauEvi De KeuckelaereKai KammTom DerooEllen SandersKatrien StaesYasmine DriegeYvan Saeys et al.

A1 Journal Article in GENOME BIOLOGY AND EVOLUTION

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice

Marlies BallegeerKelly Van LooverenSteven TimmermansMelanie EggermontSofie VandevyverFabien Henri TheryKaren DendonckerJolien SouffriauJolien VandewalleLise Van Wyngene et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

How good roommates can protect against microbial sepsis

Rudi BeyaertClaude Libert

Editorial material

IL-33 signalling contributes to pollutant-induced allergic airway inflammation

Katrien De GroveSharen ProvoostHarald BraunEvy BlommeAndrea Renate TeufelbergerOlga KryskoRudi BeyaertGuy BrusselleGuy JoosTania Maes

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Impact of the paracaspase MALT1 on rabies virus-induced neuroinflammation and disease

Elodie KipRudi BeyaertSteven Van Gucht

Importance of validating antibodies and small compound inhibitors using genetic knockout studies : T cell receptor-induced CYLD phosphorylation by IKKε/TBK1 as a case study

Marie LorkMarja KreikeJens StaalRudi Beyaert

A1 Journal Article in FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

Inflammation and NF-κB signaling in prostate cancer : mechanisms and clinical implications

Jens StaalRudi Beyaert

A1 Journal Article in CELLS

Inhibition of MALT1 decreases neuroinflammation and pathogenicity of virulent rabies virus in mice

Elodie KipJens StaalHG TimaLynn VerstrepenM RomanoKelly LemeireV SuinA HamoudaM BaensClaude Libert et al.

A1 Journal Article in JOURNAL OF VIROLOGY

Lipid A structural characterization from the LPS of the Siberian psychro-tolerant Psychrobacter arcticus 273-4 grown at low temperature

Angela CasilloMarcello ZiacoBuko LindnerErmenegilda ParrilliDominik SchwudkeAurora Holgado MuñozRudi BeyaertRosa LanzettaMaria Luisa TutinoMaria Michela Corsaro

A1 Journal Article in EXTREMOPHILES

MALT1 controls attenuated rabies virus by inducing early inflammation and T cell activation in the brain

Elodie KipJens StaalLynn VerstrepenHG TimaS TerrynM RomanoKelly LemeireV SuinA HamoudaM Kalai et al.

A1 Journal Article in JOURNAL OF VIROLOGY

Mepazine inhibits RANK-induced osteoclastogenesis independent of its MALT1 inhibitory function

Laura MeloniLynn VerstrepenMarja KreikeJens StaalYasmine DriegeInna AfoninaRudi Beyaert

A1 Journal Article in MOLECULES

Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasis

Patrik AnderssonYunlong YangKayoko HosakaYin ZhangCarina FischerHarald BraunShuzhen LiuGuohua YuShihai LiuRudi Beyaert et al.

A1 Journal Article in JCI INSIGHT

Psoriasis plays a wild CARD

Elien Van NuffelInna AfoninaRudi Beyaert

Editorial material

Structure-activity relationship in monosaccharide-based Toll-like receptor 4 (TLR4) antagonists

Fabio A FacchiniLenny ZaffaroniAlberto MinottiSilvia RapisardaValentina CalabreseMatilde ForcellaPaola FusiCristina AiroldiCarlotta CiaramelliJean-Marc Billod et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Synthetic glycan-based TLR4 agonists targeting caspase-4/11 for the development of adjuvants and immunotherapeutics

Florian AdanitschJianjin ShiFeng ShaoRudi BeyaertHolger HeineAlla Zamyatina

A1 Journal Article in CHEMICAL SCIENCE

The E3 ubiquitin ligases HOIP and cIAP1 are recruited to the TNFR2 signaling complex and mediate TNFR2-induced canonical NF-κB signaling

Alice BorghiMira HaegmanRoman FischerIsabelle CarpentierMathieu BertrandClaude LibertInna AfoninaRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

The IL-33/ST2 axis is crucial in type 2 airway responses induced by Staphylococcus aureus-derived serine protease-like protein D

Andrea Renate TeufelbergerMaria NordengrünHarald BraunTania MaesKatrien De GroveGabriële HoltappelsClara O'BrienSharen ProvoostHamida HammadAmanda Gonçalves et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

2017

A CARD9 Turkisch founder mutation disrupts NF-κB signaling by inhibiting Bcl10 recruitment

Marieke De BruyneLevi HosteDelfien BogaertMélanie MigaudDeborah KonopnickiBart LambrechtRudi BeyaertElfride De BaereAnne PuelJean-Christophe Goffard et al.

A20 deletion in T cells modulates acute graft-versus-host disease in mice

Julius C FischerVera OttenKatja SteigerMartina SchmicklJulia Slotta-HuspeninaRudi BeyaertGeert van LooChristian PeschelHendrik PoeckTobias Haas et al.

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

A20 inhibition of STAT1 expression in myeloid cells : a novel endogenous regulatory mechanism preventing development of enthesitis

Katelijne De WildeArne MartensStijn LambrechtPeggy JacquesMichael DrennanKarlijn DebusschereSrinath GovindarajanJulie CoudenysEveline VerheugenFien Windels et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

A20 restrains thymic regulatory T cell development

Julius Clemens FischerVera OttenMaike KoberChristoph DreesMarc RosenbaumMartina SchmicklSimon HeideggerRudi BeyaertGeert van LooXian Chang Li et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Abscisic acid as pathogen effector and immune regulator

Laurens LievensJacob PollierAlain GoossensRudi BeyaertJens Staal

A1 Journal Article in FRONTIERS IN PLANT SCIENCE

CARD14-mediated activation of paracaspase MALT1 in keratinocytes : implications for psoriasis

Elien Van NuffelAnja SchmittInna AfoninaKlaus Schulze-OsthoffRudi BeyaertStephan Hailfinger

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

CARD9 p.R70W, a Turkish founder mutation associated with mucosal and invasive fungal infections, disrupts downstream NF-κB signaling by inhibiting Bcl10 recruitment

Marieke De BruyneDelfien BogaertLevi HosteMélanie MigaudJean-Christophe GoffardDeborah KonopnickiBart LambrechtRudi BeyaertElfride De BaereAnne Puel et al.

CARD9 p.R70W, a Turkish founder mutation associated with mucosal and invasive fungal infections, disrupts downstream NF-κB signaling by inhibiting Bcl10 recruitment

Marieke De BruyneLevi HosteDelfien BogaertMélanie MigaudJean-Christophe GoffardDeborah KonopnickiBart LambrechtRudi BeyaertElfride De BaereAnne Puel et al.

CARD9 p.R70W, a Turkish founder mutation associated with mucosal and invasive fungal infections, disrupts downstream NF-κB signaling by inhibiting Bcl10 recruitment

Marieke De BruyneDelfien BogaertLevi HosteMélanie MigaudJean-Christophe GoffardDeborah KonopnickiBart LambrechtRudi BeyaertElfride De BaereAnne Puel et al.

CYLD, A20 and OTULIN deubiquitinases in NF-κB signaling and cell death : so similar, yet so different

Marie LorkKelly VerhelstRudi Beyaert

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Diabetes and inflammation : how A20 regulates tissue homeostasis in metabolic tissues

Leen CatrysseGeert van LooRudi Beyaert

IL-17 Signaling triggers degradation of the constitutive NF-κB inhibitor ABIN-1

J Agustin CruzErin E ChildsNilesh AmatyaAbhishek V GargRudi BeyaertLawrence P KaneBrian J AneskievichAveril MaSarah L Gaffen

A2 Journal Article in IMMUNOHORIZONS

Impact of caspase-1/11, -3, -7, or IL-1β/IL-18 deficiency on rabies virus-induced macrophage cell death and onset of disease

Elodie KipF NazéV SuinTom Vanden BergheA FrancartS LamoralPeter VandenabeeleRudi BeyaertSteven Van GuchtM Kalai

A1 Journal Article in CELL DEATH DISCOVERY

Inflammatory properties and adjuvant potential of synthetic glycolipids homologous to mycolate esters of the cell wall of Mycobacterium tuberculosis

Hermann Giresse TimaJuma'a Raheem Al DulayymiOlivier DenisPauline LehebelKlarah Sherzad BaolsMohsin Omar MohammedLaurent L'HommeMohaned Mohammed SahbGeorges PotembergSylvie Legrand et al.

A1 Journal Article in JOURNAL OF INNATE IMMUNITY

Limiting inflammation : the negative regulation of NF-κB and the NLRP3 inflammasome

Inna AfoninaZhenyu ZhongMichael KarinRudi Beyaert

A1 Journal Article in NATURE IMMUNOLOGY

Patterns, receptors, and signals : regulation of phagosome maturation

Eik HoffmannAnne-Marie PauwelsMatthias TrostRudi Beyaert

A1 Journal Article in TRENDS IN IMMUNOLOGY

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma

Kenneth VerstraeteFrank PeelmanHarald BraunJuan LopezDries Van RompaeyAnn DansercoerIsabel VandenbergheKris PauwelsJan TavernierBart Lambrecht et al.

