Project

GATA-3: a novel tumor suppressor gene during human T cell development

Acronym

GATA-3

Code

3G053916

Duration

01 January 2016 → 31 December 2019

Funding

Research Foundation - Flanders (FWO)

Promotor

Tom Taghon

Research disciplines

Natural sciences
- Systems biology
Medical and health sciences
- Hematology
- Immunology
- Laboratory medicine
- Medical systems biology
- Hematology
- Immunology
- Laboratory medicine
- Medical systems biology
- Molecular and cell biology
- Hematology
- Immunology
- Laboratory medicine
- Medical systems biology
- Molecular and cell biology

Keywords

T lymphocyte Transcription factors leukemia

Project description

GATA-3 is a critical regulatory protein for the development of T lymphocytes and mutations in this protein have been described recently in patients with acute T cell leukemia. In this project, we wish to study the specific role of GATA-3 during normal and malignant T cell development by investigating such mutations.