Research Explorer

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Researcher

Tom Taghon

Publications & Research Data

Awards & Distinctions

183 Results

2025

From cortex to medulla : navigating the thymic landscape of T cell education

Lena BoehmeNadav YayonSarah A. TeichmannTom Taghon

Editorial material

HNRNPC and m6A RNA methylation control oncogenic transcription and metabolism in T-cell leukemia

Jonas De KeselIgor FijalkowskiTim PietersCristina BorinKasper Thorhauge ChristensenManou WittouckJolien Van LaereLaura GuerreroLindy ReunesMarino Caruso et al.

A1 Journal Article in BLOOD

Plate-based 10X Genomics-compatible single-cell RNA-sequencing based on Smart-seq3xpress

Koen DeserrannoElise CallensDanique BerrevoetAaron VerplanckeTamara De VosTom TaghonDieter DeforceFilip Van Nieuwerburgh

A1 Journal Article in BMC GENOMICS

Sox11-induced reprogramming of B2 cells to a B1a-like phenotype promotes Mantle Cell Lymphoma in mice

Tim PietersLuca PagliaroAndré Pedro Pinto De AlmeidaFritz OffnerTom TaghonPieter Van VlierbergheSteven Goossens

Thymic pioneers : charting the origin, identity, and fate of human thymus seeding progenitors

Kai Ling LiangLena BoehmeSilke PaepensMaryam HassanTom Taghon

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

2024

A dual role for PSIP1/LEDGF in T cell acute lymphoblastic leukemia

Lisa DemoenFilip MatthijssensLindy ReunesBruno PalhaisBéatrice LintermansSara T'SasIgor FijalkowskiJoachim TaminauMuluembet Z. AkeleSiska Van Belle et al.

A1 Journal Article in SCIENCE ADVANCES

A spatial human thymus cell atlas mapped to a continuous tissue axis

Nadav YayonVeronika R. KedlianLena BoehmeChenqu SuoBrianna T. WachterRebecca T. BeuschelOren AmsalemKrzysztof PolanskiSimon KoplevElizabeth Tuck et al.

A1 Journal Article in NATURE

Functional evaluation of transcription factors in T-ALL : MYB and SOX11

André Pedro Pinto De AlmeidaPieter Van VlierbergheSteven GoossensTim PietersTom Taghon

HES6 knockdown in human hematopoietic precursor cells reduces their in vivo engraftment potential and their capacity to differentiate into erythroid cells, B cells, T cells and plasmacytoid dendritic cells

Tamara De VosNicole OatmanLena BoehmeTom PuttemanImke VelgheYana Van DroogenbroeckStijn De MunterMichaela CesnekovaFilip Van NieuwerburghBart Vandekerckhove et al.

A1 Journal Article in HAEMATOLOGICA

KLRG1 cell depletion as a novel therapeutic strategy in patients with mature T-cell lymphoma subtypes

Bimarzhan AssatovaRobert WillimChristopher TrevisaniGarrett HaskettKhyati Maulik KariyaKusha ChopraSung Rye ParkMichael Yevgeniy TolstorukovSean M. McCabeJessica Duffy et al.

A1 Journal Article in CLINICAL CANCER RESEARCH

Knocking out CD70 rescues CD70-specific nanoCAR T cells from antigen-induced exhaustion

Stijn De MunterJuliane L. BuhlLaurenz De CockAlexander Van ParysWillem DaneelsEva PascalLucas DeseinsJoline IngelsGlenn GoetgelukHanne Jansen et al.

A1 Journal Article in CANCER IMMUNOLOGY RESEARCH

Neoantigen-targeted dendritic cell vaccination in lung cancer patients induces long-lived T cells exhibiting the full differentiation spectrum

Joline IngelsLaurenz De CockDieter StevensRupert MayerFabien Henri TheryGuillem Sanchez SanchezDavid VermijlenKarin WeeningSaskia De SmetNele Lootens et al.

A1 Journal Article in CELL REPORTS MEDICINE

New molecular drivers and cell surface markers that characterize normal human hematopoiesis

Tamara De VosTom TaghonJan Philippé

ThymoSpheres culture : a model to study human polyclonal unconventional T cells

Lore BillietHanne JansenMelissa PilleLena BoehmeGuillem Sanchez SanchezLaurenz De CockGlenn GoetgelukEva PascalStijn De MunterLucas Deseins et al.

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

TL1A and IL-18 synergy promotes GM-CSF-dependent thymic granulopoiesis in mice

Mario Ruiz PérezChristian MaueröderWolf SteelsBruno VerstraetenSahine LameireWei XieLaura WyckaertJelle HuysentruytTatyana DivertRia Roelandt et al.

A1 Journal Article in CELLULAR & MOLECULAR IMMUNOLOGY

Type 1 immunity enables neonatal thymic ILC1 production

Peter TougaardMario Ruiz PérezWolf SteelsJelle HuysentruytBruno VerstraetenJessica VettersTatyana DivertAmanda GonçalvesRia RoelandtNozomi Takahashi et al.

A1 Journal Article in SCIENCE ADVANCES

2023

A spatial human thymus cell atlas mapped to a continuous tissue axis

Nadav YayonVeronika R. KedlianLena BöhmeChenqu SuoBrianna WachterRebecca T. BeuschelOren AmsalemKrzysztof PolanskiSimon KoplevElizabeth Tuck et al.

Circulating IRF8-expressing CD123+CD127+ lymphoid progenitors : key players in human hematopoiesis

Kai Ling LiangElisa LaurentiTom Taghon

A1 Journal Article in TRENDS IN IMMUNOLOGY

Dendritic cell-biased precursors support early human thymopoiesis

Tom TaghonKai Ling Liang

Editorial material

Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF

Kai Ling LiangJuliette RoelsMarieke LavaertTom PuttemanLena BoehmeLaurentijn TillemanImke VelgheValentina PegorettiInge Van de WalleStephanie Sontag et al.

A1 Journal Article in NATURE IMMUNOLOGY

Pre-clinical evaluation of the hypomethylating agent decitabine for the treatment of T-cell lymphoblastic lymphoma

Lien ProvezTom PuttemanMattias LandforsJuliette RoelsLindy ReunesSara T'SasWouter Van LoockeBéatrice LintermansStien De ConinckMorgan Thenoz et al.

A1 Journal Article in CANCERS

RNA helicase DHX15 exemplifies a unique dependency in acute leukemia

Hao GuoJin XuPeiqi XingQilong LiDonghai WangChao TangBruno PalhaisJuliette RoelsJiaxu LiuSa Pan et al.

