Research Explorer

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Researcher

Bart Lambrecht

Publications & Research Data

Awards & Distinctions

585 Results

2026

Effectiveness of biologics for reducing occlusive mucus plugs in patients with severe asthma: a systematic review

Helena Catharine AegerterChristopher E. BrightlingEleanor M. DunicanBart LambrechtNjira L. LugogoJohn D. NewellCeleste PorsbjergSarah SvenningsenDeborah ClarkeAndrew W. Lindsley et al.

U Journal Article in RESPIRATORY RESEARCH

PIDgeon : an explainable AI model for improved flow cytometry-based screening of lymphoid primary immunodeficiencies

Annelies EmmaneelJana NeirinckAlba Torres-ValleSofie Van GassenSarah BonteMalicorne BuysseJacques J. M. Van DongenAlberto OrfaoMirjam Van Der BurgTomas Kalina et al.

A1 Journal Article in CLINICAL CHEMISTRY

2025

A f entanyl hapten-displaying lipid nanoparticle vaccine that non-covalently encapsulates a TLR7/8 agonist and T-helper epitope induces protective anti-fentanyl immunity

Zifu ZhongMarie DeventerYong ChenStijn VanheeInés LammensKim DeswarteYi HuangTingting YeHaixiu WangLutz Nuhn et al.

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A genetically encoded endogenous antibody recruitment strategy for innate immune-mediated killing of cancer cells

Justine AelvoetZifu ZhongClaudia Mariela Brenis GómezHelena Catharine AegerterBenoit LouageBart LambrechtBruno De GeestMartijn Schuijs

A1 Journal Article in ADVANCED MATERIALS

A reappraisal of IL-9 in inflammation and cancer

Fabian BickChristophe BlanchetotBart LambrechtMartijn Schuijs

A1 Journal Article in MUCOSAL IMMUNOLOGY

Airway epithelial cells as drivers of severe asthma pathogenesis

Del DorscheidGail M. GauvreauSteve N. GeorasPieter S. HiemstraGilda VarricchiBart LambrechtGianni Marone

A1 Journal Article in MUCOSAL IMMUNOLOGY

Allergy-triggering proteins share a common characteristic

CREB regulates Foxp3+ST-2+ TREGS with enhanced IL-10 production

Sudheendra Hebbar SubramanyamJudit Turyne HriczkoSaskia SchulzThomas LookTannaz GoodarziTim ClarnerMiriam ScheldMarkus KippEva VerjansSvenja Boell et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Cystic fibrosis as a modulable model for CFTR-related Immune dysregulation

Leander JonckheereCedric BosteelsIris JanssensSebastian RiemannLieve Vande SandeTania MaesYannick Vande WeygaerdeStephanie Van BiervlietFilomeen HaerynckBart Lambrecht et al.

Cystic fibrosis as a modulable model for CFTR-related immune dysregulation

Leander JonckheereCedric BosteelsIris JanssensSebastian RiemannLieve Vande SandeTania MaesYannick Vande WeygaerdeStephanie Van BiervlietFilomeen HaerynckBart Lambrecht et al.

GM-CSF and specific type 2 cytokines induce CD103+and CD301b+cell states in cDC1s and cDC2s

Lukas AmonDamir VurnekAnna SeichterGiorgi TchitashviliTomasz KaszubowskiMarkus MrozNincy DebeufTina VoglerNicole KuepperKaushikk Ravi Rengarajan et al.

A1 Journal Article in CELL REPORTS

Immunotherapy for asthma

Hamida HammadEngi AhmedBart Lambrecht

A1 Journal Article in CELLULAR & MOLECULAR IMMUNOLOGY

Physicochemical and biological stability of diluted vedolizumab in intravenous infusion bags

Tine C. J. HendrickxKevin BalcaenMarielle BaertJurgen HaustraeteBart Lambrecht

A1 Journal Article in EUROPEAN JOURNAL OF HOSPITAL PHARMACY

RIPK1 ablation in T cells results in spontaneous enteropathy and TNF-driven villus atrophy

Jelle HuysentruytWolf SteelsMario Ruiz PérezBruno VerstraetenTatyana DivertKayleigh FliesKelly LemeireNozomi TakahashiElke De BruynMarie Joossens et al.

A1 Journal Article in EMBO REPORTS

Stage-specific transcriptomic analysis reveals insights into the development, reproduction and biological function of allergens in the European house dust mite Dermatophagoides pteronyssinus

Jose Cristian Vidal-QuistFelix OrtegoBart LambrechtStephane RombautsPedro Hernandez-Crespo

A1 Journal Article in BMC GENOMICS

Targeting IL-9 and IL-21 in ashtma and immuno-oncology

Fabian BickBart LambrechtChristophe BlanchetotMartijn Schuijs

Targeting γc family cytokines with biologics : current status and future prospects

Fabian BickChristophe BlanchetotBart LambrechtMartijn Schuijs

A1 Journal Article in MABS

Thioamides adjacent to the ionizable amine headgroup in ionizable lipids reduce the pKa of lipid nanoparticles and enhance mRNA transfection efficiency in vitro and in vivo

Yong ChenEmily De LombaerdeAimee-Rose Bugler-LambZifu ZhongMartijn SchuijsClaudia Mariela Brenis GómezJamie De BaereMark GontsarikHeleen LauwersKim Deswarte et al.

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Type 2 immune responses to allergens : influence of the perinatal environment

Elisabeth De LeeuwBart LambrechtHamida HammadCedric Bosteels

Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that clamp the spike at its base

Sieglinde De CaeInge Van MolleLoes van SchieSophie R. ShoemakerJulie DeckersNincy DebeufSahine LameireWim NerinckxKenny RooseDaria Fijalkowska et al.

A1 Journal Article in NATURE COMMUNICATIONS

2024

Airway remodelling in asthma and the epithelium : on the edge of a new era

Gilda VarricchiChristopher E. BrightlingChristopher GraingeBart LambrechtPascal Chanez

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Amplification of protein expression by self-amplifying mRNA delivered in lipid nanoparticles containing a β-aminoester ionizable lipid correlates with reduced innate immune activation

Emily De LombaerdeXiaole CuiYong ChenZifu ZhongJulie DeckersGiulia MencarelliLisa OpsomerHaixiu WangJamie De BaereStefan Lienenklaus et al.

A1 Journal Article in ACS NANO

Aspergillus and the lung

Iris JanssensBart LambrechtEva Van Braeckel

A1 Journal Article in SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

CAR T cells put the brakes on asthma

Bart LambrechtHamida Hammad

A1 Journal Article in NATURE IMMUNOLOGY

Case report : dual monoclonal antibody therapy in chronic rhinosinusitis with nasal polyps and severe eosinophilic asthma : a proteome analysis

Manon BlauwblommePhilippe GevaertSharon Van NevelSebastian RiemannElke VandewalleGabriële HoltappelsNatalie De RuyckLara DeryckeAnne-Sophie EeckelsStijn Vanhee et al.

A2 Journal Article in FRONTIERS IN ALLERGY

CO-DELIVERY of glutamic acid-extended peptide antigen and imidazoquinoline TLR7/8 agonist via ionizable lipid nanoparticles induces protective anti-tumor immunity

Tingting YeZifu ZhongFederica CappellessoKim DeswarteYong ChenHeleen LauwersEmily De LombaerdeMark GontsarikStefan LienenklausDorien Van Lysebetten et al.

A1 Journal Article in BIOMATERIALS

Combinatorial screening of biscarbamate ionizable lipids identifies a low reactogenicity lipid for lipid nanoparticle mRNA delivery

Emily De LombaerdeYong ChenTingting YeJulie DeckersGiulia MencarelliKim DeswarteHeleen LauwersRuben De CoenSabah KasmiSanne Bevers et al.

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Cystic fibrosis and the role of CFTR in circulating immune cells : a human single-cell atlas

Leander JonckheereCedric BosteelsIris JanssensYannick Vande WeygaerdeTania MaesRobin BrowaeysNiels VandammeSimon TavernierBart LambrechtEva Van Braeckel

Development of human innate immune responses in a humanized mouse model expressing four human myelopoiesis transgenes

Hannah StocksElisabeth De LeeuwBart LambrechtLinos VandekerckhoveGeert van LooAndy Wullaert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Effect of pneumatic tube transport on monoclonal antibody stability

Tine HendrickxPhilippe De GrooteKevin BalcaenAns DevreeseN KizilmeseMarielle BaertJurgen HaustraeteBart Lambrecht

A4 Journal Article in BELGIAN JOURNAL OF HOSPITAL PHARMACY

Effector functions of humoral immunity : lost in translation?

Karel Van DammeBart Lambrecht

Eosinophilic mucin in chronic rhinosinusitis : clinical implications and long-term outcome

Stephan VlaminckPhilippe GevaertBart LambrechtFrederic Acke

IL-2 family cytokines IL-9 and IL-21 differentially regulate innate and adaptive type 2 immunity in asthma

Fabian BickClaudia Mariela Brenis GómezInés LammensJustine Van MoorleghemCaroline De WolfSam DupontLaure DumoutierNeal P. SmithAlexandra-Chloé VillaniRobin Browaeys et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inhaled GM-CSF administered during ongoing pneumovirus infection alters myeloid and CD8 T cell immunity without affecting disease outcome

Nincy DebeufJulie DeckersSahine LameireCedric BosteelsHamida HammadBart Lambrecht

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Interleukin-33-activated basophils promote asthma by regulating Th2 cell entry into lung tissue

Martijn SchuijsClaudia Mariela Brenis GómezFabian BickJustine Van MoorleghemManon VanheerswynghelsGeert van LooRudi BeyaertDavid VoehringerRichard M. LocksleyHamida Hammad et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection

Astrid MarchalElizabeth T. CirulliIva NeveuxEvangelos BellosRyan S. ThwaitesKelly M. Schiabor BarrettYu ZhangIvana Nemes-BokunMariya KalinovaAndrew Catchpole et al.

A2 Journal Article in HUMAN GENETICS AND GENOMICS ADVANCES

Lipid nanoparticle encapsulation empowers poly(I:C) to activate cytoplasmic RLRs and thereby increases its adjuvanticity

Alexander LamootSonia JangraGabriel LaghlaliPrajakta WarangLauren A. ChangSeok‐Chan ParkGagandeep SinghKim DeswarteZifu ZhongBenoit Louage et al.

A1 Journal Article in SMALL

Modulation is not an independent determinant of the viscoelastic properties of sputum in cystic fibrosis

Iris JanssensLeander JonckheereHelena Catharine AegerterM. De ConinckYannick Vande WeygaerdeBart LambrechtEva Van Braeckel

Modélisation de l’asthme sévère par la technologie des cellules humaines souches pluripotentes induites (hiPSC)

Engi AhmedS AssouF FoissetC BourdaisManon VanheerswynghelsA PetitA S GamezD GrasP ChanezJ de Vos et al.

A1 Journal Article in REVUE DES MALADIES RESPIRATOIRES

PH-triggered, lymph node focused immunodrug release by polymeric 2-propionic-3-methyl-maleic anhydrides with cholesteryl end groups

Alina G. HeckCarolina Medina-MontanoZifu ZhongKim DeswarteKatharina EigenJudith StickdornJohannes KockelmannMaximilian SchergerNiek SandersStefan Lienenklaus et al.

A1 Journal Article in ADVANCED HEALTHCARE MATERIALS

Repeated COVID-19 mRNA-based vaccination contributes to SARS-CoV-2 neutralizing antibody responses in the mucosa

Jozefien DeclercqSarah GerloSharon Van NevelNatalie De RuyckGabriële HoltappelsLiesbeth DelesieEls TobbackInés LammensNikita GerebtsovKoen Sedeyn et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

RIPK1 protects naive and regulatory T cells from TNFR1-induced apoptosis

Jelle HuysentruytWolf SteelsMario Ruiz PérezBruno VerstraetenMike VadiTatyana DivertKayleigh FliesNozomi TakahashiBart LambrechtWim Declercq et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Shared lung and joint T cell repertoire in early rheumatoid arthritis driven by cigarette smoking

Koen VenkenMatthias JarlborgFrederik StevenaertThomas MalfaitCarolien VliegheYann AbrahamTeddy ManuelloTine DecruyStijn VanheeHans Wils et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Single-cell proteomics and transcriptomics capture eosinophil development and identify the role of IL-5 in their lineage transit amplification

Joseph JorssenGlenn Van HulstKirena MollersJulien PujolGeorgios PetrellisAntonio Pires da Silva BaptistaSjoerd SchettersFrederic BaronJo CaersBart Lambrecht et al.

A1 Journal Article in IMMUNITY

Spatial microniches of IL-2 combine with IL-10 to drive lung migratory TH2 cells in response to inhaled allergen

Kun HeHanxi XiaoWilliam A. MacDonaldIsha MehtaAkash KishoreAugusta VincentZhongli XuAnuradha RayWei ChenCasey T. Weaver et al.

A1 Journal Article in NATURE IMMUNOLOGY

Sublingual allergen immunotherapy prevents house dust mite inhalant type 2 immunity through dendritic cell-mediated induction of Foxp3+ regulatory T cells

Katrien Van Der BorghtJens BrimnesEline HaspeslaghStephanie BrandKatrijn NeytShashank GuptaNiels Peter Hell KnudsenHamida HammadPeter S. AndersenBart Lambrecht

A1 Journal Article in MUCOSAL IMMUNOLOGY

TCR transgenic clone selection guided by immune receptor analysis and single-cell RNA expression of polyclonal responders

Nincy DebeufSahine LameireManon VanheerswynghelsJulie DeckersCaroline De WolfWendy ToussaintRein VerbekeKevin VerstaenHamida HammadStijn Vanhee et al.

A2 Journal Article in ELIFE

The unfolded protein sensor IRE1a is essential for homeostatic dendritic cell maturation

Sophie JanssensVictor BosteelsSandra MaréchalEva ClootsLaurien Van HeddegemSimon TavernierSofie RennenClint De NolfSeraja AmstelveenJonathan Maelfait et al.

TL1A and IL-18 synergy promotes GM-CSF-dependent thymic granulopoiesis in mice

Mario Ruiz PérezChristian MaueröderWolf SteelsBruno VerstraetenSahine LameireWei XieLaura WyckaertJelle HuysentruytTatyana DivertRia Roelandt et al.

A1 Journal Article in CELLULAR & MOLECULAR IMMUNOLOGY

Ym1 protein crystals promote type 2 immunity

Ines HeyndrickxKim DeswarteKenneth VerstraeteKoen VerschuerenUrsula SmoleHelena Catharine AegerterAnn DansercoerHamida HammadSavvas SavvidesBart Lambrecht

A1 Journal Article in ELIFE

2023

A Complement Atlas identifies interleukin 6 dependent alternative pathway dysregulation as a key druggable feature of COVID-19

Karel Van DammeLevi HosteJozefien DeclercqElisabeth De LeeuwBastiaan MaesLiesbet MartensRoos ColmanRobin BrowaeysCedric BosteelsStijn Verwaerde et al.

A complement atlas identifies interleukin-6-dependent alternative pathway dysregulation as a key druggable feature of COVID-19

Karel Van DammeLevi HosteJozefien DeclercqElisabeth De LeeuwBastiaan MaesLiesbet MartensRoos ColmanRobin BrowaeysCedric BosteelsStijn Verwaerde et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

A conversation on allergy : recognizing the past and looking to the future

Erik MelenBart LambrechtClare M. LloydMarc E. RothenbergKenji KabashimaFabio LucianiJonathan M. CoquetCarole OberMartijn C. NawijnThomas Platts-Mills et al.

A1 Journal Article in IMMUNOLOGY AND CELL BIOLOGY

A novel role for the IRE1/XBP1 branch in dendritic cells : a signaling cascade matures

Victor BosteelsSophie JanssensBart Lambrecht

Canonical IRE1 function needed to sustain vigorous natural killer cell proliferation during viral infection

Jessica VettersMary van HeldenClint De NolfSofie RennenEva ClootsEvelien Van De VeldeFarzaneh FayazpourJustine Van MoorleghemManon VanheerswynghelsKarl Vergote et al.

A1 Journal Article in ISCIENCE

CCL5-producing migratory dendritic cells guide CCR5+ monocytes into the draining lymph nodes

Kavita RawatAnita TewariXin LiArlind B. B. MaraWilliam T. T. KingSophie L. L. GibbingsChinaza F. F. NnamFred W. W. KollingBart LambrechtClaudia V. V. Jakubzick

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Chitinases and chitinase-like proteins in asthma

Jozefien DeclercqHamida HammadBart LambrechtUrsula Smole

A1 Journal Article in SEMINARS IN IMMUNOLOGY

Lipid nanoparticle delivery alters the adjuvanticity of the TLR9 agonist CpG by innate immune activation in lymphoid tissue

Zifu ZhongYong ChenKim DeswarteHeleen LauwersEmily De LombaerdeXiaole CuiSimon Van HerckTingting YeMark GontsarikStefan Lienenklaus et al.

A1 Journal Article in ADVANCED HEALTHCARE MATERIALS

LXR signaling controls homeostatic dendritic cell maturation

Victor BosteelsSandra MaréchalClint De NolfSofie RennenJonathan MaelfaitSimon TavernierJessica VettersEvelien Van De VeldeFarzaneh FayazpourKim Deswarte et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

PD-L1 checkpoint blockade promotes regulatory T cell activity that underlies therapy resistance

Mandy van GulijkAnneloes van KrimpenSjoerd SchettersMike EtermanMarit van ElsasJoanne MankorLarissa KlaaseMarjolein de BruijnMenno van NimwegenTim van Tienhoven et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice

Karel Van DammePieter HertensArne MartensElisabeth GilisDario PriemInge BruggemanAmelie FossoulJozefien DeclercqHelena Catharine AegerterAndy Wullaert et al.

A1 Journal Article in SCIENTIFIC REPORTS

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Daniela MatuozzoEstelle TalouarnAstrid MarchalPeng ZhangJeremy ManryYoann SeeleuthnerYu ZhangAlexandre BolzeMatthieu ChaldebasBaptiste Milisavljevic et al.

