Research Explorer

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Researcher

Tom Desmet

Publications & Research Data

Awards & Distinctions

209 Results

2025

A molecular dance : deciphering the dynamic mechanisms of GDP-sugar epimerases

Carlos Alvarez QuispeTom DesmetKoen Beerens

Biochemical and biological properties of a bifunctional GH27 enzyme from rice

Tibo De ConinckEls Van DammeTom Desmet

Bioconversion of mushroom chitin-rich waste into valuable chitin oligosaccharides using a combined approach of biocatalysis and precision fermentation

Alex WindelsLuna DeclerckSofie SnoeckWouter DemeesterChiara GuidiTom DesmetMarjan De Mey

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Colorimetric assays for the detection of C4- and C2-epimerization of NDP-glucose to NDP-galactose and NDP-mannose

Ulrike VogelRenger Siebren DijkstraKoen BeerensTom Desmet

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

Discovery of a novel sucrose 6F-phosphate phosphorylase and its application for isomelezitose production

Manon SteynenJorick FranceusDavy Van de WalleKoen DewettinckVladimír KřenHelena PelantováTom Desmet

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Enzymatic modification of dihydromyricetin by glucosylation and acylation, and its effect on the solubility and antioxidant activity

David Rodriguez-GarciaCarlos UcedaLaura BarahonaMarta Ruiz-NuñezAntonio O. BallesterosTom DesmetJulia Sanz-AparicioMaria Fernandez-LobatoJose L. Gonzalez-AlfonsoFrancisco J. Plou

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Exploration and engineering of dehydratases and epimerases for the biocatalytic synthesis of nucleotide diphosphate deoxy sugars

Ulrike VogelTom DesmetKoen Beerens

Expression and characterization of an endo-β-1,6-galactanase from Arabidopsis thaliana

Koen GistelinckXiaolan YuArthur LeyderVinicius Jose Da Silva OsterneTom DesmetTheodora TryfonaEls Van Damme

A1 Journal Article in BIOCHEMICAL JOURNAL

Future fibres : exploration, engineering, and application of β-glucan phosphorylases

Marc De DonckerTom DesmetKoen Beerens

Novel approaches in chitin bioconversion : exploration, characterization and engineering of chitinases for chitin oligosaccharide production

Alex WindelsTom DesmetMarjan De Mey

OsAPSE modulates non-covalent interactions between arabinogalactan protein O-glycans and pectin in rice cell walls

Tibo De ConinckIsabel VerbekePierre RougéTom DesmetEls Van Damme

A1 Journal Article in FRONTIERS IN PLANT SCIENCE

Protein flexibility drives sugar rotation and high substrate promiscuity in a GDP-sugar 4-epimerase

Carlos Alvarez QuispeKoen BeerensAndy-Mark W.H. ThunnissenXevi BiarnésAntoni PlanasTom Desmet

A1 Journal Article in COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL

Synthesis and functional screening of novel inhibitors targeting the HDAC6 zinc finger ubiquitin-binding domain

Silke GeursEleni StaessensKato BredaelStefaan BorghgraefJordy De RidderLeentje PersoonsSteven De JongheDominique ScholsMandeep K. MannRachel J. Harding et al.

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The P134Q sucrose phosphorylase : subtle changes in the catalytic properties benefit the production of 2-O-α-glucosyl glycerol

Alexander SiggMario KlimacekMartin PfeifferJorick FranceusTom DesmetBernd Nidetzky

A1 Journal Article in BIOTECHNOLOGY AND BIOENGINEERING

2024

CANDy : automated analysis of domain architectures in carbohydrate-active enzymes

Alex WindelsJorick FranceusJuergen PleissTom Desmet

A1 Journal Article in PLOS ONE

Carbohydrate-active enzymes involved in rice cell wall metabolism

Tibo De ConinckTom DesmetEls Van Damme

A1 Journal Article in JOURNAL OF EXPERIMENTAL BOTANY

Converting bulk sugars into functional fibers : discovery and application of a thermostable β-1,3-oligoglucan phosphorylase

Marc De DonckerSofie VleminckxJorick FranceusRonny VercauterenTom Desmet

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Discovery and characterization of a novel Ricin-B lectin-like module, restricted to the glycoside hydrolase family 27 family of Viridiplantae

Tibo De ConinckGarry P. GippertBernard HenrissatTom DesmetEls Van Damme

Evolution of phosphorylase activity in an ancestral glycosyltransferase

Jorick FranceusJose Pablo Rivas-FernandezJolien LormansCarme RoviraTom Desmet

A1 Journal Article in ACS CATALYSIS

Exploring and engineering the substrate specificity of glycoside hydrolases and phosphorylases

Emma De BeulTom DesmetKoen Beerens

GH5_11 enzymes involved in plant and cell wall development?

Koen GistelinckTom DesmetEls Van Damme

High-yield synthesis of 2-O-α-d-glucosyl-d-glycerate by a bifunctional glycoside phosphorylase

Jorick FranceusManon SteynenYentl AllaertKato BredaelMatthias D'hoogheTom Desmet

A1 Journal Article in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Investigating diversity and similarity between CBM13 modules and ricin-B lectin domains using sequence similarity networks

Tibo De ConinckGarry P. GippertBernard HenrissatTom DesmetEls Van Damme

A1 Journal Article in BMC GENOMICS

Strategies for the synthesis of the osmolyte glucosylglycerate and its precursor glycerate

Yentl AllaertArthur LeyderJorick FranceusTom Desmet

A1 Journal Article in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Strategy for the enzymatic acylation of the apple flavonoid phloretin based on prior α-glucosylation

Jose L Gonzalez-AlfonsoCristina AlonsoAna PovedaZorica UbiparipAntonio O BallesterosTom DesmetJesús Jiménez-BarberoLuisa CoderchFrancisco J Plou

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Sustainable bioconversion of mushroom chitin-rich waste into valuable biobased chitooligosaccharides using a combined approach of biocatalysis and precision fermentation

Alex WindelsLuna DeclerckSofie SnoeckWouter DemeesterChiara GuidiTom DesmetMarjan De Mey

Sustainable chitooligosaccharide production from chitin-rich fungal waste via precision fermentation with metabolically engineered E. coli

Luna DeclerckAlex WindelsSofie SnoeckWouter DemeesterChiara GuidiTom DesmetMarjan De Mey