A1 Journal Article in HAEMATOLOGICA

Single-cell profiling identifies a novel human polyclonal unconventional T cell lineage

Lore BillietLaurenz De CockGuillem Sanchez SanchezRupert MayerGlenn GoetgelukStijn De MunterMelissa PilleJoline IngelsHanne JansenKarin Weening et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

The Wiskott–Aldrich syndrome protein is required for positive selection during T-cell lineage differentiation

Melissa PilleJohn AvilaGuillem Sanchez SanchezGlenn GoetgelukStijn De MunterHanne JansenLore BillietKarin WeeningHaipeng XueSarah Bonte et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2022

Development of gamma delta T cells in the thymus : a human perspective

Lena BöhmeJuliette RoelsTom Taghon

A1 Journal Article in SEMINARS IN IMMUNOLOGY

Identification and purification of human T cell precursors

Inge Van de WalleNina LambrechtsAnaïs DerveeuwMarieke LavaertJuliette RoelsTom Taghon

Bookchapter in T-cell development : methods and protocols

In vitro model systems to study human T cell development

Nina LambrechtsKai Ling LiangImke VelgheSteven StrubbeAnne-Catherine DolensTom Taghon

Bookchapter in T-cell development : methods and protocols

IRF2 is required for development and functional maturation of human NK cells

Eva PersynSigrid WahlenLaura KiekensWouter Van LoockeHannah SiweEls Van AmmelZenzi De VosFilip Van NieuwerburghPatrick MatthysTom Taghon et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Multiomics to investigate the mechanisms contributing to repression of PTPRC and SOCS2 in pediatric T-ALL : focus on miR-363-3p and promoter methylation

Monika Drobna-SledzinskaNatalia Mackowska-MaslakRoman JaksikMaria KosmalskaBronislawa SzarzynskaMonika LejmanLukasz SedekTomasz SzczepanskiTom TaghonPieter Van Vlierberghe et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

Small-scale manufacturing of neoantigen-encoding messenger RNA for early-phase clinical trials

Joline IngelsLaurenz De CockRupert MayerPam DevrekerKarin WeeningKelly HeynsNele LootensSaskia De SmetMarieke BrusseelStijn De Munter et al.

A1 Journal Article in CYTOTHERAPY

T-BET drives the conversion of human type 3 innate lymphoid cells into functional NK cells

Laura KiekensSigrid WahlenEva PersynZenzi De VosTom TaghonBart VandekerckhoveGeorges Leclercq

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency

Sigrid WahlenFilip MatthijssensWouter Van LoockeSylvie TaveirneLaura KiekensEva PersynEls Van AmmelZenzi De VosStijn De MunterPatrick Matthys et al.

A1 Journal Article in ELIFE

Transcriptional dynamics and epigenetic regulation of E and ID protein encoding genes during human T cell development

Juliette RoelsJolien Van HulleMarieke LavaertAnna KuchmiySteven StrubbeTom PuttemanBart VandekerckhoveGeorges LeclercqFilip Van NieuwerburghLena Boehme et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

TXNIP promotes human NK cell development but is dispensable for NK cell functionality

Eva PersynSigrid WahlenLaura KiekensSylvie TaveirneWouter Van LoockeEls Van AmmelFilip Van NieuwerburghTom TaghonBart VandekerckhovePieter Van Vlierberghe et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2021

A DL-4-and TNF alpha-based culture system to generate high numbers of nonmodified or genetically modified immunotherapeutic human T-lymphoid progenitors

Ranjita Devi MoirangthemKuiying MaSabrina LizotAnne CordesseJuliette OlivreCorinne de ChappedelaineAkshay JoshiAgata CieslakJohn TchenNicolas Cagnard et al.

A1 Journal Article in CELLULAR & MOLECULAR IMMUNOLOGY

A novel non-coding variant in DCLRE1C results in deregulated splicing and induces SCID through the generation of a truncated ARTEMIS protein that fails to support V(D)J recombination and DNA damage repair

Steven StrubbeMarieke De BruyneUlrich PannickeElien BeylsBart VandekerckhoveGeorges LeclercqElfride De BaereVictoria BordonAnne VralKlaus Schwarz et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

A tumor suppressor enhancer of PTEN in T-cell development and leukemia

L TottoneO LanchoJW LohA SinghS KimuraJuliette RoelsAnna KuchmiySteven StrubbeMA LawlorV da Silva-Diz et al.

A2 Journal Article in BLOOD CANCER DISCOVERY

HES1 and HES4 have non-redundant roles downstream of Notch during early human T-cell development

Matthias De DeckerMarieke LavaertJuliette RoelsLaurentijn TillemanBart VandekerckhoveGeorges LeclercqFilip Van NieuwerburghPieter Van VlierbergheTom Taghon

A1 Journal Article in HAEMATOLOGICA

In vitro modeling of SCID using primary patient cells

Steven StrubbeTom Taghon

In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality

Sarah BonteStijn De MunterLore BillietGlenn GoetgelukJoline IngelsHanne JansenMelissa PilleLaurenz De CockKarin WeeningTom Taghon et al.

A1 Journal Article in ONCOIMMUNOLOGY

Modeling of human T cell development in vitro as a read-out for hematopoietic stem cell multipotency

Steven StrubbeTom Taghon

A1 Journal Article in BIOCHEMICAL SOCIETY TRANSACTIONS

Molecular and functional dissection of early T lymphocyte development in human at the single cell level

Marieke LavaertTom Taghon

PRL3 enhances T-cell acute lymphoblastic leukemia growth through suppressing T-cell signaling pathways and apoptosis

E. G. GarciaA. VelosoM. L. OliveiraJ. R. AllenS. LoontiensD. BrunsonD. DoC. YanR. MorrisS. Iyer et al.

A1 Journal Article in LEUKEMIA

T-BET and EOMES accelerate and enhance functional differentiation of human natural killer cells

Laura KiekensWouter Van LoockeSylvie TaveirneSigrid WahlenEva PersynEls Van AmmelZenzi De VosPatrick MatthysFilip Van NieuwerburghTom Taghon et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

The RNA Atlas expands the catalog of human non-coding RNAs

Lucia LorenziHua-Sheng ChiuFrancisco Avila CobosStephen GrossPieter-Jan VoldersRobrecht CannoodtJustine NuytensKatrien VanderheydenJasper AnckaertSteve Lefever et al.