A1 Journal Article in GENOME MEDICINE

RNA viruses alter house dust mite physiology and allergen production with no detected consequences for allergenicity

José Cristian Vidal‐QuistJozefien DeclercqStijn VanheeBart LambrechtJosé Gómez‐RialCarmen VidalEylem Aydogdu LohausStephane RombautsPedro Hernández‐Crespo

A1 Journal Article in INSECT MOLECULAR BIOLOGY

STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity

Bastiaan MaesFarzaneh FayazpourLeen CatrysseGuillaume LornetEvelien Van De VeldeCaroline De WolfSofie De PrijckJustine Van MoorleghemManon VanheerswynghelsKim Deswarte et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

TAOK3 regulates type 2 immune responses in the lung and adipose tissue

Bastiaan MaesSophie JanssensBart LambrechtHamida Hammad

The pathology of asthma : what is obstructing our view?

Helena Catharine AegerterBart Lambrecht

A1 Journal Article in ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE

2022

Advancing lung immunology research : an official American Thoracic Society workshop report

Rod A. RahimiJosalyn L. ChoV Jakubzick, ClaudiaShabaana A. KhaderBart LambrechtClare M. LloydAri B. MolofskySebastien TalbotCatherine A. BonhamWonder P. Drake et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Biology of lung macrophages in health and disease

Helena Catharine AegerterBart LambrechtClaudia V. Jakubzick

A1 Journal Article in IMMUNITY

Distinct transcriptional programs in ascitic and solid cancer cells induce different responses to chemotherapy in high-grade serous ovarian cancer

Nele LoretNiels VandammeJordy De ConinckJoachim TaminauKato De ClercqGillian BlanckeSven JonckheereSteven GoossensKelly LemeireSofie De Prijck et al.

A1 Journal Article in MOLECULAR CANCER RESEARCH

Efficacy and safety of the investigational complement C5 inhibitor zilucoplan in patients hospitalized with COVID-19 : an open-label randomized controlled trial

Elisabeth De LeeuwKarel Van DammeJozefien DeclercqCedric BosteelsBastiaan MaesSimon TavernierLaurent DetalleTrevor SmartSophie GlattNincy Debeuf et al.

A1 Journal Article in RESPIRATORY RESEARCH

Emerging paradigms in type 2 immunity

Hamida HammadNincy DebeufHelena Catharine AegerterAndrew BrownBart Lambrecht

A1 Journal Article in ANNUAL REVIEW OF IMMUNOLOGY

Granulocyte colony-stimulating factor : missing link for stratification of type 2-high and type 2-low chronic rhinosinusitis patients

Sharon Van NevelJozefien DeclercqGabriële HoltappelsBart LambrechtClaus Bachert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141

Leslie NaesensSantoshi MuppalaDhiraj AcharyaJosephine NemegeerDelfien BogaertJung-Hyun LeeKatrien StaesVeronique DebackerPieter De BleserMarieke De Bruyne et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

Inflammasomes and IL-1 family cytokines in SARS-CoV-2 infection : from prognostic marker to therapeutic agent

Jozefien DeclercqElisabeth De LeeuwBart Lambrecht

A1 Journal Article in CYTOKINE

Isolation of conventional murine lung dendritic cell subsets

Elisabeth De LeeuwCedric BosteelsBart LambrechtHamida Hammad

Bookchapter in Asthma : methods and protocols

Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment

Cedric BosteelsKarel Van DammeElisabeth De LeeuwJozefien DeclercqBastiaan MaesVictor BosteelsLevi HosteLeslie NaesensNincy DebeufJulie Deckers et al.

A1 Journal Article in CELL REPORTS MEDICINE

Prospective longitudinal evaluation of hospitalised COVID-19 survivors 3 and 12 months after discharge

Natalie LorentYannick Vande WeygaerdeEveline ClaeysIpek Guler Caamano FajardoNicolas De VosWalter De WeverBihiyga SalhiIwein GyselinckCedric BosteelsBart Lambrecht et al.

A1 Journal Article in ERJ OPEN RESEARCH

The Charcot-Leyden crystal protein Galectin-10 is not a major determinant of human regulatory T-cell function

Rebeca Arroyo-HorneroHelena Catharine AegerterIbrahim HamadBeatriz Corte-RealKatrien StaesBas van Der WoningKenneth VerstraeteSavvas SavvidesBart LambrechtMarkus Kleinewietfeld

A1 Journal Article in ALLERGY

The Euroflow PID Orientation Tube in the diagnostic workup of primary immunodeficiency : daily practice performance in a tertiary university hospital

Jana NeirinckAnnelies EmmaneelMalicorne BuysseJan PhilippéSofie Van GassenYvan SaeysXavier BossuytStefanie De BuyserMirjam van der BurgMartin Perez-Andres et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

The role of protein crystals in type 2 immunity

Ines HeyndrickxBart LambrechtHamida Hammad

The state of complement in COVID-19

Behdad AfzaliMarina NorisBart LambrechtClaudia Kemper

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

The STE20 kinase TAOK3 controls the development of house dust mite-induced asthma in mice

Bastiaan MaesUrsula SmoleMatthias VanderkerkenKim DeswarteJustine Van MoorleghemKarl VergoteManon VanheerswynghelsCaroline De WolfSofie De PrijckNincy Debeuf et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C

Levi HosteLisa RoelsLeslie NaesensVictor BosteelsStijn VanheeSam DupontCedric BosteelsRobin BrowaeysNiels VandammeKevin Verstaen et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

WS17.04 CFTR modulation alters the visco-elastic properties of airway mucus in cystic fibrosis patients

Iris JanssensHelena Catharine AegerterUrsula SmoleM. De ConinckYannick Vande WeygaerdeBart LambrechtEva Van Braeckel

2021

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation

Richard de ReuverEvelien DierickBartosz WiernickiKatrien StaesLeen SeysEllen De MeesterTuur MuyldermansAlexander BotzkiBart LambrechtFilip Van Nieuwerburgh et al.

A1 Journal Article in CELL REPORTS

Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation

Nikos OikonomouMartijn SchuijsAntonis ChatzigiagkosAriadne AndroulidakiVassilis AidinisHamida HammadBart LambrechtManolis Pasparakis

A1 Journal Article in MUCOSAL IMMUNOLOGY

Association between administration of IL-6 antagonists and mortality among patients hospitalized for COVID-19 : a meta-analysis

[missing] The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working GroupIsabel MurGracia María MateoMaria del Mar GutierrezVirginia PomarNatividad de BenitoNoemí CorbachoSilvia HerreraLucia MillanJessica Muñoz et al.

A1 Journal Article in JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Paul BastardAdrian GervaisTom Le VoyerJérémie RosainQuentin PhilippotJérémy ManryEleftherios MichailidisHans-Heinrich HoffmannShohei EtoMarina Garcia-Prat et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

CCR2-and Flt3-dependent inflammatory conventional type 2 dendritic cells are necessary for the induction of adaptive immunity by the human vaccine adjuvant system AS01

Cedric BosteelsKaat FierensSofie De PrijckJustine Van MoorleghemManon VanheerswynghelsCaroline De WolfAurelie ChalonCatherine CollignonHamida HammadArnaud M. Didierlaurent et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Cellular plasticity and heterogeneity in ovarian cancer progression and therapy resistance

Nele LoretGeert BerxPhilippe TummersBart Lambrecht

Charcot-Leyden crystals and other protein crystals driving type 2 immunity and allergy

Helena Catharine AegerterUrsula SmoleInes HeyndrickxKenneth VerstraeteSavvas SavvidesHamida HammadBart Lambrecht

A1 Journal Article in CURRENT OPINION IN IMMUNOLOGY

Conceptions of the pathophysiology of happy hypoxemia in COVID-19

Sebastiaan DhontEric DeromEva Van BraeckelPieter DepuydtBart Lambrecht

A1 Journal Article in RESPIRATORY RESEARCH

Coronavirus disease 2019 in patients with inborn errors of immunity : an international study

Isabelle MeytsGiorgia BucciolIsabella QuintiBénédicte NevenAlain FischerElena SeoaneEduardo Lopez-GranadosCarla GianelliAngel Robles-MarhuendaPierre-Yves Jeandel et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

DALI (Diversity AnaLysis Interface) : a novel tool for the integrated analysis of multimodal single cell RNAseq data and immune receptor profiling

Kevin VerstaenInés LammensJana RoelsYvan SaeysBart LambrechtNiels VandammeStijn Vanhee

Effect of anti-interleukin drugs in patients with COVID-19 and signs of cytokine release syndrome (COV-AID) : a factorial, randomised, controlled trial

Jozefien DeclercqKarel Van DammeElisabeth De LeeuwBastiaan MaesCedric BosteelsSimon TavernierStefanie De BuyserRoos ColmanMaya HitesGil Verschelden et al.

A1 Journal Article in LANCET RESPIRATORY MEDICINE

GTF3A mutations in a patient with herpes simplex encephalitis reveals a novel role in viral immunity by transcribing 5S rRNA pseudogenes serving as RIG-I ligands

Leslie NaesensSantoshi MuppalaJung-Hyun LeeJosephine NemegeerDhiraj AcharyaDelfien BogaertMichiel van GentJens StaalKatrien StaesVeronique Debacker et al.

ILC3s control airway inflammation by limiting T cell responses to allergens and microbes

Fei TengRoser Tacho-PinotBiin SungDonna L. FarberStefan WorgallHamida HammadBart LambrechtMatthew R. HepworthGregory F. Sonnenberg

A1 Journal Article in CELL REPORTS

ILC3s control splenic cDC homeostasis via lymphotoxin signaling

Matthias VanderkerkenAntonio Pires da Silva BaptistaMarco De GiovanniSatoshi FukuyamaRobin BrowaeysCharlotte ScottPaula S. NorrisGerard EberlJames P. Di SantoEric Vivier et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

IRE1 beta does not affect mucus secretion during allergic asthma development in a house dust mite murine model

Eva ClootsNincy DebeufKim DeswarteFarzaneh FayazpourManon VanheerswynghelsCaroline De WolfEvelien Van de VeldeHamida HammadBart LambrechtSven Eyckerman et al.

A1 Journal Article in ALLERGY

Lipid nature and alkyl length influence lymph node accumulation of lipid-polyethylene glycol amphiphiles

Jana De VriezeAntonio Pires da Silva BaptistaLutz NuhnSimon Van HerckKim DeswarteHaijun YuBart LambrechtBruno De Geest

A1 Journal Article in ADVANCED THERAPEUTICS

Lipid-polyglutamate nanoparticle vaccine platform

Dorien Van LysebettenAlessio MalfantiKim DeswarteKaloian KoynovBianka GolbaTingting YeZifu ZhongSabah KasmiAlexander LamootYong Chen et al.

A1 Journal Article in ACS APPLIED MATERIALS & INTERFACES

Local immune response to food antigens drives meal-induced abdominal pain

Javier Aguilera-LizarragaMorgane V. FlorensMaria Francesca ViolaPiyush JainLisse DecraeckerIris AppeltansMaria Cuende-EstevezNaomi FabreKim Van BeekEluisa Perna et al.

A1 Journal Article in NATURE

Missing heritability in Bloom syndrome : first report of a deep intronic variant leading to pseudo‐exon activation in the BLM gene

Lynn BackersBram PartonMarieke De BruyneSimon TavernierKris Van Den BogaertBart LambrechtFilomeen HaerynckKathleen Claes

A1 Journal Article in CLINICAL GENETICS

Missing heritability in Bloom syndrome : First report of a deep-intronic variant leading to pseudo-exon activation in the BLM gene

Lynn BackersBram PartonMarieke De BruyneSimon TavernierKris Van Den BogaertBart LambrechtFilomeen HaerynckKathleen Claes

Pathophysiological and clinical aspects of chronic rhinosinusitis : current concepts

Stephan VlaminckFrederic AckeGlenis K. ScaddingBart LambrechtPhilippe Gevaert

A2 Journal Article in FRONTIERS IN ALLERGY

Ribosome-targeting antibiotics impair T cell effector function and ameliorate autoimmunity by blocking mitochondrial protein synthesis

Luis AlmeidaAyesha Dhillon-LaBrooyCarla N. CastroNigatu AdossaGuilhermina M. CarricheMelanie GuderianSaskia LippensSven DennerleinChristina HesseBart Lambrecht et al.

A1 Journal Article in IMMUNITY

RNA viruses in the house dust mite Dermatophagoides pteronyssinus, detection in environmental samples and in commercial allergen extracts used for in vivo diagnosis

Jose Cristian Vidal-QuistCarmen VidalFernando EscolarBart LambrechtStephane RombautsPedro Hernandez-Crespo

A1 Journal Article in ALLERGY

Squaric ester-based, pH-degradable nanogels : modular nanocarriers for safe, systemic administration of toll-like receptor 7/8 agonistic immune modulators

Anne HuppertsbergLeonard KapsZifu ZhongSascha SchmittJudith StickdornKim DeswarteFrancis CombesChristian CzyschJana De VriezeSabah Kasmi et al.

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sterilizing immunity against SARS‐CoV‐2 infection in mice by a single‐shot and lipid amphiphile imidazoquinoline TLR7/8 agonist‐adjuvanted recombinant spike protein vaccine**

Sonia JangraJana De VriezeAngela ChoiRaveen RathnasingheGabriel LaghlaliAnnemiek UvynSimon Van HerckLutz NuhnKim DeswarteZifu Zhong et al.

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Surgery in nasal polyp patients : outcome after a minimum observation of 10 years

Stephan VlaminckFrederic AckeEmmanuel ProkopakisKato SpelemanHideyuki KawauchiJean-Christophe van CutsemPeter HellingsMark JorissenSven SeysClaus Bachert et al.

A1 Journal Article in AMERICAN JOURNAL OF RHINOLOGY & ALLERGY

The basic immunology of asthma

Hamida HammadBart Lambrecht

A1 Journal Article in CELL

The pharmacology of the prostaglandin D-2 receptor 2 (DP2) receptor antagonist, fevipiprant

Chris BrightlingSwarupa KulkarniBart LambrechtDavid SandhamMarkus WeissPablo Altman

A1 Journal Article in PULMONARY PHARMACOLOGY & THERAPEUTICS

The role of DC subsets in respiratory viral infections and vaccination : a case of mistaken identity

Cedric BosteelsBart LambrechtHamida Hammad

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19

Takaki AsanoBertrand BoissonFanny OnodiDaniela MatuozzoMarcela Moncada-VelezMajistor Raj Luxman Maglorius RenkilarajPeng ZhangLaurent MeertensAlexandre BolzeMarie Materna et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

2020

A randomized, multicentre, open-label phase II proof-of-concept trial investigating the clinical efficacy and safety of the addition of convalescent plasma to the standard of care in patients hospitalized with COVID-19 : the Donated Antibodies Working against nCoV (DAWn-Plasma) trial

Timothy DevosTatjana GeukensAlexander SchauwvliegheKevin K. ArienCyril BarbezangeMyriam CleerenVeerle CompernolleNicolas DaubyDaniel DesmechtDavid Grimaldi et al.

A1 Journal Article in TRIALS

Adult chronic rhinosinusitis

Claus BachertBradley MarpleRodney J. SchlosserClaire HopkinsRobert P. SchleimerBart LambrechtBarbara M. BrokerTanya LaidlawWoo-Jung Song

A1 Journal Article in NATURE REVIEWS DISEASE PRIMERS

An anti-siglec-8 antibody depletes sputum eosinophils from asthmatic subjects and inhibits lung mast cells

Sheena C. KerrJeanmarie R. GonzalezJulia SchaninMichael C. PetersBart LambrechtEmily C. BrockAnnabelle CharbitK. Mark AnselBradford A. YoungbloodJohn V. Fahy

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Case report : convalescent plasma, a targeted therapy for patients with CVID and severe COVID-19

Karel Van DammeSimon TavernierNele Van RoyElisabeth De LeeuwJozefien DeclercqCedric BosteelsBastiaan MaesMarieke De BruyneDelfien BogaertVictor Bosteels et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Charcot-Leyden crystals promote neutrophilic inflammation in patients with nasal polyposis

Elien GevaertTim DelemarreJoyceline De VolderNan ZhangGabriële HoltappelsNatalie De RuyckEmma PerssonInes HeyndrickxKenneth VerstraeteHelena Catharine Aegerter et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Clarifying the translational potential of B-I09

Juan R. Del ValleBrian C. BettsXue-Zhong YuSophie JanssensBart LambrechtM. Celeste SimonChih-Chi Andrew Hu

A1 Journal Article in NATURE CHEMICAL BIOLOGY

Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome

Vivien BéziatSimon TavernierYin-Huai ChenCindy S. MaMarie MaternaArian LaurenceJens StaalDominik AschenbrennerLisa RoelsLisa Worley et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

First patient with bloom syndrome caused by a deep intronic variant leading to pseudoexon activation

Lynn BackersBram PartonStephanie VermeulenMarieke De BruyneSimon TavernierKris Van Den BogaertAnne VralAns BaeyensFilomeen HaerynckBart Lambrecht et al.

GATA2 deficiency and haematopoietic stem cell transplantation : challenges for the clinical practitioner

Delfien BogaertGenevieve LaureysLeslie NaesensDominiek MazureMarieke De BruyneAmy P. HsuMaria Bordon Cueto De BraemErik WoutersSimon TavernierBart Lambrecht et al.

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Human lung conventional dendritic cells orchestrate lymphoid neogenesis during chronic obstructive pulmonary disease

Thomas NaessensYannick MoriasEva HamrudUlf GehrmannRamachandramouli BudidaJohan MattssonTina BakerGabriel SkogbergElisabeth IsraelssonKristofer Thorn et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inflammatory type 2 cDCs acquire features of cDC1s and macrophages to orchestrate immunity to respiratory virus infection

Cedric BosteelsKatrijn NeytManon VanheerswynghelsMary van HeldenDorine SichienNincy DebeufSofie De PrijckVictor BosteelsNiels VandammeLiesbet Martens et al.

A1 Journal Article in IMMUNITY

Missing heritability in Bloom syndrome : first report of a deep-intronic variant leading to pseudo-exon activation in the BLM gene

Lynn BackersBram PartonMarieke De BruyneSimon TavernierKris Van Den BogaertBart LambrechtFilomeen HaerynckKathleen Claes

Missing heritability in Bloom syndrome : first report of a deep-intronic variant leading to pseudo-exon activation in the BLM gene

Lynn BackersBram PartonMarieke De BruyneSimon TavernierKris Van Den BogaertBart LambrechtFilomeen HaerynckKathleen Claes

Potent and prolonged innate immune activation by enzyme-responsive imidazoquinoline TLR7/8 agonist prodrug vesicles

Bi WangSimon Van HerckYong ChenXiangyang BaiZifu ZhongKim DeswarteBart LambrechtNiek SandersStefan LienenklausHans W. Scheeren et al.