Sustainable production of well-defined chitooligosaccharides from chitin-rich fungal waste by integrating biocatalysis and precision fermentation

Luna DeclerckAlex WindelsSofie SnoeckWouter DemeesterChiara GuidiTom DesmetMarjan De Mey

Synthesis and evaluation of glucosyl-, acyl- and silyl- resveratrol derivatives as retinoprotective agents : piceid octanoate notably delays photoreceptor degeneration in a retinitis pigmentosa mouse model

Lourdes Valdés-SánchezSeyed Mohamadmehdi MoshtaghionEstefanía Caballano-InfantesPablo PeñalverRosario Rodríguez-RuizJosé Luis González-AlfonsoFrancisco José PlouTom DesmetJuan C. MoralesFrancisco J. Díaz-Corrales

A1 Journal Article in PHARMACEUTICALS

Synthesis of pyrrolidine-fused β-lactams as potential β-lactamase inhibitors

Sari DeketelaereCarlos Diez-PozaMargot AelbrechtJonas MortierBram Van Den BosscheJorick FranceusTom DesmetKristof Van HeckeChristian StevensMatthias D'hooghe

A1 Journal Article in ASIAN JOURNAL OF ORGANIC CHEMISTRY

The many functions of carbohydrate-active enzymes in family GH65 : diversity and application

Emma De BeulJorick FranceusTom Desmet

A1 Journal Article in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

2023

Characterization of a putative senescence-associated α-D-galactosidase/β-L-arabinopyranosidase from rice

Tibo De ConinckAnne-Sophie ChysVinicius Jose Da Silva OsterneTom DesmetEls Van Damme

Chemoenzymatic syntheses of fluorine-18-labeled disaccharides from [18F] FDG yield potent sensors of living bacteria in vivo

Alexandre M. SorlinMarina López-ÁlvarezSarah J. RabbittAryn A. AlaniziRebecca ShuereKondapa Naidu BobbaJoseph BlechaSasank SakhamuriMichael J. EvansKenneth W. Bayles et al.

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

GH5_11 enzymes involved in plant and cell wall development?

Koen GistelinckTom DesmetEls Van Damme

Glycosidic linkage of rare and new-to-nature disaccharides reshapes gut microbiota in vitro

Stanley Omondi OnyangoKoen BeerensQiqiong LiJohn Van CampTom DesmetTom Van de Wiele

A1 Journal Article in FOOD CHEMISTRY

Integration of high-throughput specificity profiling and engineering of xylan-active enzymes and xylanosomes

Maria João de Carvalho Maurício da FonsecaYves BriersIngeborg StalsTom DesmetAnita Van Landschoot

Rare sugar metabolism and impact on insulin sensitivity along the gut-liver-muscle axis in vitro

Amar Daniël Emanuel Van LaarCharlotte GrootaertAndreja RajkovicTom DesmetKoen BeerensJohn Van Camp

A1 Journal Article in NUTRIENTS

The conversion of UDP-Glc to UDP-Man : in silico and biochemical exploration to improve the catalytic efficiency of CDP-tyvelose C2-epimerases

Ulrike VogelMatthieu Da CostaCarlos Alvarez QuispeRobin StragierHenk‐Jan JoostenKoen BeerensTom Desmet

A1 Journal Article in CHEMBIOCHEM

2022

A colorimetric assay for the screening and kinetic analysis of nucleotide sugar 4,6-dehydratases

Ulrike VogelKoen BeerensTom Desmet

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

A sweet story : exploring microbial enzymes for the biocatalytic production of rare sugars and their in vitro digestibility

Shari DhaeneTom Desmet

Building mutational bridges between carbohydrate-active enzymes

Jorick FranceusJolien LormansTom Desmet

A1 Journal Article in CURRENT OPINION IN BIOTECHNOLOGY

Enzyme colocalisation on synthetic protein scaffolds : a VersaTile approach

Julie VanderstraetenYves BriersTom Desmet

Exploration of archaeal nucleotide sugar epimerases unveils a new and highly promiscuous GDP-Gal4E subgroup

Carlos Alvarez QuispeMatthieu Da CostaKoen BeerensTom Desmet

A2 Journal Article in CURRENT RESEARCH IN BIOTECHNOLOGY

Exploring glycoside phosphorylases for the production of functional carbohydrates and glycosides

Zorica UbiparipTom DesmetMarjan De Mey

Exploring the structure-function relationship of C2-epimerases

Matthieu Da CostaTom DesmetMarjan De Mey

GDP-mannose 3,5-epimerase : a view on structure, mechanism, and industrial potential

Koen BeerensOphelia GevaertTom Desmet

A1 Journal Article in FRONTIERS IN MOLECULAR BIOSCIENCES

Identification of mercaptoacetamide-based HDAC6 inhibitors via a lean inhibitor strategy : screening, synthesis, and biological evaluation

Silke GeursDorien ClarisseFreya BaeleJorick FranceusTom DesmetKarolien De BosscherMatthias D'hooghe

A1 Journal Article in CHEMICAL COMMUNICATIONS

In vitro stability and ex vivo absorption of thymol monoglucosides in the porcine gut

Noémie Van NotenElout Van LiefferingeJeroen DegrooteStefaan De SmetTom DesmetJoris Michiels

A1 Journal Article in ANIMAL

Insertions and deletions in protein evolution and engineering

Simone SavinoTom DesmetJorick Franceus

A1 Journal Article in BIOTECHNOLOGY ADVANCES

Metabolism and health effects of rare sugars in a CACO-2/HepG2 coculture model

Amar Daniël Emanuel Van LaarCharlotte GrootaertFilip Van NieuwerburghDieter DeforceTom DesmetKoen BeerensJohn Van Camp

A1 Journal Article in NUTRIENTS

Nucleotide sugar dehydratases : structure, mechanism, substrate specificity, and application potential

Ulrike VogelKoen BeerensTom Desmet

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Sweet biotechnology : enzymatic production and digestibility screening of novel kojibiose and nigerose analogues

Shari DhaeneAmar Daniël Emanuel Van LaarMarc De DonckerEmma De BeulKoen BeerensCharlotte GrootaertJurgen CaroenJohan Van der EyckenJohn Van CampTom Desmet

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

2021

Defined synthesis of cellotriose by cellobiose phosphorylase mutant

Zorica UbiparipDavid SáezKoen BeerensTom Desmet

Development of microbial cell factories for the production of chitooligosaccharides through integrating metabolic and protein engineering

