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Researcher
Tom Desmet
Profile
Projects
Publications & Research Data
Activities
Awards & Distinctions
Patents
207
Results
2025
A molecular dance : deciphering the dynamic mechanisms of GDP-sugar epimerases
Carlos Alvarez Quispe
Tom Desmet
Koen Beerens
Dissertation
2025
Biochemical and biological properties of a bifunctional GH27 enzyme from rice
Tibo De Coninck
Els Van Damme
Tom Desmet
Dissertation
2025
Bioconversion of mushroom chitin-rich waste into valuable chitin oligosaccharides using a combined approach of biocatalysis and precision fermentation
Alex Windels
Luna Declerck
Sofie Snoeck
Wouter Demeester
Chiara Guidi
Tom Desmet
Marjan De Mey
A1
Journal Article
in
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
2025
Colorimetric assays for the detection of C4- and C2-epimerization of NDP-glucose to NDP-galactose and NDP-mannose
Ulrike Vogel
Renger Siebren Dijkstra
Koen Beerens
Tom Desmet
A1
Journal Article
in
ANALYTICAL BIOCHEMISTRY
2025
Discovery of a novel sucrose 6F-phosphate phosphorylase and its application for isomelezitose production
Manon Steynen
Jorick Franceus
Davy Van de Walle
Koen Dewettinck
Vladimír Křen
Helena Pelantová
Tom Desmet
A1
Journal Article
in
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
2025
Enzymatic modification of dihydromyricetin by glucosylation and acylation, and its effect on the solubility and antioxidant activity
David Rodriguez-Garcia
Carlos Uceda
Laura Barahona
Marta Ruiz-Nuñez
Antonio O. Ballesteros
Tom Desmet
Julia Sanz-Aparicio
Maria Fernandez-Lobato
Jose L. Gonzalez-Alfonso
Francisco J. Plou
A1
Journal Article
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2025
Exploration and engineering of dehydratases and epimerases for the biocatalytic synthesis of nucleotide diphosphate deoxy sugars
Ulrike Vogel
Tom Desmet
Koen Beerens
Dissertation
2025
Novel approaches in chitin bioconversion : exploration, characterization and engineering of chitinases for chitin oligosaccharide production
Alex Windels
Tom Desmet
Marjan De Mey
Dissertation
2025
OsAPSE modulates non-covalent interactions between arabinogalactan protein O-glycans and pectin in rice cell walls
Tibo De Coninck
Isabel Verbeke
Pierre Rougé
Tom Desmet
Els Van Damme
A1
Journal Article
in
FRONTIERS IN PLANT SCIENCE
2025
Protein flexibility drives sugar rotation and high substrate promiscuity in a GDP-sugar 4-epimerase
Carlos Alvarez Quispe
Koen Beerens
Andy-Mark W.H. Thunnissen
Xevi Biarnés
Antoni Planas
Tom Desmet
A1
Journal Article
in
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
2025
Synthesis and functional screening of novel inhibitors targeting the HDAC6 zinc finger ubiquitin-binding domain
Silke Geurs
Eleni Staessens
Kato Bredael
Stefaan Borghgraef
Jordy De Ridder
Leentje Persoons
Steven De Jonghe
Dominique Schols
Mandeep K. Mann
Rachel J. Harding
et al.
A1
Journal Article
in
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2025
The P134Q sucrose phosphorylase : subtle changes in the catalytic properties benefit the production of 2-O-α-glucosyl glycerol
Alexander Sigg
Mario Klimacek
Martin Pfeiffer
Jorick Franceus
Tom Desmet
Bernd Nidetzky
A1
Journal Article
in
BIOTECHNOLOGY AND BIOENGINEERING
2025
2024
CANDy : automated analysis of domain architectures in carbohydrate-active enzymes
Alex Windels
Jorick Franceus
Juergen Pleiss
Tom Desmet
A1
Journal Article
in
PLOS ONE
2024
Carbohydrate-active enzymes involved in rice cell wall metabolism
Tibo De Coninck
Tom Desmet
Els Van Damme
A1
Journal Article
in
JOURNAL OF EXPERIMENTAL BOTANY
2024
Converting bulk sugars into functional fibers : discovery and application of a thermostable β-1,3-oligoglucan phosphorylase
Marc De Doncker
Sofie Vleminckx
Jorick Franceus
Ronny Vercauteren
Tom Desmet
A1
Journal Article
in
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
2024
Discovery and characterization of a novel Ricin-B lectin-like module, restricted to the glycoside hydrolase family 27 family of Viridiplantae
Tibo De Coninck
Garry P. Gippert
Bernard Henrissat
Tom Desmet
Els Van Damme
C3
Conference
2024
Evolution of phosphorylase activity in an ancestral glycosyltransferase
Jorick Franceus
Jose Pablo Rivas-Fernandez
Jolien Lormans
Carme Rovira
Tom Desmet
A1
Journal Article
in
ACS CATALYSIS
2024
Exploring and engineering the substrate specificity of glycoside hydrolases and phosphorylases
Emma De Beul
Tom Desmet
Koen Beerens
Dissertation
2024
GH5_11 enzymes involved in plant and cell wall development?
Koen Gistelinck
Tom Desmet
Els Van Damme
C3
Conference
2024
High-yield synthesis of 2-O-α-d-glucosyl-d-glycerate by a bifunctional glycoside phosphorylase
Jorick Franceus
Manon Steynen
Yentl Allaert
Kato Bredael
Matthias D'hooghe
Tom Desmet
A1
Journal Article
in
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
2024
Investigating diversity and similarity between CBM13 modules and ricin-B lectin domains using sequence similarity networks
Tibo De Coninck
Garry P. Gippert
Bernard Henrissat
Tom Desmet
Els Van Damme
A1
Journal Article
in
BMC GENOMICS
2024
Strategies for the synthesis of the osmolyte glucosylglycerate and its precursor glycerate
Yentl Allaert
Arthur Leyder
Jorick Franceus
Tom Desmet
A1
Journal Article
in
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
2024
Strategy for the enzymatic acylation of the apple flavonoid phloretin based on prior α-glucosylation
Jose L Gonzalez-Alfonso
Cristina Alonso
Ana Poveda
Zorica Ubiparip
Antonio O Ballesteros
Tom Desmet
Jesús Jiménez-Barbero
Luisa Coderch
Francisco J Plou
A1
Journal Article
in
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
2024
Sustainable bioconversion of mushroom chitin-rich waste into valuable biobased chitooligosaccharides using a combined approach of biocatalysis and precision fermentation
Alex Windels
Luna Declerck
Sofie Snoeck
Wouter Demeester
Chiara Guidi
Tom Desmet
Marjan De Mey
C3
Conference
2024
Sustainable chitooligosaccharide production from chitin-rich fungal waste via precision fermentation with metabolically engineered E. coli
Luna Declerck
Alex Windels
Sofie Snoeck
Wouter Demeester
Chiara Guidi
Tom Desmet
Marjan De Mey
C3
Conference
2024
Sustainable production of well-defined chitooligosaccharides from chitin-rich fungal waste by integrating biocatalysis and precision fermentation
Luna Declerck
Alex Windels
Sofie Snoeck
Wouter Demeester
Chiara Guidi
Tom Desmet
Marjan De Mey
C3
Conference
2024
Synthesis and evaluation of glucosyl-, acyl- and silyl- resveratrol derivatives as retinoprotective agents : piceid octanoate notably delays photoreceptor degeneration in a retinitis pigmentosa mouse model
Lourdes Valdés-Sánchez
Seyed Mohamadmehdi Moshtaghion
Estefanía Caballano-Infantes
Pablo Peñalver
Rosario Rodríguez-Ruiz
José Luis González-Alfonso
Francisco José Plou
Tom Desmet
Juan C. Morales
Francisco J. Díaz-Corrales
A1
Journal Article
in
PHARMACEUTICALS
2024
Synthesis of pyrrolidine-fused β-lactams as potential β-lactamase inhibitors
Sari Deketelaere
Carlos Diez-Poza
Margot Aelbrecht
Jonas Mortier
Bram Van Den Bossche
Jorick Franceus
Tom Desmet
Kristof Van Hecke
Christian Stevens
Matthias D'hooghe
A1
Journal Article
in
ASIAN JOURNAL OF ORGANIC CHEMISTRY
2024
The many functions of carbohydrate-active enzymes in family GH65 : diversity and application
Emma De Beul
Jorick Franceus
Tom Desmet
A1
Journal Article
in
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
2024
2023
Characterization of a putative senescence-associated α-D-galactosidase/β-L-arabinopyranosidase from rice
Tibo De Coninck
Anne-Sophie Chys
Vinicius Jose Da Silva Osterne
Tom Desmet
Els Van Damme
C3
Conference
2023
Chemoenzymatic syntheses of fluorine-18-labeled disaccharides from [18F] FDG yield potent sensors of living bacteria in vivo
Alexandre M. Sorlin
Marina López-Álvarez
Sarah J. Rabbitt
Aryn A. Alanizi
Rebecca Shuere
Kondapa Naidu Bobba
Joseph Blecha
Sasank Sakhamuri
Michael J. Evans
Kenneth W. Bayles
et al.
