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Researcher
Tom Taghon
Profile
Projects
Publications
Activities
Awards & Distinctions
177
Results
2024
A dual role for PSIP1/LEDGF in T cell acute lymphoblastic leukemia
Lisa Demoen
Filip Matthijssens
Lindy Reunes
Bruno Palhais
Béatrice Lintermans
Sara T'Sas
Igor Fijalkowski
Joachim Taminau
Muluembet Z. Akele
Siska Van Belle
et al.
A1
Journal Article
in
SCIENCE ADVANCES
2024
Functional evaluation of transcription factors in T-ALL : MYB and SOX11
André Pedro Pinto De Almeida
Pieter Van Vlierberghe
Steven Goossens
Tim Pieters
Tom Taghon
Dissertation
2024
HES6 knockdown in human hematopoietic precursor cells reduces their in vivo engraftment potential and their capacity to differentiate into erythroid cells, B cells, T cells and plasmacytoid dendritic cells
Tamara De Vos
Nicole Oatman
Lena Boehme
Tom Putteman
Imke Velghe
Yana Van Droogenbroeck
Stijn De Munter
Michaela Cesnekova
Filip Van Nieuwerburgh
Bart Vandekerckhove
et al.
A1
Journal Article
in
HAEMATOLOGICA
2024
KLRG1 cell depletion as a novel therapeutic strategy in patients with mature T-cell lymphoma subtypes
Bimarzhan Assatova
Robert Willim
Christopher Trevisani
Garrett Haskett
Khyati Maulik Kariya
Kusha Chopra
Sung Rye Park
Michael Yevgeniy Tolstorukov
Sean M. McCabe
Jessica Duffy
et al.
A1
Journal Article
in
CLINICAL CANCER RESEARCH
2024
Knocking out CD70 rescues CD70-specific nanoCAR T cells from antigen-induced exhaustion
Stijn De Munter
Juliane L. Buhl
Laurenz De Cock
Alexander Van Parys
Willem Daneels
Eva Pascal
Lucas Deseins
Joline Ingels
Glenn Goetgeluk
Hanne Jansen
et al.
A1
Journal Article
in
CANCER IMMUNOLOGY RESEARCH
2024
Neoantigen-targeted dendritic cell vaccination in lung cancer patients induces long-lived T cells exhibiting the full differentiation spectrum
Joline Ingels
Laurenz De Cock
Dieter Stevens
Rupert Mayer
Fabien Henri Thery
Guillem Sanchez Sanchez
David Vermijlen
Karin Weening
Saskia De Smet
Nele Lootens
et al.
A1
Journal Article
in
CELL REPORTS MEDICINE
2024
New molecular drivers and cell surface markers that characterize normal human hematopoiesis
Tamara De Vos
Tom Taghon
Jan Philippé
Dissertation
2024
TL1A and IL-18 synergy promotes GM-CSF-dependent thymic granulopoiesis in mice
Mario Ruiz Pérez
Christian Maueröder
Wolf Steels
Bruno Verstraeten
Sahine Lameire
Wei Xie
Laura Wyckaert
Jelle Huysentruyt
Tatyana Divert
Ria Roelandt
et al.
A1
Journal Article
in
CELLULAR & MOLECULAR IMMUNOLOGY
2024
ThymoSpheres culture : a model to study human polyclonal unconventional T cells
Lore Billiet
Hanne Jansen
Melissa Pille
Lena Boehme
Guillem Sanchez Sanchez
Laurenz De Cock
Glenn Goetgeluk
Eva Pascal
Stijn De Munter
Lucas Deseins
et al.
A1
Journal Article
in
EUROPEAN JOURNAL OF IMMUNOLOGY
2024
Type 1 immunity enables neonatal thymic ILC1 production
Peter Tougaard
Mario Ruiz Pérez
Wolf Steels
Jelle Huysentruyt
Bruno Verstraeten
Jessica Vetters
Tatyana Divert
Amanda Gonçalves
Ria Roelandt
Nozomi Takahashi
et al.