Chiara GuidiMarjan De MeyTom Desmet

Discovery of a kojibiose hydrolase by analysis of specificity-determining correlated positions in Glycoside Hydrolase Family 65

Emma De BeulAlana JongbloetJorick FranceusTom Desmet

A1 Journal Article in MOLECULES

Discovery of a novel GDP-glucose 4-epimerase in archaea reveals an uncommon promiscuity

Carlos Alvarez QuispeMatthieu Da CostaKoen BeerensTom Desmet

Engineering of a thermostable biocatalyst for the synthesis of 2-O-glucosylglycerol

Jorick FranceusZorica UbiparipKoen BeerensTom Desmet

A1 Journal Article in CHEMBIOCHEM

Engineering of cellobiose phosphorylase for the synthesis of prebiotic cellotriose

Zorica UbiparipDavid Sáez MorenoKoen BeerensTom Desmet

Enzymatic synthesis of phloretin α‐glucosides using a sucrose phosphorylase mutant and its effect on solubility, antioxidant properties and skin absorption

Jose Luis González AlfonsoZorica UbiparipElena Jimenez‐OrtegaAna PovedaCristina AlonsoLuisa CoderchJesus Jimenez‐BarberoJulia Sanz‐AparicioAntonio O. BallesterosTom Desmet et al.

A1 Journal Article in ADVANCED SYNTHESIS & CATALYSIS

Evolution of phosphorylases from N-acetylglucosaminide hydrolases in family GH3

Jorick FranceusJolien LormansLore CoolsMatthias D'hoogheTom Desmet

A1 Journal Article in ACS CATALYSIS

Expanding the enzyme repertoire for sugar nucleotide epimerization : the CDP-tyvelose 2-epimerase from Thermodesulfatator atlanticus for glucose/mannose interconversion

Christian RappStevie Van OvertveldtKoen BeerensHansjörg WeberTom DesmetBernd Nidetzky

A1 Journal Article in APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Exploration of GH94 sequence space for enzyme discovery reveals a novel glucosylgalactose phosphorylase specificity

Marc De DonckerChloé De GraeveJorick FranceusKoen BeerensVladimír KřenHelena PelantováRonny VercauterenTom Desmet

A1 Journal Article in CHEMBIOCHEM

Kojibiose and trehalose long-term supplementation reveals significant metabolic differences and disaccharide dependent microbial community shift in a human gastrointestinal model

Stanley Omondi OnyangoKoen BeerensXinlin JiaoTom DesmetTom Van de Wiele

Stereo-electronic control of reaction selectivity in short-chain dehydrogenases : decarboxylation, epimerization, and dehydration

Annika J.E. BorgKoen BeerensMartin PfeifferTom DesmetBernd Nidetzky

A1 Journal Article in CURRENT OPINION IN CHEMICAL BIOLOGY

Structure-function relationships in NDP-sugar active SDR enzymes : fingerprints for functional annotation and enzyme engineering

Matthieu Da CostaOphelia GevaertStevie Van OvertveldtJoanna LangeHenk-Jan JoostenTom DesmetKoen Beerens

A1 Journal Article in BIOTECHNOLOGY ADVANCES

Towards sustainable production of defined oligosaccharides : enzymatic synthesis of high purity cellotriose

Zorica UbiparipDavid Sáez MorenoKoen BeerensTom Desmet

β-Glucan phosphorylases in carbohydrate synthesis

Zorica UbiparipMarc De DonckerKoen BeerensJorick FranceusTom Desmet

A1 Journal Article in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

2020

Determinants of the nucleotide specificity in the carbohydrate epimerase family 1

Stevie Van OvertveldtMatthieu Da CostaOphelia GevaertHenk-Jan JoostenKoen BeerensTom Desmet

A1 Journal Article in BIOTECHNOLOGY JOURNAL

Effects of thymol and thymol α-D-Glucopyranoside on intestinal function and microbiota of weaned pigs

Noémie Van NotenJeroen DegrooteElout Van LiefferingeBernard TaminiauStefaan De SmetTom DesmetJoris Michiels

A1 Journal Article in ANIMALS

Engineering of cellobiose phosphorylase for the defined synthesis of cellotriose

Zorica UbiparipDavid Sáez MorenoKoen BeerensTom Desmet

A1 Journal Article in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Exploring C5-epimerases for the production of L-sugars and derivatives

Ophelia GevaertTom DesmetMarjan De Mey

Fate of thymol and its monoglucosides in the gastrointestinal tract of piglets

Noémie Van NotenElout Van LiefferingeJeroen DegrooteStefaan De SmetTom DesmetJoris Michiels

A1 Journal Article in ACS OMEGA

Fermentation of rare sugar kojibiose by the oral bacteria is slow yet bacteria specific

Stanley Omondi OnyangoNele De ClercqKoen BeerensTom DesmetTom Van de Wiele

GDP-altrose as novel product of GDP-mannose 3,5-epimerase : revisiting its reaction mechanism

Ophelia GevaertStevie Van OvertveldtMatthieu Da CostaKoen BeerensTom Desmet

A1 Journal Article in INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Novel insights into the existence of the putative UDP-glucuronate 5-epimerase specificity

Ophelia GevaertStevie Van OvertveldtMatthieu Da CostaKoen BeerensTom Desmet

A1 Journal Article in CATALYSTS

Oral microbiota display profound differential metabolic kinetics and community shifts upon incubation with sucrose, trehalose, kojibiose, and xylitol

Stanley Omondi OnyangoNele De ClercqKoen BeerensJohn Van CampTom DesmetTom Van de Wiele

A1 Journal Article in APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Sucrose phosphorylase and related enzymes in glycoside hydrolase family 13 : discovery, application and engineering

Jorick FranceusTom Desmet

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis of novel nitroxoline analogs with potent cathepsin B exopeptidase inhibitory activity

Tim Van de WalleMarina BriandAna MitrovićIzidor SosičStanislav GobecJanko KosLeentje PersoonsDirk DaelemansSteven De JongheZorica Ubiparip et al.