A1
Journal Article
in
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2023
GH5_11 enzymes involved in plant and cell wall development?
Koen Gistelinck
Tom Desmet
Els Van Damme
C3
Conference
2023
Glycosidic linkage of rare and new-to-nature disaccharides reshapes gut microbiota in vitro
Stanley Omondi Onyango
Koen Beerens
Qiqiong Li
John Van Camp
Tom Desmet
Tom Van de Wiele
A1
Journal Article
in
FOOD CHEMISTRY
2023
Integration of high-throughput specificity profiling and engineering of xylan-active enzymes and xylanosomes
Maria João de Carvalho Maurício da Fonseca
Yves Briers
Ingeborg Stals
Tom Desmet
Anita Van Landschoot
Dissertation
2023
Rare sugar metabolism and impact on insulin sensitivity along the gut-liver-muscle axis in vitro
Amar Daniël Emanuel Van Laar
Charlotte Grootaert
Andreja Rajkovic
Tom Desmet
Koen Beerens
John Van Camp
A1
Journal Article
in
NUTRIENTS
2023
The conversion of UDP-Glc to UDP-Man : in silico and biochemical exploration to improve the catalytic efficiency of CDP-tyvelose C2-epimerases
Ulrike Vogel
Matthieu Da Costa
Carlos Alvarez Quispe
Robin Stragier
Henk‐Jan Joosten
Koen Beerens
Tom Desmet
A1
Journal Article
in
CHEMBIOCHEM
2023
2022
A colorimetric assay for the screening and kinetic analysis of nucleotide sugar 4,6-dehydratases
Ulrike Vogel
Koen Beerens
Tom Desmet
A1
Journal Article
in
ANALYTICAL BIOCHEMISTRY
2022
A sweet story : exploring microbial enzymes for the biocatalytic production of rare sugars and their in vitro digestibility
Shari Dhaene
Tom Desmet
Dissertation
2022
Building mutational bridges between carbohydrate-active enzymes
Jorick Franceus
Jolien Lormans
Tom Desmet
A1
Journal Article
in
CURRENT OPINION IN BIOTECHNOLOGY
2022
Enzyme colocalisation on synthetic protein scaffolds : a VersaTile approach
Julie Vanderstraeten
Yves Briers
Tom Desmet
Dissertation
2022
Exploration of archaeal nucleotide sugar epimerases unveils a new and highly promiscuous GDP-Gal4E subgroup
Carlos Alvarez Quispe
Matthieu Da Costa
Koen Beerens
Tom Desmet
A2
Journal Article
in
CURRENT RESEARCH IN BIOTECHNOLOGY
2022
Exploring glycoside phosphorylases for the production of functional carbohydrates and glycosides
Zorica Ubiparip
Tom Desmet
Marjan De Mey
Dissertation
2022
Exploring the structure-function relationship of C2-epimerases
Matthieu Da Costa
Tom Desmet
Marjan De Mey
Dissertation
2022
GDP-mannose 3,5-epimerase : a view on structure, mechanism, and industrial potential
Koen Beerens
Ophelia Gevaert
Tom Desmet
A1
Journal Article
in
FRONTIERS IN MOLECULAR BIOSCIENCES
2022
Identification of mercaptoacetamide-based HDAC6 inhibitors via a lean inhibitor strategy : screening, synthesis, and biological evaluation
Silke Geurs
Dorien Clarisse
Freya Baele
Jorick Franceus
Tom Desmet
Karolien De Bosscher
Matthias D'hooghe
A1
Journal Article
in
CHEMICAL COMMUNICATIONS
2022
In vitro stability and ex vivo absorption of thymol monoglucosides in the porcine gut
Noémie Van Noten
Elout Van Liefferinge
Jeroen Degroote
Stefaan De Smet
Tom Desmet
Joris Michiels
A1
Journal Article
in
ANIMAL
2022
Insertions and deletions in protein evolution and engineering
Simone Savino
Tom Desmet
Jorick Franceus
A1
Journal Article
in
BIOTECHNOLOGY ADVANCES
2022
Metabolism and health effects of rare sugars in a CACO-2/HepG2 coculture model
Amar Daniël Emanuel Van Laar
Charlotte Grootaert
Filip Van Nieuwerburgh
Dieter Deforce
Tom Desmet
Koen Beerens
John Van Camp
A1
Journal Article
in
NUTRIENTS
2022
Nucleotide sugar dehydratases : structure, mechanism, substrate specificity, and application potential
Ulrike Vogel
Koen Beerens
Tom Desmet
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2022
Sweet biotechnology : enzymatic production and digestibility screening of novel kojibiose and nigerose analogues
Shari Dhaene
Amar Daniël Emanuel Van Laar
Marc De Doncker
Emma De Beul
Koen Beerens
Charlotte Grootaert
Jurgen Caroen
Johan Van der Eycken
John Van Camp
Tom Desmet
A1
Journal Article
in
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
2022
2021
Defined synthesis of cellotriose by cellobiose phosphorylase mutant
Zorica Ubiparip
David Sáez
Koen Beerens
Tom Desmet
C3
Conference
2021
Development of microbial cell factories for the production of chitooligosaccharides through integrating metabolic and protein engineering
Chiara Guidi
Marjan De Mey
Tom Desmet
Dissertation
2021
Discovery of a kojibiose hydrolase by analysis of specificity-determining correlated positions in Glycoside Hydrolase Family 65
Emma De Beul
Alana Jongbloet
Jorick Franceus
Tom Desmet
A1
Journal Article
in
MOLECULES
2021
Discovery of a novel GDP-glucose 4-epimerase in archaea reveals an uncommon promiscuity
Carlos Alvarez Quispe
Matthieu Da Costa
Koen Beerens
Tom Desmet
C3
Conference
2021
Engineering of a thermostable biocatalyst for the synthesis of 2-O-glucosylglycerol
Jorick Franceus
Zorica Ubiparip
Koen Beerens
Tom Desmet
A1
Journal Article
in
CHEMBIOCHEM
2021
Engineering of cellobiose phosphorylase for the synthesis of prebiotic cellotriose
Zorica Ubiparip
David Sáez Moreno
Koen Beerens
Tom Desmet
C3
Conference
2021
Enzymatic synthesis of phloretin α‐glucosides using a sucrose phosphorylase mutant and its effect on solubility, antioxidant properties and skin absorption
Jose Luis González Alfonso
Zorica Ubiparip
Elena Jimenez‐Ortega
Ana Poveda
Cristina Alonso
Luisa Coderch
Jesus Jimenez‐Barbero
Julia Sanz‐Aparicio
Antonio O. Ballesteros
Tom Desmet
et al.