A1
Journal Article
in
SCIENCE ADVANCES
2024
2023
A spatial human thymus cell atlas mapped to a continuous tissue axis
Nadav Yayon
Veronika R. Kedlian
Lena Böhme
Chenqu Suo
Brianna Wachter
Rebecca T. Beuschel
Oren Amsalem
Krzysztof Polanski
Simon Koplev
Elizabeth Tuck
et al.
Preprint
2023
Circulating IRF8-expressing CD123+CD127+ lymphoid progenitors : key players in human hematopoiesis
Kai Ling Liang
Elisa Laurenti
Tom Taghon
A1
Journal Article
in
TRENDS IN IMMUNOLOGY
2023
Dendritic cell-biased precursors support early human thymopoiesis
Tom Taghon
Kai Ling Liang
Editorial material
2023
Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF
Kai Ling Liang
Juliette Roels
Marieke Lavaert
Tom Putteman
Lena Boehme
Laurentijn Tilleman
Imke Velghe
Valentina Pegoretti
Inge Van de Walle
Stephanie Sontag
et al.
A1
Journal Article
in
NATURE IMMUNOLOGY
2023
Pre-clinical evaluation of the hypomethylating agent decitabine for the treatment of T-cell lymphoblastic lymphoma
Lien Provez
Tom Putteman
Mattias Landfors
Juliette Roels
Lindy Reunes
Sara T'Sas
Wouter Van Loocke
Béatrice Lintermans
Stien De Coninck
Morgan Thenoz
et al.
A1
Journal Article
in
CANCERS
2023
RNA helicase DHX15 exemplifies a unique dependency in acute leukemia
Hao Guo
Jin Xu
Peiqi Xing
Qilong Li
Donghai Wang
Chao Tang
Bruno Palhais
Juliette Roels
Jiaxu Liu
Sa Pan
et al.
A1
Journal Article
in
HAEMATOLOGICA
2023
Single-cell profiling identifies a novel human polyclonal unconventional T cell lineage
Lore Billiet
Laurenz De Cock
Guillem Sanchez Sanchez
Rupert Mayer
Glenn Goetgeluk
Stijn De Munter
Melissa Pille
Joline Ingels
Hanne Jansen
Karin Weening
et al.
A1
Journal Article
in
JOURNAL OF EXPERIMENTAL MEDICINE
2023
The Wiskott–Aldrich syndrome protein is required for positive selection during T-cell lineage differentiation
Melissa Pille
John Avila
Guillem Sanchez Sanchez
Glenn Goetgeluk
Stijn De Munter
Hanne Jansen
Lore Billiet
Karin Weening
Haipeng Xue
Sarah Bonte
et al.
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2023
2022
Development of gamma delta T cells in the thymus : a human perspective
Lena Böhme
Juliette Roels
Tom Taghon
A1
Journal Article
in
SEMINARS IN IMMUNOLOGY
2022
IRF2 is required for development and functional maturation of human NK cells
Eva Persyn
Sigrid Wahlen
Laura Kiekens
Wouter Van Loocke
Hannah Siwe
Els Van Ammel
Zenzi De Vos
Filip Van Nieuwerburgh
Patrick Matthys
Tom Taghon
et al.
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2022
Identification and purification of human T cell precursors
Inge Van de Walle
Nina Lambrechts
Anaïs Derveeuw
Marieke Lavaert
Juliette Roels
Tom Taghon
Bookchapter
in
T-cell development : methods and protocols
2022
In vitro model systems to study human T cell development
Nina Lambrechts
Kai Ling Liang
Imke Velghe
Steven Strubbe
Anne-Catherine Dolens
Tom Taghon
Bookchapter
in
T-cell development : methods and protocols
2022
Multiomics to investigate the mechanisms contributing to repression of PTPRC and SOCS2 in pediatric T-ALL : focus on miR-363-3p and promoter methylation
Monika Drobna-Sledzinska
Natalia Mackowska-Maslak
Roman Jaksik
Maria Kosmalska
Bronislawa Szarzynska
Monika Lejman
Lukasz Sedek
Tomasz Szczepanski
Tom Taghon
Pieter Van Vlierberghe
et al.
