Research Explorer

Project

Study of the role of NF-kB regulatory signalling molecules involved in multiple sclerosis through gene targeting in the mouse
Code
365F9108
Duration
01 January 2008 → 31 December 2014
Funding
Funding by bilateral agreement (private and foundations)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Immunology
    • Medical biochemistry and metabolism
    • Molecular and cell biology
    • Immunology
    • Medical biochemistry and metabolism
    • Immunology
    • Medical biochemistry and metabolism
    • Molecular and cell biology
Keywords
Multiple Sclerosis (MS) NF-kB transgenesis
 
Project description
 

In this project we investigate the role of NF-kB in multiple sclerosis. Therefore we make use of knockout mice that are deficient in specific NF-kB regulatory genes, and we use these mice in models of multiple sclerose. In this way we hope to better understand the function of specific genes in multiple sclerosis.