A1 Journal Article in NATURE BIOTECHNOLOGY

The RNA Atlas expands the catalog of human non-coding RNAs (June, 10.1038/s41587-021-00936-1, 2021)

Lucia LorenziHua-Sheng ChiuFrancisco Avila CobosStephen GrossPieter-Jan VoldersRobrecht CannoodtJustine NuytensKatrien VanderheydenJasper AnckaertSteve Lefever et al.

Thymic epithelial cell alterations and defective thymopoiesis lead to central and peripheral tolerance perturbation in MHCII deficiency

Francesca FerruaIleana BortolomaiElena FontanaDario Di SilvestreRosita RigoniGenni Enza MarcovecchioElena DraghiciFrancesca BrambillaMaria Carmina CastielloGloria Delfanti et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Treatment of a patient with severe cytomegalovirus (CMV) infection after haploidentical stem cell transplantation with donor-derived CMV-specific T cells

Joline IngelsSaskia De SmetKelly HeynsNele LootensJonas SegaertTom TaghonGeorges LeclercqKarim VermaelenEvelyne WillemsEtienne Baudoux et al.

A1 Journal Article in ACTA CLINICA BELGICA

2020

A cell atlas of human thymic development defines T cell repertoire formation

Jong-Eun ParkRachel A. BottingCecilia Domínguez CondeDorin-Mirel PopescuMarieke LavaertDaniel J. KunzIssac GohEmily StephensonRoberta RagazziniElizabeth Tuck et al.

A1 Journal Article in SCIENCE

Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia

Juliette RoelsMorgan ThénozBronislawa SzarzynskaMattias LandforsStien De ConinckLisa DemoenLien ProvezAnna KuchmiySteven StrubbeLindy Reunes et al.

Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia

Juliette RoelsMorgan ThénozB SzarzyńskaM LandforsStien De ConinckLisa DemoenLien ProvezAnna KuchmiySteven StrubbeLindy Reunes et al.

A2 Journal Article in BLOOD CANCER DISCOVERY

Conventional and computational flow cytometry analyses reveal sustained human intrathymic T cell development from birth until puberty

Marieke LavaertBrecht ValckeBart VandekerckhoveGeorges LeclercqKai Ling LiangTom Taghon

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Dissecting the Notch signaling pathway and its modulators during human T cell development

Anne-Catherine DolensTom Taghon

Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development

Juliette RoelsAnna KuchmiyMatthias De DeckerSteven StrubbeMarieke LavaertKai Ling LiangGeorges LeclercqBart VandekerckhoveFilip Van NieuwerburghPieter Van Vlierberghe et al.

A1 Journal Article in NATURE IMMUNOLOGY

Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development

Anne-Catherine DolensKaat DurinckMarieke LavaertJoni Van der MeulenImke VelgheJelle De MedtsKarin WeeningJuliette RoelsKatrien De MulderPieter-Jan Volders et al.

A1 Journal Article in EMBO REPORTS

hsa-miR-20b-5p and hsa-miR-363-3p affect expression of PTEN and BIM tumor suppressor genes and modulate survival of T-ALL cells in vitro

Monika DrobnaBronisława SzarzyńskaRoman JaksikŁukasz SędekAnna KuchmiyTom TaghonPieter Van VlierbergheTomasz SzczepańskiMichał WittMałgorzata Dawidowska

A1 Journal Article in CELLS

Human thymic CD10+ PD-1+ intraepithelial lymphocyte precursors acquire interleukin-15 responsiveness at the CD1a– CD95+ CD28– CCR7– developmental stage

Lore BillietGlenn GoetgelukSarah BonteStijn De MunterLaurenz De CockMelissa PilleJoline IngelsHanne JansenKarin WeeningFilip Van Nieuwerburgh et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Integrated scRNA-seq identifies human postnatal thymus seeding progenitors and regulatory dynamics of differentiating immature thymocytes

Marieke LavaertKai Ling LiangNiels VandammeJong-Eun ParkJuliette RoelsMonica S. KowalczykBo LiOrr AshenbergMarcin TabakaDanielle Dionne et al.

A1 Journal Article in IMMUNITY

Large-scale circular RNA deregulation in T-ALL : unlocking unique ectopic expression of molecular subtypes

Alessia BuratinMaddalena PaganinEnrico GaffoAnna Dal MolinJuliette RoelsGiuseppe GermanoMaria Teresa SiddiValentina SerafinMatthias De DeckerStéphanie Gachet et al.

A1 Journal Article in BLOOD ADVANCES

PHF6 expression levels impact human hematopoietic stem cell differentiation

Siebe LoontiensAnne-Catherine DolensSteven StrubbeInge Van de WalleFinola E. MooreLisa DepestelSuzanne VanhauwaertFilip MatthijssensDavid M. LangenauFranki Speleman et al.

A1 Journal Article in FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

Posttranslational regulation of the exon skipping machinery controls aberrant splicing in leukemia

Yalu ZhouCuijuan HanEric WangAdam H. LorchValentina SerafinByoung-Kyu ChoBlanca T. Guttierrez DiazJulien CalvoCelestia FangAlireza Khodadadi-Jamayran et al.

A1 Journal Article in CANCER DISCOVERY

Rapid and effective generation of nanobody based CARs using PCR and Gibson Assembly

Stijn De MunterAlexander Van ParysLayla BralJoline IngelsGlenn GoetgelukSarah BonteMelissa PilleLore BillietKarin WeeningAnnick Verhee et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources

Sarah BonteStijn De MunterGlenn GoetgelukJoline IngelsMelissa PilleLore BillietTom TaghonGeorges LeclercqBart VandekerckhoveTessa Kerre

A1 Journal Article in ONCOIMMUNOLOGY

Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma

Renate De SmedtJulie MorscioLindy ReunesJuliette RoelsValentina BardelliBéatrice LintermansWouter Van LoockeAfonso AlmeidaLaurence C. CheungRishi S. Kotecha et al.

A1 Journal Article in BLOOD

The epigenetic landscape of normal and malignant T cell development

Juliette RoelsPieter Van VlierbergheTom Taghon

The role of Notch ligands and downstream HES target genes on human T cell development

Matthias De DeckerTom Taghon

The transcription factor ETS1 is an important regulator of human NK cell development and terminal differentiation

Sylvie TaveirneSigrid WahlenWouter Van LoockeLaura KiekensEva PersynEls Van AmmelKatrien De MulderJuliette RoelsLaurentijn TillemanMarc Aumercier et al.

