Acronym
GATA-3
Code
3G053916
Duration
01 January 2016 → 31 December 2019
Funding
Research Foundation - Flanders (FWO)
Promotor
Research disciplines
-
Natural sciences
- Systems biology
-
Medical and health sciences
- Hematology
- Immunology
- Laboratory medicine
- Medical systems biology
- Hematology
- Immunology
- Laboratory medicine
- Medical systems biology
- Molecular and cell biology
- Hematology
- Immunology
- Laboratory medicine
- Medical systems biology
- Molecular and cell biology
Keywords
T lymphocyte
Transcription factors
leukemia
Project description
GATA-3 is a critical regulatory protein for the development of T lymphocytes and mutations in this protein have been described recently in patients with acute T cell leukemia. In this project, we wish to study the specific role of GATA-3 during normal and malignant T cell development by investigating such mutations.