Code
01J10711
Duration
01 July 2011 → 30 April 2016
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Natural sciences
- Microbiology
- Systems biology
-
Medical and health sciences
- Laboratory medicine
- Microbiology
- Laboratory medicine
- Laboratory medicine
- Microbiology
Keywords
vaccine
tuberculosis
immunology
Project description
We study the immunomodulatory mechanism of action of a phosphatase secreted by pathogenic Mycobacteria, and the attenuated vaccine strain M. bovis BCG. Inactivation of this phosphatase in BCG has yielded a vaccine prolonging survival of experimental animals upon lethal infection with tuberculosis. We will also combine this mutation with further BCG-improving manipulations testing synergism towards a strongly improved TB vaccine.