Acronym
SuSy
Code
41V08913
Duration
01 September 2013 → 31 October 2017
Funding
European funding: framework programme, Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Natural sciences
- Biochemistry and metabolism
- Systems biology
-
Medical and health sciences
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism
-
Engineering and technology
- Catalysis and reacting systems engineering
- Chemical product design and formulation
- General chemical and biochemical engineering
- Process engineering
- Separation and membrane technologies
- Transport phenomena
- Other (bio)chemical engineering
- Biomaterials engineering
- Biological system engineering
- Biomaterials engineering
- Biomechanical engineering
- Other (bio)medical engineering
- Environmental engineering and biotechnology
- Industrial biotechnology
- Other biotechnology, bio-engineering and biosystem engineering
Keywords
glycosyl transferases
enzyme engineering
biocatalysis
Project description
This project focusses on sucrose synthase as mediator for recycling of expensive nucleotide-activated sugar donors necessary for glycosylation of organic compounds by glycosyl transferases. To that end, an optimized variant of sucrose synthase will be generated by means of enzyme engineering. The whole process will be optimized and scaled-up to pilot facilities to allow for commercial exploitation of glycosylated compounds.