Project

Development and use of relevant hamster and mouse SARS-COV-2 infection models to aid in the design of therapeutic and prophylactic options for COVID-19

Code
3G0G4820
Duration
22 May 2020 → 31 May 2021
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Vaccinology
    • Inflammation
    • Medical intensive care
    • Respiratory medicine
    • Clinical trials
    • Vaccines
Keywords
COVID-19 sars-cov-2 infection model corona virus vaccine clinical trial ther animal models virus inhibitors therapeutic agents
 
Project description

In some patients, COVID-19 progresses from an initially mild viral syndrome to a severe and life-threatening multi-system disorder with cytokine storm. This coronavirus pandemic is putting healthcare systems worldwide under unprecedented and increasing pressure. Efficient vaccines as well antiviral (small molecules and biologicals) and anti-inflammatory drugs are urgently needed. Given the emergency, the repurposing of small molecules and/or biologicals with proven effect and safety in humans against other indications, offer the best chance for rapid success. To speed up translation to the clinic, the consortium is building innovative animal models for COVID-19 to assess the effectiveness of vaccines, antiviral & antiinflammatory strategies in various disease phases of COVID-19.