A1
Journal Article
in
GENES CHROMOSOMES & CANCER
2022
Small-scale manufacturing of neoantigen-encoding messenger RNA for early-phase clinical trials
Joline Ingels
Laurenz De Cock
Rupert Mayer
Pam Devreker
Karin Weening
Kelly Heyns
Nele Lootens
Saskia De Smet
Marieke Brusseel
Stijn De Munter
et al.
A1
Journal Article
in
CYTOTHERAPY
2022
T-BET drives the conversion of human type 3 innate lymphoid cells into functional NK cells
Laura Kiekens
Sigrid Wahlen
Eva Persyn
Zenzi De Vos
Tom Taghon
Bart Vandekerckhove
Georges Leclercq
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2022
TXNIP promotes human NK cell development but is dispensable for NK cell functionality
Eva Persyn
Sigrid Wahlen
Laura Kiekens
Sylvie Taveirne
Wouter Van Loocke
Els Van Ammel
Filip Van Nieuwerburgh
Tom Taghon
Bart Vandekerckhove
Pieter Van Vlierberghe
et al.
A1
Journal Article
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2022
The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency
Sigrid Wahlen
Filip Matthijssens
Wouter Van Loocke
Sylvie Taveirne
Laura Kiekens
Eva Persyn
Els Van Ammel
Zenzi De Vos
Stijn De Munter
Patrick Matthys
et al.
A1
Journal Article
in
ELIFE
2022
Transcriptional dynamics and epigenetic regulation of E and ID protein encoding genes during human T cell development
Juliette Roels
Jolien Van Hulle
Marieke Lavaert
Anna Kuchmiy
Steven Strubbe
Tom Putteman
Bart Vandekerckhove
Georges Leclercq
Filip Van Nieuwerburgh
Lena Boehme
et al.
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2022
2021
A DL-4-and TNF alpha-based culture system to generate high numbers of nonmodified or genetically modified immunotherapeutic human T-lymphoid progenitors
Ranjita Devi Moirangthem
Kuiying Ma
Sabrina Lizot
Anne Cordesse
Juliette Olivre
Corinne de Chappedelaine
Akshay Joshi
Agata Cieslak
John Tchen
Nicolas Cagnard
et al.
A1
Journal Article
in
CELLULAR & MOLECULAR IMMUNOLOGY
2021
A novel non-coding variant in DCLRE1C results in deregulated splicing and induces SCID through the generation of a truncated ARTEMIS protein that fails to support V(D)J recombination and DNA damage repair
Steven Strubbe
Marieke De Bruyne
Ulrich Pannicke
Elien Beyls
Bart Vandekerckhove
Georges Leclercq
Elfride De Baere
Victoria Bordon
Anne Vral
Klaus Schwarz
et al.
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2021
A tumor suppressor enhancer of PTEN in T-cell development and leukemia
L Tottone
O Lancho
JW Loh
A Singh
S Kimura
Juliette Roels
Anna Kuchmiy
Steven Strubbe
MA Lawlor
V da Silva-Diz
et al.
A2
Journal Article
in
BLOOD CANCER DISCOVERY
2021
HES1 and HES4 have non-redundant roles downstream of Notch during early human T-cell development
Matthias De Decker
Marieke Lavaert
Juliette Roels
Laurentijn Tilleman
Bart Vandekerckhove
Georges Leclercq
Filip Van Nieuwerburgh
Pieter Van Vlierberghe
Tom Taghon
A1
Journal Article
in
HAEMATOLOGICA
2021
In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality
Sarah Bonte
Stijn De Munter
Lore Billiet
Glenn Goetgeluk
Joline Ingels
Hanne Jansen
Melissa Pille
Laurenz De Cock
Karin Weening
Tom Taghon
et al.