A1 Journal Article in CHEMMEDCHEM

Synthesis, trehalase hydrolytic resistance and inhibition properties of 4-and 6-substituted trehalose derivatives

Shari DhaeneJohan Van der EyckenKoen BeerensJorick FranceusTom DesmetJurgen Caroen

A1 Journal Article in JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

The application of thymol and its glucosides in weaned piglets

Noémie Van NotenStefaan De SmetJoris MichielsTom Desmet

Uncovering a superfamily of nickel-dependent hydroxyacid racemases and epimerases

Benoît DesguinJulian Urdiain-ArraizaMatthieu Da CostaMatthias FellnerJian HuRobert P. HausingerTom DesmetPascal HolsPatrice Soumillion

A1 Journal Article in SCIENTIFIC REPORTS

Unlocking new biocatalytic pathways by engineering of carbohydrate epimerases

Stevie Van OvertveldtTom Desmet

Weaning affects the glycosidase activity towards phenolic glycosides in the gut of piglets

Noémie Van NotenElout Van LiefferingeJeroen DegrooteStefaan De SmetTom DesmetJoris Michiels

A1 Journal Article in JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION

2019

CARBAFIN : developing a glycosylation platform technology to an industrial level

Zorica UbiparipChristiane LuleyTom DesmetBernd Nidetzky

Characterization of the first bacterial and thermostable GDP-mannose 3,5-epimerase

Ophelia GevaertStevie Van OvertveldtKoen BeerensTom Desmet

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Discovery of novel cellodextrin phosphorylases : where bioinformatics meets biochemistry

Zorica UbiparipJorick FranceusNídia MartinsKoen BeerensTom Desmet

Effect of age on the functional glycosidase activity in the small intestinal mucosa of piglets

Noémie Van NotenElout Van LiefferingeJeroen DegrooteTom DesmetStefaan De SmetJoris Michiels

Exploring and engineering the functional diversity of glycoside phosphorylases

Jorick FranceusTom Desmet

Rational design of an improved transglucosylase for production of the rare sugar nigerose

Jorick FranceusShari DhaeneHannes DecadtJudith VandepitteJurgen CaroenJohan Van der EyckenKoen BeerensTom Desmet

A1 Journal Article in CHEMICAL COMMUNICATIONS

Structural comparison of a promiscuous and a highly specific sucrose 6F-phosphate phosphorylase

Jorick FranceusNikolas CapraTom DesmetAndy-Mark W.H. Thunnissen

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural features on the substrate-binding surface of fungal lytic polysaccharide monooxygenases determine their oxidative regioselectivity

Barbara DanneelsMagali TangheTom Desmet

A1 Journal Article in BIOTECHNOLOGY JOURNAL

Synthesis of indoline‐based benzhydroxamic acids as potential HDAC6 inhibitors

Yves DepetterSilke GeursJorick FranceusDamijan KnezTom DesmetKarolien De BosscherOlivier De WeverStanislav GobecMatthias D'hooghe

A1 Journal Article in CHEMISTRYSELECT

Synthesis of non‐symmetrical nitrogen‐containing curcuminoids in the pursuit of new anticancer candidates

Atiruj TheppawongTim Van de WalleCharlotte GrootaertKristof Van HeckeNathalie CatryTom DesmetJohn Van CampMatthias D'hooghe

A1 Journal Article in CHEMISTRYOPEN

2018

Analysis of the substrate specificity of α-L-arabinofuranosidases by DNA sequencer-aided fluorophore-assisted carbohydrate electrophoresis

Maria João de Carvalho Maurício da FonsecaEdita JurakKim KatajaEmma R MasterJean-Guy BerrinIngeborg StalsTom DesmetAnita Van LandschootYves Briers

A1 Journal Article in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Assessment of the trifluoromethyl ketone functionality as an alternative zinc-binding group for selective HDAC6 inhibition

Yves DepetterSilke GeursFlore Vanden BusscheRob De VreeseJorick FranceusTom DesmetOlivier De WeverMatthias D'hooghe

A1 Journal Article in MEDCHEMCOMM

CARBAFIN : developing a glycosylation platform technology to an industrial level

Zorica UbiparipChristiane LuleyTom DesmetBernd Nidetzky

Chemoenzymatic approach toward the synthesis of 3-O-(α/β)-glucosylated 3-hydroxy-β-lactams

Lena DecuyperJorick FranceusShari DhaeneMaarten DebruyneKevin VandoorneNicola PiensGriet DewitteTom DesmetMatthias D'hooghe

A1 Journal Article in ACS OMEGA

Converting galactose into the rare sugar talose with cellobiose 2-epimerase as biocatalyst

Stevie Van OvertveldtOphelia GevaertMartijn CherletKoen BeerensTom Desmet

A1 Journal Article in MOLECULES

Exploring the sequence diversity in glycoside hydrolase family 13_18 reveals a novel glucosylglycerol phosphorylase

Jorick FranceusLena DecuyperMatthias D'hoogheTom Desmet

A1 Journal Article in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Glycosylation of thymol to alter its kinetics along the gastro-intestinal tract of the piglet

Noémie Van NotenElout Van LiefferingeJoris MichielsTom DesmetStefaan De Smet

Kinetics of thymol and its glucosides along the gastro-intestinal tract of weaned piglets

Noémie Van NotenElout Van LiefferingeJoris MichielsTom DesmetStefaan De Smet

Recombinant production and regioselectivity study of lytic polysaccharide monooxygenases

Barbara DanneelsTom DesmetWim Soetaert

Synthesis of Novel Aza‐aromatic Curcuminoids with Improved Biological Activities towards Various Cancer Cell Lines

Atiruj TheppawongTim Van de WalleCharlotte GrootaertMargot BultinckTom DesmetJohn Van CampMatthias D'hooghe

A1 Journal Article in CHEMISTRYOPEN

Thermostable alpha-glucan phosphorylases : characteristics and industrial applications

Zorica UbiparipKoen BeerensJorick FranceusRonny VercauterenTom Desmet

A1 Journal Article in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

2017

A quantitative indicator diagram for lytic polysaccharide monooxygenases reveals the role of aromatic surface residues in HjLPMO9A regioselectivity

Barbara DanneelsMagali TangheHenk-Jan JoostenThomas GundingerOliver SpadiutIngeborg StalsTom Desmet

A1 Journal Article in PLOS ONE

Biocatalytic synthesis of the rare sugar kojibiose : process scale-up and application testing

Koen BeerensKarel De WinterDavy Van de WalleCharlotte GrootaertSenem KamilogluLisa MiclotteTom Van de WieleJohn Van CampKoen DewettinckTom Desmet

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

CorNet : assigning function to networks of co-evolving residues by automated literature mining

Tom van den BerghGiorgio TamoAlberto NobiliYifeng TaoTianwei TanUwe T BornscheuerRemko KP KuipersBas VrolingRené M de JongKalyanasundaram Subramanian et al.