A1 Journal Article in NATURE COMMUNICATIONS

The paracaspase MALT1 plays a central role in the pathogenesis of rheumatoid arthritis

Elisabeth GilisJens StaalRudi BeyaertDirk Elewaut

Unusual lipid A from a cold-adapted bacterium : detailed structural characterization

Angela CasilloMarcello ZiacoBuko LindnerErmenegilda ParrilliDominik SchwudkeAurora Holgado MuñozLynn VerstrepenFilomena SanninoRudi BeyaertRosa Lanzetta et al.

A1 Journal Article in CHEMBIOCHEM

2016

99mTc-labelled S-HYNIC certolizumab pegol in rheumatoid arthritis and spondyloarthritis patients : a biodistribution and dosimetry study

Bieke LambertPhilippe CarronYves D'AsselerKlaus BacherFilip Van den BoschDirk ElewautAugust VerbruggenRudi BeyaertCaroline DumolynFilip De Vos

A1 Journal Article in EJNMMI RESEARCH

A20 deficiency in lung epithelial cells protects against influenza A virus infection

Jonathan MaelfaitKenny RooseLars VereeckeConor Mc GuireMozes SzeMartijn SchuijsMonique WillartLorena IbanezHamida HammadBart Lambrecht et al.

A1 Journal Article in PLOS PATHOGENS

A20 inhibits β-cell apoptosis by multiple mechanisms and predicts residual β-cell function in type 1 diabetes

Makiko FukayaCaroline A BrorssonKira MeyerovichLeen CatrysseDiane DelarocheEmerielle C VanzelaFernanda OrtisRudi BeyaertLotte B NielsenMarie L Andersen et al.

A1 Journal Article in MOLECULAR ENDOCRINOLOGY

A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death

Leen CatrysseMorvarid Farhang GhahremaniLars VereeckeSA YoussefConor Mc GuireMozes SzeA WeberM HeikenwalderA de BruinRudi Beyaert et al.

A1 Journal Article in CELL DEATH & DISEASE

Functional characterization of the paracaspase MALT1 in T cells

Annelies DemeyerRudi BeyaertJens Staal

MALT1 cleaves the E3 ubiquitin ligase HOIL-1 in activated T cells, generating a dominant negative inhibitor of LUBAC-induced NF-κB signaling

Lynn EltonIsabelle CarpentierJens StaalYasmine DriegeMira HaegmanRudi Beyaert

A1 Journal Article in FEBS JOURNAL

MALT1 contributes to the pathogenicity of the virulent rabies virus CVS-11 in mice

Elodie KipVanessa SuinJens StaalRudi BeyaertSteven Van Gucht

MALT1 is not alone after all : identification of novel paracaspases

Paco HulpiauYasmine DriegeJens StaalRudi Beyaert

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Molecular mechanisms of mechanotransduction and osteoclastogenesis in arthritis

Laura MeloniRudi BeyaertKelly Verhelst

Monitoring ubiquitin-coated bacteria via confocal microscopy

Marie LorkMieke DelvaeyeAmanda GonçalvesEvelien Van HammeRudi Beyaert

Bookchapter in Proteostasis

New insight into the ubiquitin-mediated regulation of TNFR2 signaling

Alice BorghiRudi BeyaertIsabelle Carpentier

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNF AIP3/A20

Michael DrennanSrinath GovindarajanEveline VerheugenJonathan CoquetJens StaalConor Mc GuireTom TaghonGeorges LeclercqRudi BeyaertGeert van Loo et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling

Karolina SlowickaLars VereeckeConor Mc GuireMozes SzeJonathan MaelfaitAnnasaheb KolpeXavier SaelensRudi BeyaertGeert van Loo

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Perinatal activation of the interleukin-33 pathway promotes type 2 immunity in the developing lung

Ismé De KleerMirjam KoolMarjolein JW de BruijnMonique WillartJustine Van MoorleghemMartijn SchuijsMaud PlantingaRudi BeyaertEmily HamsPadraic G Fallon et al.

A1 Journal Article in IMMUNITY

Targeting MALT1 proteolytic activity in immunity, inflammation and disease: good or bad?

Annelies DemeyerJens StaalRudi Beyaert

A1 Journal Article in TRENDS IN MOLECULAR MEDICINE

The paracaspase MALT1 mediates CARD14-induced signaling in keratinocytes

Inna AfoninaElien Van NuffelGriet BaudeletYasmine DriegeMarja KreikeJens StaalRudi Beyaert

A1 Journal Article in EMBO REPORTS

The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages

Yunlong YangPatrik AnderssonKayoko HosakaYin ZhangRenhai CaoHideki IwamotoXiaojuan YangMasaki NakamuraJian WangRujie Zhuang et al.

A1 Journal Article in NATURE COMMUNICATIONS

The protease SplD provides a link between asthma and mucosal S. aureus colonization

Andrea Renate TeufelbergerS StentzelHarald BraunTania MaesGabriële HoltappelsSharen ProvoostKatrien De GroveRudi BeyaertDmitri KryskoB Broeker et al.

Trabid epigenetically drives expression of IL-12 and IL-23

Inna AfoninaRudi Beyaert

Editorial material

TRAF2 multitasking in TNF receptor-induced signaling to NF-κB, MAP kinases and cell death

Alice BorghiLynn VerstrepenRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Yolk sac macrophages, fetal liver, and adult monocytes can colonize an empty niche and develop into functional tissue-resident macrophages

Lianne van de LaarWouter SaelensSofie De PrijckLiesbet MartensCharlotte ScottGert Van IsterdaelEik HoffmannRudi BeyaertYvan SaeysBart Lambrecht et al.

A1 Journal Article in IMMUNITY

2015

A20 deficiency sensitizes pancreatic beta cells to cytokine-induced apoptosis in vitro but does not influence type 1 diabetes development in vivo

Leen CatrysseM FukayaMozes SzeK MeyerovichRudi BeyaertAK CardozoGeert van Loo

A1 Journal Article in CELL DEATH & DISEASE

Anti-endotoxic activity and structural basis for human MD-2∙TLR4 antagonism of tetraacylated lipid A mimetics based on βGlcN(l↔l)αGlcN scaffold

Jose Antonio GarateJohannes StöcklMaría del Carmen Fernández-AlonsoDaniel ArtnerMira HaegmanChris OostenbrinkJesús Jiménez-BarberoRudi BeyaertHolger HeinePaul Kosma et al.

A1 Journal Article in INNATE IMMUNITY

Chemical synthesis of Burkholderia Lipid A modified with glycosyl phosphodiester-linked 4-amino-4-deoxy-beta-L-arabinose and its immunomodulatory potential

Ralph HollausSimon IttigAndreas HofingerMira HaegmanRudi BeyaertPaul KosmaAlla Zamyatina

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

Martijn SchuijsMonique WillartKarl VergoteDelphine GrasKim DeswarteMarkus J EgeFilipe Branco MadeiraRudi BeyaertGeert van LooFranz Bracher et al.

A1 Journal Article in SCIENCE

Interleukin-21-producing CD4(+) T cells promote type 2 immunity to house dust mites

Jonathan CoquetMartijn SchuijsMark J SmythKim DeswarteRudi BeyaertHarald BraunLouis BoonGunilla B Karlsson HedestamSteven L NuttHamida Hammad et al.

A1 Journal Article in IMMUNITY

MALT1-a universal soldier: multiple strategies to ensure NF-κB activation and target gene expression

Inna AfoninaLynn EltonIsabelle CarpentierRudi Beyaert

A1 Journal Article in FEBS JOURNAL

MicroRNA let-7 modulates the immune response to Mycobacterium tuberculosis infection via control of A20, an inhibitor of the NF-κB pathway

Manish KumarSanjaya Kumar SahuRanjeet KumarArijita SubuddhiRanjan Kumar MajiKuladip JanaPushpa GuptaJohanna RaffetsederMaria LermZhumur Ghosh et al.

A1 Journal Article in CELL HOST & MICROBE

Proteolytic processing of interleukin-1 family cytokines: variations on a common theme

Inna AfoninaChristina MüllerSeamus J MartinRudi Beyaert

A1 Journal Article in IMMUNITY

Regulation of macrophage motility by the water channel aquaporin-1 : crucial role of M0/M2 phenotype switch

Donatienne TytecaTomoya NishinoHuguette DebaixPatrick Van Der SmissenFrancisca N'KuliDelia HoffmannYvette CnopsVirginie RabolliGeert van LooRudi Beyaert et al.

A1 Journal Article in PLOS ONE

Role of the bacterial type VI secretion system in the modulation of mammalian host cell immunity

Marlies De CeuleneerMartine VanhouckeRudi Beyaert

A1 Journal Article in CURRENT MEDICINAL CHEMISTRY

The multifaceted role of the E3 ubiquitin ligase HOIL-1: beyond linear ubiquitination

Lynn EltonIsabelle CarpentierKelly VerhelstJens StaalRudi Beyaert

A1 Journal Article in IMMUNOLOGICAL REVIEWS

Toll-like receptor 4 engagement on dendritic cells restrains phago-lysosome fusion and promotes cross-presentation of antigens

Andrés AlloattiFiorlla KotsiasAnne-Marie PauwelsJean-Marie CarpierMabel JouveEvy TimmermanLuigia PacePablo VargasMathieu MaurinUlf Gehrmann et al.