A1
Journal Article
in
ADVANCED SYNTHESIS & CATALYSIS
2021
Evolution of phosphorylases from N-acetylglucosaminide hydrolases in family GH3
Jorick Franceus
Jolien Lormans
Lore Cools
Matthias D'hooghe
Tom Desmet
A1
Journal Article
in
ACS CATALYSIS
2021
Expanding the enzyme repertoire for sugar nucleotide epimerization : the CDP-tyvelose 2-epimerase from Thermodesulfatator atlanticus for glucose/mannose interconversion
Christian Rapp
Stevie Van Overtveldt
Koen Beerens
Hansjörg Weber
Tom Desmet
Bernd Nidetzky
A1
Journal Article
in
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
2021
Exploration of GH94 sequence space for enzyme discovery reveals a novel glucosylgalactose phosphorylase specificity
Marc De Doncker
Chloé De Graeve
Jorick Franceus
Koen Beerens
Vladimír Křen
Helena Pelantová
Ronny Vercauteren
Tom Desmet
A1
Journal Article
in
CHEMBIOCHEM
2021
Kojibiose and trehalose long-term supplementation reveals significant metabolic differences and disaccharide dependent microbial community shift in a human gastrointestinal model
Stanley Omondi Onyango
Koen Beerens
Xinlin Jiao
Tom Desmet
Tom Van de Wiele
C3
Conference
2021
Stereo-electronic control of reaction selectivity in short-chain dehydrogenases : decarboxylation, epimerization, and dehydration
Annika J.E. Borg
Koen Beerens
Martin Pfeiffer
Tom Desmet
Bernd Nidetzky
A1
Journal Article
in
CURRENT OPINION IN CHEMICAL BIOLOGY
2021
Structure-function relationships in NDP-sugar active SDR enzymes : fingerprints for functional annotation and enzyme engineering
Matthieu Da Costa
Ophelia Gevaert
Stevie Van Overtveldt
Joanna Lange
Henk-Jan Joosten
Tom Desmet
Koen Beerens
A1
Journal Article
in
BIOTECHNOLOGY ADVANCES
2021
Towards sustainable production of defined oligosaccharides : enzymatic synthesis of high purity cellotriose
Zorica Ubiparip
David Sáez Moreno
Koen Beerens
Tom Desmet
C3
Conference
2021
β-Glucan phosphorylases in carbohydrate synthesis
Zorica Ubiparip
Marc De Doncker
Koen Beerens
Jorick Franceus
Tom Desmet
A1
Journal Article
in
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
2021
2020
Determinants of the nucleotide specificity in the carbohydrate epimerase family 1
Stevie Van Overtveldt
Matthieu Da Costa
Ophelia Gevaert
Henk-Jan Joosten
Koen Beerens
Tom Desmet
A1
Journal Article
in
BIOTECHNOLOGY JOURNAL
2020
Effects of thymol and thymol α-D-Glucopyranoside on intestinal function and microbiota of weaned pigs
Noémie Van Noten
Jeroen Degroote
Elout Van Liefferinge
Bernard Taminiau
Stefaan De Smet
Tom Desmet
Joris Michiels
A1
Journal Article
in
ANIMALS
2020
Engineering of cellobiose phosphorylase for the defined synthesis of cellotriose
Zorica Ubiparip
David Sáez Moreno
Koen Beerens
Tom Desmet
A1
Journal Article
in
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
2020
Exploring C5-epimerases for the production of L-sugars and derivatives
Ophelia Gevaert
Tom Desmet
Marjan De Mey
Proefschrift
2020
Fate of thymol and its monoglucosides in the gastrointestinal tract of piglets
Noémie Van Noten
Elout Van Liefferinge
Jeroen Degroote
Stefaan De Smet
Tom Desmet
Joris Michiels
A1
Artikel in een tijdschrift
in
ACS OMEGA
2020
Fermentation of rare sugar kojibiose by the oral bacteria is slow yet bacteria specific
Stanley Omondi Onyango
Nele De Clercq
Koen Beerens
Tom Desmet
Tom Van de Wiele
C3
Conferentie
2020
GDP-altrose as novel product of GDP-mannose 3,5-epimerase : revisiting its reaction mechanism
Ophelia Gevaert
Stevie Van Overtveldt
Matthieu Da Costa
Koen Beerens
Tom Desmet
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
2020
Novel insights into the existence of the putative UDP-glucuronate 5-epimerase specificity
Ophelia Gevaert
Stevie Van Overtveldt
Matthieu Da Costa
Koen Beerens
Tom Desmet
A1
Artikel in een tijdschrift
in
CATALYSTS
2020
Oral microbiota display profound differential metabolic kinetics and community shifts upon incubation with sucrose, trehalose, kojibiose, and xylitol
Stanley Omondi Onyango
Nele De Clercq
Koen Beerens
John Van Camp
Tom Desmet
Tom Van de Wiele
A1
Artikel in een tijdschrift
in
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
2020
Sucrose phosphorylase and related enzymes in glycoside hydrolase family 13 : discovery, application and engineering
Jorick Franceus
Tom Desmet
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2020
Synthesis of novel nitroxoline analogs with potent cathepsin B exopeptidase inhibitory activity
Tim Van de Walle
Marina Briand
Ana Mitrović
Izidor Sosič
Stanislav Gobec
Janko Kos
Leentje Persoons
Dirk Daelemans
Steven De Jonghe
Zorica Ubiparip
et al.
