Universal, cost-effective and hypersensitive open-source technology platform for liquid biopsy based on methylome profiling of circulating DNA.

Developing methods for the production of antiviral VHH-Fc antibodies in <i>Pichia pastoris</i> for fast pandemic response

Doctoral project Andreia Sofia da Costa de Monica Ferreira

Doctoral project Andries De Koker

Doctoral project Bram Laukens

Doctoral project Charlot De Wachter

Doctoral project Charlotte De Visscher

Doctoral project Dries Van Herpe

Doctoral project Edwin Alexander Rodríguez López

Doctoral project Francis Santens

Doctoral project Joemar Taganna

Doctoral project Justine Naessens

Doctoral project Katlyn Borgers

Doctoral project Kristof Vandewalle

Doctoral project Loes van Schie

Doctoral project Marie Goossens

Doctoral project Mouna Guerfal

Doctoral project Robin Vanluchene

Doctoral project Veerle Billiau

Exploration of yeast-produced edible antibodies for the management of gastrointestinal diseases

Improving therapeutic proteins by N-glycosylation engineering and conjugation

Massively parallel analysis of protein libraries using yeast surface display

Method Development for the Structural and Functional Analysis of (CAR) T cell Glycome Alterations

Novel glycoproteomics methodology for discovering tumor-specific, cell surface, glycopeptide epitopes

Single-domain antibodies for biopharmaceutical targeting to the lysosome

Doctoral project Philipp Arendt

A mycobacterium bovis BCG transposon insertion library as a tool to study the role of mycobacterial glycolipids and other components in pathogenesis.

Analysis of glycosylation changes on the surface of lymphocytes and their pathophysiological relevance during chronic necro-inflammation

Arming therapeutic CAR-T cells with glyco-engineered suppressors of tumor-infiltrating regulatory T cells

Bio-encapsulation in yeast for delivery of intestinal epithelium-protecting and microbiome-manipulating biopharmaceuticals

Biofarmaceutical proteins: glyco-engineering technology to produce enhanced, homogene glycoforms

cfRRBS: translation of technological advances in methylation profiling of circulating free DNA for minimally invasive classification and relapse detection of high-grade lymphoma

Customized glycosylation engineering to enhance lysosomal enzyme delivery to muscle tissue in congenital and acquired lysosomal dysfunction.

Design and use of a novel HEK293S-based expression system for eukaryotic (membrane) proteins

Development and use of new genetic engineering and testing for BCG-based anti-tuberculosis vaccines

Development of a high sensitivity circulating cell free DNA methylation analysis method and its application in cancer management

Development of a novel antibody-based platform for lysosome-mediated targeted protein degradation

Development of inhaled anti-SARS-CoV-2 antibody.

Development of novel expression technology for eukaryotic membrane proteins: application to G-protein coupled receptors

Development of novel expression technology for eukaryotic membrane proteins: application to G-protein coupled receptors

Empowering biomanufacturing with advanced Pichia-based VHH-Fc production and engineering

Enabling antibody prophylaxis of the elderly and vulnerable using yeast-based biotechnology.

Engineering of the CAR-T cell glycocalyx to enhance anti-tumor efficacy.

ERC Professorship: GlycoTarget

Exploration of differentiated iPSCs as peptide antigen source for tolerizing immunizations in autoimmune disease

Expression and glyco-engineering of lysosomal enzymes in yeasts for the treatment of lysosomal storage diseases.

Fight against Mycobacterium tuberculosis infection with cell wall enzymes

Genome engineering method development for the functional study of cytotoxic T-cell glycome alterations. 

Glycan structure-mediated targeted delivery of therapeutic enzymes and cytokines

GlycoCirrhoTest: manufacturing demonstration, CE mark preparation and establishing link to pathology of cirrhotic liver regeneration.

GlycoDelete-ADC, a novel antibody-drug conjugate platform.

Glyco(Double)Delete technology: maturation, development of compatible GlyConnect coupling technology

Glyco-engineering of allergens for active immunotherapy

Glyco-engineering of IL-10 and IL-22 for tissue-specific delivery via lectin receptors

GlyConnect: developing glyco-active enzyme reagents for therapeutic glycoprotein functionality enhancement

Improved glycoconjugate purification using temperature-controlled lectin multimers

Improving monoclonal antibody production in glycosylationhumanized Pichia pastoris strains

Investigation of Nanobody-based LYsosome TArgeting Chimeras (nanoLYTACs): a novel concept in therapy of cancer and viral infection.

In vitro and in vivo glyco-engineering of human IgG, and the leukocyte-cell surface with new fucosidasen

Manipulation of the eukaryotic secretory system: production of homogenously modified proteins for structural analysis and biotechnology

Medical biotechnology research in Callewaert lab

Novel forward genetics screening methodology in human HEK293 cells.

Novel glycoproteomics methodology for discovering tumor-specific cell surface glycopeptide epitopes.

Novel molecular intervention technology for infectious and allergic respiratory diseases

Orally deliverable antibodies against gastrointestinal targets of importance in human medicine.

Proteomes screening for protein fragments which can be secreted by yeast

Proteome-wide analysis of protein fragment expressability

PROTG

Replacement of N-glycan analysis equipment

Screening entire proteomes for yeast-expressable fragments

SECRiFY: a new tool for studying eukaryotic protein secretion.

SECRiFY: a new tool for studying eukaryotic protein secretion.

Special Research Fund Professorship in medical biotechnology

Study of inducible glycome manipulation of CAR-T cells upon antigen exposure in the tumor environment

Study of the synthesis of mycobacterial ManLAM and its function in the interaction with phagocytes

Synthetic glyco-biotechnology: arming therapeutic CAR-T cells with glyco-engineered suppressors of tumor-infiltrating regulatory T cells.

Targeting Glycosylation Pathways to Enhance CAR T Therapy

Technology development for more efficient production of membrane proteins in Pichia pastoris

Tn-Miner: Technology for the discovery of tumor-specific glycopeptide immunotherapy targets.

Towards more effective enzyme replacement therapy for inherited and acquired Lysosomal Storage Diseases of muscle tissue.

Understanding and exploiting glycosylation in immunotherapy.

Understanding Bacille Calmette Guerin's immune-defenses to generate a truly protective TB vaccine.

Understanding, optimizing and expanding target space of yeast-secreted, edible antibodies.

Unesco Abdulladim

Validation and implementation of a prognostic biomarker of early graft failure after liver transplantation (GlycoTransplantTest)

A MALDI-8020 mass spectrometer for peptide and protein analysis.

Flow imaging microscope for advanced analysis of biopharmaceuticals and biological samples

Method development for the characterization of serum/plasma protein glycosylation. Application in clinical hepatology, endocrinology, oncology and anti-doping control

Prophylaxis of at risks persons with an ultrapotent SARS-CoV-2-neutralizing antibody

ReHiFiNMR - Rejuvenation of High-Field NMR equipment for the continued and enhanced characterization of complex molecular architectures and their interactions

Role of glycosylation in the immunogenicity of the nematode specific activation-associated secreted proteins (ASPs) and its implication in vaccine efficacy.

ERC Professorship: GlycoTarget

Special Research Fund Professorship in medical biotechnology

Development of a minimally-invasive test for accurate diagnosis of Cancer of Unknown Primary (CUP) using DNA methylation profiling