A1 Journal Article in IMMUNITY

XEDAR activates the non-canonical NF-κB pathway

Kelly VerhelstSandra GardamAlice BorghiMarja KreikeIsabelle CarpentierRudi Beyaert

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

2014

A20 controls intestinal homeostasis through cell-specific activities

Lars VereeckeSara Vieira-SilvaThomas BillietJohan H van EsConor Mc GuireKarolina SlowickaMozes SzeMaaike van den BornGert De HertoghHans Clevers et al.

A1 Journal Article in NATURE COMMUNICATIONS

A20 in inflammation and autoimmunity

Leen CatrysseLars VereeckeRudi BeyaertGeert van Loo

A1 Journal Article in TRENDS IN IMMUNOLOGY

A20-Deficient mast cells exacerbate inflammatory responses in vivo

Klaus HegerKaat FierensJ Christoph VahlAttila AszodiKatrin PeschkeDominik SchentenHamida HammadRudi BeyaertDieter SaurGeert van Loo et al.

A1 Journal Article in PLOS BIOLOGY

A20: attractive without showing cleavage

Kelly VerhelstGeert van LooRudi Beyaert

Editorial material

An E3 ubiquitin ligase-independent role of LUBAC

Editorial material

Development of αGlcN(1 <-> 1)αMan-based Lipid A mimetics as a novel class of potent Toll-like Receptor 4 agonists

Florian AdanitschSimon IttigJohannes StöcklAlja OblakMira HaegmanRoman JeralaRudi BeyaertPaul KosmaAlla Zamyatina

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Epithelial-mesenchymal crosstalk during lung development and regeneration

Thomas VolckaertRudi BeyaertStijn De Langhe

Identification and functional characterization of novel MALT1 substrates

Lynn EltonRudi BeyaertJens Staal

IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice

R GuabirabaAG BesnardGB MenezesT SecherMS JabirSS AmaralHarald BraunRCP LimaRA RibeiroFQ Cunha et al.

A1 Journal Article in MUCOSAL IMMUNOLOGY

Molecular and functional characterization of interleukin-33 signaling

Christina MüllerRudi Beyaert

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

Lieselotte Vande WalleNina Van OpdenboschPeggy JacquesAmelie FossoulEveline VerheugenPeter VogelRudi BeyaertDirk ElewautThirumala-Devi KannegantiGeert van Loo et al.

A1 Journal Article in NATURE

Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis

Conor Mc GuireLynn EltonPeter WieghoferJens StaalSofie VoetAnnelies DemeyerDaniel NagelDaniel KrappmannMarco PrinzRudi Beyaert et al.

A1 Journal Article in JOURNAL OF NEUROINFLAMMATION

Priming IKKβ kinase for action

Steven C LeyRudi Beyaert

Editorial material

Receptor proximal kinases in NF-κB signaling as potential therapeutic targets in cancer and inflammation

Lynn VerstrepenRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

The biology of A20-binding inhibitors of NF-κB activation (ABINs)

Lynn VerstrepenIsabelle CarpentierRudi Beyaert

A1 Journal Article in Advances in Experimental Medicine and Biology

The tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) imposes a brake on antitumor activity of CD8 T cells

Marilyn GiordanoRomain RoncagalliPierre BourdelyLionel ChassonMichel BuferneSho YamasakiRudi BeyaertGeert van LooNathalie Auphan-AnezinAnne-Marie Schmitt-Verhulst et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2013

Cancer risk in immune-mediated inflammatory diseases (IMID)

Rudi BeyaertLaurent BeaugerieGert Van AsscheLieve BrochezJean-Christophe RenauldManuelle ViguierVeronique CocquytGuy JerusalemJean-Pascal MachielsHans Prenen et al.

A1 Journal Article in MOLECULAR CANCER

IκB kinase ε (IKKε): a therapeutic target in inflammation and cancer

Kelly VerhelstLynn VerstrepenIsabelle CarpentierRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology

Conor Mc GuireMarco PrinzRudi BeyaertGeert van Loo

A1 Journal Article in TRENDS IN MOLECULAR MEDICINE

Overexpression of the nuclear factor kappaB inhibitor A20 is neurotoxic after an excitotoxic injury to the immature rat brain

Hugo PeluffoPaul GonzalezLaia AcarinAnna ArísRudi BeyaertAntonio VillaverdeBerta Gonzalez

A1 Journal Article in NEUROLOGICAL RESEARCH

Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination

Conor Mc GuirePeter WieghoferLynn EltonDavid MuylaertMarco PrinzRudi BeyaertGeert van Loo

A1 Journal Article in JOURNAL OF IMMUNOLOGY

The study of signaling pathways controlling central nervous system inflammation and pathology

Conor Mc GuireGeert van LooRudi Beyaert

The ubiquitin editing enzyme A20 (TNFAIP3) is upregulated during permanent middle cerebral artery occlusion but does not influence disease outcome

Conor Mc GuireM RahmanM SchwaningerRudi BeyaertGeert van Loo

A1 Journal Article in CELL DEATH & DISEASE

2012

A two-step activation mechanism of MALT1 paracaspase

Jens StaalRudi Beyaert

Editorial material

A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection

Jonathan MaelfaitKenny RoosePieter BogaertMozes SzeXavier SaelensManolis PasparakisIsabelle CarpentierGeert van LooRudi Beyaert

A1 Journal Article in PLOS PATHOGENS

A20 and CYLD do not share significant overlapping functions during B cell development and activation

Yuanyuan ChuValeria SoberonLaura GlocknerRudi BeyaertRamin MassoumiGeert van LooDaniel KrappmannMarc Schmidt-Supprian

A1 Journal Article in JOURNAL OF IMMUNOLOGY

A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7

Kelly VerhelstIsabelle CarpentierMarja KreikeLaura MeloniLynn VerstrepenTobias KenscheIvan DikicRudi Beyaert

A1 Journal Article in EMBO JOURNAL

Emerging role of ubiquitination in antiviral RIG-I signaling

Jonathan MaelfaitRudi Beyaert

A1 Journal Article in MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Identification of interaction sites for dimerization and adapter recruitment in Toll/interleukin-1 receptor (TIR) domain of Toll-like receptor 4

Celia BovijnPeter UlrichtsAnne-Sophie De SmetDominiek CatteeuwRudi BeyaertJan TavernierFrank Peelman

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33

Monique WillartKim DeswartePhilippe PouliotHarald BraunRudi BeyaertBart LambrechtHamida Hammad

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

No ubiquitin anchors and fully RIGged

Lynn VerstrepenRudi Beyaert

Editorial material

Structure and function of the type III secretion system of Pseudomonas aeruginosa

Marlies GalleIsabelle CarpentierRudi Beyaert

A1 Journal Article in CURRENT PROTEIN & PEPTIDE SCIENCE

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock

Ezra AksoySalma TaboubiDavid TorresSandrine DelbauveAbderrahman HachaniMaria A WhiteheadWayne P PearceInma Berenjeno-MartinGemma NockAlain Filloux et al.

A1 Journal Article in NATURE IMMUNOLOGY

The Pseudomonas aeruginosa type III secretion system has an exotoxin S/T/Y independent pathogenic role during acute lung infection

Marlies GalleShouguang JinPieter BogaertMira HaegmanPeter VandenabeeleRudi Beyaert

A1 Journal Article in PLOS ONE

2011

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

Mourad MatmatiPeggy JacquesJonathan MaelfaitEveline VerheugenMirjam KoolMozes SzeLies GeboesEls LouagieConor Mc GuireLars Vereecke et al.

A1 Journal Article in NATURE GENETICS

A20 (TNFAIP3) deficiency in myeloid cells triggers rheumatoid arthritis

Dirk ElewautMourad MatmatiPeggy JacquesJonathan MaelfaitEveline VerheugenMirjam KoolMozes SzeLies GeboesEls LouagieConor Mc Guire et al.

B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice

Yuanyuan ChuJ Christoph VahlDilip KumarKlaus HegerArianna BertossiEdyta WojtowiczValeria SoberonDominik SchentenBrigitte MackMiriam Reutelshofer et al.