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Publisher correction : Zeb2 drives invasive and microbiota-dependent colon carcinoma

Karolina SlowickaIoanna PettaGillian BlanckeEsther HosteEmilie DumasMozes SzeHanna-Kaisa VikkulaEnrico RadaelliJody J. HaighSven Jonckheere et al.

Rbm7 in structural cells : a NEAT way to control fibrosis

Hamida HammadBart Lambrecht

Editorial material

Sargramostim to treat patients with acute hypoxic respiratory failure due to COVID-19 (SARPAC) : a structured summary of a study protocol for a randomised controlled trial

Cedric BosteelsBastiaan MaesKarel Van DammeElisabeth De LeeuwJozefien DeclercqANJA DELPORTEBENEDICTE DEMEYEREStefanie VermeerschMarnik VuylstekeJoren Willaert et al.

A1 Journal Article in TRIALS

Sargramostim to treat patients with acute hypoxic respiratory failure due to COVID-19 (SARPAC) : a structured summary of a study protocol for a randomised controlled trial (vol 21, 491, 2020)

Cedric BosteelsBastiaan MaesKarel Van DammeElisabeth De LeeuwJozefien DeclercqAnja DelporteBenedicte DemeyereStefanie VermeerschMarnik VuylstekeJoren Willaert et al.

Short-term preoperative protein restriction attenuates vein graft disease via induction of cystathionine γ-lyase

Kaspar M TrochaPeter KipMing TaoMichael R MacArthurJ Humberto Treviño-VillarrealAlban LongchampWendy ToussaintBart LambrechtMargreet R de VriesPaul H A Quax et al.

A1 Journal Article in CARDIOVASCULAR RESEARCH

Sterilizing immunity against SARS-CoV-2 infection in mice by a single-shot and modified imidazoquinoline TLR7/8 agonist-adjuvanted recombinant spike protein vaccine

Sonia JangraJana De VriezeAngela ChoiRaveen RathnasingheGabriel LaghlaliAnnemiek UvynSimon Van HerckLutz NuhnKim DeswarteZifu Zhong et al.

TAO-kinase 3 governs the terminal differentiation of conventional dendritic cells

Matthias VanderkerkenBastiaan MaesLana VandersarrenWendy ToussaintKim DeswarteManon VanheerswynghelsPhilippe PouliotLiesbet MartensSofie Van GassenConnie M. Arthur et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization

Zan LiHwanhee OhMichelle CungSofia Jenia MarquezJun SunHamida HammadSophie JanssensPhilippe PouliotBart LambrechtYeon-Suk Yang et al.

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The global response to the COVID-19 pandemic : how have immunology societies contributed?

Faith OsierJenny P. Y. TingJohn FraserBart LambrechtMarta RomanoRicardo T. GazzinelliKarina R. BortoluciDario S. ZamboniArne N. AkbarJennie Evans et al.

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

The pathophysiology of 'happy' hypoxemia in COVID-19

Sebastiaan DhontEric DeromEva Van BraeckelPieter DepuydtBart Lambrecht

A1 Journal Article in RESPIRATORY RESEARCH

Tnfaip3 expression in pulmonary conventional type 1 Langerin‐expressing dendritic cells regulates T helper 2‐mediated airway inflammation in mice

Heleen VromanDenise van UdenIngrid M. BergenJennifer A.C. van HulstMelanie LukkesGeert van LooBjörn E. ClausenLouis BoonBart LambrechtHamida Hammad et al.

A1 Journal Article in ALLERGY

Treatment of severely ill COVID-19 patients with anti-interleukin drugs (COV-AID) : a structured summary of a study protocol for a randomised controlled trial

Bastiaan MaesCedric BosteelsElisabeth De LeeuwJozefien DeclercqKarel Van DammeANJA DELPORTEBENEDICTE DEMEYEREStefanie VermeerschMarnik VuylstekeJoren Willaert et al.

A1 Journal Article in TRIALS

Treatment of severely ill COVID-19 patients with anti-interleukin drugs (COV-AID) : a structured summary of a study protocol for a randomised controlled trial (vol 21, 468, 2020)

Bastiaan MaesCedric BosteelsElisabeth De LeeuwJozefien DeclercqKarel Van DammeAnja DelporteBenedicte DemeyereStefanie VermeerschMarnik VuylstekeJoren Willaert et al.

Wnt and Hippo pathways in regulatory T cells : a NOTCH above in asthma

Hamida HammadBart Lambrecht

Editorial material

Zeb2 drives invasive and microbiota-dependent colon carcinoma

Karolina SlowickaIoanna PettaGillian BlanckeEsther HosteEmilie DumasMozes SzeHanna-Kaisa VikkulaEnrico RadaelliJody J. HaighSven Jonckheere et al.

A1 Journal Article in NATURE CANCER

Zilucoplan in patients with acute hypoxic respiratory failure due to COVID-19 (ZILU-COV) : a structured summary of a study protocol for a randomised controlled trial

Jozefien DeclercqCedric BosteelsKarel Van DammeElisabeth De LeeuwBastiaan MaesAns VandecauterStefanie VermeerschAnja DelporteBénédicte DemeyereMarnik Vuylsteke et al.

A1 Journal Article in TRIALS

2019

A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation

Simon TavernierV AthanasopoulosPATRICK VERLOOG BehrensJens StaalDelfien BogaertLeslie NaesensMarieke De BruyneSofie Van GassenEef Parthoens et al.

A1 Journal Article in NATURE COMMUNICATIONS

A synthetic, transiently thermoresponsive homopolymer with UCST behaviour within a physiologically relevant window

Zhiyue ZhangHui LiSabah KasmiSimon Van HerckKim DeswarteBart LambrechtRichard HoogenboomLutz NuhnBruno De Geest

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Antigen-presenting dendritic cells

Bart LambrechtHamida Hammad

Bookchapter in Middleton's allergy : principles & practice

Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells

Annemiek UvynRuben De CoenOlivier De WeverKim DeswarteBart LambrechtBruno De Geest

A1 Journal Article in CHEMICAL COMMUNICATIONS

Developing and benchmarking methods for analysing transcriptomics data

Wouter SaelensYvan SaeysBart Lambrecht

Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux

Jeanne-Marie PerotinJames PR SchofieldSusan J WilsonJonathan WardJoost BrandsmaFabio StrazzeriAruna BansalXian YangAnthony RoweJulie Corfield et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

From ER stress to T cell biology : IRE1 signaling and TAOK3 function

Lana VandersarrenSophie JanssensBart Lambrecht

GATA2 deficiency and hematopoietic stem cell transplantation : challenges for the clinical practitioner

Delfien BogaertLeslie NaesensGenevieve LaureysMaria Bordon Cueto De BraemErik WoutersSimon TavernierBart LambrechtFilomeen HaerynckTessa Kerre

How a farming environment protects from atopy

Julie DeckersBart LambrechtHamida Hammad

A1 Journal Article in CURRENT OPINION IN IMMUNOLOGY

IL-33trap is a novel IL-33-neutralizing biologic that inhibits allergic airway inflammation

Aurora Holgado MuñozHarald BraunElien Van NuffelSammy DetryMartijn SchuijsKim DeswarteKarl VergoteMira HaegmanGriet BaudeletJurgen Haustraete et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy

Cristina Gil-CruzChristian Perez-ShibayamaAngelina De MartinFrancesca RonchiKatrien Van Der BorghtRebekka NiedererLucas OnderMechthild LutgeMario NovkovicVeronika Nindl et al.

A1 Journal Article in SCIENCE

Molecular interactions controlling immune homeostasis in the marginal zone

Matthias VanderkerkenBart LambrechtTessa Kerre

ORMDL3 in the regulation of sphingolipid synthesis and in the pathogenesis of allergic asthma

Nincy DebeufBart LambrechtSophie Janssens

Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists

Jana De VriezeBenoit LouageKim DeswarteZifu ZhongRuben De CoenSimon Van HerckLutz NuhnCamilla Kaas FrichAlexander N ZelikinStefan Lienenklaus et al.

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Professional and 'amateur' antigen-presenting cells in type 2 immunity

Martijn SchuijsHamida HammadBart Lambrecht

A1 Journal Article in TRENDS IN IMMUNOLOGY

Prophylactic allergen immunotherapy with Der p 2 prevents murine asthma by regulating lung GM-CSF

Eline HaspeslaghManon VanheerswynghelsKim DeswarteJustine Van MoorleghemAlain JacquetBart LambrechtHamida Hammad

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Protein crystallization promotes type 2 immunity and is reversible by antibody treatment

Emma PerssonKenneth VerstraeteInes HeyndrickxElien GevaertHelena Catharine AegerterJean-Michel PercierKim DeswarteKoen VerschuerenAnn DansercoerDelphine Gras et al.

A1 Journal Article in SCIENCE

Pulmonary immunomodulation of house dust mite-induced allergic asthma

Eline HaspeslaghHamida HammadBart Lambrecht

Regulators of A20 (TNFAIP3) : new drug-able targets in inflammation

G MomtaziBart LambrechtJR NaranjoBC Schock

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Single-cell RNA sequencing of the T helper cell response to house dust mites defines a distinct gene expression signature in airway Th2 cells

Christopher Andrew TibbittJulian Mario StarkLiesbet MartensJunjie MaJeff Eron MoldKim DeswarteGanna OliynykXiaogang FengBart LambrechtPieter De Bleser et al.

A1 Journal Article in IMMUNITY

Stellate cells, hepatocytes, and endothelial cells imprint the Kupffer cell identity on monocytes colonizing the liver macrophage niche

Johnny BonnardelWouter T'JonckDjoere GaublommeRobin BrowaeysCharlotte ScottLiesbet MartensBavo VannesteSofie De PrijckSergei A NedospasovAnna Kremer et al.

A1 Journal Article in IMMUNITY

The cytokines of asthma

Bart LambrechtHamida HammadJohn V. Fahy

A1 Journal Article in IMMUNITY

The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice

Nincy DebeufAssem ZhakupovaRegula SteinerSofie Van GassenKim DeswarteFarzaneh FayazpourJustine Van MoorleghemKarl VergoteBenjamin PavieKelly Lemeire et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF

Jessica VettersMary van HeldenSigrid WahlenSimon TavernierArne MartensFarzaneh FayazpourKarl VergoteManon VanheerswynghelsKim DeswarteJustine Van Moorleghem et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2018

A bispecific antibody strategy to target multiple type 2 cytokines in asthma

Marie GodarKim DeswarteKarl VergoteMichael SaundersHans de HaardHamida HammadChristophe BlanchetotBart Lambrecht

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A CARD9 founder mutation disrupts NF-κB signaling by inhibiting BCL10 and MALT1 recruitment and signalosome formation

Marieke De BruyneLevi HosteDelfien BogaertLien Van den BosscheSimon TavernierEef ParthoensMélanie MigaudDeborah KonopnickiJean Cyr YombiBart Lambrecht et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

A pathophysiological role of PDE3 in allergic airway inflammation

Jan BeuteMelanie LukkesEwout P KoekoekHedwika NastitiKeerthana GaneshMarjolein JW de BruijnSteve HockmanMenno van NimwegenGert-Jan BraunstahlLouis Boon et al.

A1 Journal Article in JCI INSIGHT

Antigen presentation unfolded : identifying convergence points between the UPR and antigen presentation pathways

Fabiola OsorioBart LambrechtSophie Janssens

A1 Journal Article in CURRENT OPINION IN IMMUNOLOGY

Characterization of a lung epithelium specific E-cadherin knock-out model : implications for obstructive lung pathology

S PostIH HeijinkL HesseHK KooF ShaheenM FouadiVNS KuchibhotlaBart LambrechtAJM Van OosterhoutTL Hackett et al.

A1 Journal Article in SCIENTIFIC REPORTS

Co-activation of glucocorticoid receptor and peroxisome proliferator-activated receptor-γ in murine skin prevents worsening of atopic march

Julie DeckersNadia BougarneViacheslav MylkaSofie DesmetAstrid LuypaertMichael DevosGiel TangheJustine Van MoorleghemManon VanheerswynghelsLode De Cauwer et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Dendritic cells in inflammatory disease

Bart LambrechtMartin GuilliamsHamida Hammad

Bookchapter in Inflammation : from molecular and cellular mechanisms to the clinic

Development of novel multifunctional antibodies to treat asthma

Marie GodarBart LambrechtChristophe Blanchetot

Eicosanoid control over antigen presenting cells in asthma

Nincy DebeufBart Lambrecht

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Exploring the influence of N-glycosylation on allergen-specific immunotherapy

Charlot De WachterNico CallewaertBart Lambrecht

FcRn is mother's milk to allergen tolerance

Editorial material

FcεRI expression and IgE binding by dendritic cells and basophils in allergic rhinitis and upon allergen immunotherapy

Margot BeringsPhilippe GevaertNatalie De RuyckLara DeryckeGabriële HoltappelsC PiletteClaus BachertBart LambrechtMelissa Dullaers

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

FRET monitoring of intracellular ketal hydrolysis in synthetic nanoparticles

Lutz NuhnSimon Van HerckAndreas BestKim DeswarteMaria KokkinopoulouIngo LieberwirthKaloian KoynovBart LambrechtBruno De Geest

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Heart macrophages and dendritic cells in sickness and in health : a tale of a complicated marriage

Katrien Van Der BorghtBart Lambrecht

A1 Journal Article in CELLULAR IMMUNOLOGY

House dust mite allergic rhinitis : a novel take on diagnosis and treatment

Margot BeringsPhilippe GevaertMelissa DullaersBart Lambrecht

Hyaluronic acid conjugates of TLR7/8 agonists for targeted delivery to secondary lymphoid tissue

Euna YooAlex CD SalyerMichael JH BrushYupeng LiKathryn L TrautmanNikunj M ShuklaAns De BeuckelaerStefan LienenklausKim DeswarteBart Lambrecht et al.

A1 Journal Article in BIOCONJUGATE CHEMISTRY

Isolated Schistosoma mansoni eggs prevent allergic airway inflammation

Katja ObiegloMartijn SchuijsArifa Ozir-FazalalikhanFrank OttoYolanda van WijckLouis BoonBart LambrechtChristian TaubeHermelijn H Smits

A1 Journal Article in PARASITE IMMUNOLOGY

Isolation of conventional murine lung dendritic cell subsets

Cedric BosteelsBart LambrechtHamida Hammad

A2 Journal Article in CURRENT PROTOCOLS IN IMMUNOLOGY

KIRA1 and ORESARA1 terminate flower receptivity by promoting cell death in the stigma of Arabidopsis

Zhen GaoAnna DanevaYuliya SalanenkaMatthias Van DurmeMarlies HuysmansZongcheng LinFreya De WinterSteffen VannesteMansour KarimiJan Van de Velde et al.

A1 Journal Article in NATURE PLANTS

Lymph-node-targeted immune activation by engineered block copolymer amphiphiles-TLR7/8 agonist conjugates

Simon Van HerckKim DeswarteLutz NuhnZifu ZhongJoão Portela CataniYupeng LiNiek SandersStefan LienenklausStefaan De KokerBart Lambrecht et al.

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Myocarditis elicits dendritic cell and monocyte infiltration in the heart and self-antigen presentation by conventional type 2 dendritic cells

Katrien Van Der BorghtCharlotte ScottLiesbet MartensDorine SichienGert Van IsterdaelVeronika NindlYvan SaeysLouis BoonBurkhard LudewigThierry Gillebert et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Nanoparticle-conjugate TLR7/8 agonist localized immunotherapy provokes safe antitumoral responses

Lutz NuhnStefaan De KokerSandra Van LintZifu ZhongJoão Portela CataniFrancis CombesKim DeswarteYupeng LiBart LambrechtStefan Lienenklaus et al.

A1 Journal Article in ADVANCED MATERIALS

Osteopontin promotes protective antigenic tolerance against experimental allergic airway disease

Themis AlissafiEvangelia KourepiniDavina C. M. SimoesNikolaos PaschalidisMaria AggelakopoulouTim SparwasserLouis BoonHamida HammadBart LambrechtVily Panoutsakopoulou

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Personalized medicine with biologics for severe type 2 asthma : current status and future prospects

Marie GodarChristophe BlanchetotHans de HaardBart LambrechtGuy Brusselle

A1 Journal Article in MABS

Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7/8 agonist

Lutz NuhnLien Van HoeckeKim DeswarteBert SchepensYupeng LiBart LambrechtStefaan De KokerSunil A DavidXavier SaelensBruno De Geest

A1 Journal Article in BIOMATERIALS

Response to Orlova et al. 'Science not art: statistically sound methods for identifying subsets in multi-dimensional flow and mass cytometry data sets'

Yvan SaeysSofie Van GassenBart Lambrecht

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

Role of NKp46⁺ natural killer cells in house dust mite-driven asthma

Eline HaspeslaghMary van HeldenKim DeswarteSofie De PrijckJustine Van MoorleghemLouis BoonHamida HammadEric VivierBart Lambrecht

A1 Journal Article in EMBO MOLECULAR MEDICINE

Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha

Srinath GovindarajanDjoere GaublommeRenée Van der CruyssenEveline VerheugenSofie Van GassenYvan SaeysSimon TavernierTakao IwawakiYehudi BlochSavvas Savvides et al.

A1 Journal Article in NATURE COMMUNICATIONS

The emerging role of ADAM metalloproteinases in immunity

Bart LambrechtMatthias VanderkerkenHamida Hammad

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

The generation and use of allergen-specific TCR transgenic animals

Manon VanheerswynghelsWendy ToussaintMartijn SchuijsLeen VanhoutteNigel KilleenHamida HammadBart Lambrecht

Bookchapter in Type 2 immunity : methods and protocols

The hygiene hypothesis : immunological mechanisms of airway tolerance

Eline HaspeslaghInes HeyndrickxHamida HammadBart Lambrecht

A1 Journal Article in CURRENT OPINION IN IMMUNOLOGY

The transcription factor ZEB2 is required to maintain the tissue-specific identities of macrophages

Charlotte ScottWouter T'JonckLiesbet MartensHelena TodorovDorine SichienBieke SoenJohnny BonnardelSofie De PrijckNiels VandammeRobrecht Cannoodt et al.

