Project

Turning sucrose synthase into a biocatalyst for the production of nucleotide sugars

Code
01D20114
Duration
01 October 2014 → 31 December 2016
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
  • Engineering and technology
    • Catalysis and reacting systems engineering
    • Chemical product design and formulation
    • General chemical and biochemical engineering
    • Process engineering
    • Separation and membrane technologies
    • Transport phenomena
    • Other (bio)chemical engineering
    • Biomaterials engineering
    • Biological system engineering
    • Biomaterials engineering
    • Biomechanical engineering
    • Other (bio)medical engineering
    • Environmental engineering and biotechnology
    • Industrial biotechnology
    • Other biotechnology, bio-engineering and biosystem engineering
Keywords
glycosyl transferase Nucleotide sugar
 
Project description

Glycosyltransferases are extremely efficient enzymes but require expensive nucleotide sugars as glycosyl donor. The current proposal aims to solve this problem by producing these compounds from sucrose (and analogues) as a cheap

and reactive substrate, using (mutant) sucrose synthase as biocatalyst.