Project

Novel glycoproteomics methodology for discovering tumor-specific cell surface glycopeptide epitopes.

Duration
01 October 2017 → Ongoing
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Morphological sciences
    • Oncology
    • Medical biochemistry and metabolism
    • Morphological sciences
    • Oncology
    • Medical biochemistry and metabolism
    • Morphological sciences
    • Oncology
Keywords
immunotherapy target identification glycoproteomics cancer
 
Project description

Finding new cancer-specific glycopeptide epitopes through the development of an entirely novel glycoproteomics methodology, fully focused on the (Sia-)Tn cancer glycotype that is almost universally overproduced in (adeno)carcinomas. This is essential to bring the enormous potential of the new, potentially curative modalities of cancer immunotherapy to the vast majority of cancer patients with solid tumors that derive from epithelial cells.