Code
01M01521
Duration
01 January 2021 → 31 December 2027
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Natural sciences
- Animal immunology
-
Medical and health sciences
- Allergology
- Inflammation
- Respiratory medicine
- Allergology
Keywords
Asthma
dendritic cells
epithelial cells
T cells
eosinophils
neutrophils
protein crystals
mucus
lung function
Project description
In severe asthma, there is persistent obstruction of the airways with mucus plugs containing mucins, fibrin, and Charcot-Leyden crystals. We hypothesize that plugged airways constitute a unique niche where type 2 immune cells thrive and communicate with structural cells to perpetuate disease. We will
study if eliminating plugs or key niche communication signals can treat persistent disease in mouse and man.