A1 Journal Article in BLOOD

Controlling inflammation and cell death at the intestinal epithelial interface and beyond: lessons from conditional A20 knockout mice

Lars VereeckeRudi BeyaertGeert van Loo

Death receptor signalling in central nervous system inflammation and demyelination

Conor Mc GuireRudi BeyaertGeert van Loo

A1 Journal Article in TRENDS IN NEUROSCIENCES

Enterocyte death and intestinal barrier maintenance in homeostasis and disease

Lars VereeckeRudi BeyaertGeert van Loo

A1 Journal Article in TRENDS IN MOLECULAR MEDICINE

Genetic relationships between A20/TNFAIP3, chronic inflammation and autoimrnune disease

Lars VereeckeRudi BeyaertGeert van Loo

A1 Journal Article in BIOCHEMICAL SOCIETY TRANSACTIONS

Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis

Saskia LippensS LefebvreBarbara GilbertMozes SzeMichael DevosKelly VerhelstLars VereeckeConor Mc GuireChris GuerinPeter Vandenabeele et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Linear ubiquitination in NF-κB signaling and inflammation: what we do understand and what we do not

Kelly VerhelstLynn VerstrepenIsabelle CarpentierRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Negative regulation of NF-κB and its involvement in rheumatoid arthritis

Geert van LooRudi Beyaert

A1 Journal Article in ARTHRITIS RESEARCH & THERAPY

Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for toll-like receptor activation and cellular signaling

Samar AbdulkhalekSchammim Ray AmithSusan L FranchukPreethi JayanthMerry GuoTrisha FinlayAlanna GilmourChristina GuzzoKatrina GeeRudi Beyaert et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of NF-κB signaling by caspases and MALT1 paracaspase

Jens StaalTine BekaertRudi Beyaert

A1 Journal Article in CELL RESEARCH

Regulation of TNF-induced NF-κB activation by different cytoplasmic ubiquitination events

Kelly VerhelstIsabelle CarpentierRudi Beyaert

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

SHP works a double shift to control TLR signaling

Editorial material

Signaling in antiviral immunity and its regulation by the ubiquitin-editing protein A20

Jonathan MaelfaitRudi BeyaertGeert van Loo

T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1

Jens StaalYasmine DriegeTine BekaertAnnelies DemeyerDavid MuyllaertPetra Van DammeKris GevaertRudi Beyaert

A1 Journal Article in EMBO JOURNAL

TAX1BP1, a ubiquitin-binding adaptor protein in innate immunity and beyond

Lynn VerstrepenKelly VerhelstIsabelle CarpentierRudi Beyaert

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

The kinase NIK as a therapeutic target in multiple myeloma

Sandra GardamRudi Beyaert

A1 Journal Article in EXPERT OPINION ON THERAPEUTIC TARGETS

The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity

Mirjam KoolGeert van LooWim WaelputSofie De PrijckFemke MuskensMozes SzeJens Van PraetFilipe Branco MadeiraSophie JanssensBoris Reizis et al.

A1 Journal Article in IMMUNITY

2010

Antiinflammatory Properties of a Plant-Derived Nonsteroidal, Dissociated Glucocorticoid Receptor Modulator in Experimental Autoimmune Encephalomyelitis

Geert van LooMozes SzeNadia BougarneJelle PraetConor Mc GuireAndrea UllrichGuy HaegemanMarco PrinzRudi BeyaertKarolien De Bosscher

A1 Journal Article in MOLECULAR ENDOCRINOLOGY

Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site

Peter UlrichtsCelia BovijnSam LievensRudi BeyaertJan TavernierFrank Peelman

A1 Journal Article in JOURNAL OF CELL SCIENCE

Caspase-11 mediates ischemia-induced astrocyte death: involvement of endoplasmic reticulum stress and C/EBP homologous protein

Noelia FradejasMaría Dolores PastorMiguel BurgosRudi BeyaertPedro TranqueSoledad Calvo

A1 Journal Article in JOURNAL OF NEUROSCIENCE RESEARCH

Cleavage by MALT1 induces cytosolic release of A20

Claire MalinverniAdeline UnterreinerJens StaalAnnelies DemeyerMarion GalaupMarcel LuytenRudi BeyaertFrédéric Bornancin

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endoplasmic reticulum chaperone gp96 is essential for infection with vesicular stomatitis virus

Stuart BloorJonathan MaelfaitRebekka KrumbachRudi BeyaertFelix Randow

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis

Lars VereeckeMozes SzeConor Mc GuireBrecht RogiersYuanyuan ChuMarc Schmidt-SupprianManolis PasparakisRudi BeyaertGeert van Loo

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Expression, biological activities and mechanisms of action of A20 (TNFAIP3)

Lynn VerstrepenKelly VerhelstGeert van LooIsabelle CarpentierSteven C LeyRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

In macrophages, Caspase-1 activation by SopE and the type III secretion system-1 of S. Typhimurium can proceed in the absence of flagellin

Claudia HoffmannMarlies GalleSabrina DillingRina KappeliAndreas J MullerPascal SonghetRudi BeyaertWolf-Dietrich Hardt

A1 Journal Article in PLOS ONE

Modulation of macrophage immune responses by the Pseudomonas aeruginosa type III secretion system

Marlies GalleRudi Beyaert

Neu1 desialylation of sialyl alpha-2,3-linked beta-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling

SR AmithP JayanthS FranchukT FinlayV SeyrantepeRudi BeyaertAV PshezhetskyMR Szewczuk

A1 Journal Article in CELLULAR SIGNALLING

Oligodendrocyte-specific FADD deletion protects mice from autoimmune-mediated demyelination

Conor Mc GuireThomas VolckaertUta WolkeMozes SzeRiet De RyckeAri WaismanMarco PrinzRudi BeyaertManolis PasparakisGeert van Loo

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Pharmacodynamics of tepoxalin, sodium-salicylate and ketoprofen in an intravenous lipopolysaccharide inflammation model in broiler chickens

Sandra De BoeverEva NeirinckxEvelyne MeyerSiegrid De BaereRudi BeyaertPatrick De BackerSiska Croubels

A1 Journal Article in JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR G alpha i proteins and matrix metalloproteinase-9

Trisha M FinlayPreethi JayanthSchammim Ray AmithAlanna GilmourChristina GuzzoKatrina GeeRudi BeyaertMyron R Szewczuk

A1 Journal Article in GLYCOCONJUGATE JOURNAL

Thymoquinone-induced Neu4 sialidase activates NFκB in macrophage cells and pro-inflammatory cytokines in vivo

Trisha M FinlaySamar AbdulkhalekAlanna GilmourChristina GuzzoPreethi JayanthSchammim Ray AmithKatrina GeeRudi BeyaertMyron R Szewczuk

A1 Journal Article in GLYCOCONJUGATE JOURNAL

2009

A20: Central Gatekeeper in Inflammation and Immunity

Beatrice CoornaertIsabelle CarpentierRudi Beyaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling

Lynn VerstrepenIsabelle CarpentierKelly VerhelstRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Attenuated Expression of A20 Markedly Increases the Efficacy of Double-Stranded RNA-Activated Dendritic Cells As an Anti-Cancer Vaccine

Karine BreckpotCindy Aerts-ToegaertCarlo HeirmanUschi PeetersRudi BeyaertJoeri L AertsKris Thielemans

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Cellular expression of A20 and ABIN-3 in response to Toll-like receptor-4 stimulation

Kelly VerhelstLynn VerstrepenBeatrice CoornaertIsabelle CarpentierRudi Beyaert

Bookchapter in Toll-like receptors : methods and protocols

Characterization of an intravenous lipopolysaccharide inflammation model in broiler chickens

Sandra De BoeverSiska CroubelsEvelyne MeyerStanislas SysRudi BeyaertRichard DucatellePatrick De Backer

A1 Journal Article in AVIAN PATHOLOGY

Characterization of epidermal growth factor (EGF) receptor targetting nanobodies and ABIN for the treatment of EGF receptor-dependent tumours

Lieven HuangPatrick De BaetselierRudi Beyaert

Dependence of pathogen molecule-induced Toll-like receptor activation and cell function on Neu1 sialidase

Schammim Ray AmithPreethi JayanthSusan FranchukSarah SiddiquiVolkan SeyrantepeKatrina GeeSameh BastaRudi BeyaertAlexey V PshezhetskyMyron R Szewczuk

A1 Journal Article in GLYCOCONJUGATE JOURNAL

High-fat nutrition reduces hepatic damage following exposure to bacterial DNA and hemorrhagic shock

Misha DP LuyerJoep PM DerikxRudi BeyaertM'hamed HadfouneToin H van KuppeveltCornelis HC DejongErik HeinemanWim A BuurmanJan Willem M Greve

A1 Journal Article in JOURNAL OF HEPATOLOGY

MAPPIT (Mammalian Protein-Protein Interaction Trap) analysis of early steps in Toll-like receptor signalling

Peter UlrichtsIrma LemmensDelphine LavensRudi BeyaertJan Tavernier

Bookchapter in Toll-like receptors : methods and protocols

Pharmacodynamic properties of salicylate, tepoxalin and ketoprofen in an intravenous LPS inflammation model in broiler chickens

Sandra De BoeverEva NeirinckxRudi BeyaertPatrick De BackerSiska Croubels

Targeting the EGF receptor ectodomain in the context of cancer

Lieven HuangPatrick De BaetselierRudi Beyaert

A1 Journal Article in EXPERT OPINION ON THERAPEUTIC TARGETS

The S. Typhimurium Effector SopE Induces Caspase-1 Activation in Stromal Cells to Initiate Gut Inflammation

Andreas J. MuellerClaudia HoffmannMarlies GalleAeke Van den BroekeMathias HeikenwalderLaura FalterBenjamin MisselwitzMarcus KremerRudi BeyaertWolf-Dietrich Hardt

A1 Journal Article in CELL HOST & MICROBE

The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology

Lars VereeckeRudi BeyaertGeert van Loo

A1 Journal Article in TRENDS IN IMMUNOLOGY

Translational control of eukaryotic gene expression

Katrien Van Der KelenRudi BeyaertDirk InzéLieven De Veylder

A1 Journal Article in Critical Reviews in Biochemistry and Molecular Biology

2008

ABINs inhibit EGF receptor-mediated NF-kappa B activation and growth of EGF receptor-overexpressing tumour cells

Lieven HuangLynn VerstrepenKaren HeyninckAndy WullaertH REVETSP DE BAETSELIERRudi Beyaert

A1 Journal Article in ONCOGENE

Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated?