A1 Journal Article in PLOS ONE

Correlated positions in protein evolution and engineering

Jorick FranceusTom VerhaegheTom Desmet

A1 Journal Article in JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Disulfide bridges as essential elements for the thermostability of lytic polysaccharide monooxygenase LPMO10C from Streptomyces coelicolor

Magali TangheBarbara DanneelsMatthias LastKoen BeerensIngeborg StalsTom Desmet

A1 Journal Article in PROTEIN ENGINEERING DESIGN & SELECTION

Glucosylglycerate phosphorylase, an enzyme with novel specificity involved in compatible solute metabolism

Jorick FranceusDenise PinelTom Desmet

A1 Journal Article in APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Glycosyltransferase cascades for natural product glycosylation : use of plant instead of bacterial sucrose synthases improves the UDP-glucose recycling from sucrose and UDP

Alexander GutmannAlexander LepakMargo DiricksTom DesmetBernd Nidetzky

A1 Journal Article in BIOTECHNOLOGY JOURNAL

High-throughput customized production of arabinoxylan-oligosaccharides (AXOS)

Maria João de Carvalho Maurício da FonsecaIngeborg StalsTom DesmetAnita Van LandschootYves Briers

Microbial enzymes for glycoside synthesis : development of sucrose phosphorylase as a test case

Tom VerhaegheKarel De WinterTom Desmet

Bookchapter in Biotechnology of microbial enzymes : production, biocatalysis and industrial applications

Recombinant expression and stability engineering of lytic polysaccharide monooxygenases

Magali TangheTom DesmetIngeborg Stals

Sequence determinants of nucleotide binding in Sucrose Synthase : improving the affinity of a bacterial Sucrose Synthase for UDP by introducing plant residues

Margo DiricksAlexander GutmannSimon DebackerGriet DewitteBernd NidetzkyTom Desmet

A1 Journal Article in PROTEIN ENGINEERING DESIGN & SELECTION

Synthesis of potent and selective HDAC6 inhibitors bearing a cyclohexane- or cycloheptane-annulated 1,5-benzothiazepine scaffold

Rob De VreeseLisa GalleYves DepetterJorick FranceusTom DesmetKristof Van HeckeVeronick BenoyLudo Van Den BoschMatthias D'hooghe

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

The 'epimerring' highlights the potential of carbohydrate epimerases for rare sugar production

Koen BeerensStevie Van OvertveldtTom Desmet

A1 Journal Article in BIOCATALYSIS AND BIOTRANSFORMATION

Unlocking nature’s glycosylation potential : characterization and engineering of novel sucrose/trehalose synthases

Margo DiricksTom Desmet

2016

A nitrilase-mediated entry to 4-carboxymethyl-β-lactams from chemically prepared 4-(cyanomethyl)azetidin-2-ones

Lena DecuyperNicola PiensJens MinckeJeroen BomonBert De SchrijverKaren MolletKarel De WinterTom DesmetMatthias D'hooghe

A1 Journal Article in RSC ADVANCES

Biocatalytic production of novel glycolipids

Karel De WinterGriet DewitteHai Giang TranTom Desmet

Bookchapter in Practical methods for biocatalysis and biotransformations 3

Collision cross section prediction of deprotonated phenolics in a travelling-wave ion mobility spectrometer using molecular descriptors and chemometrics

Bryan GonzalesGuy SmaggheSofie CoelusDieter AdriaenssensKarel De WinterTom DesmetKatleen RaesJohn Van Camp

A1 Journal Article in ANALYTICA CHIMICA ACTA

Converting bulk sugars into prebiotics : semirational design of a transglucosylase with controlled selectivity

Tom VerhaegheKarel De WinterMagali BerlandRob De VreeseMatthias D'hoogheBernard OffmannTom Desmet

A1 Journal Article in CHEMICAL COMMUNICATIONS

Diastereoselective synthesis of 3-acetoxy-4-(3-aryloxiran-2-yl)azetidin-2-ones and their transformation into 3,4-oxolane-fused bicyclic β-lactams

Nicola PiensSven De CraeneJorick FranceusKaren MolletKristof Van HeckeTom DesmetMatthias D'hooghe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Expanding the application potential of glycoside phosphorylases through process engineering

Karel De WinterTom DesmetWim Soetaert

Integrating biocatalytical processes into organic synthesis: nitrilase-mediated conversion of 2-aryl-3-(2-cyanoethyl)aziridines and 4-(cyanomethyl)azetidin-2-ones as a sustainable entry to functionalized γ-lactams and β-lactams

Nicola PiensLena DecuyperSaskia Vander MeerenJens MinckeJeroen BomonBert De SchrijverKaren MolletKarel De WinterTom DesmetMatthias D'hooghe

Screening of recombinant glycosyltransferases reveals the broad acceptor specificity of stevia UGT-76G1

Griet DewitteMaarten WalmaghMargo DiricksAlexander LepakAlexander GutmannBernd NidetzkyTom Desmet

A1 Journal Article in JOURNAL OF BIOTECHNOLOGY

Stability analysis of a plant glycosyltransferase

Griet DewitteKoen BeerensMargo DiricksTom Desmet

Sucrose synthase : a unique glycosyltransferase for biocatalytic glycosylation process development

Katharina SchmölzerAlexander GutmannMargo DiricksTom DesmetBernd Nidetzky

A1 Journal Article in BIOTECHNOLOGY ADVANCES

Synthesis and applications of 3-methylene-4-(trifluoromethyl)azetidin-2-ones as building blocks for the preparation of mono- and spirocyclic 4-CF3-β-lactams

Hang Dao ThiBarbara DanneelsTom DesmetKristof Van HeckeTuyen Van NguyenMatthias D'hooghe

A1 Journal Article in ASIAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis and chemical/enzymatic hydrolysis of 2-aryl-3-(2-cyanoethyl)aziridines and 4-(cyanomethyl)azetidin-2-ones

Lena DecuyperNicola PiensSaskia Vander MeerenJens MinckeJeroen BomonBert De SchrijverKaren MolletKarel De WinterTom DesmetMatthias D'hooghe

Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors

Rob De VreeseYves DepetterTom VerhaegheTom DesmetVeronick BenoyWanda HaeckLudo Van Den BoschMatthias D'hooghe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Using DSA-FACE to reveal the substrate specificity of α-L-arabinofuranosidases

Maria João de Carvalho Maurício da FonsecaTom DesmetAnita Van LandschootIngeborg StalsYves Briers

2015

A structural classification of carbohydrate epimerases : from mechanistic insights to practical applications

Stevie Van OvertveldtTom VerhaegheHenk-Jan JoostenTom van den BerghKoen BeerensTom Desmet

A1 Journal Article in BIOTECHNOLOGY ADVANCES

Capillary electrophoresis for the functional annotation of carbohydrate-active enzymes: two preliminary case studies

Maria João de Carvalho Maurício da FonsecaTom DesmetAnita Van LandschootIngeborg Stals

Chemoenzymatic synthesis of β-D-glucosides using cellobiose phosphorylase from Clostridium thermocellum

Karel De WinterLisa Van RenterghemKathleen WuytsHelena PelantováVladimír KřenWim SoetaertTom Desmet

A1 Journal Article in ADVANCED SYNTHESIS & CATALYSIS

Creating space for large acceptors: rational biocatalyst design for resveratrol glycosylation in an aqueous system

Mareike Dirks-HofmeisterTom VerhaegheKarel De WinterTom Desmet

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzymatic glycosylation of phenolic antioxidants: phosphorylase-mediated synthesis and characterization

Karel De WinterGriet DewitteMareike Dirks-HofmeisterSylvie De LaetHelena PelantovaVladimír KrenTom Desmet

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Identification of sucrose synthase in nonphotosynthetic bacteria and characterization of the recombinant enzymes

Margo DiricksFrederik De BruynPaul Van DaeleMaarten WalmaghTom Desmet

A1 Journal Article in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Recombinant expression of Trichoderma reesei Cel61A in Pichia pastoris: optimizing yield and N-terminal processing

Magali TangheBarbara DanneelsAndrea CamattariAnton GliederIsabel VandenbergheBart DevreeseIngeborg StalsTom Desmet

A1 Journal Article in MOLECULAR BIOTECHNOLOGY

Synthesis and antimicrobial/cytotoxic assessment of ferrocenyl oxazinanes, oxazinan-2-ones, and tetrahydropyrimidin-2-ones

Anka PejovićBarbara DanneelsTom DesmetBa Thi ChamTuyen Van NguyenNiko S RadulovićRastko D VukicevićMatthias D'hooghe

A1 Journal Article in SYNLETT

Synthesis of 2-aryl-3-(2-cyanoethyl)aziridines and their chemical and enzymatic hydrolysis towards γ-lactams and γ-lactones

Karen MolletLena DecuyperSaskia Vander MeerenNicola PiensKarel De WinterTom DesmetMatthias D'hooghe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors

Rob De VreeseNicholas Van SteenTom VerhaegheTom DesmetNadia BougarneKarolien De BosscherVeronick BenoyWanda HaeckLudo Van Den BoschMatthias D'hooghe

A1 Journal Article in CHEMICAL COMMUNICATIONS

Synthesis of functionalized 3-, 5-, 6- and 8-aminoquinolines via intermediate (3-pyrrolin-1-yl)- and (2-oxopyrrolidin-1-yl)quinolines and evaluation of their antiplasmodial and antifungal activity

Stephanie VandekerckhoveSofie Van HerrewegheJasmine WillemsBarbara DanneelsTom DesmetCarmen de KockPeter J SmithKelly ChibaleMatthias D'hooghe

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Trehalose analogues: latest insights in properties and biocatalytic production

Maarten WalmaghRenfei ZhaoTom Desmet

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

UDP-hexose 4-epimerases: a view on structure, mechanism and substrate specificity

Koen BeerensWim SoetaertTom Desmet

A1 Journal Article in CARBOHYDRATE RESEARCH

2014

Biphasic catalysis with disaccharide phosphorylases: chemoenzymatic synthesis of α-D-glucosides using sucrose phosphorylase

Karel De WinterTom DesmetTim DevlamynckLisa Van RenterghemTom VerhaegheHelena PelantováVladimír KřenWim Soetaert

A1 Journal Article in ORGANIC PROCESS RESEARCH & DEVELOPMENT

Engineering the carbohydrate-binding site of Epa1p from Candida glabrata: generation of adhesin mutants with different carbohydrate specificity

Francesco S IelasiTom VerhaegheTom DesmetRonnie G Willaert

A1 Journal Article in GLYCOBIOLOGY

Engineering the specificity of trehalose phosphorylase as a general strategy for the production of glycosyl phosphates

Chao ChenJef Van der BorghtRob De VreeseMatthias D'hoogheWim SoetaertTom Desmet

A1 Journal Article in CHEMICAL COMMUNICATIONS

Enhanced biomass degradation by polysaccharide monooxygenases

Magali TangheBarbara DanneelsIngeborg StalsTom Desmet

Bookchapter in Renewable resources for biorefineries

Improving the glycosylation potential of sucrose phosphorylase through enzyme engineering

Tom VerhaegheTom DesmetWim Soetaert

Synthesis of 2-aryl-3-(2-cyanoethyl)aziridines and their chemical and enzymatic hydrolysis towards γ-lactams and γ-lactones

Lena DecuyperKaren MolletSaskia Vander MeerenNicola PiensKarel De WinterTom DesmetMatthias D'hooghe

Synthesis of halogenated 4-quinolones and evaluation of their antiplasmodial activity

Stephanie VandekerckhoveTom DesmetHai Giang TranCarmen de KockPeter J SmithKelly ChibaleMatthias D'hooghe

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The quest for a thermostable sucrose phosphorylase reveals sucrose 6'-phosphate phosphorylase as a novel specificity

Tom VerhaegheDirk AertsMargo DiricksWim SoetaertTom Desmet

A1 Journal Article in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

2013

Characterization and engineering of epimerases for the production of rare sugars

Koen BeerensWim SoetaertTom Desmet

Characterization and mutational analysis of the UDP-Glc(NAc) 4-epimerase from Marinithermus hydrothermalis

Koen BeerensWim SoetaertTom Desmet

A1 Journal Article in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Chemoenzymatic synthesis of α-L-rhamnosides using recombinant α-L-rhamnosidase from Aspergillus terreus

