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Medical and health sciences
- Cancer biology
Lung cancer is the leading cause of cancer-related deaths worldwide and
has a poor prognosis. The influence of inflammation on tumorigenicity has
mostly been studied in the context of its contribution to primary tumor
initiation and promotion, with a strong focus on type-1 antitumor immunity.
However, the contribution of type-2 immunity, hallmarked by eosinophilia,
epithelial remodeling and repair driven by IL-4, IL-5, IL-9, and IL-13 from
innate lymphoid cells (ILC2), is still unclear. Here, we will investigate the
impact of local type-2 inflammation on the progression of NSCLC. Our
preliminary data show that treatment with the type-2 alarmin IL-33 results in
lower tumor burden in this model. Within this proposal we will use various
newly generated mouse lines and therapeutic intervention strategies in a
model of NSCLC to advance our understanding on the role of type-2
inflammation in antitumor immunity. Ultimately helping to develop new
strategies for immunotherapeutic interventions.