TL CHAUR GIOIAJS GATOTF PATRASCUIsabelle CarpentierJP CHAPELLEL O'NEILRudi BeyaertJ PIETTEA CHARIOT

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

Expression of the NF-kappa B inhibitor ABIN-3 in response to TNF and toll-like receptor 4 stimulation is itself regulated by NF-kappa B

Lynn VerstrepenM ADIB-CONQUYMarja KreikeIsabelle CarpentierC ADRIEJM CAVAILLONRudi Beyaert

A1 Journal Article in JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappa B activation

H IHAJM PELOPONESELynn VerstrepenG ZAPARTF IKEDACD SMITHMF STAROSTV YEDAVALLIKaren HeyninckI DIKIC et al.

A1 Journal Article in EMBO JOURNAL

Non-apoptotic functions of caspase-8

Jonathan MaelfaitRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Prolonged exposure to IL-1 beta and IFN gamma induces necrosis of L929 tumor cells via a p38MAPK/NF-kappa B/NO-dependent mechanism

Elisabeth VercammenJens StaalAeke Van Den BroekeMira HaegmanLars VereeckePeter SchotteRudi Beyaert

A1 Journal Article in ONCOGENE

Sensing of viral infection and activation of innate immunity by toll-like receptor 3

Elisabeth VercammenJens StaalRudi Beyaert

A1 Journal Article in CLINICAL MICROBIOLOGY REVIEWS

Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation

Isabelle CarpentierBeatrice CoornaertRudi Beyaert

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8

Jonathan MaelfaitElisabeth VercammenSophie JanssensPeter SchotteMira HaegmanStefan MagezRudi Beyaert

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappa B inhibitor A20

Beatrice CoornaertM BAENSKaren HeyninckTine BekaertMira HaegmanJens StaalLJ SUNZJJ CHENP MARYNENRudi Beyaert

A1 Journal Article in NATURE IMMUNOLOGY

The influence of age and repeated lipopolysaccharide administration on body temperature and the concentration of interleukin-6 and IgM antibodies against lipopolysaccharide in broiler chickens

Sandra De BoeverRudi BeyaertF VANDEMAELEKris BaertLuc DuchateauBruno GoddeerisPatrick De BackerSiska Croubels

A1 Journal Article in AVIAN PATHOLOGY

The Pseudomonas aeruginosa Type III secretion system plays a dual role in the regulation of caspase-1 mediated IL-1 beta maturation

Marlies GallePeter SchotteMira HaegmanAndy WullaertHJ YANGS JINRudi Beyaert

A1 Journal Article in JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

TLR-4, IL-1R and TNF-R signaling to NF-kappa B: variations on a common theme

Lynn VerstrepenTine BekaertTL CHAUJan TavernierA CHARIOTRudi Beyaert

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Ubiquitin binding mediates the NF-kappa B inhibitory potential of ABIN proteins

S WAGNERIsabelle CarpentierV ROGOVMarja KreikeF IKEDAF LOHRCJ WUJD ASHWELLV DOTSCHI DIKIC et al.

A1 Journal Article in ONCOGENE

2007

A novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappa B activation by API2 center dot MALT1 fusions

H NOELSGeert van LooS HAGENSV BROECKXRudi BeyaertP MARYNENM BAENS

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

A role for hnRNP C1/C2 and Unr in internal initiation of translation during mitosis

Bert SchepensSandrine TintonYanik BruynoogheEef ParthoensMira HaegmanRudi BeyaertSigrid Cornelis

A1 Journal Article in EMBO JOURNAL

Functional characterization of ABIN-3 and TAX1BP1 as negative regulators of NF-kappaB signaling

Lynn VerstrepenRudi Beyaert

Hepatic tumor necrosis factor signaling and nuclear factor-kappa B: Effects on liver homeostasis and beyond

Andy WullaertGeert van LooKaren HeyninckRudi Beyaert

A1 Journal Article in ENDOCRINE REVIEWS

Identification and evaluation of protein-protein interactions involved in NF-kB signaling using MAPPIT technology

Lars VereeckeSam LievensJan TavernierGeert van LooMozes SzeRudi Beyaert

Immune modulation by the pseudomonas type III secretion system

Rudi BeyaertMarlies GalleMira HaegmanP SCHOTT

Inhibition of NF-kappa B activation by the histone deacetylase inhibitor 4-Me2N-BAVAH induces an early G(1) cell cycle arrest in primary hepatocytes

P PAPELEUAndy WullaertG ELAUTT HENKENSM VINKENG LAUSD TOURWERudi BeyaertV ROGIERST VANHAECKE

A1 Journal Article in CELL PROLIFERATION

LIND/ABIN-3 is a novel lipopolysaccharide-inducible inhibitor of NF-kappa B activation

Andy WullaertLynn VerstrepenSofie Van HuffelM Adib-ConquySigrid CornelisMarja KreikeMira HaegmanKarim El BakkouriMatthew SandersKelly Verhelst et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

MALT1 paracaspase-mediated regulation of the NF-kappaB inhibitory protein A20 in antigen receptor signaling

Beatrice CoornaertRudi Beyaert

MAPPIT analysis of TLR adaptor complexes

Peter UlrichtsFrank PeelmanRudi BeyaertJan Tavernier

A1 Journal Article in FEBS LETTERS

Pellino proteins: novel players in TLR and IL-1R signalling

Reinout SchauvliegeSophie JanssensRudi Beyaert

A1 Journal Article in JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Study of the role of FAS-associated death domain protein FADD in brain pathology by conditional gene inactivation

Geert van LooRudi BeyaertA WAISMANM PRINZM PASPARAKIS

The Secret Life of Interleukin-1beta: Molecular Mechanisms involved in its Production and Biological Activities

Elisabeth VercammenRudi Beyaert

2006

A novel link between Lck, Bak expression and chemosensitivity

Karen HeyninckRudi Beyaert

Editorial material

Karen HeyninckRudi Beyaert

A4 Journal Article in Nature Molecule Pages

Karen HeyninckRudi Beyaert

A4 Journal Article in Nature Molecule Pages

Charaterisation of an LPS inflammation model in chickens

Sandra De BoeverRudi BeyaertF VANDEMAELEBruno GoddeerisPatrick De BackerSiska Croubels

Effect of ABINs on intracellular signaling pathways involved in TNF-mediated liver injury

Andy WullaertRudi Beyaert

Mechanisms of crosstalk between TNF-induced NF-kappa B and JNK activation in hepatocytes

Andy WullaertKaren HeyninckRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Molecular mechanisms of LPS-induced pro-inflammatory signalling

Reinout SchauvliegeRudi Beyaert

Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases

Reinout SchauvliegeSophie JanssensRudi Beyaert

A1 Journal Article in FEBS LETTERS

TNF alpha- and IKK beta-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKK gamma and NF-kappa B activation

M BONIFMA MEUWISP CLOSEV BENOITKaren HeyninckJP CHAPELLEV BOURSMP MERVILLEJ PIETTERudi Beyaert et al.

A1 Journal Article in BIOCHEMICAL JOURNAL

Ubiquitin: tool and target for intracellular NF-κB inhibitors

Andy WullaertKaren HeyninckSophie JanssensRudi Beyaert

A1 Journal Article in TRENDS IN IMMUNOLOGY

Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients

M ADIB-CONQUYC ADRIEC FITTINGO GATTOLLIATRudi BeyaertJM CAVAILLON

A1 Journal Article in CRITICAL CARE MEDICINE

2005

A20 inhibits NF-κB activation by dual ubiquitin-editing functions

Karen HeyninckRudi Beyaert

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

Adenoviral gene transfer of ABIN-1 protects mice from TNF/galactosamine-induced acute liver failure and lethality

Andy WullaertBen WielockxSofie Van HuffelVeerle BogaertB DE GEESTP PAPELEUPeter SchotteKarim El BakkouriKaren HeyninckClaude Libert et al.

