Code
3F022909
Duration
01 October 2009 → 30 September 2013
Funding
Research Foundation - Flanders (FWO)
Promotor
Fellow
Research disciplines
-
Medical and health sciences
- Immunology
- Immunology
- Immunology
Keywords
asthma
mast cell
GATA transcription factor
Project description
A conditional GATA knock-out will be induced in mastcells by using Cre/loxP technology. In vitro experiments will define the expression pattern of Gata-genes en their regulators during development of mast cells and the effect og gata-deficiency on the development and funtion of mastcells. In vivoo experiments will define the effects of GATA-deficiency in a mousemodel of asthma.