An integrated approach to unravel eosinophil function in chronic eosinophilic disorders

Transmission Electron Microscopy Expertise Centre

Understanding the alveolar macrophage niche in health and disease

Role of Endoplasmic Retriculum Stress in dendritic cells and immune-mediated lung disesases

ABPA Crystal Clear project: Charcot-Leyden crystals and galectin-10 as a potential diagnostic marker and therapeutic target in allergic bronchopulmonary aspergillose (ABPA) in patients with cystic fibrosis

Doctoral project Elisabeth De Leeuw

Doctoral project Fabian Bick

Doctoral project Inés Lammens

Doctoral project Jozefien Declercq

Doctoral project Marie Godar

Doctoral project Monique Willart

Doctoral project Sahine Lameire

Effector Functions of Humoral Immunity – Lost in Translation?

Modelling type 2 immunity driven by protein crystallization

The influence of the nervous system on interstitial macrophages, dendritic cells and T cell activation in allergic asthma

The role of alveolar macrophages as a crucial regulator of pulmonary homeostasis

The role of eosinophils in type 2 immune responses after vaccination

The role of resident memory T cells in allergic asthma

Type 2 immuniteit en het genereren van metastasen

Cellular plasticity and heterogeneity in ovarian cancer progression and therapy resistance

Doctoral project Charlot De Wachter

Doctoral project Inés Lammens

Doctoral project Lana Vandersarren

Eosinophil mucin in chronic rhinosinusitis: clinical implications and long-term outcome

The study of bacterial extracellular vesicle-mediated immune responses in cancer

Unraveling Inflammation in Chronic Rhinosinusitis: From Endotyping to Impact of Biologicals

A ‘crystal clear’ view on Th2 immunity

Alliance Research Group: Immunomodulation in chronic inflammatory diseases

A local memory: the role of resident Th2 memory cells in allergic asthma

A new IRE-1 dependent pathway in ER stress involving TAOK3

An integrated strategy for preclinical development of improved vaccines against dendritrische cell lung cancer

A novel model of airway obstruction to spatially investigate mucus plugging in asthma and Type-2 diseases

AUSEM: AUtomatic freeze-Substitution for advanced Electron Microscopy techniques

BOF staff support in the framework of an ERC-Grant

BOF-ZAP professorship in clinical immunology and lung diseases

CHITINAIR: the role of CHItinases and chitinase like proteins in human Type 2 INflammatory AIRway diseases

Chitinase-like proteins shaping the pulmonary metastatic niche

ClinicalTrials.COV : Clinical long term-follow up of COVID-19 patients that underwent immuneintervention clinical trials or standard of care.

Deciphering mechanisms of respiratory virus-induced asthma predispositions and exacerbations. 

Dendritic cells and protective long lasting immunity to influenza virus

Determining the molecular blueprint underlying the homeostatic functional specialization of tissue-resident macrophages

Development and use of relevant hamster and mouse SARS-COV-2 infection models to aid in the design of therapeutic and prophylactic options for COVID-19

Development of an in vivo two-photon microscopy platform to study dynamic interactions in the immune system of the lung

Double hydroxide compounds (LDH)

Education of lung epithelial cells as an alternative explanation for the protective effect of infectious pressure on development of allergy and asthma.

Effect of microbiome on the skin-lung axis in asthma

Effect of skin microbiome diversity on epicutaneous sensitization to allergens

Elucidating the role of liver resident Kupffer cells in the regulation of the immune responses to intestinal antigens

Induction of IgA2 class switching in human Ige+B cells as theraphy for allergic disease

Induction of IgA² class switching in human IgE*Bcells as therapy for allergic disease

Involvement of the endoplasmic reticulum stress response in lung dendritic cell function and inflammatory lung disease

Lymphatic vessels in the asthmatic lung - Unexplored roads to the lymph node

Mechanisms of the Development of ALLergy (MeDALL)

MITACS: Multivalent Immune TArgeting synthetic Chimeric therapeuticS.