A1 Journal Article in HEPATOLOGY

Adenoviral gene transfer of the NF-kappa B inhibitory protein ABIN-1 decreases allergic airway inflammation in a murine asthma model

Karim El BakkouriAndy WullaertMira HaegmanKaren HeyninckRudi Beyaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Apoptosis of hematopoietic cells induced by growth factor withdrawal is associated with caspase-9 mediated cleavage of Raf-1

Sigrid CornelisYanik BruynoogheGeert van LooXavier SaelensPeter VandenabeeleRudi Beyaert

A1 Journal Article in ONCOGENE

Regulation of the cell-cycle-dependent internal ribosome entry site of the PITSLRE protein kinase: roles of Unr (upstream of N-ras) protein and phosphorylated translation initiation factor eIF-2 alpha

Sandrine TintonBert SchepensYanik BruynoogheRudi BeyaertSigrid Cornelis

A1 Journal Article in BIOCHEMICAL JOURNAL

Role of the adaptor protein Trif in Toll-like receptor signaling to caspase-1

Elisabeth VercammenRudi Beyaert

Role of the adaptor protein Trif in Toll-like receptor signaling to caspase-1

Elisabeth VercammenRudi Beyaert

The polypyrimidine tract-binding protein stimulates HIF-1α IRES-mediated translation during hypoxia

Bert SchepensSandrine TintonYanik BruynoogheRudi BeyaertSigrid Cornelis

A1 Journal Article in NUCLEIC ACIDS RESEARCH

UNR translation can be driven by an IRES element that is negatively regulated by polypyrimidine tract binding protein

Sigrid CornelisSandrine TintonBert SchepensYanik BruynoogheRudi Beyaert

A1 Journal Article in NUCLEIC ACIDS RESEARCH

2004

Enhanced osteoclast development in collagen-induced arthritis in interferon-gamma receptor knock-out mice as related to increased splenic CD11b(+) myelopoiesis

B DE KLERCKIsabelle CarpentierRJ LORIESY HABRAKENJ PIETTEG CARMELIETRudi BeyaertA BILLIAUP MATTHYS

A1 Journal Article in ARTHRITIS RESEARCH & THERAPY

Function and regulation of tumor necrosis factor receptor type 2

Isabelle CarpentierBeatrice CoornaertRudi Beyaert

A1 Journal Article in CURRENT MEDICINAL CHEMISTRY

Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin-1 beta

Peter SchotteGeertrui DeneckerAeke Van Den BroekePeter VandenabeeleGR CORNELISRudi Beyaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The yeast three-hybrid system as a tool to study caspases

Wim Van CriekingePeter SchotteKaren HeyninckRudi Beyaert

Bookchapter in Apoptosis methods and protocols

Yeast two-hybrid screening for proteins interacting with the anti-apoptotic protein A20

Karen HeyninckSofie Van HuffelMarja KreikeRudi Beyaert

Bookchapter in Apoptosis methods and protocols

2003

A novel type of deubiquitinating enzyme*

PC EVANSTS SMITHMJ LAIMG WILLIAMSDF BURKEKaren HeyninckMarja KreikeRudi BeyaertTL BLUNDELLPJ KILSHAW

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Cytotoxicity of gamma versus alpha radiation in lymphoid cell lines with defects in the TNF receptor family mediated and NF-kappa B related apoptotic and anti-apoptotic pathways

KJ VANDENBULCKEK VANDENBULCKERudi BeyaertC APOSTOLIDEST NIKULAW JANSSENSANN JANSSENSVirginie de GelderAnnick WillemsGuido Slegers et al.

Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members

Sophie JanssensRudi Beyaert

A1 Journal Article in MOLECULAR CELL

Inhibition of interleukin 1 receptor/toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4

Kimberly BurnsSophie JanssensBrian BrissoniNatalia OlivosRudi BeyaertJürg Tschopp

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Molecular and functional characterisation of the tumor necrosis factor associated proteins TRAF1 and TRAF2

Isabelle CarpentierRudi BeyaertFrans Van Roy

MyD88S, a splice variant of MyD88, differentially modulates NF-κB- and AP-1-dependent gene expression

Sophie JanssensKim BurnsElisabeth VercammenJurg TschoppRudi Beyaert

A1 Journal Article in FEBS LETTERS

NF-κB activation by tumor necrosis factor and interleukin-1

Isabelle CarpentierSophie JanssensKaren HeyninckRudi Beyaert

Bookchapter in Nuclear factor κB : regulation and role in disease

Nuclear factor kB: Regulation and role in disease

Nuclear factor-kappa B plays a central role in tumour necrosis factor-mediated liver disease

Karen HeyninckAndy WullaertRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Regulation of interleukin-1 and endotoxin induced responses by alternative splicing of MyD88

Sophie JanssensRudi BeyaertFrans Van Roy

Regulation of IL-1 receptor- and TLR-induced NF-κB activation by alternative splicing of MyD88

Rudi BeyaertKimberley BurnsSophie JanssensJurg TschoppElisabeth Vercammen

Role of toll-like receptors in pathogen recognition

Sophie JanssensRudi Beyaert

A1 Journal Article in CLINICAL MICROBIOLOGY REVIEWS

Structure-function analysis of the A20-binding inhibitor of NF-kappa B activation, ABIN-1

Karen HeyninckMarja KreikeRudi Beyaert

A1 Journal Article in FEBS LETTERS

2002

A matrix-assisted laser desorption ionization post-source decay (MALDI-PSD) analysis of proteins released from isolated liver mitochondria treated with recombinant truncated Bid

Geert van LooHans DemolMaria (Marjan) van GurpB HoorelbekePeter SchotteRudi BeyaertB ZhivotovskyKris GevaertWim DeclercqJoël Vandekerckhove et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

A universal role for MyD88 in TLR/IL-1R-mediated signaling

Sophie JanssensRudi Beyaert

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

Caspase-11 gene expression in response to lipopolysaccharide and interferon-gamma requires nuclear factor-kappa B and signal transducer and activator of transcription (STAT) 1.

Reinout SchauvliegeJ VANROBAEYSPeter SchotteRudi Beyaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Caspases are not localized in mitochondria during life or death

Geert van LooXavier SaelensFilip MatthijssensPeter SchotteRudi BeyaertWim DeclercqPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Regulation of interleukin-1- and lipopolysaccharide-induced NF-κB activation by alternative splicing of MyD88

Sophie JanssensKim BurnsJurg TschoppRudi Beyaert

A1 Journal Article in CURRENT BIOLOGY

Reversion of autoimmune lymphoproliferative syndrome with an antimalarial drug: preliminary results of a clinical cohort study and molecular observations.

JV TEN BOSCHPeter SchotteA FERSTERN AZZIT BOEHLERGenevieve LaureysM AROLAC DEMANETRudi BeyaertK THIELEMANS et al.

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Signaling to gene activation and cell death by tumor necrosis factor receptors and Fas

Rudi BeyaertGeert van LooKaren HeyninckPeter Vandenabeele

A1 Journal Article in International Review of Cytology : a Survey of Cell Biology

2001

Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3.

T WIEDERF ESSMANNA PROKOPK SCHMELZK SCHULZE-OSTHOFFRudi BeyaertB DORKENPT DANIEL

A1 Journal Article in BLOOD

Crosstalk between NF-êB-activating and apoptosis-inducing proteins of the TNF-receptor complex

Karen HeyninckRudi Beyaert

A2 Journal Article in MOLECULAR CELL BIOLOGY RESEARCH COMMUNICATIONS

Dimethylfumarate is an inhibitor of cytokine-induced nuclear translocation of NF-κB1, but not RelA in normal human dermal fibroblast cells

M VandermeerenSophie JanssensHilde WoutersInge BorghmansMarcel BorgersRudi BeyaertJohan Geysen

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspaseindependent DNA degradation

Geert van LooPeter SchotteMaria (Marjan) van GurpHans DemolB HOORELBEKEKris GevaertI RODRIGUEZA RUIZ-CARRILLOJoël VandekerckhoveWim Declercq et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappa B activation and protein-protein interactions.

Marco KlinkenbergSofie Van HuffelKaren HeyninckRudi Beyaert

A1 Journal Article in FEBS LETTERS

Identificatie en functionele karakterisering van eiwitten die binden met het zinkvingereiwit A20

Sofie Van HuffelFrans Van RoyRudi Beyaert

Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2.

Sofie Van HuffelFilip DelaeiKaren HeyninckDirk De ValckRudi Beyaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Isolation and characterization of two novel A20-like proteins.

PC EVANSER TAYLORJ COADWELLKaren HeyninckRudi BeyaertPJ KILSHAW

A1 Journal Article in BIOCHEMICAL JOURNAL

Lithium sensitizes tumor cells in an NF-kappa B-independent way to caspase activation and apoptosis induced by tumor necrosis factor (TNF) - Evidence for a role of the TNF receptor-associated death domain protein.

Peter SchotteGeert van LooIsabelle CarpentierPeter VandenabeeleRudi Beyaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The cathepsin B inhibitor z-FA.fmk inhibits cytokine production in macrophages stimulated by lipopolysaccharide

Peter SchotteReinout SchauvliegeSophie JanssensRudi Beyaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2000

A20 and A20-binding proteins as cellular inhibitors of nuclear factor-kappa B-dependent gene expression and apoptosis.

Rudi BeyaertKaren HeyninckSofie Van Huffel

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Identification and characterization of a novel cell cycle-regulated internal ribosome entry site.

Sigrid CornelisY BRUYNOOGHEGeertrui DeneckerSofie Van HuffelSandrine TintonRudi Beyaert

A1 Journal Article in MOLECULAR CELL

Studie van caspasen en hun activeringsmechanismen

Peter SchotteRudi BeyaertFrans Van Roy

Ultrastructural localization of cytochrome c in apoptosis demonstrates mitochondrial heterogeneity.

