Research Explorer

Project

Understanding Bacille Calmette Guerin's immune-defenses to generate a truly protective TB vaccine.
Code
01J10711
Duration
01 July 2011 → 30 April 2016
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Microbiology not elsewhere classified
    • Systems biology not elsewhere classified
  • Medical and health sciences
    • Laboratory medicine not elsewhere classified
    • Microbiology not elsewhere classified
    • Laboratory medicine not elsewhere classified
    • Laboratory medicine not elsewhere classified
    • Microbiology not elsewhere classified
Keywords
vaccine tuberculosis immunology
 
Project description
 

We study the immunomodulatory mechanism of action of a phosphatase secreted by pathogenic Mycobacteria, and the attenuated vaccine strain M. bovis BCG. Inactivation of this phosphatase in BCG has yielded a vaccine prolonging survival of experimental animals upon lethal infection with tuberculosis. We will also combine this mutation with further BCG-improving manipulations testing synergism towards a strongly improved TB vaccine.