Research Explorer

Project

Molecular mechanisms involved in the regulation of the paracaspase MALT1 in T cel receptor induced signal transduction
Code
3G008910
Duration
01 January 2010 → 31 December 2015
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Immunology
    • Medical biochemistry and metabolism
    • Immunology
    • Medical biochemistry and metabolism
    • Immunology
    • Medical biochemistry and metabolism
Keywords
proteases signal transduction immunity
 
Project description

MALT1 is an intracellular signalling protein that plays a crucial role in antigen induced activation of nuclear factor kB (NF-kB) dependent gene expression in T activation can result in autoimmune disease and some lymphomas. This project aims to elucidate the intracellular mechanisms that regulate MALT1 activity.