Katharina D'HerdeB DE PRESTSylvie MusschePeter SchotteRudi BeyaertRudy Van CosterFrank Roels

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

1999

A sensitizing function for lithium ions in tumor necrosis factor and interleukin-1 signalling

Bookchapter in Lithium : 50 years of psychopharmacology : new perspectives in biomedical and clinical research

A sensitizing function for lithium ions in tumor necrosis factor apoptosis

Peter SchotteRudi Beyaert

Bookchapter in Lithium, 50 years : recent advances in biology and medicine

Alzheimer's disease associated presenilin 1 interacts with HC5 and ZETA, subunits of the catalytic 20S proteasome.

G VAN GASSENC DE JONGHES PYPEWim Van CriekingeA JULLIAMSI VANDERHOEVENS WOODROWRudi BeyaertD HUYLEBROECKC VAN BROECKHOVEN

A1 Journal Article in NEUROBIOLOGY OF DISEASE

Apoptosis induced by γ irradiation in peripheral blood mononuclear cells is not mediated by cytochrome-c release and only partially involves caspase-3-like proteases

Henk LouagiePeter SchotteAnne VralMaria CornelissenHubert ThierensRudi BeyaertLeo De RidderJan Philippé

A1 Journal Article in CELL BIOLOGY INTERNATIONAL

Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosis.

A RICKERSN PETERSV BADOCKRudi BeyaertPeter VandenabeeleB DORKENK BOMMERT

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

GAL4 is a substrate for caspases : implications for two-hybrid screening and other GAL4-based assays

Wim Van CriekingeSigrid CornelisMarc Van De CraenPeter VandenabeeleWalter FiersRudi Beyaert

A2 Journal Article in MOLECULAR CELL BIOLOGY RESEARCH COMMUNICATIONS

Identificatie en karakterisering van cellulaire inhibitoren van NF-kB-afhankelijke genexpressie

Karen HeyninckRoland ContrerasRudi Beyaert

Inhibition of Tumor Necrosis Factor-induced necrotic cell death by the zinc finger protein A20.

Karen HeyninckGeertrui DeneckerDirk De ValckWalter FiersRudi Beyaert

A1 Journal Article in ANTICANCER RESEARCH

More than one way to die: apoptosis, necrosis and reactive oxygen damage.

Walter FiersRudi BeyaertWim DeclercqPeter Vandenabeele

A1 Journal Article in ONCOGENE

NF-KB as an emerging target in atopy

A2 Journal Article in EMERGING THERAPEUTIC TARGETS

Non-specific effects of methyl ketone peptide inhibitors of caspases.

Peter SchotteWim DeclercqSofie Van HuffelPeter VandenabeeleRudi Beyaert

A1 Journal Article in FEBS LETTERS

The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappa B activation at the level of TRAF6.

Karen HeyninckRudi Beyaert

A1 Journal Article in FEBS LETTERS

The zinc finger protein A20 inhibits TNF-induced NF-kappa B-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappa B-inhibiting protein ABIN.

Karen HeyninckDirk De ValckWim Vanden BergheWim Van CriekingeRoland ContrerasWalter FiersGuy HaegemanRudi Beyaert

A1 Journal Article in JOURNAL OF CELL BIOLOGY

The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases.

Dirk De ValckDY JINKaren HeyninckMarc Van De CraenRoland ContrerasWalter FiersKT JEANGRudi Beyaert

A1 Journal Article in ONCOGENE

TRAF1 is a TNF inducible regulator of NF-kappa B activation.

Isabelle CarpentierRudi Beyaert

A1 Journal Article in FEBS LETTERS

Yeast two-hybrid : state of the art

Wim Van CriekingeRudi Beyaert

A2 Journal Article in BIOLOGICAL PROCEDURES ONLINE

1998

Cathepsin B-mediated activation of the proinflammatory caspase-11

Peter SchotteWim Van CriekingeMarc Van De CraenGeert van LooMarjory DesmedtJohan GrootenMaria CornelissenLeo De RidderJoël VandekerckhoveWalter Fiers et al.

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differential activation of phospholipases during necrosis or apoptosis: A comparative study using tumor necrosis factor and anti-Fas antibodies.

Dirk De ValckDominique VercammenWalter FiersRudi Beyaert

A1 Journal Article in JOURNAL OF CELLULAR BIOCHEMISTRY

Identificatie en karakterisering van fosfolipasen en TNF-resistente eiwitten betrokken bij TNF-geïnduceerde celdood en genactivering

Dirk De ValckRudi BeyaertRoland Contreras

Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

Dominique VercammenRudi BeyaertGeertrui DeneckerVera GoossensGeert van LooWim DeclercqJohan GrootenWalter FiersPeter Vandenabeele

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Is er leven na de (cel)dood?

Wim Van CriekingeElke SmitsChristian Paul G. BurvenichRudi Beyaert

A2 Journal Article in VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT

Karakterisering van caspasen in een '2 en 3-hybrid'-systeem

Wim Van CriekingeRudi BeyaertWalter FiersRoland Contreras

Sensitization of TNF-induced apoptosis with polyamine synthesis inhibitors in different human and murine tumour cell lines.

LC PENNINGRG SCHIPPERDominique VercammenAAJ VERHOFSTADT DENECKERRudi BeyaertPeter Vandenabeele

A1 Journal Article in CYTOKINE

TRAF2 plays a dual role in NF-kappa B-dependent gene activation by mediating the TNF-induced activation of p38 MAPK and I kappa B kinase pathways.

Isabelle CarpentierWim DeclercqNL MALININD WALLACHWalter FiersRudi Beyaert

A1 Journal Article in FEBS LETTERS

Tumor necrosis factor and lymphotoxin

Rudi BeyaertWalter Fiers

Bookchapter in Cytokines

Use of the yeast three-hybrid system as a tool to study caspases.

Wim Van CriekingeMaria (Marjan) van GurpEls DecosterPeter SchotteMarc Van De CraenWalter FiersPeter VandenabeeleRudi Beyaert

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

1997

A20 inhibits NF-kappa B activation independently of binding to 14-3-3 proteins.

Dirk De ValckKaren HeyninckWim Van CriekingePeter VandenabeeleWalter FiersRudi Beyaert

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cell death induction by receptors of the TNF family: Towards a molecular understanding.

D WALLACHM BOLDINE VARFOLOMEEVRudi BeyaertPeter VandenabeeleWalter Fiers

A1 Journal Article in FEBS LETTERS

Characterization of seven murine caspase family members

Marc Van de CraenPeter VandenabeeleWim DeclercqIlse Van den BrandeGeert van LooFrancis MolemansPeter SchotteWim Van CriekingeRudi BeyaertWalter Fiers

A1 Journal Article in FEBS LETTERS

Cleavage of caspase family members by granzyme B: A comparative study in vitro.

M VANDECRAENI VANDENBRANDEWim DeclercqM IRMLERRudi BeyaertJ TSCHOPPWalter FiersPeter Vandenabeele

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor.

Rudi BeyaertVJ KIDDSigrid CornelisM VANDECRAENGeertrui DeneckerJM LAHTIR GURURAJANPeter VandenabeeleWalter Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal.

RMY BARGER WILLEMZEPeter VandenabeeleWalter FiersRudi Beyaert

A1 Journal Article in FEBS LETTERS

Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma.

Geertrui DeneckerPeter VandenabeeleJohan GrootenLC PENNINGWim DeclercqRudi BeyaertWA BUURMANWalter Fiers

A1 Journal Article in CYTOKINE

Presenilins and Alzheimer's disease: identification of proteins that interact with presenilin I using the yeast two-hybrid system

Geert Van GassenWim Van CriekingeRudi BeyaertJurgen Del-FaveroChristine Van BroeckhovenM Cruts

A2 Journal Article in ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Resistance to tumor necrosis factor (TNF) cytotoxicity by autocrine TNF production is independent of intracellular signaling pathways.

Els DecosterVeronique VandevoordeRudi BeyaertGuy HaegemanWalter Fiers

A1 Journal Article in FEBS LETTERS

Tumour necrosis factor-induced necrosis versus anti-Fas-induced apoptosis in L929 cells.

Dominique VercammenPeter VandenabeeleRudi BeyaertWim DeclercqWalter Fiers

A1 Journal Article in CYTOKINE

Tumour necrosis factor: intracellular mechanism of action

Walter FiersRudi BeyaertElke BooneWim DeclercqEls DecosterDirk De ValckVera GoossensJohan GrootenGuy HaegemanKaren Heyninck et al.

Bookchapter in HIV and cytokines

1996

A20, an inhibitor of cell death, self-associates by its zinc finger domain.

Dirk De ValckKaren HeyninckWim Van CriekingeRoland ContrerasRudi BeyaertWalter Fiers

A1 Journal Article in FEBS LETTERS

Dexamethasone alters messenger RNA levels but not synthesis of collagens, fibronectin, or laminin by cultured rat fat-storing cells.