A1
Journal Article
in
ONCOIMMUNOLOGY
2021
In vitro modeling of SCID using primary patient cells
Steven Strubbe
Tom Taghon
Dissertation
2021
Modeling of human T cell development in vitro as a read-out for hematopoietic stem cell multipotency
Steven Strubbe
Tom Taghon
A1
Journal Article
in
BIOCHEMICAL SOCIETY TRANSACTIONS
2021
Molecular and functional dissection of early T lymphocyte development in human at the single cell level
Marieke Lavaert
Tom Taghon
Dissertation
2021
PRL3 enhances T-cell acute lymphoblastic leukemia growth through suppressing T-cell signaling pathways and apoptosis
E. G. Garcia
A. Veloso
M. L. Oliveira
J. R. Allen
S. Loontiens
D. Brunson
D. Do
C. Yan
R. Morris
S. Iyer
et al.
A1
Journal Article
in
LEUKEMIA
2021
T-BET and EOMES accelerate and enhance functional differentiation of human natural killer cells
Laura Kiekens
Wouter Van Loocke
Sylvie Taveirne
Sigrid Wahlen
Eva Persyn
Els Van Ammel
Zenzi De Vos
Patrick Matthys
Filip Van Nieuwerburgh
Tom Taghon
et al.
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2021
The RNA Atlas expands the catalog of human non-coding RNAs
Lucia Lorenzi
Hua-Sheng Chiu
Francisco Avila Cobos
Stephen Gross
Pieter-Jan Volders
Robrecht Cannoodt
Justine Nuytens
Katrien Vanderheyden
Jasper Anckaert
Steve Lefever
et al.
A1
Journal Article
in
NATURE BIOTECHNOLOGY
2021
The RNA Atlas expands the catalog of human non-coding RNAs (June, 10.1038/s41587-021-00936-1, 2021)
Lucia Lorenzi
Hua-Sheng Chiu
Francisco Avila Cobos
Stephen Gross
Pieter-Jan Volders
Robrecht Cannoodt
Justine Nuytens
Katrien Vanderheyden
Jasper Anckaert
Steve Lefever
et al.
Correction
2021
Thymic epithelial cell alterations and defective thymopoiesis lead to central and peripheral tolerance perturbation in MHCII deficiency
Francesca Ferrua
Ileana Bortolomai
Elena Fontana
Dario Di Silvestre
Rosita Rigoni
Genni Enza Marcovecchio
Elena Draghici
Francesca Brambilla
Maria Carmina Castiello
Gloria Delfanti
et al.
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2021
Treatment of a patient with severe cytomegalovirus (CMV) infection after haploidentical stem cell transplantation with donor-derived CMV-specific T cells
Joline Ingels
Saskia De Smet
Kelly Heyns
Nele Lootens
Jonas Segaert
Tom Taghon
Georges Leclercq
Karim Vermaelen
Evelyne Willems
Etienne Baudoux
et al.
A1
Journal Article
in
ACTA CLINICA BELGICA
2021
2020
A cell atlas of human thymic development defines T cell repertoire formation
Jong-Eun Park
Rachel A. Botting
Cecilia Domínguez Conde
Dorin-Mirel Popescu
Marieke Lavaert
Daniel J. Kunz
Issac Goh
Emily Stephenson
Roberta Ragazzini
Elizabeth Tuck
et al.
A1
Journal Article
in
SCIENCE
2020
Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia
Juliette Roels
Morgan Thénoz
Bronislawa Szarzynska
Mattias Landfors
Stien De Coninck
Lisa Demoen
Lien Provez
Anna Kuchmiy
Steven Strubbe
Lindy Reunes
et al.
C3
Conference
2020
Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia
Juliette Roels
Morgan Thénoz
B Szarzyńska
M Landfors
Stien De Coninck
Lisa Demoen
Lien Provez
Anna Kuchmiy
Steven Strubbe
Lindy Reunes
et al.
A2
Journal Article
in
BLOOD CANCER DISCOVERY
2020
Conventional and computational flow cytometry analyses reveal sustained human intrathymic T cell development from birth until puberty
Marieke Lavaert
Brecht Valcke
Bart Vandekerckhove
Georges Leclercq
Kai Ling Liang
Tom Taghon
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2020
Dissecting the Notch signaling pathway and its modulators during human T cell development
Anne-Catherine Dolens
Tom Taghon
Dissertation
2020
Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development
Anne-Catherine Dolens
Kaat Durinck
Marieke Lavaert
Joni Van der Meulen
Imke Velghe
Jelle De Medts
Karin Weening
Juliette Roels
Katrien De Mulder
Pieter-Jan Volders
et al.