A1
Artikel in een tijdschrift
in
CHEMMEDCHEM
2020
Synthesis, trehalase hydrolytic resistance and inhibition properties of 4-and 6-substituted trehalose derivatives
Shari Dhaene
Johan Van der Eycken
Koen Beerens
Jorick Franceus
Tom Desmet
Jurgen Caroen
A1
Artikel in een tijdschrift
in
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
2020
The application of thymol and its glucosides in weaned piglets
Noémie Van Noten
Stefaan De Smet
Joris Michiels
Tom Desmet
Proefschrift
2020
Uncovering a superfamily of nickel-dependent hydroxyacid racemases and epimerases
Benoît Desguin
Julian Urdiain-Arraiza
Matthieu Da Costa
Matthias Fellner
Jian Hu
Robert P. Hausinger
Tom Desmet
Pascal Hols
Patrice Soumillion
A1
Artikel in een tijdschrift
in
SCIENTIFIC REPORTS
2020
Unlocking new biocatalytic pathways by engineering of carbohydrate epimerases
Stevie Van Overtveldt
Tom Desmet
Proefschrift
2020
Weaning affects the glycosidase activity towards phenolic glycosides in the gut of piglets
Noémie Van Noten
Elout Van Liefferinge
Jeroen Degroote
Stefaan De Smet
Tom Desmet
Joris Michiels
A1
Artikel in een tijdschrift
in
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
2020
2019
CARBAFIN : developing a glycosylation platform technology to an industrial level
Zorica Ubiparip
Christiane Luley
Tom Desmet
Bernd Nidetzky
C3
Conferentie
2019
Characterization of the first bacterial and thermostable GDP-mannose 3,5-epimerase
Ophelia Gevaert
Stevie Van Overtveldt
Koen Beerens
Tom Desmet
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2019
Discovery of novel cellodextrin phosphorylases : where bioinformatics meets biochemistry
Zorica Ubiparip
Jorick Franceus
Nídia Martins
Koen Beerens
Tom Desmet
C3
Conferentie
2019
Effect of age on the functional glycosidase activity in the small intestinal mucosa of piglets
Noémie Van Noten
Elout Van Liefferinge
Jeroen Degroote
Tom Desmet
Stefaan De Smet
Joris Michiels
C3
Conferentie
2019
Exploring and engineering the functional diversity of glycoside phosphorylases
Jorick Franceus
Tom Desmet
Proefschrift
2019
Rational design of an improved transglucosylase for production of the rare sugar nigerose
Jorick Franceus
Shari Dhaene
Hannes Decadt
Judith Vandepitte
Jurgen Caroen
Johan Van der Eycken
Koen Beerens
Tom Desmet
A1
Artikel in een tijdschrift
in
CHEMICAL COMMUNICATIONS
2019
Structural comparison of a promiscuous and a highly specific sucrose 6F-phosphate phosphorylase
Jorick Franceus
Nikolas Capra
Tom Desmet
Andy-Mark W.H. Thunnissen
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2019
Structural features on the substrate-binding surface of fungal lytic polysaccharide monooxygenases determine their oxidative regioselectivity
Barbara Danneels
Magali Tanghe
Tom Desmet
A1
Artikel in een tijdschrift
in
BIOTECHNOLOGY JOURNAL
2019
Synthesis of indoline‐based benzhydroxamic acids as potential HDAC6 inhibitors
Yves Depetter
Silke Geurs
Jorick Franceus
Damijan Knez
Tom Desmet
Karolien De Bosscher
Olivier De Wever
Stanislav Gobec
Matthias D'hooghe
A1
Artikel in een tijdschrift
in
CHEMISTRYSELECT
2019
Synthesis of non‐symmetrical nitrogen‐containing curcuminoids in the pursuit of new anticancer candidates
Atiruj Theppawong
Tim Van de Walle
Charlotte Grootaert
Kristof Van Hecke
Nathalie Catry
Tom Desmet
John Van Camp
Matthias D'hooghe
A1
Artikel in een tijdschrift
in
CHEMISTRYOPEN
2019
2018
Analysis of the substrate specificity of α-L-arabinofuranosidases by DNA sequencer-aided fluorophore-assisted carbohydrate electrophoresis
Maria João de Carvalho Maurício da Fonseca
Edita Jurak
Kim Kataja
Emma R Master
Jean-Guy Berrin
Ingeborg Stals
Tom Desmet
Anita Van Landschoot
Yves Briers
A1
Artikel in een tijdschrift
in
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
2018
Assessment of the trifluoromethyl ketone functionality as an alternative zinc-binding group for selective HDAC6 inhibition
Yves Depetter
Silke Geurs
Flore Vanden Bussche
Rob De Vreese
Jorick Franceus
Tom Desmet
Olivier De Wever
Matthias D'hooghe
A1
Artikel in een tijdschrift
in
MEDCHEMCOMM
2018
CARBAFIN : developing a glycosylation platform technology to an industrial level
Zorica Ubiparip
Christiane Luley
Tom Desmet
Bernd Nidetzky
C3
Conferentie
2018
Chemoenzymatic approach toward the synthesis of 3-O-(α/β)-glucosylated 3-hydroxy-β-lactams
Lena Decuyper
Jorick Franceus
Shari Dhaene
Maarten Debruyne
Kevin Vandoorne
Nicola Piens
Griet Dewitte
Tom Desmet
Matthias D'hooghe
A1
Artikel in een tijdschrift
in
ACS OMEGA
2018
Converting galactose into the rare sugar talose with cellobiose 2-epimerase as biocatalyst
Stevie Van Overtveldt
Ophelia Gevaert
Martijn Cherlet
Koen Beerens
Tom Desmet
A1
Artikel in een tijdschrift
in
MOLECULES
2018
Exploring the sequence diversity in glycoside hydrolase family 13_18 reveals a novel glucosylglycerol phosphorylase
Jorick Franceus
Lena Decuyper
Matthias D'hooghe
Tom Desmet
A1
Artikel in een tijdschrift
in
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
2018
Glycosylation of thymol to alter its kinetics along the gastro-intestinal tract of the piglet
Noémie Van Noten
Elout Van Liefferinge
Joris Michiels
Tom Desmet
Stefaan De Smet
C3
Conferentie
2018
Kinetics of thymol and its glucosides along the gastro-intestinal tract of weaned piglets
Noémie Van Noten
Elout Van Liefferinge
Joris Michiels
Tom Desmet
Stefaan De Smet
C3
Conferentie
2018
Recombinant production and regioselectivity study of lytic polysaccharide monooxygenases
Barbara Danneels
Tom Desmet
Wim Soetaert
Proefschrift
2018
Synthesis of Novel Aza‐aromatic Curcuminoids with Improved Biological Activities towards Various Cancer Cell Lines
Atiruj Theppawong
Tim Van de Walle
Charlotte Grootaert
Margot Bultinck
Tom Desmet
John Van Camp
Matthias D'hooghe
A1
Artikel in een tijdschrift
in
CHEMISTRYOPEN
2018
Thermostable alpha-glucan phosphorylases : characteristics and industrial applications
Zorica Ubiparip
Koen Beerens
Jorick Franceus
Ronny Vercauteren
Tom Desmet
A1
Artikel in een tijdschrift
in
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
2018
2017
A quantitative indicator diagram for lytic polysaccharide monooxygenases reveals the role of aromatic surface residues in HjLPMO9A regioselectivity
Barbara Danneels
Magali Tanghe
Henk-Jan Joosten
Thomas Gundinger
Oliver Spadiut
Ingeborg Stals
Tom Desmet
A1
Artikel in een tijdschrift
in
PLOS ONE
2017
Biocatalytic synthesis of the rare sugar kojibiose : process scale-up and application testing
Koen Beerens
Karel De Winter
Davy Van de Walle
Charlotte Grootaert
Senem Kamiloglu
Lisa Miclotte
Tom Van de Wiele
John Van Camp
Koen Dewettinck
Tom Desmet
A1
Artikel in een tijdschrift
in
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
2017
CorNet : assigning function to networks of co-evolving residues by automated literature mining
Tom van den Bergh
Giorgio Tamo
Alberto Nobili
Yifeng Tao
Tianwei Tan
Uwe T Bornscheuer
Remko KP Kuipers
Bas Vroling
René M de Jong
Kalyanasundaram Subramanian
et al.