T NIKID SCHUPPANPJ DEBLESERR VRIJSENM PIPELEERSMARICHALRudi BeyaertE WISSEA GEERTS

A1 Journal Article in HEPATOLOGY

Functional characterization of the prodomain of interleukin-1 beta-converting enzyme.

Wim Van CriekingeRudi BeyaertM VANDECRAENPeter VandenabeelePeter SchotteD DEVALCKWalter Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis in response to tumour necrosis factor.

Rudi BeyaertA CUENDAW VANDENBERGHES PLAISANCEJC LEEGuy HaegemanP COHENWalter Fiers

A1 Journal Article in EMBO JOURNAL

TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis.

Walter FiersRudi BeyaertElke BooneSigrid CornelisWim DeclercqEls DecosterGeertrui DeneckerBart DepuydtDirk De ValckG DEWILDE et al.

A1 Journal Article in JOURNAL OF INFLAMMATION

1995

2 TUMOR-NECROSIS-FACTOR RECEPTORS - STRUCTURE AND FUNCTION.

Peter VandenabeeleWim DeclercqRudi BeyaertWalter Fiers

A1 Journal Article in TRENDS IN CELL BIOLOGY

Casein kinase-1 phosphorylates the p75 tumor-necrosis-factor receptor and negatively regulates tumor-necrosis-factor signaling for apoptosis.

Rudi BeyaertBart VanhaesebroeckWim DeclercqJ VANLINTPeter VandenabeeleP AGOSTINISJR VANDENHEEDEWalter Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Two tumour necrosis factor receptors : structure and function

Peter VandenabeeleWim DeclercqRudi BeyaertWalter Fiers

A2 Journal Article in TRENDS IN CELL BIOLOGY

1994

FUNCTIONAL REQUIREMENT OF THE 2 TNF RECEPTORS FOR INDUCTION OF APOPTOSIS IN PC60 CELLS AND THE ROLE OF MITOCHONDRIA IN TNF-INDUCED CYTOTOXICITY.

Peter VandenabeeleV GOOSSENSRudi BeyaertWim DeclercqJohan GrootenB VANHAESEBROECKM VANDECRAEND VERCAMMENB DEPUYDTG DENECKER et al.

A1 Journal Article in CIRCULATORY SHOCK

Molecular mechanisms of tumor necrosis factor-induced cytotoxicity - What we do understand and what we do not.

Rudi BeyaertWalter Fiers

A1 Journal Article in FEBS LETTERS

1993

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

K SCHULZEOSTHOFFRudi BeyaertVeronique VandevoordeGuy HaegemanWalter Fiers

A1 Journal Article in EMBO JOURNAL

Effect of bcl-2-proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity.

Bart VanhaesebroeckJC REEDD DEVALCKJohan GrootenT MIYASHITAS TANAKARudi BeyaertFrans Van RoyWalter Fiers

A1 Journal Article in ONCOGENE

ENHANCEMENT OF TUMOR-NECROSIS-FACTOR CYTOTOXICITY BY LITHIUM-CHLORIDE IS ASSOCIATED WITH INCREASED INOSITOL PHOSPHATE ACCUMULATION.

Rudi BeyaertKaren HeyninckDirk De ValckF BOEYKENSFrans Van RoyWalter Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine

Rudi BeyaertBart VanhaesebroeckKaren HeyninckElke BooneDirk De ValckKlaus Schulze-OsthoffGuy HaegemanFrans Van RoyWalter Fiers

A1 Journal Article in CANCER RESEARCH

Tumor necrosis factor cytotoxicity is associated with activation of cellular phospholipases

Dirk De ValckRudi BeyaertFrans Van RoyWalter Fiers

TUMOR-NECROSIS-FACTOR CYTOTOXICITY IS ASSOCIATED WITH PHOSPHOLIPASE-D ACTIVATION.

D DEVALCKRudi BeyaertFrans Van RoyWalter Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Two pathways of tumor necrosis factor signal transduction: in vitro and in vivo implications

Walter FiersRudi BeyaertPeter BrouckaertAnje CauwelsWim DeclercqDirk De ValckB EveraerdtVera GoossensJohan GrootenGuy Haegeman et al.

1992

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

K SCHULZEOSTHOFFAC BAKKERBart VanhaesebroeckRudi BeyaertWA JACOBWalter Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Potentiation of tumour necrosis factor-mediated activities by lithium salts: a review

Rudi BeyaertWalter Fiers

A2 Journal Article in LITHIUM

Synergistic induction of interleukin-6 by tumor necrosis factor and lithium chloride in mice: Possible role in the triggering and exacerbation of psoriasis by lithium treatment.

Rudi BeyaertK SCHULZEOSTHOFFFrans Van RoyWalter Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor necrosis factor : mechanism of action and its potential for anticancer therapy

W HersRudi BeyaertPeter BrouckaertEls DecosterDirk De ValckB EveraerdtJohan GrootenAnne LenaertsClaude LibertK Schulze-Osthoff et al.

Tumor-necrosis-factor : mechanism of action at the molecular, cellular and in vivo level

Walter FiersRudi BeyaertPeter BrouckaertEls DecosterDirk De ValckBart EveraerdtJohan GrootenAnne LenaertsClaude LibertK. Schulzeosthoff et al.

1991

Induction of inflammatory cell infiltration and necrosis in normal mouse skin by the combined treatment of tumor-necrosis-factor and lithium-chloride

Rudi BeyaertChristian De PotterBart VanhaesebroeckFrans Van RoyWalter Fiers

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

Lithium chloride potentiates tumor necrosis factor-induced and interleukin 1-induced cytokine and cytokine receptor expression

Rudi BeyaertKlaus Schulze-OsthoffFrans Van RoyWalter Fiers

A1 Journal Article in CYTOKINE

Tumour-necrosis-factor-mediated cytotoxicity is correlated with phospholipase-A2 activity, but not with arachidonic acid release per se

Philip SuffysRudi BeyaertDirk De ValckBart VanhaesebroeckFrans Van RoyWalter Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Two discrete types of tumor necrosis factor-resistant cells derived from the same cell line

Bart VanhaesebroeckSigrid Van BladelAnne LenaertsPhilippe SuffysRudi BeyaertRudolf LucasFrans Van RoyWalter Fiers

A1 Journal Article in CANCER RESEARCH

1990

Cytotoxic activity of tumor necrosis factor is inhibited by amiloride derivatives without involvement of the Na+/H+ antiporter

B VanhaesebroeckEJ Jr CragoeJ PouysségurRudi BeyaertFrans Van RoyWalter Fiers

A1 Journal Article in FEBS LETTERS

HORMONE SENSITIVITY INVITRO AND INVIVO OF V-RAS-TRANSFECTED MCF-7 CELL DERIVATIVES.

Frans Van RoyMarcus MareelKris VleminckxRudi BeyaertWalter FiersN DEVLEESCHOUWERC MUQUARDTN LEGROSmarc brackeG LECLERCQ

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

In vitro and in vivo action of tumor necrosis factor

Walter FiersRudi BeyaertPeter BrouckaertBart EveraerdtGuy HaegemanClaude LibertPhilip SuffysNozomi TakahashiJan TavernierSigrid Van Bladel et al.

Inhibition by glucocorticoids of tumor necrosis factor-mediated cytotoxicity: evidence against lipocortin involvement

Rudi BeyaertPhilip SuffysFrans Van RoyWalter Fiers

A1 Journal Article in FEBS LETTERS

Tumor-necrosis-factor : mechanism of action at the molecular, cellular and in vivo level

Walter FiersRudi BeyaertPeter BrouckaertBart EveraerdtJohan GrootenAnne LenaertsClaude LibertP. SuffysNozomi TakahashiJan Tavernier et al.

A1 Journal Article in SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

1989

Lithium chloride potentiates tumor necrosis factor-mediated cytotoxicity in vitro and in vivo

Rudi BeyaertBart VanhaesebroeckPhilip SuffysFrans Van RoyWalter Fiers

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNF in combination with interferon-γ is cytotoxic to normal, untransformed mouse and rat embryo fibroblast-like cells

Philip SuffysRudi BeyaertFrans Van RoyWalter Fiers

A1 Journal Article in ANTICANCER RESEARCH

1988

Involvement of a serine protease in tumour-necrosis-factor-mediated cytotoxicity

Philip SuffysRudi BeyaertFrans Van RoyWalter Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

1987

Gene cloning and structure: function relationship of cytokines such as TNF and interleukins

Walter FiersRudi BeyaertPeter BrouckaertBart EveraerdtGuy HaegemanPhilip SuffysJan TavernierPeter VandenabeeleBart VanhaesebroeckXaveer Van Ostade et al.

A1 Journal Article in IMMUNOLOGY LETTERS

Reduced tumour necrosis factor-induced cytotoxicity by inhibitors of the arachidonic acid metabolism

Philip SuffysRudi BeyaertFrans Van RoyWalter Fiers

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tumor necrosis factor: a potential antitumor agent?

Walter FiersRudi BeyaertPeter BrouckaertBart EveraerdtPhilip SuffysJan TavernierBart VanhaesebroeckFrans Van Roy

A1 Journal Article in JOURNAL OF INTERFERON RESEARCH