A1 Journal Article in IMMUNITY

The unfolded protein response in the immune cell development : putting the caretaker in the driving seat

Simon TavernierBart LambrechtSophie Janssens

A1 Journal Article in CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY

TNF-α-induced protein 3 levels in lung dendritic cells instruct TH2 or TH17 cell differentiation in eosinophilic or neutrophilic asthma

Heleen VromanIngrid M BergenJennifer AC van HulstMenno van NimwegenDenise van UdenMartijn SchuijsSaravanan Y PillaiGeert van LooHamida HammadBart Lambrecht et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Type III collagen affects dermal and vascular collagen fibrillogenesis and tissue integrity in a mutant Col3a1 transgenic mouse model

Sanne D'hondtBrecht GuillemynDelfien SyxSofie SymoensRiet De RyckeLeen VanhoutteWendy ToussaintBart LambrechtAnne De PaepeDouglas R Keene et al.

A1 Journal Article in MATRIX BIOLOGY

2017

A CARD9 Turkisch founder mutation disrupts NF-κB signaling by inhibiting Bcl10 recruitment

Marieke De BruyneLevi HosteDelfien BogaertMélanie MigaudDeborah KonopnickiBart LambrechtRudi BeyaertElfride De BaereAnne PuelJean-Christophe Goffard et al.

A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes

Bénédicte MachielsMickael DourcyXue XiaoJustine JavauxClaire MesnilCatherine SabatelDaniel DesmechtFrançois LallemandPhilippe MartiniveHamida Hammad et al.

A1 Journal Article in NATURE IMMUNOLOGY

Bacteria isolated from lung modulate asthma susceptibility in mice

Aude RemotDelphyne DescampsMarie-Louise NoordineAbdelhak BoukadiriElliot MathieuVéronique RobertSabine RiffaultBart LambrechtPhilippe LangellaHamida Hammad et al.

A1 Journal Article in ISME JOURNAL

CARD9 p.R70W, a Turkish founder mutation associated with mucosal and invasive fungal infections, disrupts downstream NF-κB signaling by inhibiting Bcl10 recruitment

Marieke De BruyneDelfien BogaertLevi HosteMélanie MigaudJean-Christophe GoffardDeborah KonopnickiBart LambrechtRudi BeyaertElfride De BaereAnne Puel et al.

CARD9 p.R70W, a Turkish founder mutation associated with mucosal and invasive fungal infections, disrupts downstream NF-κB signaling by inhibiting Bcl10 recruitment

Marieke De BruyneLevi HosteDelfien BogaertMélanie MigaudJean-Christophe GoffardDeborah KonopnickiBart LambrechtRudi BeyaertElfride De BaereAnne Puel et al.

CARD9 p.R70W, a Turkish founder mutation associated with mucosal and invasive fungal infections, disrupts downstream NF-κB signaling by inhibiting Bcl10 recruitment

Marieke De BruyneDelfien BogaertLevi HosteMélanie MigaudJean-Christophe GoffardDeborah KonopnickiBart LambrechtRudi BeyaertElfride De BaereAnne Puel et al.

Cardiac dendritic cell subsets activate autoreactive T cells in the healthy and diseased heart

Katrien Van Der BorghtBart LambrechtThierry Gillebert

Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity

Margherita CocciaCatherine CollignonCaroline HervéAurélie ChalonIain WelsbySophie DetienneMary van HeldenSheetij DuttaChristopher J GenitoNorman C Waters et al.

A1 Journal Article in NPJ VACCINES

Computational analysis of multimorbidity between asthma, eczema and rhinitis

Daniel AguilarMariona PinartGerard H KoppelmanYvan SaeysMartijn C NawijnDirkje S PostmaMübeccel AkdisCharles AuffrayStéphane BallereauMarta Benet et al.

A1 Journal Article in PLOS ONE

Dendritic cells under stress : on the role of the unfolded protein response and hypoxia signaling

Simon TavernierSophie JanssensBart Lambrecht

Development of conventional dendritic cells : from common bone marrow progenitors to multiple subsets in peripheral tissues

Dorine SichienBart LambrechtMartin GuilliamsCharlotte Scott

A1 Journal Article in MUCOSAL IMMUNOLOGY

Differential requirement for IRF8 in the development and function of monocytes and dendritic cells

Dorine SichienBart LambrechtMartin Guilliams

Early-onset primary antibody deficiency resembling common variable immunodeficiency challenges the diagnosis of Wiedeman-Steiner and Roifman syndromes

Delfien BogaertMelissa DullaersHye Sun KuehnBart LeroyJulie E NiemelaHans De WildeSarah De SchryverMarieke De BruyneFrauke CoppietersBart Lambrecht et al.

A1 Journal Article in SCIENTIFIC REPORTS

Effects of domestic chemical stressors on expression of allergen genes in the European house dust mite

JC Vidal-QuistF OrtegoBart LambrechtP CastañeraP Hernández-Crespo

A1 Journal Article in MEDICAL AND VETERINARY ENTOMOLOGY

Epicutaneous sensitization to house dust mite allergen requires interferon regulatory factor 4-dependent dermal dendritic cells

Julie DeckersDorine SichienMaud PlantingaJustine Van MoorleghemManon VanheerswynghelsEsther HosteBernard MalissenDavid DombrowiczMartin GuilliamsKarolien De Bosscher et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Epitope mapping and kinetics of CD4 T cell immunity to pneumonia virus of mice in the C57BL/6 strain

Lana VandersarrenCedric BosteelsManon VanheerswynghelsJames J MoonAndrew J EastonGert Van IsterdaelSophie JanssensBart LambrechtMary van Helden

A1 Journal Article in SCIENTIFIC REPORTS

Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis

Sophie Van WeldenMartine De VosBen WielockxSimon TavernierMelissa DullaersSara NeytBenedicte DescampsLindsey DevisscherSarah DevrieseLien Van den Bossche et al.

A1 Journal Article in JOURNAL OF PATHOLOGY

House dust mite-driven asthma and allergen-specific T cells depend on B cells when the amount of inhaled allergen is limiting

Melissa DullaersMartijn SchuijsMonique WillartKaat FierensJustine Van MoorleghemHamida HammadBart Lambrecht

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-21 is increased in nasal polyposis and after stimulation with Staphylococcus aureus enterotoxin B

Lien CalusLara DeryckeMelissa DullaersThibaut Van ZeleNatalie De RuyckClaudina Perez NovoGabriële HoltappelsGeert De VosBart LambrechtClaus Bachert et al.

A1 Journal Article in INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12

Stefaan De KokerLien Van HoeckeAns De BeuckelaerKenny RooseKim DeswarteMonique WillartPieter BogaertThomas NaessensBruno De GeestXavier Saelens et al.

A1 Journal Article in SCIENTIFIC REPORTS

Interplay between barrier epithelial cells and dendritic cells in allergic sensitization through the lung and the skin

Julie DeckersKarolien De BosscherBart LambrechtHamida Hammad

A1 Journal Article in IMMUNOLOGICAL REVIEWS

Location, function, and ontogeny of pulmonary macrophages during the steady state

Natalio GarbiBart Lambrecht

A1 Journal Article in PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Mechanisms of the Development of Allergy (MeDALL) : introducing novel concepts in allergy phenotypes

Josep M AntoJean BousquetMubeccel AkdisCharles AuffrayThomas KeilIsabelle MomasDirkje S PostmaRudolf ValentaMagnus WickmanAnne Cambon-Thomsen et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mitochondrial priming by CD28

Ramon I Klein GeltinkDavid O'SullivanMauro CorradoAnna BremserMichael D BuckJoerg M BuescherElke FiratXuekai ZhuGabriele NiedermannGeorge Caputa et al.

A1 Journal Article in CELL

Murine models of allergic asthma

Eline HaspeslaghNincy DebeufHamida HammadBart Lambrecht

Bookchapter in Inflammation : methods and protocols

Myeloid cells in asthma

Bart LambrechtEmma PerssonHamida Hammad

A1 Journal Article in MICROBIOLOGY SPECTRUM

Myocardial infarction primes autoreactive T cells through activation of dendritic cells

Katrien Van Der BorghtCharlotte ScottVeronika NindlAnn BouchéLiesbet MartensDorine SichienJustine Van MoorleghemManon VanheerswynghelsSofie De PrijckYvan Saeys et al.

A1 Journal Article in CELL REPORTS

Opposing regulation and roles for PHD3 in lung dendritic cells and alveolar macrophages

Simon TavernierNele VanlangenakkerJessica VettersPeter CarmelietSophie JanssensBart Lambrecht

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

PPAR-γ promotes type 2 immune responses in allergy and nematode infection

Ting ChenChristopher A TibbittXiaogang FengJulian M StarkLeona RohrbeckLisa RauschSaikiran K SedimbiMikael CI KarlssonBart LambrechtGunilla B Karlsson Hedestam et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

Probiotics-impregnated bedding covers for house dust mite allergic rhinitis : a pilot randomized clinical trial

Margot BeringsAnton JultHanne VermeulenNatalie De RuyckLara DeryckeH UcarP GhekiereR TemmermanJ EllisClaus Bachert et al.

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Probiotics-impregnated bedding covers in house dust mite allergic rhinitis patients : a double-blind, randomised, placebo-controlled, crossover clinical trial

Margot BeringsAnton JultHans VermeulenNatalie De RuyckLara DeryckeH. UcarP. GhekiereR. TemmermanJ. EllisClaus Bachert et al.

Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival

Simon TavernierFabiola OsorioLana VandersarrenJessica VettersNele VanlangenakkerGert Van IsterdaelKarl VergoteRiet De RyckeEef ParthoensLianne van de Laar et al.

A1 Journal Article in NATURE CELL BIOLOGY

Reliable mite-specific IgE testing in nasal secretions by means of allergen microarray

Margot BeringsStefania ArasiNatalie De RuyckSerena PernaYvonne ReschChristian LupinekKuan-Wei ChenSusanne VrtalaGiovanni Battista PajnoClaus Bachert et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma

Kenneth VerstraeteFrank PeelmanHarald BraunJuan LopezDries Van RompaeyAnn DansercoerIsabel VandenbergheKris PauwelsJan TavernierBart Lambrecht et al.

A1 Journal Article in NATURE COMMUNICATIONS

Suppression of allergen-induced basophil activation upon treatment with subcutaneous house dust mite immunotherapy: a prospective study

Margot BeringsNatalie De RuyckLara DeryckeGabriële HoltappelsClaus BachertBart LambrechtMelissa DullaersPhilippe Gevaert

TGF-β gives an air of exclusivity to alveolar macrophages

Editorial material

The immunology of the allergy epidemic and the hygiene hypothesis

Bart LambrechtHamida Hammad

A1 Journal Article in NATURE IMMUNOLOGY

The immunophenotypic fingerprint of patients with primary antibody deficiencies is partially present in their asymptomatic first-degree relatives

Delfien BogaertMarieke De BruyneVeronique DebackerPauline DepuydtKatleen De PreterCarolien BonroyJan PhilippéMaria Bordon Cueto De BraemBart LambrechtTessa Kerre et al.

A1 Journal Article in HAEMATOLOGICA

The immunophenotypical fingerprint of patients with primary antibody deficiencies is partially present in their asymptomatic first-degree relatives

Delfien BogaertMarieke De BruyneVeronique DebackerPauline DepuydtKatleen De PreterCarolien BonroyJan PhilippéMaria Bordon Cueto De BraemBart LambrechtTessa Kerre et al.

The pathogenesis of house dust mite-driven asthma : from barn to bedside

Martijn SchuijsHamida HammadBart Lambrecht

The transcriptome of lung tumor-infiltrating dendritic cells reveals a tumor-supporting phenotype and a microRNA signature with negative impact on clinical outcome

Lotte PyfferoenElisabeth BrabantsCeline EveraertNancy De CabooterKelly HeynsKim DeswarteManon VanheerswynghelsSofie De PrijckGlenn WaegemansMelissa Dullaers et al.

A1 Journal Article in ONCOIMMUNOLOGY

Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10

Hamida HammadMatthias VanderkerkenPhilippe PouliotKim DeswarteWendy ToussaintKarl VergoteLana VandersarrenSophie JanssensIoanna RamouSavvas Savvides et al.

A1 Journal Article in NATURE IMMUNOLOGY

U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics

Diane LefaudeuxBertrand De MeulderMatthew J LozaNancy PefferAnthony RoweFrederic BaribaudAruna T BansalRene LutterAna R SousaJulie Corfield et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

2016

A benchmark for evaluation of algorithms for identification of cellular correlates of clinical outcomes

N AghaeepourP ChattopadhyayM ChikinaTom DhaeneSofie Van GassenM KursaBart LambrechtM MalekGJ McLachlanY Qian et al.

A1 Journal Article in CYTOMETRY PART A

A generic polymer-protein ligation strategy for vaccine delivery

Lien LybaertNane VanparijsKaat FierensMartijn SchuijsLutz NuhnBart LambrechtBruno De Geest

A1 Journal Article in BIOMACROMOLECULES

A new aDENNDum to genetics of childhood asthma

Marie GodarBart Lambrecht

Editorial material

A20 deficiency in lung epithelial cells protects against influenza A virus infection

Jonathan MaelfaitKenny RooseLars VereeckeConor Mc GuireMozes SzeMartijn SchuijsMonique WillartLorena IbanezHamida HammadBart Lambrecht et al.

A1 Journal Article in PLOS PATHOGENS

ARIA 2016 : care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

J BousquetPW HellingsI AgacheA BedbrookClaus BachertKC BergmannM BewickC Bindslev-JensenS Bosnic-AnticevitchC Bucca et al.

A1 Journal Article in CLINICAL AND TRANSLATIONAL ALLERGY

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

Charlotte ScottFang ZhengPatrick De BaetselierLiesbet MartensYvan SaeysSofie De PrijckSaskia LippensChloé AbelsSteve SchoonoogheGeert Raes et al.

A1 Journal Article in NATURE COMMUNICATIONS

Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice

Muriel SmetLien Van HoeckeAns De BeuckelaerSeppe Vander BekenThomas NaessensKarl VergoteMonique WillartBart LambrechtJan-Ake GustafssonKnut R Steffensen et al.

A2 Journal Article in IMMUNITY INFLAMMATION AND DISEASE

Chronic and invasive fungal infections in a family with CARD9 deficiency

Ana Alves de MedeirosEVELYNE LODEWICKDelfien BogaertFilomeen HaerynckSabine Van daeleBart LambrechtSarah BosmaLaure VanderdoncktOlivier LortholaryMélanie Migaud et al.

A1 Journal Article in JOURNAL OF CLINICAL IMMUNOLOGY

Chronic and invasive fungal infections in a family with CARD9 deficiency (vol 36, pg 204, 2016)

Ana Karina Alves de MedeirosEVELYNE LODEWICKDelfien BogaertFilomeen HaerynckSabine Van daeleBart LambrechtSarah BosmaLaure VanderdoncktOlivier LortholaryMélanie Migaud et al.

Computational flow cytometry: helping to make sense of high-dimensional immunology data

Yvan SaeysSofie Van GassenBart Lambrecht

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

Conventional dendritic cells : identification, subsets, development, and functions

Charlotte ScottBart Lambrecht

Bookchapter in Encyclopedia of immunobiology, vol. 3 : activation of the immune system

CVID, isolated IgG deficiency and isolated IgG subclass deficiency : clinical features and B cell maturation of the Ghent cohort

Delfien BogaertVeronique De BackerTessa KerreMaria Bordon Cueto De BraemBart LambrechtKarim VermaelenFrans De BaetsElfride De BaereMelissa DullaersFilomeen Haerynck

Dendritic cells and type 2 inflammation

Bart LambrechtMary van HeldenHamida Hammad

Bookchapter in The Th2 type immune response in health and disease

Double-negative T resident memory cells of the lung react to influenza virus infection via CD11chi dendritic cells

Katrijn NeytCH GeurtsvanKesselBart Lambrecht

A1 Journal Article in MUCOSAL IMMUNOLOGY

Dual anti-idiotypic purification of a novel, native-format biparatopic anti-MET antibody with improved in vitro and in vivo efficacy

Marie GodarVirginia MorelloAva SadiAnna HultbergNatalie De JongeCristina BasilicoValérie HanssensMichael SaundersBart LambrechtMohamed El Khattabi et al.

A1 Journal Article in SCIENTIFIC REPORTS

Early IL-1 signaling promotes iBALT induction after influenza virus infection

Katrijn NeytCorine H GeurtsvanKesselKim DeswarteHamida HammadBart Lambrecht

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

FloReMi : flow density survival regression using minimal feature redundancy

Sofie Van GassenCeline VensTom DhaeneBart LambrechtYvan Saeys

A1 Journal Article in CYTOMETRY PART A

GATA1-deficient dendritic cells display impaired CCL21-dependent migration toward lymph nodes due to reduced levels of polysialic acid

Maaike R ScheenstraIris M De CuyperFilipe Branco MadeiraPieter De BleserMirjam KoolMarjolein MeindersMark HoogenboezemErik MuMonika C WolkersFiamma Salerno et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Genes associated with common variable immunodeficiency: one diagnosis to rule them all?

Delfien BogaertMelissa DullaersBart LambrechtKarim VermaelenElfride De BaereFilomeen Haerynck

A1 Journal Article in JOURNAL OF MEDICAL GENETICS

GM-CSF treatment prevents respiratory syncytial virus– induced pulmonary exacerbation responses in postallergic mice by stimulating alveolar macrophage maturation

Thomas NaessensBert SchepensMuriel SmetCharlotte PollardLien Van HoeckeAns De BeuckelaerMonique WillartBart LambrechtStefaan De KokerXavier Saelens et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IRF8 transcription factor controls survival and function of terminally differentiated conventional and plasmacytoid dendritic cells, respectively

Dorine SichienCharlotte ScottLiesbet MartensMatthias VanderkerkenSofie Van GassenMaud PlantingaThorsten JoerisSofie De PrijckLeen VanhoutteManon Vanheerswynghels et al.

A1 Journal Article in IMMUNITY

IRF8 transcription-factor-dependent classical dendritic cells are essential for intestinal T cell homeostasis

Katarzyna M LudaThorsten JoerisEmma PerssonAymeric RivollierMimoza DemiriKatarzyna M SitnikLieneke PoolJacob B HolmFelipe Melo-GonzalezLisa Richter et al.

A1 Journal Article in IMMUNITY

JAK2 deficiency as a novel cause of impaired Th17 immunity

Filomeen HaerynckDelfien BogaertElfride De BaereKristof Van SchilFrauke CoppietersMarieke De BruyneMargot HagendorensTessa KerreFrans De BaetsMaria Bordon Cueto De Braem et al.