A1
Artikel in een tijdschrift
in
PLOS ONE
2017
Correlated positions in protein evolution and engineering
Jorick Franceus
Tom Verhaeghe
Tom Desmet
A1
Artikel in een tijdschrift
in
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
2017
Disulfide bridges as essential elements for the thermostability of lytic polysaccharide monooxygenase LPMO10C from Streptomyces coelicolor
Magali Tanghe
Barbara Danneels
Matthias Last
Koen Beerens
Ingeborg Stals
Tom Desmet
A1
Artikel in een tijdschrift
in
PROTEIN ENGINEERING DESIGN & SELECTION
2017
Glucosylglycerate phosphorylase, an enzyme with novel specificity involved in compatible solute metabolism
Jorick Franceus
Denise Pinel
Tom Desmet
A1
Artikel in een tijdschrift
in
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
2017
Glycosyltransferase cascades for natural product glycosylation : use of plant instead of bacterial sucrose synthases improves the UDP-glucose recycling from sucrose and UDP
Alexander Gutmann
Alexander Lepak
Margo Diricks
Tom Desmet
Bernd Nidetzky
A1
Artikel in een tijdschrift
in
BIOTECHNOLOGY JOURNAL
2017
High-throughput customized production of arabinoxylan-oligosaccharides (AXOS)
Maria João de Carvalho Maurício da Fonseca
Ingeborg Stals
Tom Desmet
Anita Van Landschoot
Yves Briers
C3
Conferentie
2017
Microbial enzymes for glycoside synthesis : development of sucrose phosphorylase as a test case
Tom Verhaeghe
Karel De Winter
Tom Desmet
Hoofdstuk in een boek
in
Biotechnology of microbial enzymes : production, biocatalysis and industrial applications
2017
Recombinant expression and stability engineering of lytic polysaccharide monooxygenases
Magali Tanghe
Tom Desmet
Ingeborg Stals
Proefschrift
2017
Sequence determinants of nucleotide binding in Sucrose Synthase : improving the affinity of a bacterial Sucrose Synthase for UDP by introducing plant residues
Margo Diricks
Alexander Gutmann
Simon Debacker
Griet Dewitte
Bernd Nidetzky
Tom Desmet
A1
Artikel in een tijdschrift
in
PROTEIN ENGINEERING DESIGN & SELECTION
2017
Synthesis of potent and selective HDAC6 inhibitors bearing a cyclohexane- or cycloheptane-annulated 1,5-benzothiazepine scaffold
Rob De Vreese
Lisa Galle
Yves Depetter
Jorick Franceus
Tom Desmet
Kristof Van Hecke
Veronick Benoy
Ludo Van Den Bosch
Matthias D'hooghe
A1
Artikel in een tijdschrift
in
CHEMISTRY-A EUROPEAN JOURNAL
2017
The 'epimerring' highlights the potential of carbohydrate epimerases for rare sugar production
Koen Beerens
Stevie Van Overtveldt
Tom Desmet
A1
Artikel in een tijdschrift
in
BIOCATALYSIS AND BIOTRANSFORMATION
2017
Unlocking nature’s glycosylation potential : characterization and engineering of novel sucrose/trehalose synthases
Margo Diricks
Tom Desmet
Proefschrift
2017
2016
A nitrilase-mediated entry to 4-carboxymethyl-β-lactams from chemically prepared 4-(cyanomethyl)azetidin-2-ones
Lena Decuyper
Nicola Piens
Jens Mincke
Jeroen Bomon
Bert De Schrijver
Karen Mollet
Karel De Winter
Tom Desmet
Matthias D'hooghe
A1
Artikel in een tijdschrift
in
RSC ADVANCES
2016
Biocatalytic production of novel glycolipids
Karel De Winter
Griet Dewitte
Hai Giang Tran
Tom Desmet
Hoofdstuk in een boek
in
Practical methods for biocatalysis and biotransformations 3
2016
Collision cross section prediction of deprotonated phenolics in a travelling-wave ion mobility spectrometer using molecular descriptors and chemometrics
Bryan Gonzales
Guy Smagghe
Sofie Coelus
Dieter Adriaenssens
Karel De Winter
Tom Desmet
Katleen Raes
John Van Camp
A1
Artikel in een tijdschrift
in
ANALYTICA CHIMICA ACTA
2016
Converting bulk sugars into prebiotics : semirational design of a transglucosylase with controlled selectivity
Tom Verhaeghe
Karel De Winter
Magali Berland
Rob De Vreese
Matthias D'hooghe
Bernard Offmann
Tom Desmet
A1
Artikel in een tijdschrift
in
CHEMICAL COMMUNICATIONS
2016
Diastereoselective synthesis of 3-acetoxy-4-(3-aryloxiran-2-yl)azetidin-2-ones and their transformation into 3,4-oxolane-fused bicyclic β-lactams
Nicola Piens
Sven De Craene
Jorick Franceus
Karen Mollet
Kristof Van Hecke
Tom Desmet
Matthias D'hooghe
A1
Artikel in een tijdschrift
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2016
Expanding the application potential of glycoside phosphorylases through process engineering
Karel De Winter
Tom Desmet
Wim Soetaert
Proefschrift
2016
Integrating biocatalytical processes into organic synthesis: nitrilase-mediated conversion of 2-aryl-3-(2-cyanoethyl)aziridines and 4-(cyanomethyl)azetidin-2-ones as a sustainable entry to functionalized γ-lactams and β-lactams
Nicola Piens
Lena Decuyper
Saskia Vander Meeren
Jens Mincke
Jeroen Bomon
Bert De Schrijver
Karen Mollet
Karel De Winter
Tom Desmet
Matthias D'hooghe
C3
Conferentie
2016
Screening of recombinant glycosyltransferases reveals the broad acceptor specificity of stevia UGT-76G1
Griet Dewitte
Maarten Walmagh
Margo Diricks
Alexander Lepak
Alexander Gutmann
Bernd Nidetzky
Tom Desmet
A1
Artikel in een tijdschrift
in
JOURNAL OF BIOTECHNOLOGY
2016
Stability analysis of a plant glycosyltransferase
Griet Dewitte
Koen Beerens
Margo Diricks
Tom Desmet
C3
Conferentie
2016
Sucrose synthase : a unique glycosyltransferase for biocatalytic glycosylation process development
Katharina Schmölzer
Alexander Gutmann
Margo Diricks
Tom Desmet
Bernd Nidetzky
A1
Artikel in een tijdschrift
in
BIOTECHNOLOGY ADVANCES
2016
Synthesis and applications of 3-methylene-4-(trifluoromethyl)azetidin-2-ones as building blocks for the preparation of mono- and spirocyclic 4-CF3-β-lactams
Hang Dao Thi
Barbara Danneels
Tom Desmet
Kristof Van Hecke
Tuyen Van Nguyen
Matthias D'hooghe
A1
Artikel in een tijdschrift
in
ASIAN JOURNAL OF ORGANIC CHEMISTRY
2016
Synthesis and chemical/enzymatic hydrolysis of 2-aryl-3-(2-cyanoethyl)aziridines and 4-(cyanomethyl)azetidin-2-ones
Lena Decuyper
Nicola Piens
Saskia Vander Meeren
Jens Mincke
Jeroen Bomon
Bert De Schrijver
Karen Mollet
Karel De Winter
Tom Desmet
Matthias D'hooghe
C3
Conferentie
2016
Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors
Rob De Vreese
Yves Depetter
Tom Verhaeghe
Tom Desmet
Veronick Benoy
Wanda Haeck
Ludo Van Den Bosch
Matthias D'hooghe
A1
Artikel in een tijdschrift
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2016
Using DSA-FACE to reveal the substrate specificity of α-L-arabinofuranosidases
