Project

Integration of Notch signaling in human T cell development

Code
3G041407
Duration
01 January 2007 → 30 December 2012
Funding
Research Foundation - Flanders (FWO)
Promotor
Research disciplines
  • Medical and health sciences
    • Immunology
    • Immunology
    • Immunology
Keywords
human T lymphocyte signal transduction
 
Project description

Notch signaling is critical for the generation of immuuncompetent T lymphocytes out of hematopoietic stem cells. However, this pathway by itself is insufficient to drive T cell development. In this project, we study the role of the individual components of the Notch signaling pathway and its interactionpartners that, together with Notch, drive human T cell development.