Macrophage precursors PLASTed INto alveolar space

Martin GuilliamsBart Lambrecht

Editorial material

MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis

Jean BousquetHolger J SchünemannPeter W HellingsSylvie ArnavielheClaus BachertAnna BedbrookKarl-Christian BergmannSinthia Bosnic-AnticevichJan BrozekMoises Calderon et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mouse models of asthma

Nincy DebeufEline HaspeslaghMary van HeldenHamida HammadBart Lambrecht

Bookchapter in Current protocols in mouse biology

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNF AIP3/A20

Michael DrennanSrinath GovindarajanEveline VerheugenJonathan CoquetJens StaalConor Mc GuireTom TaghonGeorges LeclercqRudi BeyaertGeert van Loo et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

ORMDL3 expression levels have no influence on the activity of serine palmitoyltransferase

Assem ZhakupovaNincy DebeufMichiel KrolsWendy ToussaintLeen VanhoutteIrina AlecuZoltán KutalikPeter VollenweiderDaniela ErnstArnold von Eckardstein et al.

A1 Journal Article in FASEB JOURNAL

Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story Mechanisms of the Development of ALLergy; EUFP7-CP-IP; project no: 261357; 2010-2015

J BousquetJM AntoM AkdisC AuffrayT KeilI MomasDS PostmaR ValentaM WickmanA Cambon-Thomsen et al.

A1 Journal Article in ALLERGY

Perinatal activation of the interleukin-33 pathway promotes type 2 immunity in the developing lung

Ismé De KleerMirjam KoolMarjolein JW de BruijnMonique WillartJustine Van MoorleghemMartijn SchuijsMaud PlantingaRudi BeyaertEmily HamsPadraic G Fallon et al.

A1 Journal Article in IMMUNITY

pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation

Lutz NuhnNane VanparijsAns De BeuckelaerLien LybaertGlenn VerstraeteKim DeswarteStefan LienenklausNikunj M ShuklaAlex CD SalyerBart Lambrecht et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pulmonary immune responses against influenza A virus infection

Katrijn NeytBart LambrechtMartin GuilliamsCorine Geurts van Kessel

Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

J BousquetJ FarrellG CrooksP HellingsEH BelM BewickNH ChavannesJ Correia de SousaAA CruzT Haahtela et al.

A1 Journal Article in CLINICAL AND TRANSLATIONAL ALLERGY

Spontaneous protein adsorption on graphene oxide nanosheets allowing efficient intracellular vaccine protein delivery

Hui LiKaat FierensZhiyue ZhangNane VanparijsMartijn SchuijsKatleen Van SteendamNatalia Feiner GraciaRiet De RyckeThomas De BeerAns De Beuckelaer et al.

A1 Journal Article in ACS APPLIED MATERIALS & INTERFACES

The immunophenotypical landscape of patients with primary antibody deficiencies and their asymptomatic first-degree relatives : arguments for a multifactorial aetiology

Delfien BogaertPauline DepuydtKatleen De PreterCarolien BonroyJan PhilippéMaria Bordon Cueto De BraemTessa KerreBart LambrechtAndrea CeruttiKarim Vermaelen et al.

The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2

Charlotte ScottBieke SoenLiesbet MartensNicolas SkrypekWouter SaelensJoachim TaminauGillian BlanckeGert Van IsterdaelDanny HuylebroeckJody Haigh et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Unsupervised high-dimensional analysis aligns dendritic cells across tissues and species

Martin GuilliamsCharles-Antoine DutertreCharlotte ScottNaomi McGovernDorine SichienSvetoslav ChakarovSofie Van GassenJinmiao ChenMichael PoidingerSofie De Prijck et al.

A1 Journal Article in IMMUNITY

Uric acid is released in the brain during seizure activity and increases severity of seizures in a mouse model for acute limbic seizures

Lisa ThyrionRobrecht RaedtJeanelle PortelliPieter Van LooWytse WadmanGriet GlorieuxBart LambrechtSophie JanssensKristl VonckPaul Boon

A1 Journal Article in EXPERIMENTAL NEUROLOGY

Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study

Matthew J. LozaRatko DjukanovicKian Fan ChungDaniel HorowitzKeying MaPatrick BraniganElliot S. BarnathanVedrana S. SusulicPhilip E. SilkoffPeter J. Sterk et al.

A1 Journal Article in RESPIRATORY RESEARCH

Yolk sac macrophages, fetal liver, and adult monocytes can colonize an empty niche and develop into functional tissue-resident macrophages

Lianne van de LaarWouter SaelensSofie De PrijckLiesbet MartensCharlotte ScottGert Van IsterdaelEik HoffmannRudi BeyaertYvan SaeysBart Lambrecht et al.

A1 Journal Article in IMMUNITY

β-Glucan exacerbates allergic airway responses to house dust mite allergen

Sabelo HadebeFrank KirsteinKaat FierensPierre RedelinghuysGraeme I MurrayDavid L WilliamsBart LambrechtFrank BrombacherGordon D Brown

A1 Journal Article in RESPIRATORY RESEARCH

2015

A novel STAT1 mutation in a patient with pneumocystis jiroveci and chronic mucocutaneous candidiasis

Delfien BogaertMelissa DullaersJens StaalSarah GerloElien VandermarliereVeronique De BackerMaria Bordon Cueto De BraemKATHLEEN DE WAELEIsabelle MeytsLeen Moens et al.

Are allergic multimorbidities and IgE polysensitization associated with the persistence or re-occurrence of foetal type 2 signalling? : the MeDALL hypothesis

J BousquetJM AntoM WickmanT KeilR ValentaT HaahtelaK Lodrup CarlsenM van HageC AkdisClaus Bachert et al.

A1 Journal Article in ALLERGY

Barrier epithelial cells and the control of type 2 immunity

Hamida HammadBart Lambrecht

A1 Journal Article in IMMUNITY

Calcineurin inhibitors dampen humoral immunity by acting directly on naive B cells

Ruth De BruyneDelfien BogaertNatalie De RuyckBart LambrechtMyriam Van WinckelPhilippe GevaertMelissa Dullaers

A1 Journal Article in CLINICAL AND EXPERIMENTAL IMMUNOLOGY

CCR2⁺CD103⁻ intestinal dendritic cells develop from DC-committed precursors and induce interleukin-17 production by T cells

Charlotte ScottCC BainPB WrightDorine SichienK KotarskyEmma PerssonK LudaMartin GuilliamsBart LambrechtWW Agace et al.

A1 Journal Article in MUCOSAL IMMUNOLOGY

Does circulating IL-17 identify a subset of patients with idiopathic pulmonary arterial hypertension?: response

Aurélie HautefortBarbara GirerdDavid MontaniSylvia Cohen-KaminskyLaura PriceBart LambrechtMarc HumbertFrédéric Perros

A1 Journal Article in CHEST

Epithelial cell regulation of immune responses in the lung

Bookchapter in Mucosal immunology

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

Martijn SchuijsMonique WillartKarl VergoteDelphine GrasKim DeswarteMarkus J EgeFilipe Branco MadeiraRudi BeyaertGeert van LooFranz Bracher et al.

A1 Journal Article in SCIENCE

FlowSOM: using self-organizing maps for visualization and interpretation of cytometry data

Sofie Van GassenBritt CallebautMary van HeldenBart LambrechtPiet DemeesterTom DhaeneYvan Saeys

A1 Journal Article in CYTOMETRY PART A

Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming

Melanie MatheuShivashankar OthyMilton L GreenbergTobias X DongMartijn SchuijsKim DeswarteHamida HammadBart LambrechtIan ParkerMichael D Cahalan

A1 Journal Article in NATURE COMMUNICATIONS

Immunological characterization of pediatric liver transplant associated food allergy

Ruth De BruynePhilippe GevaertMyriam Van WinckelNatalie De RuyckAurelie MinneDelfien BogaertStephanie Van BiervlietSaskia Vande VeldeFrançoise SmetsEtienne Sokal et al.

Impaired survival of regulatory T cells in pulmonary sarcoidosis

Caroline E BroosMenno van NimwegenAlex KleinjanBregje ten BergeFemke MuskensJohannes CCM In't VeenJouke T AnnemaBart LambrechtHenk C HoogstedenRudy W Hendriks et al.

A1 Journal Article in RESPIRATORY RESEARCH

In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis

Stijn VanheeKatrien De MulderYasmine Van CaeneghemGreet VerstichelNadine Van RoyBjörn MentenImke VelgheJan PhilippéDominique De BleserBart Lambrecht et al.

A1 Journal Article in HAEMATOLOGICA

Interleukin-21-producing CD4(+) T cells promote type 2 immunity to house dust mites

Jonathan CoquetMartijn SchuijsMark J SmythKim DeswarteRudi BeyaertHarald BraunLouis BoonGunilla B Karlsson HedestamSteven L NuttHamida Hammad et al.

A1 Journal Article in IMMUNITY

MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation

J BousquetHJ SchunemannJ FonsecaB SamolinskiClaus BachertGW CanonicaT CasaleAA CruzP DemolyP Hellings et al.

A1 Journal Article in ALLERGY

Microbial ligand costimulation drives neutrophilic steroid-refractory asthma

Sabelo HadebeFrank KirsteinKaat FierensKong ChenRebecca A DrummondSimon VautierSara SajaniemiGraeme MurrayDavid L WilliamsPierre Redelinghuys et al.

A1 Journal Article in PLOS ONE

Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy

Yves-Paul VandewynckelDebby LaukensEliene BogaertsAnnelies ParidaensAnja Van den BusscheXavier VerhelstChristophe Van SteenkisteBenedicte DescampsChristian VanhoveLouis Libbrecht et al.

A1 Journal Article in HEPATOLOGY INTERNATIONAL

Mucosal dendritic cells : origins, subsets and biology

Bart LambrechtAkiko IwasakiBrian L Kelsall

Bookchapter in Mucosal immunology

Mucosal Immunity in the oral cavity, upper respiratory tract and adjacent areas : an overview

Michael W RussellBart Lambrecht

Bookchapter in Mucosal immunology

Mucosal immunology

Mucosal immunology

Nasal immunity, rhinitis, rhinosinustis

Claus BachertOlga KryskoPhilippe GevaertMargot BeringsClaudina Perez NovoKoen Van Crombruggen

Bookchapter in Mucosal immunology

Neutralizing TNFα restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation

Lien DejagerKaren DendonckerMelanie EggermontJolien SouffriauFilip Van HauwermeirenMonique WillartElien Van WonterghemThomas NaessensMarlies BallegeerSofie Vandevyver et al.

A1 Journal Article in MUCOSAL IMMUNOLOGY

Overview : mucosal immunity and disease in the respiratory tract

Bookchapter in Mucosal immunology

Overview : the mucosal immune system

Michael W RussellJiri MesteckyWarren StroberBart LambrechtBrian L. KelsallHilde Cheroutre

Bookchapter in Mucosal immunology

Phenotyping asthma, rhinitis and eczema in MeDALL population-based birth cohorts: an allergic comorbidity cluster

J Garcia-AymerichM BenetYvan SaeysM PinartX BasagañaHA SmitV SirouxJ JustI MomasF Rancière et al.

A1 Journal Article in ALLERGY

Raised immunoglobulin A and circulating T follicular helper cells are linked to the development of food allergy in paediatric liver transplant patients

Ruth De BruynePhilippe GevaertMyriam Van WinckelNatalie De RuyckAurelie MinneDelfien BogaertStephanie Van BiervlietSaskia Vande VeldeFrancoise SmetsEtienne Sokal et al.

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Raised immunoglobulin A and circulating T follicular helper cells are linked to the development of food allergy in pediatric liver transplant patients

Ruth De BruyneMyriam Van WinckelPhilippe GevaertNatalie De RuyckDelfien BogaertBart LambrechtMelissa DullaersFrancoise SmetsEtienne SokalFréderic Gottrand et al.

Role of B cell-activating factor in chronic obstructive pulmonary disease

Leen SeysFien VerhammeAnja SchinwaldHamida HammadDanen Mootoosamy CunoosamyClaudie Bantsimba-MalandaAlan SabirshEileen McCallLiz FlavellRonald Herbst et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

SnapShot: integrated type 2 immune responses

Bart LambrechtStephen J Galli

Editorial material

T-Helper 17 cell polarization in pulmonary arterial hypertension

Aurélie HautefortBarbara GirerdDavid MontaniSylvia Cohen-KaminskyLaura PriceBart LambrechtMarc HumbertFrédéric Perros

A1 Journal Article in CHEST

Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection

Mary van HeldenSteven GoossensCécile DaussyAnne-Laure MathieuFabrice FaureAntoine MarçaisNiels VandammeNatalie FarlaKatia MayolSébastien Viel et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

The immunology of asthma

Bart LambrechtHamida Hammad

A1 Journal Article in NATURE IMMUNOLOGY

The mucosal immune response to respiratory viruses

Bart LambrechtKatrijn NeytMary van Helden

Bookchapter in Mucosal immunology

The potential of radiotherapy to enhance the efficacy of renal cell carcinoma therapy

Katrien De WolfKarim VermaelenGert De MeerleerBart LambrechtPiet Ost

A1 Journal Article in ONCOIMMUNOLOGY

Type III collagen is important for collagen fibrillogenesis and for dermal and cardiovascular development

Sanne D'hondtBrecht GuillemynSofie SymoensWendy ToussaintLeen VanhoutteRiet De RyckePaul CouckeBart LambrechtPatrick SegersAnne De Paepe et al.

Type III collagen is important for type I collagen fibrillogenesis and for dermal and cardiovascular development

Sanne D'hondtBrecht GuillemynSofie SymoensWendy ToussaintLeen VanhoutteRiet De RyckePaul CouckePatrick SegersBart LambrechtAnne De Paepe et al.

Van hygiënehypothese tot theorie

Patrick VankrunkelsvenMarleen FinoulstHamida HammadBart Lambrecht

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

2014

A bidirectional crosstalk between iNKT cells and adipocytes mediated by leptin modulates susceptibility for T cell mediated hepatitis

Koen VenkenSylvie SeeuwsLennart ZabeauPeggy JacquesTine DecruyJulie CoudenysEveline VerheugenFien WindelsDominiek CatteeuwMichael Drennan et al.

A1 Journal Article in JOURNAL OF HEPATOLOGY

A case of dendritic cell, monocyte, B and NK lymphoid deficiency (DCML)

Melissa DullaersTessa KerreFrauke CoppietersDorine SichienNancy De CabooterVeronique DebackerReinhart SpeeckaertPaul CouckeElias DebaereFilomeen Haerynck et al.

A novel Stat1 mutation leading to hyperphosphorylation in a patient with Pneumocystis jjiroveci and chronic mucocutaneous candidiasis

Melissa DullaersJens StaalSarah GerloElien VandermarliereV DebackerMaria Bordon Cueto De BraemK De WaeleI MeytsL MoensX Bossuyt et al.

A20-Deficient mast cells exacerbate inflammatory responses in vivo

Klaus HegerKaat FierensJ Christoph VahlAttila AszodiKatrin PeschkeDominik SchentenHamida HammadRudi BeyaertDieter SaurGeert van Loo et al.

A1 Journal Article in PLOS BIOLOGY

Allergens and the airway epithelium response: gateway to allergic sensitization

Bart LambrechtHamida Hammad

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Allopurinol reduces seizure severity and the inflammatory response in a mouse model for status epilepticus : a potential role for uric acid in ictogenesis

Lisa ThyrionRobrecht RaedtElke YdensSophie JanssensJulie KipsPieter Van LooJeanelle PortelliBart LambrechtAlfred MeursKristl Vonck et al.

Antigen-presenting dendritic cells

Bart LambrechtHamida Hammad

Bookchapter in Middleton's allergy : principles & practice

Clinical presentation of hyper-IgE syndrome in a family with impaired IL-22 production and STAT3 phosphorylation

Filomeen HaerynckDelfien BogaertElfride De BaereBart LambrechtKarim VermaelenVeronique DebackerKristof Van SchilFrans De BaetsPetra SchelstraeteMaria Bordon Cueto De Braem et al.

Dendritic cell and epithelial cell interactions at the origin of murine asthma

Bart LambrechtHamida Hammad

A2 Journal Article in ANNALS OF THE AMERICAN THORACIC SOCIETY

Dendritic cells

Bookchapter in Global atlas of allergy

Emerging functions of the unfolded protein response in immunity

Sophie JanssensBali PulendranBart Lambrecht

A1 Journal Article in NATURE IMMUNOLOGY

Enhancement of adaptive immunity by the human vaccine adjuvant AS01 depends on activated dendritic cells

Arnaud M DidierlaurentCatherine CollignonPatricia BourguignonSandrine WoutersKaat FierensMichel FochesatoNajoua DendougaChristelle LangletBernard MalissenBart Lambrecht et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Flow cytometric sexing of spider sperm reveals an equal sperm production ratio in a female-biased species

Bram VanthournoutKim DeswarteHamida HammadT BildeBart LambrechtFrederik Hendrickx

A1 Journal Article in BIOLOGY LETTERS

How to generate large numbers of CD103⁺ dendritic cells

Lianne van de LaarBart Lambrecht

Editorial material

Immunity induced by a broad class of inorganic crystalline materials is directly controlled by their chemistry

Gareth R WilliamsKaat FierensStephen G PrestonDaniel LunnOliwia RysnikSofie De PrijckMirjam KoolHannah C BuckleyBart LambrechtDermot O'Hare et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Innate immune cells to the help

Bart LambrechtHamida Hammad

Editorial material

Lung tumours reprogram pulmonary dendritic cell immunogenicity at the microRNA level

Lotte PyfferoenPieter MestdaghKarl VergoteNancy De CabooterJo VandesompeleBart LambrechtKarim Vermaelen

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Monocytes find a new place to dwell in the niche of heartbreak hotel

Bart LambrechtMartin Guilliams

Editorial material

Nanoporous hydrogen bonded polymeric microparticles: facile and economic production of cross presentation promoting vaccine carriers

Marijke DierendonckKaat FierensRiet De RyckeLien LybaertSamarendra MajiZhiyue ZhangQilu ZhangRichard HoogenboomBart LambrechtJohan Grooten et al.

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Nanoporous polyelectrolyte vaccine microcarriers: a formulation platform for enhancing humoral and cellular immune responses

Stefaan De KokerKaat FierensMarijke DierendonckRiet De RyckeBart LambrechtJohan GrootenJean Paul RemonBruno De Geest

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Ontogeny of myeloid cells

Ismé De KleerFabienne WillemsBart LambrechtStanislas Goriely

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Temporal dynamics and therapeutic potential of the unfolded protein espouse in hepatocellular carcinoma

Yves-Paul VandewynckelDebby LaukensAnja GeertsEliene BogaertsAnnelies ParidaensXavier VerhelstChristophe Van SteenkisteBenedicte DescampsChristian VanhoveLouis Libbrecht et al.

