Project

GlyConnect: developing glyco-active enzyme reagents for therapeutic glycoprotein functionality enhancement

Acronym
GlyConnect
Duration
01 January 2019 → Ongoing
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
Keywords
Glycobiology Glycoprotein conjugation protein engineering Antibody drug conjugates
 
Project description

In the biopharmaceutical industry, proteins are the main category of biotechnological drugs. To enhace their functionality, often non-protein molecules need to be attached to these proteins. At present, technologies that can do this in a site-specific way without requiring highly expensive chemistry, are in high demand. In this project, we develop such novel technology, through the use of a sugar-specific oxidase to enable coupling to engineered protein-linked glycans.