Maria João de Carvalho Maurício da Fonseca
Tom Desmet
Anita Van Landschoot
Ingeborg Stals
Yves Briers
C3
Conferentie
2016
2015
A structural classification of carbohydrate epimerases : from mechanistic insights to practical applications
Stevie Van Overtveldt
Tom Verhaeghe
Henk-Jan Joosten
Tom van den Bergh
Koen Beerens
Tom Desmet
A1
Artikel in een tijdschrift
in
BIOTECHNOLOGY ADVANCES
2015
Capillary electrophoresis for the functional annotation of carbohydrate-active enzymes: two preliminary case studies
Maria João de Carvalho Maurício da Fonseca
Tom Desmet
Anita Van Landschoot
Ingeborg Stals
C3
Conferentie
2015
Chemoenzymatic synthesis of β-D-glucosides using cellobiose phosphorylase from Clostridium thermocellum
Karel De Winter
Lisa Van Renterghem
Kathleen Wuyts
Helena Pelantová
Vladimír Křen
Wim Soetaert
Tom Desmet
A1
Artikel in een tijdschrift
in
ADVANCED SYNTHESIS & CATALYSIS
2015
Creating space for large acceptors: rational biocatalyst design for resveratrol glycosylation in an aqueous system
Mareike Dirks-Hofmeister
Tom Verhaeghe
Karel De Winter
Tom Desmet
A1
Artikel in een tijdschrift
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2015
Enzymatic glycosylation of phenolic antioxidants: phosphorylase-mediated synthesis and characterization
Karel De Winter
Griet Dewitte
Mareike Dirks-Hofmeister
Sylvie De Laet
Helena Pelantova
Vladimír Kren
Tom Desmet
A1
Artikel in een tijdschrift
in
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
2015
Identification of sucrose synthase in nonphotosynthetic bacteria and characterization of the recombinant enzymes
Margo Diricks
Frederik De Bruyn
Paul Van Daele
Maarten Walmagh
Tom Desmet
A1
Artikel in een tijdschrift
in
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
2015
Recombinant expression of Trichoderma reesei Cel61A in Pichia pastoris: optimizing yield and N-terminal processing
Magali Tanghe
Barbara Danneels
Andrea Camattari
Anton Glieder
Isabel Vandenberghe
Bart Devreese
Ingeborg Stals
Tom Desmet
A1
Artikel in een tijdschrift
in
MOLECULAR BIOTECHNOLOGY
2015
Synthesis and antimicrobial/cytotoxic assessment of ferrocenyl oxazinanes, oxazinan-2-ones, and tetrahydropyrimidin-2-ones
Anka Pejović
Barbara Danneels
Tom Desmet
Ba Thi Cham
Tuyen Van Nguyen
Niko S Radulović
Rastko D Vukicević
Matthias D'hooghe
A1
Artikel in een tijdschrift
in
SYNLETT
2015
Synthesis of 2-aryl-3-(2-cyanoethyl)aziridines and their chemical and enzymatic hydrolysis towards γ-lactams and γ-lactones
Karen Mollet
Lena Decuyper
Saskia Vander Meeren
Nicola Piens
Karel De Winter
Tom Desmet
Matthias D'hooghe
A1
Artikel in een tijdschrift
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2015
Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors
Rob De Vreese
Nicholas Van Steen
Tom Verhaeghe
Tom Desmet
Nadia Bougarne
Karolien De Bosscher
Veronick Benoy
Wanda Haeck
Ludo Van Den Bosch
Matthias D'hooghe
A1
Artikel in een tijdschrift
in
CHEMICAL COMMUNICATIONS
2015
Synthesis of functionalized 3-, 5-, 6- and 8-aminoquinolines via intermediate (3-pyrrolin-1-yl)- and (2-oxopyrrolidin-1-yl)quinolines and evaluation of their antiplasmodial and antifungal activity
Stephanie Vandekerckhove
Sofie Van Herreweghe
Jasmine Willems
Barbara Danneels
Tom Desmet
Carmen de Kock
Peter J Smith
Kelly Chibale
Matthias D'hooghe
A1
Artikel in een tijdschrift
in
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2015
Trehalose analogues: latest insights in properties and biocatalytic production
Maarten Walmagh
Renfei Zhao
Tom Desmet
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2015
UDP-hexose 4-epimerases: a view on structure, mechanism and substrate specificity
Koen Beerens
Wim Soetaert
Tom Desmet
A1
Artikel in een tijdschrift
in
CARBOHYDRATE RESEARCH
2015
2014
Biphasic catalysis with disaccharide phosphorylases: chemoenzymatic synthesis of α-D-glucosides using sucrose phosphorylase
Karel De Winter
Tom Desmet
Tim Devlamynck
Lisa Van Renterghem
Tom Verhaeghe
Helena Pelantová
Vladimír Křen
Wim Soetaert
A1
Artikel in een tijdschrift
in
ORGANIC PROCESS RESEARCH & DEVELOPMENT
2014
Engineering the carbohydrate-binding site of Epa1p from Candida glabrata: generation of adhesin mutants with different carbohydrate specificity
Francesco S Ielasi
Tom Verhaeghe
Tom Desmet
Ronnie G Willaert
A1
Artikel in een tijdschrift
in
GLYCOBIOLOGY
2014
Engineering the specificity of trehalose phosphorylase as a general strategy for the production of glycosyl phosphates
Chao Chen
Jef Van der Borght
Rob De Vreese
Matthias D'hooghe
Wim Soetaert
Tom Desmet
A1
Artikel in een tijdschrift
in
CHEMICAL COMMUNICATIONS
2014
Enhanced biomass degradation by polysaccharide monooxygenases
Magali Tanghe
Barbara Danneels
Ingeborg Stals
Tom Desmet
Hoofdstuk in een boek
in
Renewable resources for biorefineries
2014
Improving the glycosylation potential of sucrose phosphorylase through enzyme engineering
Tom Verhaeghe
Tom Desmet
Wim Soetaert
Proefschrift
2014
Synthesis of 2-aryl-3-(2-cyanoethyl)aziridines and their chemical and enzymatic hydrolysis towards γ-lactams and γ-lactones
Lena Decuyper
Karen Mollet
Saskia Vander Meeren
Nicola Piens
Karel De Winter
Tom Desmet
Matthias D'hooghe
C3
Conferentie
2014
Synthesis of halogenated 4-quinolones and evaluation of their antiplasmodial activity
Stephanie Vandekerckhove
Tom Desmet
Hai Giang Tran
Carmen de Kock
Peter J Smith
Kelly Chibale
Matthias D'hooghe
A1
Artikel in een tijdschrift
in
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2014
The quest for a thermostable sucrose phosphorylase reveals sucrose 6'-phosphate phosphorylase as a novel specificity
Tom Verhaeghe
Dirk Aerts
Margo Diricks
Wim Soetaert
Tom Desmet
A1
Artikel in een tijdschrift
in
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
2014
2013
Characterization and engineering of epimerases for the production of rare sugars
Koen Beerens
Wim Soetaert
Tom Desmet
Proefschrift
2013
Characterization and mutational analysis of the UDP-Glc(NAc) 4-epimerase from Marinithermus hydrothermalis
Koen Beerens
Wim Soetaert
Tom Desmet
A1
Artikel in een tijdschrift
in
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
2013
Chemoenzymatic synthesis of α-L-rhamnosides using recombinant α-L-rhamnosidase from Aspergillus terreus
Karel De Winter