Temporal dynamics and therapeutic potential of the unfolded protein response in hepatocellular carcinoma

Yves-Paul VandewynckelDebby LaukensAnja GeertsEliene BogaertsAnnelies ParidaensXavier VerhelstChristophe Van SteenkisteBenedicte DescampsChristian VanhoveLouis Libbrecht et al.

The function of Fcγ receptors in dendritic cells and macrophages

Martin GuilliamsPierre BruhnsYvan SaeysHamida HammadBart Lambrecht

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

The unfolded-protein-response sensor IRE-1α regulates the function of CD8α⁺ dendritic cells

Fabiola OsorioSimon TavernierEik HoffmannYvan SaeysLiesbet MartensJessica VettersIris DelrueRiet De RyckeEef ParthoensPhilippe Pouliot et al.

A1 Journal Article in NATURE IMMUNOLOGY

Therapeutic effects of artesunate in hepatocellular carcinoma : repurposing an ancient antimalarial agent

Yves-Paul VandewynckelDebby LaukensAnja GeertsChristian VanhoveBenedicte DescampsLindsey DevisscherEliene BogaertsAnnelies ParidaensXavier VerhelstChristophe Van Steenkiste et al.

Therapeutic effects of artesunate in hepatocellular carcinoma: repurposing an ancient antimalarial agent

Yves-Paul VandewynckelDebby LaukensAnja GeertsChristian VanhoveBenedicte DescampsIsabelle ColleLindsey DevisscherEliene BogaertsAnnelies ParidaensXavier Verhelst et al.

A1 Journal Article in EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

2013

Absence of Siglec-H in MCMV infection elevates interferon alpha production but does not enhance viral clearance

Franz PutturCatharina Arnold-SchraufKatharina LahlGulhas SolmazMarc LindenbergChristian Thomas MayerMelanie GohmertMaxine SwallowChristopher van HeltHeike Schmitt et al.

A1 Journal Article in PLOS PATHOGENS

Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF

Martin GuilliamsIsmé De KleerSandrine HenriSijranke PostLeen VanhoutteSofie De PrijckKim DeswarteBernard MalissenHamida HammadBart Lambrecht

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Asthma and coagulation

Bart LambrechtHamida Hammad

Editorial material

Asthma: the importance of dysregulated barrier immunity

Bart LambrechtHamida Hammad

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Bacterial CD1d-restricted glycolipids induce IL-10 production by human regulatory T cells upon cross-talk with invariant NKT cells

Koen VenkenTine DecruySANDRINE ASPESLAGHSerge Van CalenberghBart LambrechtDirk Elewaut

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Conventional and monocyte-derived CD11b⁺ dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen

Maud PlantingaMartin GuilliamsManon VanheerswynghelsKim DeswarteFilipe Branco MadeiraWendy ToussaintLeen VanhoutteKatrijn NeytNigel KilleenBernard Malissen et al.

A1 Journal Article in IMMUNITY

Cytokine targets in airway inflammation

Martijn SchuijsMonique WillartHamida HammadBart Lambrecht

A1 Journal Article in CURRENT OPINION IN PHARMACOLOGY

Death at the airway epithelium in asthma

Bart LambrechtHamida Hammad

Editorial material

Dendritic cells in asthma

Mary van HeldenBart Lambrecht

A1 Journal Article in CURRENT OPINION IN IMMUNOLOGY

Division of labor between lung dendritic cells and macrophages in the defense against pulmonary infections

Martin GuilliamsBart LambrechtHamida Hammad

A1 Journal Article in MUCOSAL IMMUNOLOGY

Immune activation at the lung epithelial barrier

Monique WillartHamida HammadBart Lambrecht

Mycobacterium tuberculosis manipulates pulmonary APCs subverting early immune responses

Gina S Garcia-RomoAlexander Pedroza-GonzalezBart LambrechtDiana Aguilar-LeonIris Estrada-GarciaRogelio Hernandez-PandoLeopoldo Flores-Romo

A1 Journal Article in IMMUNOBIOLOGY

Natural and long-lasting cellular immune responses against influenza in the M2e-immune host

Michael SchotsaertTine YsenbaertKristien NeytsLorena IbanezPieter BogaertBert SchepensBart LambrechtWalter FiersXavier Saelens

A1 Journal Article in MUCOSAL IMMUNOLOGY

PAMPs and DAMPs in allergy exacerbation models

Monique WillartPhilippe PoulliotBart LambrechtMirjam Kool

Bookchapter in Mouse models in allergic disease : methods and protocols

Pooling birth cohorts in allergy and asthma: European Union-funded initiatives: a MeDALL, CHICOS, ENRIECO, and GA²LEN joint paper

Jean BousquetJosep AntoJordi SunyerMark NieuwenhuijsenMartine VrijheidThomas Keilthe MeDALL Study GroupBart LambrechtClaus Bachertthe GA²LEN Study Group et al.

A1 Journal Article in INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Potential of immunoglobulin A to prevent allergic asthma

Anouk K GloudemansBart LambrechtHermelijn H Smits

A1 Journal Article in CLINICAL & DEVELOPMENTAL IMMUNOLOGY

Role of CXCL13 in cigarette smoke-induced lymphoid follicle formation and chronic obstructive pulmonary disease

Ken BrackeFien VerhammeLeen SeysClaudie Bantsimba-MalandaDanen Mootoosamy CunoosamyRonald HerbstHamida HammadBart LambrechtGuy JoosGuy Brusselle

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Short cigarette smoke exposure facilitates sensitisation and asthma development in mice

Ellen LanckackerKurt TournoyHamida HammadGabriële HoltappelsBart LambrechtGuy JoosTania Maes

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Temporal dynamics of the unfolded protein response and chemoresistance in hepatocellular carcinoma

Yves-Paul VandewynckelIsabelle ColleDebby LaukensBart LambrechtBenedicte DescampsChristian VanhoveHans Van Vlierberghe

The European Respiratory Society fellowship programme: supporting young careers and building networks

Robert BalsJosephine Ricou YanmazCéline SchaffterCarine PannetierNadia KamelRoelinde MiddelveldSvan-Erik DahlénBart LambrechtBenoit NemeryLaurent Nicod et al.

Editorial material

The mucosal adjuvant cholera toxin B instructs non-mucosal dendritic cells to promote IgA production via retinoic acid and TGF-β

Anouk K GloudemansMaud PlantingaMartin GuilliamsMonique WillartArifa Ozir-FazalalikhanAlwin van der HamLouis BoonNicola L HarrisHamida HammadHenk C Hoogsteden et al.

A1 Journal Article in PLOS ONE

The multi-faceted role of allergen exposure to the local airway mucosa

K GolebskiKIL RoschmannS Toppila-SalmiHamida HammadBart LambrechtR RenkonenWJ FokkensCM van Drunen

A1 Journal Article in ALLERGY

The pathogenesis of pulmonary fibrosis: a moving target

Wim A WuytsCarlo AgostiniKaterina M AntoniouDemosthenes BourosRacherl C ChambersVincent CottinJim J EganBart LambrechtRik LoriesHelen Parfrey et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

The role of lung dendritic cell subsets in immunity to respiratory viruses

Katrijn NeytBart Lambrecht

A1 Journal Article in IMMUNOLOGICAL REVIEWS

The therapeutic potential of artesunate in hepatocellular carcinoma

Yves-Paul VandewynckelDebby LaukensAnja GeertsIsabelle ColleLouis LibbrechtEliene BogaertsLindsey DevisscherAnnelies ParidaensXavier VerhelstChristian Vanhove et al.

The UPR and lung disease

Fabiola OsorioBart LambrechtSophie Janssens

A1 Journal Article in SEMINARS IN IMMUNOPATHOLOGY

Topical treatment targeting sphingosine-1-phosphate and sphingosine lyase abrogates experimental allergic rhinitis in a murine model

A KleinJanM van NimwegenK LemanHC HoogstedenBart Lambrecht

A1 Journal Article in ALLERGY

2012

A dissociated glucocorticoid receptor modulator reduces airway hyperresponsiveness and inflammation in a mouse model of asthma

Laurent L ReberFrançois DaubeufMaud PlantingaLode De CauwerSarah GerloWim WaelputSerge Van CalenberghJan TavernierGuy HaegemanBart Lambrecht et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1

Jonathan ElegheertNathalie BrackePhilippe PouliotIrina GutscheAlexander V ShkumatovNicolas TarbouriechKenneth VerstraeteAnaïs BekaertWim P BurmeisterDmitri I Svergun et al.

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY

Alum adjuvant: some of the tricks of the oldest adjuvant

Mirjam KoolKaat FierensBart Lambrecht

A1 Journal Article in JOURNAL OF MEDICAL MICROBIOLOGY

Alveolar preservation with high inflation pressure and intermediate oxygen concentration reduces ischemia-reperfusion injury of the lung

Niels P van der KaaijJolanda KluinRobert A LachmannMichael A den BakkerBart LambrechtBurkhard LachmannRon WF de BruinAd JJC Bogers

A1 Journal Article in JOURNAL OF HEART AND LUNG TRANSPLANTATION

Cellular networks controlling Th2 polarization in allergy and immunity

Mirjam KoolHamida HammadBart Lambrecht

A2 Journal Article in F1000 BIOLOGY REPORTS

Contribution of regulatory T cells to alleviation of experimental allergic asthma after specific immunotherapy

H MaaziS ShirinbakMonique WillartHamida HammadM CabanskiL BoonV GaneshAM BaruG HansenBart Lambrecht et al.

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Development of a novel COL3A1 transgenic mouse model for vascular Ehlers Danlos Syndrome

Yike KangSofie SymoensFransiska MalfaitPaul CouckeMarjolijn RenardBrecht GuillemynJulie De BackerFilipe Branco MadeiraWendy ToussaintLeen Vanhoutte et al.

Directed antigen targeting in vivo identifies a role for CD103+ dendritic cells in both tolerogenic and immunogenic T-cell responses

M SemmrichMaud PlantingaM Svensson-FrejH Uronen-HanssonT GustafssonAM MowatU YrlidBart LambrechtWW Agace

A1 Journal Article in MUCOSAL IMMUNOLOGY

Engineered 3D microporous gelatin scaffolds to study cell migration

Liesbeth De CockOlivier De WeverHamida HammadBart LambrechtEls VanderleydenPeter DubruelFilip De VosChris VervaetJean Paul RemonBruno De Geest

A1 Journal Article in CHEMICAL COMMUNICATIONS

Evidence for local dendritic cell activation in pulmonary sarcoidosis

Bregje Ten BergeAlex KleinJanFemke MuskensHamida HammadHenk C HoogstedenRudi W HendriksBart LambrechtBernt Van den Blink

A1 Journal Article in RESPIRATORY RESEARCH

IL-21 is increased in nasal polyposis and after stimulation with Staphylococus aureus enterotoxins

LIEN CALUSIne DeryckeNatalie De RuyckGabriële HoltappelsMelissa DullaersBart LambrechtClaus BachertPhilippe Gevaert

Increased IL-17A expression in granulomas and in circulating memory T cells in sarcoidosis

Bregje ten BergeMarthe S PaatsIngrid M BergenBernt van den BlinkHenk C HoogstedenBart LambrechtRudi W HendriksAlex KleinJan

A1 Journal Article in RHEUMATOLOGY

Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33

Monique WillartKim DeswartePhilippe PouliotHarald BraunRudi BeyaertBart LambrechtHamida Hammad

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Lung dendritic cells in respiratory viral infection and asthma : from protection to immunopathology

Bart LambrechtHamida Hammad

A1 Journal Article in Annual Review of Immunology

Polymeric multilayer capsule-mediated vaccination induces protective immunity against cancer and viral infection

Bruno De GeestMonique WillartHamida HammadBart LambrechtCharlotte PollardPieter BogaertMarina De FiletteXavier SaelensChris VervaetJean Paul Remon et al.

A1 Journal Article in ACS NANO

Pulmonary lymphoid neogenesis in idiopathic pulmonary arterial hypertension

Frédèric PerrosPeter DorfmüllerDavid MontaniHamida HammadWim WaelputBarbara GirerdNicolas RaymondOlaf MercierSacha MussotSylvia Cohen-Kaminsky et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

SCID-like symptoms in a patient with chronic mucocutaneous candidiasis caused by STAT1 mutation

Melissa DullaersMaria Bordon Cueto De BraemK De WaeleI MeytsL MoensX BossuytKarim VermaelenBart LambrechtF De BaetsFilomeen Haerynck

Surface-engineered polyelectrolyte multilayer capsules: synthetic vaccines mimicking microbial structure and function

Bruno De GeestMonique WillartBart LambrechtCharlotte PollardChris VervaetJean Paul RemonJohan GrootenStefaan De Koker

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

TCR gene transfer: MAGE-C2/HLA-A2 and MAGE-A3/HLA-DP4 epitopes as melanoma-specific immune targets

Trudy StraetemansMandy van BrakelSabine van SteenbergenMarieke BroertjesJoost DrexhageJoost HegmansBart LambrechtCor LamersPierre van der BruggenPierre G Coulie et al.

A1 Journal Article in CLINICAL & DEVELOPMENTAL IMMUNOLOGY

Tertiary lymphoid organs in infection and autoimmunity

Katrijn NeytFrédéric PerrosCorine H GeurtsvanKesselHamida HammadBart Lambrecht

A1 Journal Article in TRENDS IN IMMUNOLOGY

The airway epithelium in asthma

Bart LambrechtHamida Hammad

A1 Journal Article in NATURE MEDICINE

The who, where, and when of IgE in allergic airway disease

Melissa DullaersRuth De BruyneFaruk RamadaniHannah J GouldPhilippe GevaertBart Lambrecht

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: a Mechanisms of the Development of Allergy (MeDALL) seminar

Josep M AntóMariona PinartMübeccel AkdisCharles AuffrayClaus BachertXavier BasagañaKai-Håkon CarlsenStefano GuerraLeena von HertzenSabina Illi et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Ursodeoxycholic acid suppresses eosinophilic airway inflammation by inhibiting the function of dendritic cells through the nuclear farnesoid X receptor

Monique WillartM van NimwegenA GrefhorstHamida HammadL MoonsHC HoogstedenBart LambrechtA KleinJan

A1 Journal Article in ALLERGY

2011

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

Mourad MatmatiPeggy JacquesJonathan MaelfaitEveline VerheugenMirjam KoolMozes SzeLies GeboesEls LouagieConor Mc GuireLars Vereecke et al.

A1 Journal Article in NATURE GENETICS

A20 (TNFAIP3) deficiency in myeloid cells triggers rheumatoid arthritis

Dirk ElewautMourad MatmatiPeggy JacquesJonathan MaelfaitEveline VerheugenMirjam KoolMozes SzeLies GeboesEls LouagieConor Mc Guire et al.

An unexpected role for uric Acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma

Mirjam KoolMonique WillartMenno van NimwegenIngrid BergenPhilippe PouliotJ Christian VirchowNeil RogersFabiola OsorioCaetano Reis E SousaHamida Hammad et al.

A1 Journal Article in IMMUNITY

Anti-inflammatory actions of phosphatidylinositol

Jolanda M van DierenYtje Simons-OosterhuisHC (Rolien) RaatgeepDicky J Lindenbergh-KortleveMargaretha EH LambersC Janneke van der WoudeErnst J KuipersGerry T SnoekRon PotmanHamida Hammad et al.

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

C-Kit-positive cells accumulate in remodeled vessels of idiopathic pulmonary arterial hypertension

David MontaniFrédéric PerrosNatalia GambaryanBarbara GirerdPeter DorfmullerLaura C PriceAlice HuertasHamida HammadBart LambrechtGérald Simonneau et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cigarette smoking alters epithelial apoptosis and immune composition in murine GALT

Stephanie VERSCHUEREKen BrackeTine DemoorMaud PlantingaPhebe VerbruggheLiesbeth FerdinandeBart LambrechtGuy BrusselleClaude Cuvelier

A1 Journal Article in LABORATORY INVESTIGATION

Cigarette smoking alters intestinal barrier function and Peyer's Patch composition

Stephanie VERSCHUEREKen BrackeTine DemoorMaud PlantingaBart LambrechtGuy BrusselleClaude Cuvelier

CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses

Diego Mourão-SáMatthew J RobinsonSantiago ZelenayDavid SanchoProbir ChakravartyRasmus LarsenMaud PlantingaNico Van RooijenMiguel P SoaresBart Lambrecht et al.

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Dendritic cells and airway epithelial cells at the interface between innate and adaptive immune responses

Hamida HammadBart Lambrecht

A1 Journal Article in ALLERGY

Designing polymeric particles for antigen delivery

Stefaan De KokerBart LambrechtMonique WillartYvette van KooykJohan GrootenChris VervaetJean Paul RemonBruno De Geest

A1 Journal Article in CHEMICAL SOCIETY REVIEWS

Disruption of the SapM locus in Mycobacterium bovis BCG improves its protective efficacy as a vaccine against M. tuberculosis

Nele FestjensPieter BogaertAnjana BatniErica HouthuysEvelyn PletsDieter VanderschaegheBram LaukensBob AsselberghEef ParthoensRiet De Rycke et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Dual role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A

Anne-Gaelle BesnardRobert SabatLaure DumoutierJean-Christophe RenauldMonique WillartBart LambrechtMauro M TeixeiraSabine CharronLizette FickFrancois Erard et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

Dmitri KryskoPatrizia AgostinisOlga KryskoAbhishek D GargClaus BachertBart LambrechtPeter Vandenabeele

A1 Journal Article in TRENDS IN IMMUNOLOGY

ERS is founding member of a new Alliance for Biomedical Research in Europe

LP NicodN KamelB WardM DecramerY SibilleBart LambrechtC DiveU SmithKR Sipido

Editorial material

Facilitated antigen uptake and timed exposure to TLR ligands dictate the antigen-presenting potential of plasmacytoid DCs

Mirjam KoolCorine GeurtsVanKesselFemke MuskensFilipe Branco MadeiraMenno van NimwegenHarmjan KuipersKris ThielemansHenk C HoogstedenHamida HammadBart Lambrecht

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

Highly pathogenic avian influenza virus H5N1 infects alveolar macrophages without virus production or excessive TNF-alpha induction

Debby van RielLonneke ME LeijtenMenno van der EerdenHenk C HoogstedenLeonie A BovenBart LambrechtAlbert DME OsterhausThijs Kuiken

A1 Journal Article in PLOS PATHOGENS

Initiation and maintenance of allergic inflammation: team work at the interface of innate and adaptive immunity

Bart LambrechtDonald YM Leung

Editorial material

Involvement of endoplasmic reticulum stress in inflammatory bowel disease : a different implication for colonic and ileal disease?

