Project

Method development for the characterization of serum/plasma protein glycosylation. Application in clinical hepatology, endocrinology, oncology and anti-doping control

Duration
01 January 2007 → 31 October 2011
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Endocrinology and metabolic diseases
    • Gastro-enterology and hepatology
    • Laboratory medicine
    • Medical systems biology
    • Endocrinology and metabolic diseases
    • Gastro-enterology and hepatology
    • Laboratory medicine
    • Medical systems biology
    • Medicinal chemistry
    • Endocrinology and metabolic diseases
    • Gastro-enterology and hepatology
    • Laboratory medicine
    • Medical systems biology
  • Engineering and technology
    • Catalysis and reacting systems engineering
    • Chemical product design and formulation
    • General chemical and biochemical engineering
    • Process engineering
    • Separation and membrane technologies
    • Transport phenomena
    • Other (bio)chemical engineering
    • Biomaterials engineering
    • Biological system engineering
    • Biomaterials engineering
    • Biomechanical engineering
    • Other (bio)medical engineering
    • Environmental engineering and biotechnology
    • Industrial biotechnology
    • Other biotechnology, bio-engineering and biosystem engineering
Keywords
plasma steroids liver cirrhosis erythropoietin tumor markers protein glycosylation glycomics
 
Project description

This project aims to develop new methods for the characterisation of protein glycosylation patterns of serum proteins, and to apply these in clinical contexts. More specifically, sensitive and specific markers for liver cirrhosis and cancer are investigated, as is the influence of ageing on the glycosylation patterns of plasma hormones and hormone-binding proteins.