Multi-labeled semi-supervised learning in big data problem

Protein crystals in asthma : markers or makers of eosinophilic inflammation

Research into the role of mite-specific B cells in allergic respiratory infections

Role of damage associated molecular patterns (DAMPs) in initiation and persistence of chronic airway inflammation

Role of hypoxia in dendritic cell biology and pathogenesis of asthma

Role of Interleukin-1 in mediating epithelial-dendritic cell crosstalk in the lung

Role of lymphatics in asthma

Role of protein crystals in asthma

Spatio-temporal control of eosinophil functioning in allergic lung inflammation

Structural and functional analysis of lymphatic vessel hyperplasia in bronchial asthma

Structured learning for hierarchically organized biological data

Study of the functional role of the distinct lund und liver antigen-presenting cells subsets in vivo

Study of the functional role of the distinct lung nd liver antigen-presenting cells subsets in vivo.

Study of the functional role of the distinct lung nd liver antigen-presenting cells subsets in vivo.

The BD FACS Symphony FACS cell sorter: the most advanced multiparameter fluorescence activated cell sorter that allows the identification and purification of rare cells for further functional characterization

The disease-modifying effect of the microbiome in a spontaneous mouse model for systemic lupus erythematosus

The role of alternatively-activated macrophages in the development of a lung pre-metastatic niche

The role of chitinase-like proteins Ym1 and Ym2 in type 2 immunity.

The role of dendritic cells in extramedullary hematopoiesis and chronic myeloproliferative disorders.

The role of Ormdl3 in asthma

The role of resident memory T cells in allergic asthma

The role of the GATA transcription factors in the development and function of mast cells in asthma.

The role of the ORMDL3 susceptibility gene in the pathogenesis of asthma

The role of the phosphoinositide 3-kinases in the regulation of dendritic

The role of the unfolded protein response in radiation-induced anti-tumor responses

The role of T resident memory cells in asthma

The who, where and when of airway immunoglobulins: dissecting the mechanisms leading to local modulation of allergic airway disease.

The working mechanism of a new class of adjuvant, the Layered Double Hydroxide (LDH) family.

TSLP and Ox40L as targets of therapeutic intervention for allergic asthma

Unbiased Biomarkers for the Predicition of Respiratory Disease Outcomes (U-Biopred)

Uncovering a role for B cells in allergy risk and protection in early life.

Understanding division of labor in interstitial macrophages

Understanding division of labor in interstitial macrophages

Understanding Heterogeneity of Eosinophils in Airway Disease

Understanding the immunological basis of persistent airway obstruction in asthma

Understanding the role of the transcription factor Zeb1 in conventional Dendritic cell development and function.

Unraveling the complexity of chitinases and chitinase-like proteins in asthma

Unraveling the regulatory landscape of dendritic cells using module networks.

Unravelling the mechanism of neonatal pneumovirus infection and subsequent virus induced asthma predisposition.

Ym and Charcot-Leyden crystals in the Airways– understanding biological function and therapeutic potential

Cancer cells and their microenvironment: from gene regulatory networks to therapy

FullPicture: Combining Spectral Flow Cytometry with High-Speed Cell Imaging to enable comprehensive profiling of plant and animal cells and their components in real time.

King Baudouin Foundation - Fund Alphonse and Jean Forton and the Belgian CF Association: "Charcot-Leyden crystals and Galectin-10 as potential diagnostic and therapeutic target in cystic fibrosis-associated allergic bronchopulmonary aspergillosis (ABPA)"

Reprogramming of tumor-associated dendritic cells on microRNA level as a novel immune escape mechanism in cancer

Role of alveolar macrophages in controlling risk or protection from asthma.

SpatialConnect: linking tissue biology to the new era of single-cell spatial transcriptomics

Suppression of asthma through education of airway epithelial cells by environmental microbial exposure

BOF-ZAP professorship in clinical immunology and lung diseases

Covid-Track: applying quantitative virology and single-cell genomics to unravel the virus-host interactions leading to severe immunopathologies in COVID-19 patients