Sara BogaertMartine De VosKim OlievierHarald PeetersDirk ElewautBart LambrechtPhilippe PouliotDebby Laukens

A1 Journal Article in PLOS ONE

MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine

J BousquetJ AntoC AuffrayM AkdisA Cambon-ThomsenT KeilT HaahtelaBart LambrechtDS PostmaJ Sunyer et al.

A1 Journal Article in ALLERGY

NLRP3/Caspase-1-independent IL-1β production mediates diesel exhaust particle-induced pulmonary inflammation

Sharen ProvoostTania MaesNele PauwelsTom Vanden BerghePeter VandenabeeleBart LambrechtGuy JoosKurt Tournoy

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Novel anti-inflammatory drugs based on targeting lung dendritic cells and airway epithelial cells

Bart LambrechtMaud PlantingaMonique WillartHamida Hammad

Bookchapter in Inflammation and allergy drug design

Persistent activation of dendritic cells after resolution of allergic airway inflammation breaks tolerance to inhaled allergens in mice

Leonie van RijtNanda VosMonique WillartFemke MuskensPaul P TakCorine van der HorstHenk C HoogstedenBart Lambrecht

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary defence mechanisms and inflammatory pathways in bronchiectasis

Bart LambrechtKatrijn NeytCH GeurtsvanKessel

Bookchapter in Bronchiectasis

Role of IL-1α and the Nlrp3/caspase-1/IL-1β axis in cigarette smoke-induced pulmonary inflammation and COPD

NS PauwelsKen BrackeLisa DupontGeert Van PottelbergeSharen ProvoostTom Vanden BerghePeter VandenabeeleBart LambrechtGuy JoosGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

The neuropeptide calcitonin gene-related peptide affects allergic airway inflammation by modulating dendritic cell function

S RochlitzerTZ VeresK KühneF PrenzlerC PilznerS KnotheC WinklerHD LauensteinMonique WillartHamida Hammad et al.

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

The role of ChemR23 in the induction and resolution of cigarette smoke-induced inflammation

Tine DemoorKen BrackeLisa DupontMaud PlantingaBenjamin BondueMarie-Odile RoyVincent LannoyBart LambrechtGuy BrusselleGuy Joos

A1 Journal Article in JOURNAL OF IMMUNOLOGY

The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity

Mirjam KoolGeert van LooWim WaelputSofie De PrijckFemke MuskensMozes SzeJens Van PraetFilipe Branco MadeiraSophie JanssensBoris Reizis et al.

A1 Journal Article in IMMUNITY

TLR4 signalling in pulmonary stromal cells is critical for inflammation and immunity in the airways

Frédèric PerrosBart LambrechtHamida Hammad

A1 Journal Article in RESPIRATORY RESEARCH

TNF driven activation of invariant NKT cells regulates combined gut and joint inflammation

Peggy JacquesSylvie SeeuwsHamida HammadBart LambrechtGeorge KolliasMartine De VosDirk Elewaut

2010

Consolidative dendritic cell-based immunotherapy elicits cytotoxicity against malignant mesothelioma

Joost P HegmansJoris D VeltmanMargaretha E LambersJolanda M de VriesCarl G FigdorRudi W HendriksHenk C HoogstedenBart LambrechtJoachim G Aerts

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Diesel exhaust particles stimulate adaptive immunity by acting on pulmonary dendritic cells

Sharen ProvoostTania MaesMonique WillartGuy JoosBart LambrechtKurt Tournoy

A1 Journal Article in Journal of Immunology

Flow cytometric differentiation of avian leukocytes and analysis of their intracellular cytokine expression

Sandra De BoeverSiska CroubelsKristel DemeyereBart LambrechtPatrick De BackerEvelyne Meyer

A1 Journal Article in AVIAN PATHOLOGY

High mobility group box-1 recognition : the beginning of a RAGEless era?

Filipe Branco MadeiraBart Lambrecht

Editorial material

Inflammatory dendritic cells - not basophils - are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen

Hamida HammadMaud PlantingaKim DeswartePhilippe PouliotMonique WillartMirjam KoolFemke MuskensBart Lambrecht

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Invariant natural killer T cells are natural regulators of murine spondylarthritis

Peggy JacquesKoen VenkenKatrien Van BenedenHamida HammadSylvie SeeuwsMichael DrennanDieter DeforceAugust VerbruggenMaria ApostolakiGeorge Kollias et al.

A1 Journal Article in ARTHRITIS AND RHEUMATISM

Lentiviral gene therapy of murine hematopoietic stem cells ameliorates the Pompe disease phenotype

Niek P van TilMerel StokFatima SF Aerts KayaMonique C de WaardElnaz FarahbakhshianTrudi P VisserMarian A KroosEdwin H JacobsMonique WillartPascal van der Wegen et al.

A1 Journal Article in BLOOD

Origin and functional specializations of DC subsets in the lung

Maud PlantingaHamida HammadBart Lambrecht

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Staphylococcus aureus enterotoxin B facilitates allergic sensitization in experimental asthma

Wouter HuvenneIna CallebautMaud PlantingaJeroen AJ VanoirbeekOlga KryskoDominique MA BullensPhilippe GevaertPaul Van CauwenbergeBart LambrechtJan L Ceuppens et al.

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Studying the function of dendritic cells in mouse models of asthma

Philippe PouliotMonique WillartHamida HammadBart Lambrecht

Bookchapter in Dendritic cell protocols

Suppression of human natural killer T cell function by CD4(+)CD25(+)FOXP3(+) regulatory T cells

Koen VenkenTine DecruyKim DeswarteSANDRINE ASPESLAGHSerge Van CalenberghBart LambrechtDirk Elewaut

Suppression of Th2-driven airway inflammation by allergen immunotherapy is independent of B cell and Ig responses in mice

Soheila ShirinbakYousef A TaherHadi MaaziRenee GrasBetty CAM van EschPaul AJ HenricksJanneke N SamsomJ Sjef VerbeekBart LambrechtAntoon JM van Oosterhout et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

T-cell regulation of neutrophil infiltrate at the early stages of a murine colitis model

Pieter PE van LieropColin de HaarDicky J Lindenbergh-KortleveYtje Simons-OosterhuisLeonie S van RijtBart LambrechtJohanna C EscherJanneke N SamsomEdward ES Nieuwenhuis

A1 Journal Article in INFLAMMATORY BOWEL DISEASES

The role of dendritic and epithelial cells as master regulators of allergic airway inflammation

Bart LambrechtHamida Hammad

A1 Journal Article in LANCET

United airways: circulating Th2 effector cells in an allergic rhinitis model are responsible for promoting lower airways inflammation

Alex KleinjanMonique WillartMenno van NimwegenKarolina LemanHenk HoogstedenRudy HendriksBart Lambrecht

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Vegf regulates embryonic erythroid development through Gata1 modulation

Benjamin DrogatJoanna KaluckaLaura GutierrezHamida HammadSteven GoossensMorvarid Farhang GhahremaniSona BartunkovaKatharina HaighKim DeswarteOmar Nyabi et al.

A1 Journal Article in BLOOD

2009

A novel method for isolating dendritic cells from human bronchoalveolar lavage fluid

B Ten BergeF MuskensA KleinJanHamida HammadHC HoogstedenBart LambrechtB Van den Blink

A1 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS

An anti-inflammatory role for plasmacytoid dendritic cells in allergic airway inflammation

Mirjam KoolMenno van NimwegenMonique WillartFemke MuskensLouis BoonJoost SmitAnthony CoyleBjörn ClausenHenk HoogstedenBart Lambrecht et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Biology of lung dendritic cells at the origin of asthma

Bart LambrechtHamida Hammad

A1 Journal Article in IMMUNITY

Blockade of CCR4 in a humanized model of asthma reveals a critical role for DC-derived CCL17 and CCL22 in attracting Th2 cells and inducing airway inflammation

Frédèric PerrosH.C. HoogstedenA.J. CoyleBart LambrechtHamida Hammad

A1 Journal Article in Allergy

Both Conventional and Interferon Killer Dendritic Cells Have Antigen-Presenting Capacity during Influenza Virus Infection

CH GeurtsvanKesselIM BergenF MuskensL BoonHC HoogstedenADME OsterhausGF RimmelzwaanBart Lambrecht

A1 Journal Article in PLOS ONE

Cholera toxin B suppresses allergic inflammation through induction of secretory IgA

H. SmitsA. GloudemansM. van NimwegenMonique WillartT. SoulliéF. MuskensE. de JongL. BoonC. PiletteF.-E. Johansen et al.

A1 Journal Article in Mucosal Immunology

Chronic airway inflammation promotes de novo sensitisation to inhaled allergens by persistent activation of dendritic cells

L van RijtN VosF MuskensMonique WillartH HoogstedenBart Lambrecht

Chronic airway inflammation promotes de novo sensitization to inhaled allergen by persistent activation of dendritic cells

LS Van RijtN VosMonique WillartF MuskensH HoogstedenBart Lambrecht

Cyclooxygenase-2 in mucosal DC mediates induction of regulatory T cells in the intestine through suppression of IL-4

F BroereMF Du PréLA Van BerkelJ GarssenCB Schmid-WeberBart LambrechtRW HendriksEES NieuwenhuisG KraalJN Samsom

A1 Journal Article in MUCOSAL IMMUNOLOGY

De rol van de dendritische cel in astma

Monique WillartBart Lambrecht

A4 Journal Article in TIJDSCHRIFT VAN DE BELGISCHE VERENIGING VAN LABORATORIUM-TECHNOLOGEN = REVUE DE L'ASSOCIATION BELGE DES TECHNOLOGUES DE LABORATOIRE

Dendritic cell-based immunotherapy for malignant pleural mesothelioma

JG AertsJ VeltmanM LambersBart LambrechtHC HoogstedenJJ Hegmans

Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus-infected mice

Corine H GeurtsvanKesselMonique WillartIngrid M BergenLeonie S van RijtFemke MuskensDirk ElewautAlbert DLE OsterhausRudi HendriksGuus F RimmelzwaanBart Lambrecht

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Dendritic cells in rhinitis

A KleinjanBart Lambrecht

Bookchapter in Dendritic cells

Effect of Cigarette Smoke Extract on Dendritic Cells and Their Impact on T-Cell Proliferation

E MortazAD KraneveldJJ SmitMirjam KoolBart LambrechtSL KunkelNW LukacsFP NijkampG Folkerts

A1 Journal Article in PLOS ONE

Function of dendritic cell subsets in allergic disease

Bart LambrechtHamida Hammad

Bookchapter in Allergy frontiers : classification and pathomechanisms

House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

Hamida HammadMarcello ChieppaFrédèric PerrosMonique WillartRonald GermainBart Lambrecht

A1 Journal Article in Nature Medicine

Immune Suppression Feature of Ursodeoxycholic Acid is DC-mediated as Measured in Eosinophilic Airway Inflammation Model

A. KleinjanMonique WillartHamida HammadM. van NimwegenL. MoonsH.C. HoogstedenBart Lambrecht

Lung dendritic cells: targets for therapy in allergic disease

Bart LambrechtHamida Hammad

Bookchapter in Dendritic cells

Mechanism of action of clinically approved adjuvants

Bart LambrechtMirjam KoolMonique WillartHamida Hammad

A1 Journal Article in Current opinion in Immunology

Protein Profiling of Pleural Effusions to Identify Malignant Pleural Mesothelioma Using SELDI-TOF MS

Joost HegmansJoris VeltmanEric FungThorsten VerchCurtis GloverFujun ZhangW. Jeffrey AllardDavy T'JampensHenk HoogstedenBart Lambrecht et al.

A1 Journal Article in Technology in cancer research and treatment

Protein tyrosine phosphatases regulate asthma development in a murine asthma model

Philippe PouliotPierre CamaterosDanuta RadziochBart LambrechtMartin Olivier

A1 Journal Article in Journal of Immunology

Selective control of SIRP-α-positive airway dendritic cell trafficking through CD47 is critical for the development of TH2-mediated allergic inflammation

M RaymondM RubioG FortinKH ShalabyHamida HammadBart LambrechtM Sarfati

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sensitization by intratracheally injected dendritic cells is independent of antigen presentation by host antigen-presenting cells

Harmjan KuipersThomas SoullieHamida HammadMonique WillartMirjam KoolDanielle HijdraHenk HoogstedenBart Lambrecht

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

Surfactant pretreatment decreases long-term damage after ischemia-reperfusion injury of the lung

Niels van der KaaijJolanda KluinJack HaitsmaMichael den BakkerBart LambrechtBurkhard LachmannRon de BruinAd Bogers

A1 Journal Article in EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Technical note: Flow cytometric identification of bovine milk neutrophils and simultaneous quantification of their viability

Sofie PiepersSarne De VliegherKristel DemeyereBart LambrechtAart de KruifEvelyne MeyerGeert Opsomer

A1 Journal Article in JOURNAL OF DAIRY SCIENCE

The danger within: endogenous danger signals, atopy and asthma

Monique WillartBart Lambrecht

A1 Journal Article in Clinical and Experimental Allergy

The influence of oxygen concentration and inflation pressure during ischemia on lung ischemia reperfusion injury

NP van der KaaijJ KluinRA LachmannMA den BakkerJJ HaitsmaBart LambrechtRWF de BruinB LachmannAJJC Bogers

The lung vascular filter as a site of immune induction for T cell responses to large embolic antigen

Monique WillartHendrik Jan de HeerHamida HammadThomas SoulliéKim DeswarteBjörn E ClausenLouis BoonHenk C HoogstedenBart Lambrecht

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

The novel adjuvant CoVaccineHT (TM) increases the immunogenicity of cell-culture derived influenza A/H5N1 vaccine and induces the maturation of murine and human dendritic cells in vitro

R BodewesMM Geelhoed-MierasJGM HeldensJ GloverBart LambrechtRAM FouchierADME OsterhausGF Rimmelzwaan

A1 Journal Article in VACCINE

2008

'United airways': Allergic rhinitis exacerbates lower airway inflammation is controlled by cellular and neurogenic processes in a mouse model

A KLEINJANMonique WillartK LEMANHC HOOGSTEDENBart Lambrecht

Altered expression of epithelial junctional proteins in atopic asthma: possible role in inflammation

WI DE BOERHS SHARMASMI BAELEMANSHC HOOGSTEDENBart LambrechtGJ BRAUNSTAHL

A1 Journal Article in CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

M KOOLT SOULLIEM VAN NIMWEGENMonique WillartF MUSKENSS JUNGHC HOOGSTEDENHamida HammadBart Lambrecht

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome

Mirjam KoolVirginie PetrilliThibaut De SmedtAline RolazHamida HammadMenno van NimwegenIngrid M. BergenRosa CastilloBart LambrechtJuerg Tschopp

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Antigen-presenting dendritic cells

Bart LambrechtHamida Hammad

Bookchapter in Middleton's allergy : principles & practice

Antigen‐presenting dendritic cells and macrophages

Bart LambrechtHamida Hammad

Bookchapter in Allergy and allergic diseases

Clearance of influenza virus from the lung depends on migratory langerin(+)CD11b(-) but not plasmacytoid dendritic cells

CH GEURTSVANKESSELMonique WillartLS VAN RIJTF MUSKENSM KOOLC BAASK THIELEMANSC BENNETTBE CLASENHC HOOGSTEDEN et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

De rol van de dendritische cel in astma

Monique WillartBart Lambrecht

A4 Journal Article in Analyse

De rol van de dendritische cel in astma

Monique WillartBart Lambrecht

A3 Journal Article in Nederlands tijdschrift voor klinische chemie en laboratoriumgeneeskunde

Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma

Hamida HammadBart Lambrecht

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

Division of labor between dendritic cell subsets of the lung

C. GeurtsvanKesselBart Lambrecht

A1 Journal Article in MUCOSAL IMMUNOLOGY

IL-2 producing memory CD4+ T lymphocytes are closely associated with the generation of IgG-secreting plasma cells

Nicolle HR LitjensMartin HuismanDanielle HijdraBart LambrechtKoert J StittelaarMichiel GH Betjes

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA(2)LEN paper

J BousquetW FokkensP BurneySR DurhamClaus BachertCA AkdisGW CanonicaSE DahlenT ZuberbierT Bieber et al.

A1 Journal Article in ALLERGY

Inducible costimulator blockade prolongs airway lumnal patency in a mouse model of obliterative bronchiolitis

Alex KleinJanMonique WillartHarmjan KuipersAnthony J. CoyleHenk C. HoogstedenBart Lambrecht

A1 Journal Article in Transplantation

Ischemia of the lung causes extensive long-term pulmonary injury: an experimental study

NP VAN DER KAAIJJ KLUINJJ HAITSMAMA DEN BAKKERBart LambrechtB LACHMANNRWF DE BRUINAJJC BOGERS

A1 Journal Article in RESPIRATORY RESEARCH

Lung dendritic cells are stimulated by ultrafine particles and play a key role in particle adjuvant activity

C DE HAARM KOOLI HASSINGM BOLBart LambrechtR PIETERS

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Lung dendritic cells: Targets for therapy in allergic disease

A1 Journal Article in CURRENT MOLECULAR MEDICINE

Proteomics in pleural disease

Joost HegmansBart Lambrecht

Bookchapter in Textbook of pleural diseases

Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection

A DIDIERLAURENTJ GOULDINGS PATELR SNELGROVEL LOWM BEBIENT LAWRENCELS VAN RIJTBart LambrechtJC SIRARD et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

The balance between plasmacytoid DC versus conventional DC determines pulmonary immunity to virus infections

Joost J SmitDennis M LindellLouis BoonMirjam KoolBart LambrechtNicholas W Lukacs

A1 Journal Article in PLOS ONE

2007

Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells

Hamida HammadM KOOLT SOULLIES NARUMIYAF TROTTEINHC HOOGSTEDENBart Lambrecht

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Cells meeting our immunophenotypic criteria of endothelial cells are large platelets

MH STRIJBOSJ KRAANMA DEN BAKKERBart LambrechtS SLEIJFERJW GRATAMA

A1 Journal Article in CYTOMETRY PART B-CLINICAL CYTOMETRY

Dendritic cells in asthma and COPD: opportunities for drug development

M KOOLBart Lambrecht

A1 Journal Article in CURRENT OPINION IN IMMUNOLOGY

Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells

M IDZKOHamida HammadM VAN NIMWEGENM KOOLMonique WillartF MUSKENSHC HOOGSTEDENW LUTTMANND FERRARIF DI VIRGILIO et al.