Karel De WinterDaniela SimcikovaBram SchalckLenka WeignerovaHelena PelantovaWim SoetaertTom DesmetVladimir Kren

A1 Journal Article in BIORESOURCE TECHNOLOGY

Consensus engineering of sucrose phosphorylase: the outcome reflects the sequence input

Dirk AertsTom VerhaegheHenk-Jan JoostenGert VriendWim SoetaertTom Desmet

A1 Journal Article in BIOTECHNOLOGY AND BIOENGINEERING

Evaluation of (4-aminobutyloxy)quinolines as a novel class of antifungal agents

Stephanie VandekerckhoveHai Giang TranTom DesmetMatthias D'hooghe

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ionic liquids as cosolvents for glycosylation by sucrose phosphorylase: balancing acceptor solubility and enzyme stability

Karel De WinterKristien VerlindenVladimír KřenLenka WeignerováWim SoetaertTom Desmet

A1 Journal Article in GREEN CHEMISTRY

Library construction in Pichia pastoris for engineering proteins

Magali TangheBarbara DanneelsSofie De MaeseneireTom Desmet

Mapping the acceptor site of sucrose phosphorylase from Bifidobacterium adolescentis by alanine scanning

Tom VerhaegheMargo DiricksDirk AertsWim SoetaertTom Desmet

A1 Journal Article in JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Potent and selective HDAC6 inhibitory activity of N-(4-hydroxycarbamoylbenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorenes as novel sulfur analogues of Tubastatin A

Rob De VreeseTom VerhaegheTom DesmetMatthias D'hooghe

A1 Journal Article in CHEMICAL COMMUNICATIONS

Synthesis of 2-aminomethyl-4-phenyl-1-azabicyclo[2.2.1]heptanes via LiAlH4-induced reductive cyclization of 2-(4-chloro-2-cyano-2-phenylbutyl) aziridines and evaluation of their antimalarial activity

Matthias D'hoogheKarel VervischKarl W TörnroosTom VerhaegheTom DesmetCarmen LateganPeter J SmithKelly ChibaleNorbert De Kimpe

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of piperidin-4-ones starting from 2-(2-bromo-1,1-dimethylethyl)-azetidines and 2-(2-mesyloxyethyl)azetidines through a ring expansion-oxidation protocol

Karen MolletMatthias D'hoogheLeen BroeckxBarbara DanneelsTom DesmetNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

Towards a carbon-negative sustainable bio-based economy

Bartel VanholmeTom DesmetFrederik RonsseKorneel RabaeyFrank Van BreusegemMarjan De MeyWim SoetaertWout Boerjan

A1 Journal Article in FRONTIERS IN PLANT SCIENCE

2012

Adsorption-desorption of trehalose analogues from a bioconversion mixture using activated carbon

Chao ChenTom DesmetJef Van der BorghtSze Ki Carol LinWim Soetaert

A1 Journal Article in SEPARATION AND PURIFICATION TECHNOLOGY

An imprinted cross-linked enzyme aggregate (iCLEA) of sucrose phosphorylase: combining improved stability with altered specificity

Karel De WinterWim SoetaertTom Desmet

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biocatalytic production of novel glycolipids with cellodextrin phosphorylase

Hai Giang TranTom DesmetKaren SaerensHendrik WaegemanStephanie VandekerckhoveMatthias D'hoogheInge Van BogaertWim Soetaert

A1 Journal Article in BIORESOURCE TECHNOLOGY

Broadening the synthetic potential of disaccharide phosphorylases through enzyme engineering

Tom DesmetWim Soetaert

A1 Journal Article in PROCESS BIOCHEMISTRY

Engineering of trehalose phosphorylase for the production of trehalose analogues

Jef Van der BorghtTom DesmetWim Soetaert

Engineering the acceptor specificity of trehalose phosphorylase for the production of trehalose analogs

Jef Van der BorghtWim SoetaertTom Desmet

A1 Journal Article in BIOTECHNOLOGY PROGRESS

Enzymatic glycosylation of small molecules: challenging substrates require tailored catalysts

Tom DesmetWim SoetaertPavla BojarováVladimir KřenLubbert DijkhuizenVanessa Eastwick-FieldAlexander Schiller

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Enzymes for the biocatalytic production of rare sugars

Koen BeerensTom DesmetWim Soetaert

A1 Journal Article in JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Galactosylation reactions catalyzed by disaccharide phosphorylases

Chao ChenTom DesmetWim Soetaert

Improving the glycosylation activity of cellobiose/cellodextrin phosphorylase through enzyme engineering

Hai Giang TranWim SoetaertTom Desmet

Preparation and use of sucrose phosphorylase as cross-linked enzyme aggregate (CLEA)

Karel De WinterTom DesmetAn CerdobbelWim Soetaert

Bookchapter in Practical methods for biocatalysis and biotransformations 2

Screening and engineering of sucrose phosphorylase for the glycosylation of small molecules

Dirk AertsWim SoetaertTom Desmet

2011

A constitutive expression system for high-throughput screening

Dirk AertsTom VerhaegheMarjan De MeyTom DesmetWim Soetaert

A1 Journal Article in ENGINEERING IN LIFE SCIENCES

Characterization of β-galactoside phosphorylases with diverging acceptor specificities

Chao ChenWim SoetaertTom Desmet

A1 Journal Article in ENZYME AND MICROBIAL TECHNOLOGY

Engineering of cellobiose phosphorylase for glycoside synthesis

Manu De GroeveTom DesmetWim Soetaert

A1 Journal Article in JOURNAL OF BIOTECHNOLOGY

Enzymatic glycosyl transfer: mechanisms and applications

Tom DesmetWim Soetaert

A1 Journal Article in BIOCATALYSIS AND BIOTRANSFORMATION

Enzymatic properties and substrate specificity of the trehalose phosphorylase from Caldanaerobacter subterraneus

Jef Van der BorghtChao ChenLieve HoflackLucas Van RenterghemTom DesmetWim Soetaert

A1 Journal Article in APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Increasing the thermostability of sucrose phosphorylase by a combination of sequence- and structure-based mutagenesis

An CerdobbelKarel De WinterDirk AertsRemko KuipersHenk-Jan JoostenWim SoetaertTom Desmet

A1 Journal Article in PROTEIN ENGINEERING DESIGN & SELECTION

Operational stability of immobilized sucrose phosphorylase: continuous proudction of α-glucose-1-phosphate at elevated temperatures

