The immune system is responsible for the eradication of unwanted harmful bacteria, fungi, viruses and other foreign materials from the body. Understanding how the immune system develops and functions is a crucial for the design of novel therapeutic interventions in the clinic. The immune system is made up of a number of different cell types that mediate specific responses to any harmful agents encountered. One cell type that has been identified to play a major role in initiating the immune response are the Dendritic cells. These cells come in 2 main subtypes or ‘lavours’each with distinct functions in the immune system. However, despite the crucial role played by these cells, much remains to be understood regarding how each subset develops and how they acquire their specific functions. Here we aim to better understand Dendritic cell development and function by examining the role played by a specific factor, Zeb1, which we believe to be involved in the development and/or function of one specific Dendritic cell subset.