Carbohydrate epimerases as cost-effective biocatalysts for the production of rare sugars

Creation of a superior industrial yeast strain with high enzyme secretion capacity for consolidated bioprocessing

Doctoral project Alex Windels

Doctoral project Carlos Alvarez Quispe

Doctoral project Griet Dewitte

Doctoral project Jarne Delanote

Doctoral project Jolien Lormans

Doctoral project Magali Tanghe

Doctoral project Margo Diricks

Doctoral project Renfei Zhao

Doctoral project Ulrike Vogel

Enzyme engineering for the cost-effective synthesis of C- glycosides

Enzyme engineering for the cost-effective synthesis of rare sugars

Exploring and engineering the substrate specificity of glycoside hydrolases and phosphorylases.

Future Fibres - exploration, engineering, and application of beta-glucan phosphorylases.

Guided by Nature: enzyme tunnel evolution as a tool for functional adaptation

Production of sucrose analogues through enzyme and process engineering (sucralogues)

Doctoral project Barbara Danneels

Doctoral project Chao Chen

Doctoral project Karel De Winter

Doctoral project Koen Beerens

Doctoral project Koen Gistelinck

Doctoral project Tibo De Coninck

Radical-based Enzymatic Degradation of Organic Pollutants

Rational design and synthesis of non-hallucinogenic psilocin analogues as selective 5-HT2A receptor agonists with therapeutic potential

A new route towards the production of L-sugars and derivatives: an integration of enzyme engineering and pathway design

Apiose exploration: reaction mechanism and applications of apiose-specific glycosyltransferases

Automated protein purification: an essential step towards further analyses and new applications.

BioCatGluCans: Biocatalytic production of beta-glucans

Carbohydrate-based fine chemicals: Development of a glycosylation platform cell factory and optimization of downstream processing for the sustainable production of glycosides

Characterization and engineering of a polysaccharide mono-oxygenase involved in the degradation of (ligno) cellulosic biomass

Chemoenzymatic radiosyntheses of [18F]FDG-derived oligosaccharides for S. aureus detection

Cofunding core facility - HTS for SynBio

DeoxyBioCat: Unlocking Synthetic Biology of Deoxy Sugars via Redesigned Biocatalytic Cascades

Development of an inverting sucrose phosphorylase and its application for rare sugar production.

doctoraatsproject Angelica Thelen: Manufacture, functionalization and application of designed inorganic supports for enzyme immobilization.

Engineering of trehalose phosphorylase for the production of trehalose analogues

Epimerases as new tools for the production of rare sugars: a powerful integration of enzyme engineering and systems biocatalysis

EpiSwitch: Characterization and engineering of the specificity determinants of carbohydrate epimerases to achieve a specificity switch.

Evolution at work: turning hydrolases into phosphorylases for the cost-efficient synthesis of glycosidic bonds.

Evolution in practice: converting hydrolases and transferases into phosphorylases

Exploration of sucrose analogues enabled by enzyme and process engineering

Exploring the scope of nickel pincer as enzymatic cofactor: engineering of gluconate epimerase towards the production of rare sugars.

GlycoProFit: Cost-efficient synthesis of health-promoting glycobioses

Guided by Nature: enzyme tunnel evolution as a tool for functional adaptation

Guided by Nature: evolution of the entrance to the active site as a tool for functional adaptation

Looking back into the future: ancestral reconstruction as a strategy for enzyme engineering

Off the beaten path of protein evolution: insertions and deletions as drivers of functional innovation

Oligosaccharide purification system – effective purification of short oligosaccharides

Phosphorylases as cost-efficient biocatalysts for carbohydrate synthesis: an exploration of natural and mutant diversity

Proof of concept for antioxidant glycosylation

Redirected evolution as strategy for the development of new enzymes.

Retracing the steps of enzyme evolution: an exploration of ancestral sequence space

Stable and selective enzymes for the production of 2-GG

Sucrose synthase as cost-effective mediator in glycosylation reactions

The design of new enzymes for the synthesis of rare sugars

The quest for an aldose C3-epimerase: the missing link in sugar conversions

Turning sucrose synthase into a biocatalyst for the production of nucleotide sugars

Unlocking Synthetic Biology of Deoxy Sugars via Enzyme Engineering and Biocatalytic Cascades

Unlocking the specificity determinants in nucleotide sugar epimerases

Biosynthetic processes with glucansucrase enzymes: scale up and product characterization

Chitinsect CHITINSECT: Production and application of chitosan based on insect biomass at lab and pilot scale. IWT FISCH 130787

Development of microbial cell factories for the production of chitoheptaose and -octaose using metabolic and protein engineering: Promising molecules with an underexplored potential for plant, animal and human health

GlycoProFit: Cost-efficient synthesis of health-promoting glycobioses

GlycoProFit: Cost-efficient synthesis of health-promoting glycobioses

GlycoProFit: Cost-efficient synthesis of health-promoting glycobioses

GlycoProFit: Cost-efficient synthesis of health-promoting glycobioses

MyCOS - Synthetic biology for a sustainable conversion of fungal chitin-rich waste streams into valuable biobased chitooligosaccharides for plant health

Novel biocatalysts for the production of glycosides

Radical-based Enzymatic Degradation of Organic Pollutants (REDOP)

Rational design and synthesis of non-hallucinogenic psilocin analogues as selective 5-HT2A receptor agonists with therapeutic potential