Code
3G016413
Duration
01 January 2013 → 31 December 2018
Funding
Research Foundation - Flanders (FWO)
Promotor
Research disciplines
-
Natural sciences
- Posttranslational modifications
- Molecular and cell biology not elsewhere classified
-
Medical and health sciences
- Dermatology
- Gastro-enterology
- Innate immunity
-
Engineering and technology
- Biological control
- Other biotechnology, bio-engineering and biosystem engineering not elsewhere classified
Keywords
caspases
ubiquitination
signal transduction
Project description
Caspase-8 and MALT1 are two proteases that are activated in parallel downstream of immune receptors. We propose an in-depth investigation of the interplay between these two proteases and their respective signaling platforms. The focus of the project will be on proteolytic cleavage of specific substrates and their effect on the ubiquitination of essential mediators in NF-kB activation.