Cofunding core facility - Flow cytometry

Deregulated mRNA transcription and protein translation in the transformation of normal T-cells to malignant cells.

Doctoral project Nina Lambrechts

Functional characterization and expansion of thymus seeding precursors in human

Functional characterization of T cell precursors in human.

Generation of iPSC-derived CAR-T cells

Generation of iPSC-derived hematopoietic stem cells.

Molecular drivers of human αβ and γδ T cell differentiation

Molecular mechanisms that control developmental decisions in early human T cell precursors.

New molecular drivers and cell surface markers that characterize normal human hematopoiesis

Single cell multi-omics to characterize early T cell precursors in human.

Study of thrombocyte development and generation of chimaeric platelets for cell therapy

The role of GATA3 in acute lymphoblastic leukemia.

Doctoral project Inge Van de Walle

Doctoral project Robin Mathijssen

Engineering of universal iPSC derived therapeutic cells by nanofiber photoporation

Genetic modification of cells by photoporation for cancer research and treatment

A genetic approach for the study of Notch signaling in normal and malignant hematopoiesis in human

A genetic approach for the study of Notch signaling in normal and malignant hematopoiesis in humans

Automated production and expansion of cell therapy products

BOF-ZAP professorship in immunology

Characterisation of Notch mediated human intrathymic T cell differentiation

Characterization of molecular pathways that drive human T cell development

Characterization of the unique molecular network that controls T cell development.

Cofunding Core Facility - Clinical Tissue and Cell Culture core

Defining teh role of GATA-3 during human hematopoiesis

Defining the molecular netwerk responsible for human T cell development

Epigenetic drivers of human αβ and γδ T cell differentiation at the single cell level.

GATA-3: a novel tumor suppressor gene during human T cell development

GATA3-mediated epigenetic control of human T cell development

Gene-targeting of human pluripotent stem cells to study human T lymphocyte development and immune deficiencies

Gene-targeting of human pluripotent stem cells to study human T lymphocyte development and immune deficiencies.

HES4: an unexplored Notch target gene in normal and malignant T cell development in human

HES proteins as critical regulators of normal and malignant hematopoiesis in human.

Human T cell development in health and disease.

Identification of the molecular drivers of ab vs. gd T cell development at single cell resolution in human

Integration of signal cascades for the expansion of hematopoietic stem cells while maintaining T cell potential

Manipulation of human pluripotent stem cells for the study of normal T cell development and immune deficiencies

NOn-VIral gene modified STEM cell therapy

Origin and molecular drivers of T cell and dendritic cell development in the human thymus.

Regulation and function of non-coding RNAs that mediate normal human T cell development.

Single cell approaches for the study of early human T cell development

Single-cell SPACE, the next frontier

The generation of bona fide T cell precursors for cell therapy

The role of TET2 in normal and malignant T cell development

Unraveling the Role of GATA3 in B-Cell Precursor Acute Lymphoblastic Leukemia

Unraveling the role of GATA3 in normal and malignant hematopoiesis in human.

Unraveling the role of GATA3-R276Q mutation in normal and malignant human T cell development

Unraveling the role of HES6 in normal and malignant hematopoesis in human.

Unravelling cellular heterogeneity and dynamics in normal and malignant hematopoiesis using singlecell bioinformatics

A flow cytometer to perform multiparameter sorting, including single-cell deposition under biohazard conditions L2

Characterization of molecular pathways that drive human T cell development

Engineering of universal iPSC-derived therapeutic cells by nanofiber photoporation.

Engineering of universal iPSC-derived therapeutic cells by nanofiber photoporation.

Functional analysis of the RNA helicase DHX15 in T-cell acutelymphoblastic leukemia

Generation of primary TRIB2-driven human leukemia models in vivo.

Integration of Notch signaling in human T cell development

Rapid ex-vivo detection, quantification and characterisation of cell-mediated immune responses induced by natural infection or vaccination with SARS-CoV-2 orr other pathogens.

SpatialConnect: linking tissue biology to the new era of single-cell spatial transcriptomics

Yellow/Green laser upgrade for LSRII analyser and FACSARIAII sorter flow cytometers

BOF-ZAP professorship in immunology

Integration of Notch signaling in human T cell differentiation.

Deciphering the functional phenotype of γδ T cells in spondyloarthritis.