A1 Journal Article in BLOOD

2019

PHF6loss drives IL7R oncogene addiction in TLX1 driven T-ALL

Siebe LoontiensKaat DurinckSuzanne VanhauwaertLisa DepestelMariana L OliveiraGivani DewynCharles De BockJoao T BarataDavid LangenauJan Cools et al.

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition

Roger A. HabetsCharles E. de BockLutgarde SerneelsInge LodewijckxDelphine VerbekeDavid NittnerRajeshwar NarlawarSofie DemeyerJames DooleyAdrian Liston et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

Stellate cells, hepatocytes, and endothelial cells imprint the Kupffer cell identity on monocytes colonizing the liver macrophage niche

Johnny BonnardelWouter T'JonckDjoere GaublommeRobin BrowaeysCharlotte ScottLiesbet MartensBavo VannesteSofie De PrijckSergei A NedospasovAnna Kremer et al.

A1 Journal Article in IMMUNITY

T-cell acute lymphoblastic leukemias express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development

Charles E de BockMichelle DownKinsha BaidyaBram SweronAndrew W BoydMark FiersGordon F BurnsTimothy J MolloyRichard B LockJean Soulier et al.

A1 Journal Article in HAEMATOLOGICA

The RNA Atlas, a single nucleotide resolution map of the human transcriptome

Lucia LorenziHua-Sheng ChiuFrancisco Avila CobosStephen GrossPieter-Jan VoldersRobrecht CannoodtJustine NuytensKatrien VanderheydenJasper AnckaertSteve Lefever et al.

ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms

Steven GoossensJueqiong WangCedric TremblayJelle De MedtsSara T'SasThao NguyenJesslyn SawKatharina HaighDavid J CurtisPieter Van Vlierberghe et al.

A1 Journal Article in HAEMATOLOGICA

ZEB2 in T-cells and T-ALL

Stien De ConinckGeert BerxTom TaghonPieter Van VlierbergheSteven Goossens

A2 Journal Article in ADVANCES IN BIOLOGICAL REGULATION

2018

A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA+ and total RNA sequencing

Karen VerboomWouter Van LoockePieter-Jan VoldersBieke DecaestekerFrancisco Avila CobosSimon BornscheinCharles E de BockZeynep Kalender AtakEmmanuelle ClappierStein Aerts et al.

A1 Journal Article in HAEMATOLOGICA

Deletion 6q drives T-cell leukemia progression by ribosome modulation

Stéphanie GachetTiama El-ChaarDavid AvranEulalia GenescaFrédéric CatezSamuel QuentinMarc DelordGabriel ThérizolsDelphine BriotGodelieve Meunier et al.

A1 Journal Article in CANCER DISCOVERY

Generation of adult human T-cell progenitors for immunotherapeutic applications

Laura SimonsKuiying MaCorinne de ChappedelaineRanjita Devi MoiranghtemElodie ElkaimJuliette OlivréSandrine SusiniKevin AppourchauxChristian ReimannHanem Sadek et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Scrutinizing PHF6 regulatory networks in T-ALL and normal hematopoiesis using zebrafish

Siebe LoontiensKaat DurinckInge Van de WalleFinola MooreSuzanne VanhauwaertEls JanssensGivani DewynLisa DepestelChristophe Van NesteDavid Langenau et al.

SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival

Hexiu SuJuncheng HuLiang HuangYang YangMorgan ThénozAnna KuchmiyYufeng HuPeng LiHui FengYu Zhou et al.

A1 Journal Article in NATURE COMMUNICATIONS

2017

A murine intestinal intraepithelial NKp46-negative innate lymphoid cell population characterized by group 1 properties

Aline Van AckerKonrad GronkeAindrila BiswasLiesbet MartensYvan SaeysJessica FiltjensSylvie TaveirneEls Van AmmelTessa KerrePatrick Matthys et al.

A1 Journal Article in CELL REPORTS

Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities

Yasmine Van CaeneghemStijn De MunterPaola TieppoGlenn GoetgelukKarin WeeningGreet VerstichelSarah BonteTom TaghonGeorges LeclercqTessa Kerre et al.

A1 Journal Article in ONCOIMMUNOLOGY

Comprehensive miRNA expression profiling in human T-cell acute lymphoblastic leukemia by small RNA-sequencing

Annelynn WallaertWouter Van LoockeLucie HernandezTom TaghonFranki SpelemanPieter Van Vlierberghe

A1 Journal Article in SCIENTIFIC REPORTS

Human T cell development notched up a level

Anne-Catherine DolensTom Taghon

Editorial material

T-ALL and thymocytes : a message of noncoding RNAs

Annelynn WallaertKaat DurinckTom TaghonPieter Van VlierbergheFranki Speleman

A1 Journal Article in JOURNAL OF HEMATOLOGY & ONCOLOGY

The checkpoint for agonist selection precedes conventional selection in human thymus

Greet VerstichelDavid VermijlenLiesbet MartensGlenn GoetgelukMargreet BrouwerNicolas ThiaultYasmine Van CaeneghemStijn De MunterKarin WeeningSarah Bonte et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

The TLX1 oncogene modulates the enhancer RNA landscape in T-ALL

Karen VerboomKaat DurinckMatthias De DeckerWouter Van LoockeFilip MatthijssensJean-Jacques SoulierWouter De LaatTom TaghonPieter Van VlierbergheFranki Speleman

2016

A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network

Ashwin UnnikrishnanYi Fang GuanYizhou HuangDominik BeckJulie AI ThomsSofie PeirsKathy KnezevicShiyong MaInge Van de WalleIneke de Jong et al.

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Approaches to study human T cell development

Anne-Catherine DolensInge Van de WalleTom Taghon

Bookchapter in T-Cell development : methods and protocols

Characterization and isolation of human T cell progenitors

Inge Van de WalleKarin DavidsTom Taghon

Bookchapter in T-Cell development : methods and protocols

CRISPR-Cas9 modeling of cell lines and zebrafish to study the TLX1-PHF6 cooperative interrelationship in T-cell acute lymphoblastic leukemia

Siebe LoontiensKaat DurinckNina De RockerAnnekatrien BoelEls JanssensSuzanne VanhauwaertPieter RondouCharles De BockInge Van de WalleFinola Moore et al.

Expanding the TLX1 regulome in T-cell acute lymphoblastic leukemia towards long noncoding RNAs

Kaat DurinckWouter Van LoockeInge Van de WalleJoni Van der MeulenPieter-Jan VoldersNadine Van RoyYves BenoitBruce PoppePieter MestdaghJo Vandesompele et al.

Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours

Jessica FiltjensJiri KeirsseEls Van AmmelSylvie TaveirneAline Van AckerTessa KerreTom TaghonBart VandekerckhoveJean PlumJo A Van Ginderachter et al.

A1 Journal Article in SCIENTIFIC REPORTS

Functional dissection of transcriptional regulation during normal and malignant T-cell development : an integrative (epi)genomic approach

Kaat DurinckFranki SpelemanPieter Van VlierbergheTom Taghon

GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate

Inge Van de WalleAnne-Catherine DolensKaat DurinckKatrien De MulderWouter Van LoockeSagar DamleEls WaegemansJelle De MedtsImke VelgheMagda De Smedt et al.

A1 Journal Article in NATURE COMMUNICATIONS

Humanized mice to study human T cell development

Sarah BonteSYLVIA SNAUWAERTStijn VanheeAnne-Catherine DolensTom TaghonBart VandekerckhoveTessa Kerre

Bookchapter in T-Cell development : methods and protocols

Long noncoding RNA signatures define oncogenic subtypes in T-cell acute lymphoblastic leukemia

Annelynn WallaertKaat DurinckWouter Van LoockeInge Van de WalleFilip MatthijssensPieter-Jan VoldersFrancisco Avila CobosDries RombautPieter RondouPieter Mestdagh et al.

A1 Journal Article in LEUKEMIA

Modeling the TLX1-PHF6 cooperative interrelationship in T-cell acute lymphoblastic leukemia in zebrafish

Siebe LoontiensKaat DurinckELS JANSSENSSuzanne VanhauwaertPieter RondouJan CoolsCharles De BockInge Van de WalleFinola MooreDavid Langenau et al.

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNF AIP3/A20

Michael DrennanSrinath GovindarajanEveline VerheugenJonathan CoquetJens StaalConor Mc GuireTom TaghonGeorges LeclercqRudi BeyaertGeert van Loo et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Persistent rotavirus diarrhea post-transplant in a novel JAK3-SCID patient after vaccination

Delfien BogaertKristof Van SchilTom TaghonMaria Bordon Cueto De BraemCarolien BonroyMelissa DullaersElfride De BaereFilomeen Haerynck

A1 Journal Article in PEDIATRIC ALLERGY AND IMMUNOLOGY

The European Hematology Association Roadmap for European hematology research: a consensus document

Andreas EngertCarlo BalduiniAnneke BrandBertrand CoiffierCatherine CordonnierHartmut DöhnerThom Duyvené de WitSabine EichingerWillem FibbeTony Green et al.

A1 Journal Article in HAEMATOLOGICA

The Ly49E receptor inhibits the immune control of acute Trypanosoma cruzi infection

Jessica FiltjensNicolas ColtelSabrina CencigSylvie TaveirneEls Van AmmelAline Van AckerTessa KerrePatrick MatthysTom TaghonBart Vandekerckhove et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

The role of Ly49E receptor expression on murine intraepithelial lymphocytes in intestinal cancer development and progression

Aline Van AckerEls LouagieJessica FiltjensSylvie TaveirneEls Van AmmelTessa KerreDirk ElewautTom TaghonBart VandekerckhoveJean Plum et al.

A1 Journal Article in CANCER IMMUNOLOGY IMMUNOTHERAPY

The T-ALL oncogene TLX1 controls enhancer lncRNA expression

Karen VerboomKaat DurinckWouter Van LoockeFilip MatthijssensInge Van de WalleAnnelynn WallaertPieter-Jan VoldersNadine Van RoyYves BenoitBruce Poppe et al.

2015

A novel Janus kinase 3 (JAK3) mutation in a patient with severe combined immunodeficiency

Delfien BogaertKristof Van SchilTom TaghonMaria Bordon Cueto De BraemMelissa DullaersElfride De BaereFilomeen Haerynck

Characterization of the genome-wide TLX1 binding profile in T-cell acute lymphoblastic leukemia

Kaat DurinckWouter Van LoockeJoni Van der MeulenInge Van de WalleMaté OngenaertPieter RondouAnnelynn WallaertCE de BockNadine Van RoyBruce Poppe et al.

A1 Journal Article in LEUKEMIA

Chimeric antigen receptor transgenic, T cell receptor/CD3 negative monospecific T cells generated from cord blood CD34 positive cells

Yasmine Van CaeneghemGlenn GoetgelukKarin WeeningGreet VerstichelSarah BonteTom TaghonGeorges LeclercqFritz OffnerHinrich AbkenTessa Kerre et al.

Epigenetics in T-cell acute lymphoblastic leukemia

Sofie PeirsJoni Van der MeulenInge Van de WalleTom TaghonFranki SpelemanBruce PoppePieter Van Vlierberghe

A1 Journal Article in IMMUNOLOGICAL REVIEWS

In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis

Stijn VanheeKatrien De MulderYasmine Van CaeneghemGreet VerstichelNadine Van RoyBjörn MentenImke VelgheJan PhilippéDominique De BleserBart Lambrecht et al.

A1 Journal Article in HAEMATOLOGICA

MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia

Evelien MetsJoni Van der MeulenGert Van PeerMichael BoicePieter MestdaghInge Van de WalleTim LammensSteven GoossensBarbara De MoerlooseYves Benoit et al.

A1 Journal Article in LEUKEMIA

The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia

Joni Van der MeulenViraj SanghviKonstantinos MavrakisKaat DurinckFang FangFilip MatthijssensPieter RondouMonica RosenTim PietersPeter Vandenberghe et al.

A1 Journal Article in BLOOD

Transcriptional antagonism between the cooperative oncogenes TLX1 and NOTCH1 in T-cell acute lymphoblastic leukemia.

Kaat DurinckWouter Van LoockeJoni Van der MeulenInge Van de WallePieter RondouCharles E De BockBruce PoppeJan CoolsJean SoulierTom Taghon et al.

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling

Steven GoossensEnrico RadaelliOdile BlanchetKaat DurinckJoni Van der MeulenSofie PeirsTom TaghonCedric S TremblayMagdaline CostaMorvarid Farhang Ghahremani et al.

A1 Journal Article in NATURE COMMUNICATIONS

2014

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in early immature T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensKirsten Canté-BarrettTim LammensBarbara De MoerlooseYves BenoitJean SoulierBruce PoppeTom Taghon et al.

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensInge Van de WalleKatia RuggeroCharles E de BockSandrine DegryseKirsten Canté-BarrettDelphine BriotEmmanuelle Clappier et al.