Daniela Simcikova
Bram Schalck
Lenka Weignerova
Helena Pelantova
Wim Soetaert
Tom Desmet
Vladimir Kren
A1
Artikel in een tijdschrift
in
BIORESOURCE TECHNOLOGY
2013
Consensus engineering of sucrose phosphorylase: the outcome reflects the sequence input
Dirk Aerts
Tom Verhaeghe
Henk-Jan Joosten
Gert Vriend
Wim Soetaert
Tom Desmet
A1
Artikel in een tijdschrift
in
BIOTECHNOLOGY AND BIOENGINEERING
2013
Evaluation of (4-aminobutyloxy)quinolines as a novel class of antifungal agents
Stephanie Vandekerckhove
Hai Giang Tran
Tom Desmet
Matthias D'hooghe
A1
Artikel in een tijdschrift
in
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2013
Ionic liquids as cosolvents for glycosylation by sucrose phosphorylase: balancing acceptor solubility and enzyme stability
Karel De Winter
Kristien Verlinden
Vladimír Křen
Lenka Weignerová
Wim Soetaert
Tom Desmet
A1
Artikel in een tijdschrift
in
GREEN CHEMISTRY
2013
Library construction in Pichia pastoris for engineering proteins
Magali Tanghe
Barbara Danneels
Sofie De Maeseneire
Tom Desmet
C3
Conferentie
2013
Mapping the acceptor site of sucrose phosphorylase from Bifidobacterium adolescentis by alanine scanning
Tom Verhaeghe
Margo Diricks
Dirk Aerts
Wim Soetaert
Tom Desmet
A1
Artikel in een tijdschrift
in
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
2013
Potent and selective HDAC6 inhibitory activity of N-(4-hydroxycarbamoylbenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorenes as novel sulfur analogues of Tubastatin A
Rob De Vreese
Tom Verhaeghe
Tom Desmet
Matthias D'hooghe
A1
Artikel in een tijdschrift
in
CHEMICAL COMMUNICATIONS
2013
Synthesis of 2-aminomethyl-4-phenyl-1-azabicyclo[2.2.1]heptanes via LiAlH4-induced reductive cyclization of 2-(4-chloro-2-cyano-2-phenylbutyl) aziridines and evaluation of their antimalarial activity
Matthias D'hooghe
Karel Vervisch
Karl W Törnroos
Tom Verhaeghe
Tom Desmet
Carmen Lategan
Peter J Smith
Kelly Chibale
Norbert De Kimpe
A1
Artikel in een tijdschrift
in
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2013
Synthesis of piperidin-4-ones starting from 2-(2-bromo-1,1-dimethylethyl)-azetidines and 2-(2-mesyloxyethyl)azetidines through a ring expansion-oxidation protocol
Karen Mollet
Matthias D'hooghe
Leen Broeckx
Barbara Danneels
Tom Desmet
Norbert De Kimpe
A1
Artikel in een tijdschrift
in
TETRAHEDRON
2013
Towards a carbon-negative sustainable bio-based economy
Bartel Vanholme
Tom Desmet
Frederik Ronsse
Korneel Rabaey
Frank Van Breusegem
Marjan De Mey
Wim Soetaert
Wout Boerjan
A1
Artikel in een tijdschrift
in
FRONTIERS IN PLANT SCIENCE
2013
2012
Adsorption-desorption of trehalose analogues from a bioconversion mixture using activated carbon
Chao Chen
Tom Desmet
Jef Van der Borght
Sze Ki Carol Lin
Wim Soetaert
A1
Artikel in een tijdschrift
in
SEPARATION AND PURIFICATION TECHNOLOGY
2012
An imprinted cross-linked enzyme aggregate (iCLEA) of sucrose phosphorylase: combining improved stability with altered specificity
Karel De Winter
Wim Soetaert
Tom Desmet
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2012
Biocatalytic production of novel glycolipids with cellodextrin phosphorylase
Hai Giang Tran
Tom Desmet
Karen Saerens
Hendrik Waegeman
Stephanie Vandekerckhove
Matthias D'hooghe
Inge Van Bogaert
Wim Soetaert
A1
Artikel in een tijdschrift
in
BIORESOURCE TECHNOLOGY
2012
Broadening the synthetic potential of disaccharide phosphorylases through enzyme engineering
Tom Desmet
Wim Soetaert
A1
Artikel in een tijdschrift
in
PROCESS BIOCHEMISTRY
2012
Engineering of trehalose phosphorylase for the production of trehalose analogues
Jef Van der Borght
Tom Desmet
Wim Soetaert
Proefschrift
2012
Engineering the acceptor specificity of trehalose phosphorylase for the production of trehalose analogs
Jef Van der Borght
Wim Soetaert
Tom Desmet
A1
Artikel in een tijdschrift
in
BIOTECHNOLOGY PROGRESS
2012
Enzymatic glycosylation of small molecules: challenging substrates require tailored catalysts
Tom Desmet
Wim Soetaert
Pavla Bojarová
Vladimir Křen
Lubbert Dijkhuizen
Vanessa Eastwick-Field
Alexander Schiller
A1
Artikel in een tijdschrift
in
CHEMISTRY-A EUROPEAN JOURNAL
2012
Enzymes for the biocatalytic production of rare sugars
Koen Beerens
Tom Desmet
Wim Soetaert
A1
Artikel in een tijdschrift
in
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
2012
Galactosylation reactions catalyzed by disaccharide phosphorylases
Chao Chen
Tom Desmet
Wim Soetaert
Proefschrift
2012
Improving the glycosylation activity of cellobiose/cellodextrin phosphorylase through enzyme engineering
Hai Giang Tran
Wim Soetaert
Tom Desmet
Proefschrift
2012
Preparation and use of sucrose phosphorylase as cross-linked enzyme aggregate (CLEA)
Karel De Winter
Tom Desmet
An Cerdobbel
Wim Soetaert
Hoofdstuk in een boek
in
Practical methods for biocatalysis and biotransformations 2
2012
Screening and engineering of sucrose phosphorylase for the glycosylation of small molecules
Dirk Aerts
Wim Soetaert
Tom Desmet
Proefschrift
2012
2011
A constitutive expression system for high-throughput screening
Dirk Aerts
Tom Verhaeghe
Marjan De Mey
Tom Desmet
Wim Soetaert
A1
Artikel in een tijdschrift
in
ENGINEERING IN LIFE SCIENCES
2011
Characterization of β-galactoside phosphorylases with diverging acceptor specificities
Chao Chen
Wim Soetaert
Tom Desmet
A1
Artikel in een tijdschrift
in
ENZYME AND MICROBIAL TECHNOLOGY
2011
Engineering of cellobiose phosphorylase for glycoside synthesis
Manu De Groeve
Tom Desmet
Wim Soetaert
A1
Artikel in een tijdschrift
in
JOURNAL OF BIOTECHNOLOGY
2011
Enzymatic glycosyl transfer: mechanisms and applications
Tom Desmet
Wim Soetaert
A1
Artikel in een tijdschrift
in
BIOCATALYSIS AND BIOTRANSFORMATION
2011
Enzymatic properties and substrate specificity of the trehalose phosphorylase from Caldanaerobacter subterraneus
Jef Van der Borght
Chao Chen
Lieve Hoflack
Lucas Van Renterghem
Tom Desmet
Wim Soetaert
A1
Artikel in een tijdschrift
in
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
2011
Increasing the thermostability of sucrose phosphorylase by a combination of sequence- and structure-based mutagenesis
An Cerdobbel
Karel De Winter
Dirk Aerts
Remko Kuipers
Henk-Jan Joosten
Wim Soetaert
Tom Desmet
A1
Artikel in een tijdschrift
in
PROTEIN ENGINEERING DESIGN & SELECTION
2011
