Universal, cost-effective and hypersensitive open-source technology platform for liquid biopsy based on methylome profiling of circulating DNA.

Empowering biomanufacturing with advanced Pichia-based VHH-Fc production and engineering

Tn-Miner: Technology for the discovery of tumor-specific glycopeptide immunotherapy targets.

Special Research Fund Professorship in medical biotechnology

Arming therapeutic CAR-T cells with glyco-engineered suppressors of tumor-infiltrating regulatory T cells

Synthetic glyco-biotechnology: arming therapeutic CAR-T cells with glyco-engineered suppressors of tumor-infiltrating regulatory T cells.

Validation and implementation of a prognostic biomarker of early graft failure after liver transplantation (GlycoTransplantTest)

cfRRBS: translation of technological advances in methylation profiling of circulating free DNA for minimally invasive classification and relapse detection of high-grade lymphoma

Investigation of Nanobody-based LYsosome TArgeting Chimeras (nanoLYTACs): a novel concept in therapy of cancer and viral infection.

Development of a novel antibody-based platform for lysosome-mediated targeted protein degradation

Study of inducible glycome manipulation of CAR-T cells upon antigen exposure in the tumor environment

Understanding, optimizing and expanding target space of yeast-secreted, edible antibodies.

Development of inhaled anti-SARS-CoV-2 antibody.

Enabling antibody prophylaxis of the elderly and vulnerable using yeast-based biotechnology.

Orally deliverable antibodies against gastrointestinal targets of importance in human medicine.

Engineering of the CAR-T cell glycocalyx to enhance anti-tumor efficacy.

SECRiFY: a new tool for studying eukaryotic protein secretion.

SECRiFY: a new tool for studying eukaryotic protein secretion.

GlyConnect: developing glyco-active enzyme reagents for therapeutic glycoprotein functionality enhancement

Replacement of N-glycan analysis equipment

Improving monoclonal antibody production in glycosylationhumanized Pichia pastoris strains

Novel glycoproteomics methodology for discovering tumor-specific cell surface glycopeptide epitopes.

Customized glycosylation engineering to enhance lysosomal enzyme delivery to muscle tissue in congenital and acquired lysosomal dysfunction.

Towards more effective enzyme replacement therapy for inherited and acquired Lysosomal Storage Diseases of muscle tissue.

Understanding and exploiting glycosylation in immunotherapy.

Genome engineering method development for the functional study of cytotoxic T-cell glycome alterations. 

Glyco(Double)Delete technology: maturation, development of compatible GlyConnect coupling technology

Bio-encapsulation in yeast for delivery of intestinal epithelium-protecting and microbiome-manipulating biopharmaceuticals

Development and use of new genetic engineering and testing for BCG-based anti-tuberculosis vaccines

Exploration of differentiated iPSCs as peptide antigen source for tolerizing immunizations in autoimmune disease

Improved glycoconjugate purification using temperature-controlled lectin multimers

ERC Professorship: GlycoTarget

Assembly and optimization of synthetic pathways Saccharonmyces cerevisiae: aurones case study

Fight against Mycobacterium tuberculosis infection with cell wall enzymes

Glyco-engineering of allergens for active immunotherapy

Novel forward genetics screening methodology in human HEK293 cells.

GlycoCirrhoTest: manufacturing demonstration, CE mark preparation and establishing link to pathology of cirrhotic liver regeneration.

Proteome-wide analysis of protein fragment expressability

Novel molecular intervention technology for infectious and allergic respiratory diseases

Analysis of glycosylation changes on the surface of lymphocytes and their pathophysiological relevance during chronic necro-inflammation

In vitro and in vivo glyco-engineering of human IgG, and the leukocyte-cell surface with new fucosidasen

Proteomes screening for protein fragments which can be secreted by yeast

Understanding Bacille Calmette Guerin's immune-defenses to generate a truly protective TB vaccine.

Glycan structure-mediated targeted delivery of therapeutic enzymes and cytokines

Biofarmaceutical proteins: glyco-engineering technology to produce enhanced, homogene glycoforms

Development of novel expression technology for eukaryotic membrane proteins: application to G-protein coupled receptors

Screening entire proteomes for yeast-expressable fragments

Technology development for more efficient production of membrane proteins in Pichia pastoris

Development of novel expression technology for eukaryotic membrane proteins: application to G-protein coupled receptors

Expression and glyco-engineering of lysosomal enzymes in yeasts for the treatment of lysosomal storage diseases.

Glyco-engineering of IL-10 and IL-22 for tissue-specific delivery via lectin receptors

A mycobacterium bovis BCG transposon insertion library as a tool to study the role of mycobacterial glycolipids and other components in pathogenesis.

Manipulation of the eukaryotic secretory system: production of homogenously modified proteins for structural analysis and biotechnology

Design and use of a novel HEK293S-based expression system for eukaryotic (membrane) proteins

Study of the synthesis of mycobacterial ManLAM and its function in the interaction with phagocytes

Unesco Abdulladim

Flow imaging microscope for advanced analysis of biopharmaceuticals and biological samples

A MALDI-8020 mass spectrometer for peptide and protein analysis.

Prophylaxis of at risks persons with an ultrapotent SARS-CoV-2-neutralizing antibody

Role of glycosylation in the immunogenicity of the nematode specific activation-associated secreted proteins (ASPs) and its implication in vaccine efficacy.

Method development for the characterization of serum/plasma protein glycosylation. Application in clinical hepatology, endocrinology, oncology and anti-doping control

Special Research Fund Professorship in medical biotechnology

ERC Professorship: GlycoTarget

Development of a minimally-invasive test for accurate diagnosis of Cancer of Unknown Primary (CUP) using DNA methylation profiling