Karel De WinterAn CerdobbelWim SoetaertTom Desmet

A1 Journal Article in PROCESS BIOCHEMISTRY

Probing the active site of cellodextrin phosphorylase from clostridium stercorarium: kinetic characterization, ligand docking, and site-directed mutagenesis

Hai Giang TranTom DesmetManu De GroeveWim Soetaert

A1 Journal Article in BIOTECHNOLOGY PROGRESS

Transglucosylation potential of six sucrose phosphorylases toward different classes of acceptors

Dirk AertsTom VerhaegheBart RomanChristian StevensTom DesmetWim Soetaert

A1 Journal Article in CARBOHYDRATE RESEARCH

2010

Construction of cellobiose phosphorylase variants with broadened acceptor specificity towards anomerically substituted glucosides

Manu De GroeveLaurens RemmeryAnnelies Van HoorebekeJan StoutTom DesmetSavvas SavvidesWim Soetaert

A1 Journal Article in BIOTECHNOLOGY AND BIOENGINEERING

Crystallization and X-ray diffraction studies of cellobiose phosphorylase from Cellulomonas uda

Annelies Van HoorebekeJan StoutJohn KyndtManu De GroeveIna DixTom DesmetWim SoetaertJozef Van BeeumenSavvas Savvides

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS

Development and application of a screening assay for glycoside phosphorylases

Manu De GroeveHai Giang TranAnnelies Van HoorebekeJan StoutTom DesmetSavvas SavvidesWim Soetaert

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

Engineering of cellobiose phosphorylase for glycoside synthesis

Tom DesmetWim Soetaert

Enzymatic production of β-D-glucose-1-phosphate from trehalose

Jef Van der BorghtTom DesmetWim Soetaert

A1 Journal Article in BIOTECHNOLOGY JOURNAL

High throughput calorimetry for evaluating enzymatic reactions generating phosphate

Lieve HoflackManu De GroeveTom DesmetPeter Van GerwenWim Soetaert

A1 Journal Article in COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Increasing the thermostability of sucrose phosphorylase by multipoint covalent immobilization

An CerdobbelTom DesmetKarel De WinterJo MaertensWim Soetaert

A1 Journal Article in JOURNAL OF BIOTECHNOLOGY

Sucrose phosphorylase as cross-linked enzyme aggregate: improved thermal stability for industrial applications

An CerdobbelKarel De WinterTom DesmetWim Soetaert

A1 Journal Article in BIOTECHNOLOGY JOURNAL

Synthesis and evaluation of 2-deoxy-2-amino-β-cellobiosides as cellulase inhibitors

Tom DesmetMarc ClaeyssensKathleen PiensWim Nerinckx

A1 Journal Article in JOURNAL OF CARBOHYDRATE CHEMISTRY

2009

Creating lactose phosphorylase enzymes by directed evolution of cellobiose phosphorylase

Manu De GroeveMiet De BaereLieve HoflackTom DesmetErick VandammeWim Soetaert

A1 Journal Article in PROTEIN ENGINEERING DESIGN & SELECTION

Enzymatic production of alpha-d-galactose 1-phosphate by lactose phosphorolysis

Manu De GroeveVeerle DepreitereTom DesmetWim Soetaert

A1 Journal Article in BIOTECHNOLOGY LETTERS

2008

Modulation of activity by Arg407 : structure of a fungal alpha-1,2-mannosidase in complex with a substrate analogue

Yuri LobsanovTakashi YoshidaTom DesmetWim NerinckxPatrick YipMarc ClaeyssensAnnette HerscovicsLynne Howell

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Production of bioflavours

Tom DesmetAn CerdobbelWim SoetaertErick Vandamme

Bookchapter in Advances in fermentation technology

2007

An investigation of the substrate specificity of the xyloglucanase Cel74A from Hypocrea jecorina

Tom DesmetTineke CantaertPeter GUALFETTIWim NerinckxLaurie GROSSColin MITCHINSONKathleen Piens

A1 Journal Article in FEBS JOURNAL

2006

Itineraries of enzymatically and non-enzymatically catalyzed substitutions at O-glycopyranosidic bonds

Wim NerinckxTom DesmetMarc Claeyssens

A1 Journal Article in ARKIVOC

2005

An elaboration on the syn-anti proton donor concept of glycoside hydrolases: electrostatic stabilisation of the transition state as a general strategy

Wim NerinckxTom DesmetKathleen PiensMarc Claeyssens

A1 Journal Article in FEBS LETTERS

Structuur-functie relaties in O-glycoside hydrolasen : nieuwe inzichten in reactiemechanismen en specificiteiten van hypocrea jecorina cellulasen en hemicellulasen

Tom DesmetMarc Claeyssens

2004

Crystal complex structures reveal how substrate is bound in the -4 to the +2 binding sites of Humicola grisea cel12A

M SANDGRENGI BERGLUNDA SHAWJ STAHLBERGL KENNETom DesmetC MITCHINSON

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Evaluation of automated nano-electrospray mass spectrometry in the determination of non-covalent protein-ligand complexes

Kris De VriendtKoen SandraTom DesmetWim NerinckxJozef Van BeeumenBart Devreese

A1 Journal Article in RAPID COMMUNICATIONS IN MASS SPECTROMETRY

On the mechanism of glycoside hydrolysis by the family GH-90 phage P-22 tailspike protein

Wim NerinckxTom DesmetMarc Claeyssens

A2 Journal Article in Internet Electronic Journal of Molecular Design

Resistance to air-born diseases and pests induced by compost in substrate cultivation of strawberry

S BobevK WillekensGeert GoeminneTom DesmetGonzalez Van DriesscheMarc ClaeyssensJozef Van BeeumenEric MessensM Maes

A4 Journal Article in COMMUNICATIONS IN AGRICULTURAL AND APPLIED BIOLOGICAL SCIENCES

2003

A hydrophobic platform as a mechanistically relevant transition state stabilising factor appears to be present in the active centre of all glycoside hydrolases

Wim NerinckxTom DesmetMarc Claeyssens

A1 Journal Article in FEBS LETTERS

2002

Novel tools for the study of class I alpha-mannosidases: a chromogenic substrate and a substrate-analog inhibitor.

Tom DesmetWim NerinckxIngeborg StalsNico CallewaertRoland ContrerasMarc Claeyssens

A1 Journal Article in ANALYTICAL BIOCHEMISTRY