A1 Journal Article in BLOOD

ABT-199 mediated inhibition of BCL2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensCharles De BockKirsten Canté-BarrettTim LammensInge Van de WalleBarbara De MoerlooseYves BenoitBruce Poppe et al.

Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia

Viraj R SanghviKonstantinos J MavrakisJoni Van der MeulenMichael BoiceAndrew L WolfeMark CartyPrathibha MohanPieter RondouNicholas D SocciYves Benoit et al.

A1 Journal Article in SCIENCE SIGNALING

Contribution of the Ly49E natural killer receptor in the immune response to Plasmodium berghei infection and control of hepatic parasite development

Jessica FiltjensLander FoquetSylvie TaveirneEls Van AmmelMandy VanheesAline Van AckerTessa KerreTom TaghonBart VandekerckhoveJean Plum et al.

A1 Journal Article in PLOS ONE

In vitro generation of mature, naive antigen-specific CD8⁺ T cells with a single T-cell receptor by agonist selection

SYLVIA SNAUWAERTGreet VerstichelSarah BonteGlenn GoetgelukStijn VanheeYasmine Van CaeneghemKatrien De MulderCarlo HeirmanHans StaussMiriam HM Heemskerk et al.

A1 Journal Article in LEUKEMIA

In vitro human embryonic stem cell hematopoiesis mimics MYB independent yolk sac hematopoiesis

Stijn VanheeKatrien De MulderYasmine Van CaeneghemNadine Van RoyBjörn MentenImke VelgheJan PhilippéTom TaghonGeorges LeclercqTessa Kerre et al.

Integrative analysis of the NOTCH1 regulatory network identifies key downstream lncRNAs in acute T-cell lymphoblastic leukemia and normal T-cell development

Annelynn WallaertKaat DurinckPieter RondouInge Van de WalleWouter Van LoockePieter-Jan VoldersMaté OngenaertNadine Van RoyBruce PoppeYves Benoit et al.

Integrative genomic and transcriptomic analysis identified candidate genes implicated in the pathogenesis of hepatosplenic T-cell lymphoma

Julio Finalet FerreiroLeila RouhigharabaeiHelena UrbankovaJo-Anne van der KrogtLucienne MichauxShashirekha ShettyLaszlo KrenacsThomas TousseynPascale De PaepeAnne Uyttebroeck et al.

A1 Journal Article in PLOS ONE

Ly49E Expression on CD8αα-expressing intestinal intraepithelial lymphocytes plays no detectable role in the development and progression of experimentally induced inflammatory bowel diseases

Aline Van AckerJessica FiltjensSophie Van WeldenSylvie TaveirneEls Van AmmelMandy VanheesLindsey DevisscherTessa KerreTom TaghonBart Vandekerckhove et al.

A1 Journal Article in PLOS ONE

MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia

Evelien MetsGert Van PeerJoni Van der MeulenMichael BoiceTom TaghonSteven GoossensPieter MestdaghYves BenoitBarbara De MoerlooseNadine Van Roy et al.

A1 Journal Article in HAEMATOLOGICA

Notch3 activation is sufficient but not required for inducing human T-lineage specification

Els WaegemansInge Van de WalleJelle De MedtsMagda De SmedtTessa KerreBart VandekerckhoveGeorges LeclercqTao WangJean PlumTom Taghon

A1 Journal Article in JOURNAL OF IMMUNOLOGY

The first lncRNA landscape of major genetic T-ALL subsets and guilt-by-association analysis for ETP-ALL specific lncRNAs

Annelynn WallaertKaat DurinckWouter Van LoockePieter-Jan VoldersInge Van de WalleYves BenoitBruce PoppeJo VandesompeleTom TaghonJean Soulier et al.

The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia

Kaat DurinckAnnelynn WallaertInge Van de WalleWouter Van LoockePieter-Jan VoldersSuzanne VanhauwaertEllen GeerdensYves BenoitNadine Van RoyBruce Poppe et al.

A1 Journal Article in HAEMATOLOGICA

The NOTCH1 driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia

Annelynn WallaertKaat DurinckPieter RondouInge Van de WalleWouter VanloockePieter-Jan VoldersSuzanne VanhauwaertEllen GeerdensMaté OngenaertNadine Van Roy et al.

The role of Notch3 at discrete developmental stages of early human T cell development

Els WaegemansTom TaghonJean Plum

2013

Abundant stage-dependent Ly49E expression by liver NK cells is not essential for their differentiation and function

Jessica FiltjensSylvie TaveirneAline Van AckerEls Van AmmelMandy VanheesTessa KerreTom TaghonBart VandekerckhoveJean PlumGeorges Leclercq

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

CMYB expression during human in vitro hematopoiesis

Stijn VanheeYasmine Van CaeneghemKatrien De MulderImke VelgheSylvie TaveirneNadine Van RoyBjörn MentenSYLVIA SNAUWAERTGreet VerstichelMelissa Dullaers et al.

Differential Ly49e expression pathways in resting versus TCR-activated intraepithelial γδ T cells

Tina Van Den BroeckEls Van AmmelMaarten DelforcheSylvie TaveirneTessa KerreBart VandekerckhoveTom TaghonJean PlumGeorges Leclercq

A1 Journal Article in JOURNAL OF IMMUNOLOGY

MiR-128 is a novel PHF6 targeting regulatory non-coding RNA acting as a T-ALL oncogene

Evelien MetsJoni Van der MeulenGert Van PeerMichael BoicePieter MestdaghTom TaghonDavid AvranBarbara De MoerlooseYves BenoitBruce Poppe et al.

Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms

Anouk Van NuffelKevin AriënVeronique StoveMichael SchindlerEduardo O'NeillJan SchmökelInge Van de WalleEvelien NaessensHanne VanderstraetenKathleen Van Landeghem et al.

A1 Journal Article in RETROVIROLOGY

Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength

Inge Van de WalleEls WaegemansJelle De MedtsGreet De SmetMagda De SmedtSYLVIA SNAUWAERTBart VandekerckhoveTessa KerreGeorges LeclercqJean Plum et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2012

Notch induces human T-cell receptor γδ+ thymocytes to differentiate along a parallel, highly proliferative and bipotent CD4 CD8 double-positive pathway

Stefanie Van CoppernolleStijn VanheeGreet VerstichelSYLVIA SNAUWAERTA van der SpekImke VelgheMieke SinnesaelMH HeemskerkTom TaghonGeorges Leclercq et al.