A1 Journal Article in NATURE MEDICINE

Gata1 regulates dendritic-cell development and survival

Laura GutiérrezTatjana NikolicThamar B van DijkHamida HammadNanda VosMonique WillartFrank GrosveldSjaak PhilipsenBart Lambrecht

A1 Journal Article in BLOOD

GATA3-driven Th2 responses inhibit TGF-beta 1-induced FOXP3 expression and the formation of regulatory T cells

PY MANTELH KUIPERSO BOYMANC RHYNERN OUAKEDB RUCKERTC KARAGIANNIDISBart LambrechtRW HENDRIKSR CRAMERI et al.

A1 Journal Article in PLOS BIOLOGY

Gene expression profiling and gene copy-number changes in malignant mesothelioma cell lines

C ZANAZZIR HERSMUSIM VELTMANAJM GILLISE VAN DRUNENHB BEVERLOOJPJJ HEGMANSM VERWEIJBart LambrechtJW OOSTERHUIS et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

HIF1a expression in bronchial biopsies correlates with tumor microvascular saturation determined using optical spectroscopy

JGJV AertsA AmelinkC van der LeestJPJJ HegmansA HemmesB den HamerHCJM SterenborgHC HoogstedenBart Lambrecht

A1 Journal Article in LUNG CANCER

Inhaled iloprost suppresses the cardinal features of asthma via inhibition of airway dendritic cell function

M IDZKOHamida HammadM VAN NIMWEGENM KOOLN VOSHC HOOGSTEDENBart Lambrecht

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Keratinocyte growth factor induces expansion of murine peripheral CD4(+)Foxp3(+) regulatory T CON and increases their thymic output

M BRUINSMAPL VAN SOESTPJM LEENENBart LambrechtT CUPEDOB LOWENBERGJJ CORNELISSENE BRAAKMAN

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Lung dendritic cell migration

Hamida HammadBart Lambrecht

A1 Journal Article in ADVANCES IN IMMUNOLOGY, VOL 93

Lung dendritic cells : from basic physiology to clinical applications

A1 Journal Article in ACTA CLINICA BELGICA

Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets

G XANTHOUT ALISSAFIM SEMITEKOLOUDCM SIMOESE ECONOMIDOUM GAGABart LambrechtCM LLOYDV PANOUTSAKOPOULOU

A1 Journal Article in NATURE MEDICINE

Protective effect of Schistosoma mansoni infection on allergic airway inflammation depends on the intensity and chronicity of infection

Hermehin H. SmitsHamida HammadMenno van NimwegenThomas SoullieMonique WillartEllen LieversJonathan KadouchMirjam KoolJanneke Kos-van OosterhoudAndre M. Deelder et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Proteomics of pleural effusion

Joost HegmansAnnabrita HemmesBart Lambrecht

Bookchapter in Proteomics of human body fluids : principles, methods, and applications

Respiratory syncytial virus differentially activates murine myeloid and plasmacytoid dendritic cells

I BOOGAARDM VAN OOSTENLS VAN RIJTF MUSKENSTG KIMMANBart LambrechtAM BUISMAN

A1 Journal Article in IMMUNOLOGY

The pressure mounts on lung dendritic cells

Bart LambrechtLM VAN DEN TOORN

Editorial material

2006

Alveolar macrophage in the driver's seat

Editorial material

An essential role for dendritic cells in human and experimental allergic rhinitis

A KLEINJANMonique WillartLS VAN RIJTGJ BRAUNSTAHLK LEMANS JUNGHC HOOGSTEDENBart Lambrecht

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An unexpected role for the anaphylatoxin C5a receptor in allergic sensitization

Editorial material

Contribution of the PD-1 ligands/PD-1 signaling pathway to dendritic cell-mediated CD4(+) T cell activation

H KUIPERSF MUSKENSMonique WillartD HIJDRAFBJ VAN ASSEMAAJ COYLEHC HOOGSTEDENBart Lambrecht

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Dendritic cells in asthma

Hamida HammadBart Lambrecht

Bookchapter in Handbook of dendritic cells : biology, diseases, and therapies

Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function

M IDZKOHamida HammadM VAN NIMWEGENM KOOLT MULLERT SOULLIEMonique WillartD HIJDRAHC HOOGSTEDENBart Lambrecht

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Mesothelioma environment comprises cytokines and T-regulatory cells that suppress immune responses

JPJJ HEGMANSA HEMMESHamida HammadL BOONHC HOOGSTEDENBart Lambrecht

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Recent progress in the biology of airway dendritic cells and implications for understanding the regulation of asthmatic inflammation

Hamida HammadBart Lambrecht

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Rôle des différentes populations de cellules dendritiques dans l'asthme allergique

Hamida HammadBart Lambrecht

A1 Journal Article in REVUE FRANCAISE D ALLERGOLOGIE ET D IMMUNOLOGIE CLINIQUE

2005

Dendritic cell subsets and immune regulation in the lung

HJ DE HEERHamida HammadMA KOOLBart Lambrecht

A1 Journal Article in SEMINARS IN IMMUNOLOGY

Dendritic cells and the regulation of the allergic immune response

A1 Journal Article in ALLERGY

Dendritic cells in asthma: a function beyond sensitization

LS VAN RIJTBart Lambrecht

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Immunotherapy of murine malignant mesothelioma using tumor lysate-pulsed dendritic cells

LPJJ HEGMANSA HEMMESJG AERTSHC HOOGSTEDENBart Lambrecht

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

In vivo depletion of lung CD11c(+) dendritic cells during allergen challenge abrogates the characteristic features of asthma

LS VAN RIJTS JUNGA KLEINJANN VOSMonique WillartC DUEZHC HOOGSTEDENBart Lambrecht

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Modification of dendritic cell function as a tool to prevent and treat allergic asthma

H KUIPERSBart Lambrecht

A1 Journal Article in VACCINE

Proinflammatory bacterial peptidoglycan as a cofactor for the development of central nervous system autoimmune disease

L VISSERHJ DE HEERLA BOVEND VAN RIELM VAN MEURSMJ MELIEFU ZAHRINGERJ VAN STRIJPBart LambrechtEE NIEUWENHUIS et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Respiratory viral infections and asthma pathogenesis: A critical role for dendritic cells?

LS VAN RIJTCHG VAN KESSELI BOOGAARDBart Lambrecht

A1 Journal Article in JOURNAL OF CLINICAL VIROLOGY

Surfactant pretreatment ameliorates ischemia-reperfusion injury of the lung

NP VAN DER KAAIJJJ HAITSMAJ KLUINBart LambrechtB LACHMANNRWF DE BRUINAJJC BOGERS

A1 Journal Article in EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Treatment of experimental asthma by decoy-mediated local inhibition of activator protein-1

Christophe DesmetPhilippe GossetEmmanuelle HenryVirginie GarzéPedro FaiscaNanda VosFabrice JasparDorothée MélotteBart LambrechtDaniel Desmecht et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

2004

A rapid flow cytometric method for determining the cellular composition of bronchoalveolar lavage fluid cells in mouse models of asthma

LS VAN RIJTH KUIPERSN VOSD HIJDRAHC HOOGSTEDENBart Lambrecht

A1 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS

Activated protein C inhibits bronchial hyperresponsiveness and Th2 cytokine expression in mice

H YUDAY ADACHIO TAGUCHIEC GABAZZAO HATAJIH FUJIMOTOS TAMAKIK NISHIKUBOK FUKUDOMECN D'ALESSANDRO-GABAZZA et al.

A1 Journal Article in BLOOD

Activation of peroxisome proliferator-activated receptor-gamma in dendritic cells inhibits the development of eosinophilic airway inflammation in a mouse model of asthma

Hamida HammadHJ DE HEERT SOULLIEV ANGELIF TROTTEINHC HOOGSTEDENBart Lambrecht

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

Activation of the D prostanoid receptor 1 regulates immune and skin allergic responses

W ANGELID STAUMONTAS CHARBONNIERHamida HammadP GOSSETM PICHAVANTBart LambrechtM CAPROND DOMBROWICZF TROTTEIN

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Airways infection with virulent Mycobacterium tuberculosis delays the influx of dendritic cells and the expression of costimulatory molecules in mediastinal lymph nodes

GS GARCIA-ROMOA PEDROZA-GONZALEZD AGUILAR-LEONH OROZCO-ESTEVEZBart LambrechtI ESTRADA-GARCIAL FLORES-ROMOR HERNANDEZ-PANDO

A1 Journal Article in IMMUNOLOGY

Dendritic cells retrovirally overexpressing IL-12 induce strong Th1 responses to inhaled antigen in the lung but fail to revert established Th2 sensitization

H KUIPERSC HEIRMAND HIJDRAF MUSKENSMonique WillartS VAN MEIRVENNEK THIELEMANSHC HOOGSTEDENBart Lambrecht

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

Differential capacity of CD8 alpha(+) or CD8 alpha(-) dendritic cell subsets to prime for eosinophilic airway inflammation in the T-helper type 2-prone milieu of the lung

Hamida HammadVC DE VRIESR MALDONADO-LOPEZM MOSERC MALISZEWSKIHC HOOGSTEDENBart Lambrecht

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Essential role of dendritic cell CD80/86 costimulation in the induction, but not reactivation, of T(H)2 effector responses in a mouse model of asthma

LS VAN RIFTN VOSMonique WillartA KLEINJANAJ COYLEHC HOOGSTEDENBart Lambrecht

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen

HJ DE HEERHamida HammadT SOULLIED HIJDRAN VOSMonique WillartHC HOOGSTEDENBart Lambrecht

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

In situ analysis of lung antigen-presenting cells during murine pulmonary infection with virulent Mycobacterium tuberculosis

A PEDROZA-GONZALEZGS GARCIA-ROMOD AGUILAR-LEONJ CALDERON-AMADORR HURTADO-ORTIZH OROZCO-ESTEVEZBart LambrechtI ESTRADA-GARCIAR HERNANDEZ-PANDOL FLORES-ROMO

A1 Journal Article in INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Proteomic analysis of exosomes isolated from human malignant pleural effusions

MP BARDJP HEGMANSA HEMMESTM LUIDERR WILLEMSENLAA SEVERIJNENJan Van MeerbeeckSA BURGERSHC HOOGSTEDENBart Lambrecht

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Proteomic analysis of exosomes secreted by human mesothelioma cells

JPJJ HEGMANSMPL BARDA HEMMESTM LUIDERMJ KLEIJMEERJB PRINSL ZITVOGELSA BURGERSHC HOOGSTEDENBart Lambrecht

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

The interplay of dendritic cells, Th2 cells and regulatory T cells in asthma

H KUIPERSBart Lambrecht

A1 Journal Article in CURRENT OPINION IN IMMUNOLOGY

2003

Airway eosinophils accumulate in the mediastinal lymph nodes but lack antigen-presenting potential for naive T cells

LS VAN RIJTN VOSD HIJDRAVC DE VRIESHC HOOGSTEDENBart Lambrecht

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Antigen-presenting cells

Henk C HoogstedenHamida HammadBart Lambrecht

Bookchapter in The immunological basis of asthma

B cell differentiation and IgE synthesis

Hamida HammadBart Lambrecht

Bookchapter in The immunological basis of asthma

Immunology of eosinophilic airway inflammation

Bart LambrechtLeonie S van RijtHarmjan Kuipers

Bookchapter in The immunological basis of asthma

Lipopolysaccharide-induced suppression of airway Th2 responses does not require IL-12 production by dendritic cells

H KUIPERSD HIJDRAVC DE VRIESHamida HammadJB PRINSAJ COYLEHC HOOGSTEDENBart Lambrecht

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Opinion - Taking our breath away: dendritic cells in the pathogenesis of asthma

Bart LambrechtHamida Hammad

Editorial material

Peroxisome proliferator-activated receptor gamma inhibits the migration of dendritic cells: Consequences for the immune response

W ANGELIHamida HammadB STAELSM CAPRONBart LambrechtF TROTTEIN

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Prostaglandin D-2 inhibits airway dentritic cell migration and function in steady state conditions by selective activation of the D prostanoid receptor 1

Hamida HammadHJ DE HEERT SOULLIEHC HOOGSTEDENF TROTTEINBart Lambrecht

A1 Journal Article in JOURNAL OF IMMUNOLOGY

The immunological basis of asthma

The other cells in asthma: dendritic cell and epithelial cell crosstalk

Bart LambrechtHamida Hammad

A1 Journal Article in CURRENT OPINION IN PULMONARY MEDICINE

2002

Allergen-induced accumulation of airway dendritic cells is supported by an increase in CD31(hi)Ly6C(neg) bone marrow precursors in a mouse model of asthma

LS VAN RIJTJB PRINSPJM LEENENK THIELEMANSVC DE VRIESHC HOOGSTEDENBart Lambrecht

A1 Journal Article in BLOOD

Effect of ozone exposure on allergic sensitization and airway inflammation induced by dendritic cells.

Pieter DepuydtBart LambrechtGuy JoosRomain Pauwels

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Monocyte-derived dendritic cells induce a house dust mite-specific Th2 allergic inflammation in the lung of humanized SCID mice: Involvement of CCR7

Hamida HammadBart LambrechtP POCHARDP GOSSETP MARQUILLIESAB TONNELJ PESTEL

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Myeloid dendritic cells make it to the top

Bart LambrechtHamida Hammad

Editorial material

2001

Dendritic cells as regulators od the immune response to inhaled allergen: Recent findings in animal models of asthma

Bart LambrechtC HOOGSTEDENRomain Pauwels

A1 Journal Article in INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Enforced expression of GATA-3 in transgenic mice inhibits Th1 differentiation and induces the formation of a T1/ST2-expressing Th2-committed T cell compartment in vivo

MC NAWIJNGM DINGJANR FERREIRABart LambrechtA KARISF GROSVELDH SAVELKOULRW HENDRIKS

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Immunologists getting nervous: neuropeptides, dendritic cells and T cell activation

Editorial material

Lung dendritic cells and host immunity to infection

Bart LambrechtJB PRINSHC HOOGSTEDEN

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Role of dendritic cells and Th2 lymphocytes in asthma: Lessons from eosinophilic airway inflammation in the mouse

LS VAN RIJTBart Lambrecht

A1 Journal Article in MICROSCOPY RESEARCH AND TECHNIQUE

Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes.

Karim VermaelenInes Carro-MuinoBart LambrechtRomain Pauwels

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

The dendritic cell in allergic airway diseases: a new player to the game

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

2000

Airway inflammation in asthma and chronic obstructive pulmonary disease with special emphasis on the antigen-presenting dendritic cell: influence of treatment with fluticasone propionate (vol 29, pg 116, 1999)

HC HoogstedenGT VerhoevenBart LambrechtJ-B Prins

Induction of rapid T cell activation, division, and recirculation by intratracheal injection of dendritic cells in a TCR transgenic model

Bart LambrechtRomain PauwelsB FAZEKAS DE ST GROTH

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation.

Bart LambrechtM DE VEERMANAJ COYLEJC GUTIERREZ-RAMOSK THEILEMANSRomain Pauwels

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Sensitization to inhaled antigen by intratracheal instillation of dendritic cells.

Bart LambrechtRenaat PelemanGillian BullockRomain Pauwels

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

1999

Airway inflammation in asthma and chronic obstructive pulmonary disease with special emphasis on the antigen-presenting dendritic cell: influence of treatment with fluticasone propionate

HC HoogstedenGT VerhoevenBart LambrechtJ-B Prins

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Allergen-induced changes in bone-marrow progenitor and airway dendritic cells in sensitized rats.

Bart LambrechtInes Carro-MuinoKarim VermaelenRomain Pauwels

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Antigen presenting dendrititic cells produce neurokinins to stimulate T cell proliferation.

Bart LambrechtEls EveraertPaul GermonpreInes Carro-MuinoM DE VEERMANK THIELEMANSS HUNT

Effect of ozone exposure on the pulmonary immune response induced by dendritic cells.

PO DEPUYDTBart LambrechtGuy JoosRomain Pauwels

Endogenously produced substance P contributes to lymphocyte proliferation induced by dendritic cells and direct TCR ligation

Bart LambrechtPaul GermonpreEls EveraertInes Carro-MuinoM DE VEERMANC DE FELIPESP HUNTK THIELEMANSGuy JoosRomain Pauwels

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Lung antigen presenting cells are an important source of substance P in allergic airway inflammation.

Els EveraertInes Carro-MuinoBart LambrechtGuy JoosRomain Pauwels

Presence of substance P and neurokinin 1 receptors in human sputum macrophages and U-937 cells.

Paul GermonpreGillian BullockBart LambrechtV VAN DE VELDEW LUYTENGuy JoosRomain Pauwels

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

1998

Cytokines and their receptors as therapeutic targets in asthma

Romain PauwelsGuy BrusselleKurt TournoyBart LambrechtJohan Kips

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Dendritic cells are required for the development of chronic eosinophilic airway inflammation in response to inhaled antigen in sensitized mice

Bart LambrechtB SALOMOND KLATZMANNRomain Pauwels

A1 Journal Article in JOURNAL OF IMMUNOLOGY

1997

The airway inflammatory response induced by intratracheal injection of antigen pulsed dendritic cells is modified by systemic adjuvant

Bart LambrechtRenaat PelemanGillian BullockRomain Pauwels

1996

Bronchiaal astma

Romain PauwelsBart Lambrecht

A4 Journal Article in BIJBLIJVEN (AMSTERDAM.)

The dendritic cell : its potent role in the respiratory immune response

Bart LambrechtRomain PauwelsGillian Bullock

A1 Journal Article in CELL BIOLOGY INTERNATIONAL

1994

AGE-RELATED DIFFERENCES IN PRESENTATION, TREATMENT AND OUTCOME OF ACUTE MYOCARDIAL-INFARCTION.

Paul CalleLuc JordaensMarc De BuyzereL RUBBENSBart LambrechtDenis Clement

A1 Journal Article in CARDIOLOGY

1993

Signal averaged electrocardiography and echocardiography in athletes and age matched controls: importance of left ventricular hypertrophy.

Luc MissaultLuc JordaensBart LambrechtC DEMEESTERDaniel DuprezDenis Clement

A2 Journal Article in ACTA CARDIOLOGICA