Research Explorer

Project

Study of the molecular mechanisms regulating the activity and expression of the de-ubiquitinase protein DUBA in innate immune signaling.
Code
3E021509
Duration
01 October 2009 → 13 January 2017
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Immunology
    • Medical biochemistry and metabolism
    • Immunology
    • Medical biochemistry and metabolism
    • Immunology
    • Medical biochemistry and metabolism
 
Project description
 

The research project wants to contribute to the study of negative regulators in the innate immune system. More precisely, we want to study the de-ubiquitinase DUBA, a negative regulator in the signaling pathway important for the production of type I interferons and antiviral responses. We want to gain a thorough knowledge of the molecular and biochemical mechanisms regulating the function of DUBA.