A1 Journal Article in LEUKEMIA

Notch ligands control the human alpha beta/gamma delta lineage choice through receptor-specific induction of differential Notch signal strength

Tom TaghonInge Van de WalleEls WaegemansJelle De MedtsGreet De SmetMagda De SmedtBart VandekerckhoveTessa KerreGeorges LeclercqTao Wang et al.

Notch signaling during human T cell development

Tom TaghonEls WaegemansInge Van de Walle

A1 Journal Article in Current Topics in Microbiology and Immunology

Quantification of reverse transcriptase activity by real-time PCR as a fast and accurate method for titration of HIV, lenti- and retroviral vectors

JOLIEN VERMEIREEvelien NaessensHanne VanderstraetenAlessia LandiVeronica IannucciAnouk Van NuffelTom TaghonMassimo PizzatoBruno Verhasselt

A1 Journal Article in PLOS ONE

RHAMM/HMMR (CD168) is not an ideal target antigen for immunotherapy of acute myeloid leukemia

SYLVIA SNAUWAERTStijn VanheeGlenn GoetgelukGreet VerstichelYasmine Van CaeneghemImke VelgheJan PhilippéZwi N BernemanJean PlumTom Taghon et al.

A1 Journal Article in HAEMATOLOGICA-THE HEMATOLOGY JOURNAL

2011

A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)

Konstantinos J MavrakisJoni Van der MeulenAndrew L WolfeXiaoping LiuEvelien MetsTom TaghonAly A KhanManu SettyPieter RondouPeter Vandenberghe et al.

A1 Journal Article in NATURE GENETICS

A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)

Evelien MetsJoni Van der MeulenKonstantinos J MavrakisAndrew L WolfeTom TaghonAly A KhanManu SettyXiaoping LiuPieter RondouPeter Vandenberghe et al.

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia

Apostolos KlinakisCamille LobryOmar Abdel-WahabPhilmo OhHiroshi HaenoSilvia BuonamiciInge van De WalleSeverine CathelinThomas TrimarchiElisa Araldi et al.

A1 Journal Article in NATURE

CD27-deficient mice show normal NK-cell differentiation but impaired function upon stimulation

Veerle De ColvenaerSylvie TaveirneMaarten DelforcheMagda De SmedtBart VandekerckhoveTom TaghonLouis BoonJean PlumGeorges Leclercq

A1 Journal Article in IMMUNOLOGY AND CELL BIOLOGY

Cooperative miRNA mediated FBXW7 suppression contributes to T-cell lymphoblastic leukemogenesis

Evelien MetsJoni Van der MeulenKonstantinos J MavrakisAndrew L WolfeTom TaghonAly A KhanManu SettyXiaoping LiuPeter VandenbergheEric Delabesse et al.

Double positive and double negative TCR gamma delta plus cells independently generate mature functional TCR gamma delta plus cells in the human thymus

Stefanie Van CoppernolleStijn VanheeGreet VerstichelSYLVIA SNAUWAERTImke VelgheMieke SinnesaelA van der SpekTom TaghonGeorges LeclercqJean Plum et al.

EVI1-mediated down regulation of MIR449A is essential for the survival of EVI1 positive leukaemic cells

An De WeerJoni Van der MeulenPieter RondouTom TaghonTorsten A KonradKatleen De PreterPieter MestdaghTom Van MaerkenNadine Van RoyMarta Jeison et al.

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

In vitro generation of immune cells from pluripotent stem cells

Bart VandekerckhoveStijn VanheeStefanie Van CoppernolleSYLVIA SNAUWAERTImke VelgheTom TaghonGeorges LeclercqTessa KerreJean Plum

A1 Journal Article in FRONTIERS IN BIOSCIENCE-LANDMARK

Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8αα intestinal intraepithelial T lymphocytes

Sylvie TaveirneJessica FiltjensEls Van AmmelVeerle De ColvenaerTessa KerreTom TaghonBart VandekerckhoveJean PlumWerner HeldGeorges Leclercq

A1 Journal Article in BLOOD

Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions

Inge Van de WalleGreet De SmetMartina GärtnerMagda De SmedtEls WaegemansBart VandekerckhoveGeorges LeclercqJean PlumJon C AsterIrwin D Bernstein et al.

A1 Journal Article in BLOOD

Langerhans cells are not required for epidermal Vγ3 T cell homeostasis and function

Sylvie TaveirneVeerle De ColvenaerTina Van Den BroeckEls Van AmmelClare L BennettTom TaghonBart VandekerckhoveJean PlumBjörn E ClausenDaniel H Kaplan et al.

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

Regulatory networks governed by microRNAs in T-ALL oncogenesis and normal T-cell development

Joni Van der MeulenEvelien MetsPieter MestdaghPeter PipelersTom TaghonDavid Camacho TrujilloDavid AvranGert Van PeerNadine Van RoyOlivier Thas et al.

T-lymphoid differentiation potential measured in vitro is higher in CD34+CD38-/lo hematopoietic stem cells from umbilical cord blood than from bone marrow and is an intrinsic property of the cells

Magda De SmedtGeorges LeclercqBart VandekerckhoveTessa KerreTom TaghonJean Plum

A1 Journal Article in HAEMATOLOGICA-THE HEMATOLOGY JOURNAL

2010

Continuous CD27 triggering in vivo strongly reduces NK cell numbers

Veerle De ColvenaerSylvie TaveirneJörg HamannAlex M de BruinMagda De SmedtTom TaghonBart VandekerckhoveJean PlumRené van LierGeorges Leclercq

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

PHF6 mutations in T-cell acute lymphoblastic leukemia

Pieter Van VlierbergheTeresa PalomeroHossein KhiabanianJoni Van der MeulenMireia CastilloNadine Van RoyBarbara De MoerlooseJan PhilippéSara Gonzalez-GarciaMaria L Toribio et al.