Operational stability of immobilized sucrose phosphorylase: continuous proudction of α-glucose-1-phosphate at elevated temperatures
Karel De Winter
An Cerdobbel
Wim Soetaert
Tom Desmet
A1
Artikel in een tijdschrift
in
PROCESS BIOCHEMISTRY
2011
Probing the active site of cellodextrin phosphorylase from clostridium stercorarium: kinetic characterization, ligand docking, and site-directed mutagenesis
Hai Giang Tran
Tom Desmet
Manu De Groeve
Wim Soetaert
A1
Artikel in een tijdschrift
in
BIOTECHNOLOGY PROGRESS
2011
Transglucosylation potential of six sucrose phosphorylases toward different classes of acceptors
Dirk Aerts
Tom Verhaeghe
Bart Roman
Christian Stevens
Tom Desmet
Wim Soetaert
A1
Artikel in een tijdschrift
in
CARBOHYDRATE RESEARCH
2011
2010
Construction of cellobiose phosphorylase variants with broadened acceptor specificity towards anomerically substituted glucosides
Manu De Groeve
Laurens Remmery
Annelies Van Hoorebeke
Jan Stout
Tom Desmet
Savvas Savvides
Wim Soetaert
A1
Artikel in een tijdschrift
in
BIOTECHNOLOGY AND BIOENGINEERING
2010
Crystallization and X-ray diffraction studies of cellobiose phosphorylase from Cellulomonas uda
Annelies Van Hoorebeke
Jan Stout
John Kyndt
Manu De Groeve
Ina Dix
Tom Desmet
Wim Soetaert
Jozef Van Beeumen
Savvas Savvides
A1
Artikel in een tijdschrift
in
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS
2010
Development and application of a screening assay for glycoside phosphorylases
Manu De Groeve
Hai Giang Tran
Annelies Van Hoorebeke
Jan Stout
Tom Desmet
Savvas Savvides
Wim Soetaert
A1
Artikel in een tijdschrift
in
ANALYTICAL BIOCHEMISTRY
2010
Engineering of cellobiose phosphorylase for glycoside synthesis
Tom Desmet
Wim Soetaert
C3
Conferentie
2010
Enzymatic production of β-D-glucose-1-phosphate from trehalose
Jef Van der Borght
Tom Desmet
Wim Soetaert
A1
Artikel in een tijdschrift
in
BIOTECHNOLOGY JOURNAL
2010
High throughput calorimetry for evaluating enzymatic reactions generating phosphate
Lieve Hoflack
Manu De Groeve
Tom Desmet
Peter Van Gerwen
Wim Soetaert
A1
Artikel in een tijdschrift
in
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
2010
Increasing the thermostability of sucrose phosphorylase by multipoint covalent immobilization
An Cerdobbel
Tom Desmet
Karel De Winter
Jo Maertens
Wim Soetaert
A1
Artikel in een tijdschrift
in
JOURNAL OF BIOTECHNOLOGY
2010
Sucrose phosphorylase as cross-linked enzyme aggregate: improved thermal stability for industrial applications
An Cerdobbel
Karel De Winter
Tom Desmet
Wim Soetaert
A1
Artikel in een tijdschrift
in
BIOTECHNOLOGY JOURNAL
2010
Synthesis and evaluation of 2-deoxy-2-amino-β-cellobiosides as cellulase inhibitors
Tom Desmet
Marc Claeyssens
Kathleen Piens
Wim Nerinckx
A1
Artikel in een tijdschrift
in
JOURNAL OF CARBOHYDRATE CHEMISTRY
2010
2009
Creating lactose phosphorylase enzymes by directed evolution of cellobiose phosphorylase
Manu De Groeve
Miet De Baere
Lieve Hoflack
Tom Desmet
Erick Vandamme
Wim Soetaert
A1
Artikel in een tijdschrift
in
PROTEIN ENGINEERING DESIGN & SELECTION
2009
Enzymatic production of alpha-d-galactose 1-phosphate by lactose phosphorolysis
Manu De Groeve
Veerle Depreitere
Tom Desmet
Wim Soetaert
A1
Artikel in een tijdschrift
in
BIOTECHNOLOGY LETTERS
2009
2008
Modulation of activity by Arg407 : structure of a fungal alpha-1,2-mannosidase in complex with a substrate analogue
Yuri Lobsanov
Takashi Yoshida
Tom Desmet
Wim Nerinckx
Patrick Yip
Marc Claeyssens
Annette Herscovics
Lynne Howell
A1
Artikel in een tijdschrift
in
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
2008
Production of bioflavours
Tom Desmet
An Cerdobbel
Wim Soetaert
Erick Vandamme
Hoofdstuk in een boek
in
Advances in fermentation technology
2008
2007
An investigation of the substrate specificity of the xyloglucanase Cel74A from Hypocrea jecorina
Tom Desmet
Tineke Cantaert
Peter GUALFETTI
Wim Nerinckx
Laurie GROSS
Colin MITCHINSON
Kathleen Piens
A1
Artikel in een tijdschrift
in
FEBS JOURNAL
2007
2006
Itineraries of enzymatically and non-enzymatically catalyzed substitutions at O-glycopyranosidic bonds
Wim Nerinckx
Tom Desmet
Marc Claeyssens
A1
Artikel in een tijdschrift
in
ARKIVOC
2006
2005
An elaboration on the syn-anti proton donor concept of glycoside hydrolases: electrostatic stabilisation of the transition state as a general strategy
Wim Nerinckx
Tom Desmet
Kathleen Piens
Marc Claeyssens
A1
Artikel in een tijdschrift
in
FEBS LETTERS
2005
Structuur-functie relaties in O-glycoside hydrolasen : nieuwe inzichten in reactiemechanismen en specificiteiten van hypocrea jecorina cellulasen en hemicellulasen
Tom Desmet
Marc Claeyssens
Proefschrift
2005
2004
Crystal complex structures reveal how substrate is bound in the -4 to the +2 binding sites of Humicola grisea cel12A
M SANDGREN
GI BERGLUND
A SHAW
J STAHLBERG
L KENNE
Tom Desmet
C MITCHINSON
A1
Artikel in een tijdschrift
in
JOURNAL OF MOLECULAR BIOLOGY
2004
Evaluation of automated nano-electrospray mass spectrometry in the determination of non-covalent protein-ligand complexes
Kris De Vriendt
Koen Sandra
Tom Desmet
Wim Nerinckx
Jozef Van Beeumen
Bart Devreese
A1
Artikel in een tijdschrift
in
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
2004
On the mechanism of glycoside hydrolysis by the family GH-90 phage P-22 tailspike protein
Wim Nerinckx
Tom Desmet
Marc Claeyssens
A2
Artikel in een tijdschrift
in
Internet Electronic Journal of Molecular Design
2004
Resistance to air-born diseases and pests induced by compost in substrate cultivation of strawberry
S Bobev
K Willekens
Geert Goeminne
Tom Desmet
Gonzalez Van Driessche
Marc Claeyssens
Jozef Van Beeumen
Eric Messens
M Maes
A4
Artikel in een tijdschrift
in
COMMUNICATIONS IN AGRICULTURAL AND APPLIED BIOLOGICAL SCIENCES
2004
2003
A hydrophobic platform as a mechanistically relevant transition state stabilising factor appears to be present in the active centre of all glycoside hydrolases
Wim Nerinckx
Tom Desmet
Marc Claeyssens
A1
Artikel in een tijdschrift
in
FEBS LETTERS
2003
2002
Novel tools for the study of class I alpha-mannosidases: a chromogenic substrate and a substrate-analog inhibitor.
Tom Desmet
Wim Nerinckx
Ingeborg Stals
Nico Callewaert
Roland Contreras
Marc Claeyssens
A1
Artikel in een tijdschrift
in
ANALYTICAL BIOCHEMISTRY
2002