A1 Journal Article in NATURE GENETICS

2009

An early decrease in Notch activation is required for human TCR-αβ lineage differentiation at the expense of TCR-γδ T cells

Inge Van de WalleGreet De SmetMagda De SmedtBart VandekerckhoveGeorges LeclercqJean PlumTom Taghon

A1 Journal Article in BLOOD

CD4 and CD8 TCR alpha beta cells are selected on MHC expressed on thymocyte precursors in OP9-DL1 cultures

Stefanie Van CoppernolleBart VandekerckhoveGreet VerstichelImke VelgheTom TaghonGeorges LeclercqJean PlumTessa Kerre

Functionally mature CD4 and CD8 TCRαβ cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells

Stefanie Van CoppernolleGreet VerstichelFrank TimmermansImke VelgheDavid VermijlenMagda De SmedtGeorges LeclercqJean PlumTom TaghonBart Vandekerckhove et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Generation of T cells from human embryonic stem cell-derived hematopoietic zones

Frank TimmermansImke VelgheLieve VanwalleghemMagda De SmedtStefanie Van CoppernolleTom TaghonHarry MooreGeorges LeclercqAnton LangerakTessa Kerre et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

MICRORNA SIGNATURES IN GENETIC SUBTYPES OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

Joni Van der MeulenPieter Van VlierberghePieter MestdaghJo VandesompeleBruce PoppeNadine Van RoyTom TaghonJean PlumB. CauwelierDLD Selleslag et al.

Notch signaling is required for proliferation but not for differentiation at a well-defined β-selection checkpoint during human T-cell development

Tom TaghonInge Van de WalleGreet De SmetMagda De SmedtGeorges LeclercqBart VandekerckhoveJean Plum

A1 Journal Article in BLOOD

Regulation of early T cell development in mouse and human by Notch

A4 Journal Article in VERHANDELINGEN VAN DE KONINKLIJKE ACADEMIE VOOR GENEESKUNDE VAN BELGIË

2008

Generation of T cells from human embryonic stem cells

Frank TimmermansImke VelgheLieve VanwalleghemMagda De SmedtStefanie Van CoppernolleGeorges LeclercqTom TaghonHarry MooreAnton W LangerakTessa Kerre et al.

Human intrathymic development: a selective approach

Jean PlumMagda De SmedtGeorges LeclercqTom TaghonTessa KerreBart Vandekerckhove

A1 Journal Article in SEMINARS IN IMMUNOPATHOLOGY

Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator

Tina Van Den BroeckFrederick StevenaertSylvie TaveirneVeronique DebackerCHRISTEL VANGESTELBart VandekerckhoveTom TaghonPatrick MatthysJean PlumWerner Held et al.

A1 Journal Article in Blood

MicroRNA signatures in genetic subtypes of T-cell acute lymphoblastic leukemia.

Pieter Van VlierbergheBruce PoppeNadine Van RoyTom TaghonJean PlumB CauwelierD SelleslagP HeimannP VandenbergheN Dastugue et al.

Molecular mechanisms that control mouse and human TCR-alpha beta and TCR-gamma delta T cell development

Tom TaghonEllen V. Rothenberg

A1 Journal Article in SEMINARS IN IMMUNOPATHOLOGY

Stage-dependent molecular changes in Notch signaling are critical for normal human T cell development

Tom TaghonInge Van de WalleGreet De SmetMagda De SmedtJean Plum

2007

Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3

Tom TaghonMA YUIEV ROTHENBERG

A1 Journal Article in NATURE IMMUNOLOGY

Molecular dissection of prethymic progenitor entry into the T lymphocyte developmental pathway

CC TYDELLES DAVID-FUNGJE MOOREL ROWENTom TaghonEV ROTHENBERG

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Notch signaling induces cytoplasmic CD3 epsilon expression in human differentiating NK cells

Magda De SmedtTom TaghonInge Van de WalleGreet De SmetGeorges LeclercqJean Plum

A1 Journal Article in BLOOD

Tumor necrosis factor promotes T-cell at the expense of B-cell lymphoid development from cultured human CD34(+) cord blood cells

K SMITSMagda De SmedtEvelien NaessensGreet De SmetVeronique StoveTom TaghonJean PlumBruno Verhasselt

A1 Journal Article in EXPERIMENTAL HEMATOLOGY

2006

Developmental and molecular characterization of emerging beta- and gamma delta-selected pre-T cells in the adult mouse thymus

Tom TaghonMA YUIR PANTRA DIAMONDEV ROTHENBERG

A1 Journal Article in IMMUNITY

Notch/Delta signaling constrains reengineering of pro-T cells by PU.1

CB FRANCODD SCRIPTURE-ADAMSI PROEKTTom TaghonAH WEISSMA YUISL ADAMSRA DIAMONDEV ROTHENBERG

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progression of regulatory gene expression states in fetal and adult pro-T-cell development

ES DAVID-FUNGMA YUIM MORALESH WANGTom TaghonRA DIAMONDEV ROTHENBERG

A1 Journal Article in IMMUNOLOGICAL REVIEWS

2005

Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling

Tom TaghonES DAVIDJC ZUNIGA-PFLUCKEREV ROTHENBERG

A1 Journal Article in GENES & DEVELOPMENT

Molecular genetics of T cell development

EV ROTHENBERGTom Taghon

A1 Journal Article in ANNUAL REVIEW OF IMMUNOLOGY

2003

Homeobox gene expression profile in human hematopoietic multipotent stem cells and T-cell progenitors: implications for human T-cell development

Tom TaghonK THYSMagda De SmedtF WEERKAMPFJT STAALJean PlumGeorges Leclercq

A1 Journal Article in LEUKEMIA

2002

Active form of notch imposes T cell fate in human progenitor cells

Magda De SmedtKatia ReynvoetTessa KerreTom TaghonBruno VerhasseltBart VandekerckhoveGeorges LeclercqJean Plum

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Enforced expression of HOX-A10 drives human hematopoietic precursor cells toward the monocytic lineage

Tom TaghonF StolzMagda De SmedtM CnockaertBruno VerhasseltJean PlumGeorges Leclercq

HOX en GATA : molecular control of human hematopoiesis

Tom TaghonGeorges LeclercqJean Plum

HOX-A10 regulates hematopoietic lineage commitment: evidence for a monocyte-specific transcription factor

Tom TaghonFrank StolzMagda De SmedtM CNOCKAERTBruno VerhasseltJean PlumGeorges Leclercq

A1 Journal Article in BLOOD

2001

Enforced expression of GATA-3 severely reduces human thymic cellularity

Tom TaghonMagda De SmedtFrank StolzM CNOCKAERTJean PlumGeorges Leclercq

A1 Journal Article in JOURNAL OF IMMUNOLOGY

2000

Langerhans cells that have matured in vivo in the absence of T cells are fully capable of inducing a helper CD4 as well as a cytotoxic CD8 response

An De CreusKatrien Van BenedenTom TaghonFrank StolzVeronique DebackerJean PlumGeorges Leclercq

A1 Journal Article in JOURNAL OF IMMUNOLOGY