A1
Journal Article
in
EMBO REPORTS
2020
Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development
Juliette Roels
Anna Kuchmiy
Matthias De Decker
Steven Strubbe
Marieke Lavaert
Kai Ling Liang
Georges Leclercq
Bart Vandekerckhove
Filip Van Nieuwerburgh
Pieter Van Vlierberghe
et al.
A1
Journal Article
in
NATURE IMMUNOLOGY
2020
Human thymic CD10+ PD-1+ intraepithelial lymphocyte precursors acquire interleukin-15 responsiveness at the CD1a– CD95+ CD28– CCR7– developmental stage
Lore Billiet
Glenn Goetgeluk
Sarah Bonte
Stijn De Munter
Laurenz De Cock
Melissa Pille
Joline Ingels
Hanne Jansen
Karin Weening
Filip Van Nieuwerburgh
et al.
A1
Journal Article
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2020
Integrated scRNA-seq identifies human postnatal thymus seeding progenitors and regulatory dynamics of differentiating immature thymocytes
Marieke Lavaert
Kai Ling Liang
Niels Vandamme
Jong-Eun Park
Juliette Roels
Monica S. Kowalczyk
Bo Li
Orr Ashenberg
Marcin Tabaka
Danielle Dionne
et al.
A1
Journal Article
in
IMMUNITY
2020
Large-scale circular RNA deregulation in T-ALL : unlocking unique ectopic expression of molecular subtypes
Alessia Buratin
Maddalena Paganin
Enrico Gaffo
Anna Dal Molin
Juliette Roels
Giuseppe Germano
Maria Teresa Siddi
Valentina Serafin
Matthias De Decker
Stéphanie Gachet
et al.
A1
Journal Article
in
BLOOD ADVANCES
2020
PHF6 expression levels impact human hematopoietic stem cell differentiation
Siebe Loontiens
Anne-Catherine Dolens
Steven Strubbe
Inge Van de Walle
Finola E. Moore
Lisa Depestel
Suzanne Vanhauwaert
Filip Matthijssens
David M. Langenau
Franki Speleman
et al.
A1
Journal Article
in
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
2020
Posttranslational regulation of the exon skipping machinery controls aberrant splicing in leukemia
Yalu Zhou
Cuijuan Han
Eric Wang
Adam H. Lorch
Valentina Serafin
Byoung-Kyu Cho
Blanca T. Guttierrez Diaz
Julien Calvo
Celestia Fang
Alireza Khodadadi-Jamayran
et al.
A1
Journal Article
in
CANCER DISCOVERY
2020
Rapid and effective generation of nanobody based CARs using PCR and Gibson Assembly
Stijn De Munter
Alexander Van Parys
Layla Bral
Joline Ingels
Glenn Goetgeluk
Sarah Bonte
Melissa Pille
Lore Billiet
Karin Weening
Annick Verhee
et al.
A1
Journal Article
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2020
T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources
Sarah Bonte
Stijn De Munter
Glenn Goetgeluk
Joline Ingels
Melissa Pille
Lore Billiet
Tom Taghon
Georges Leclercq
Bart Vandekerckhove
Tessa Kerre
A1
Journal Article
in
ONCOIMMUNOLOGY
2020
Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma
Renate De Smedt
Julie Morscio
Lindy Reunes
Juliette Roels
Valentina Bardelli
Béatrice Lintermans
Wouter Van Loocke
Afonso Almeida
Laurence C. Cheung
Rishi S. Kotecha
et al.
A1
Journal Article
in
BLOOD
2020
The epigenetic landscape of normal and malignant T cell development
Juliette Roels
Pieter Van Vlierberghe
Tom Taghon
Dissertation
2020
The role of Notch ligands and downstream HES target genes on human T cell development
Matthias De Decker
Tom Taghon
Dissertation
2020
The transcription factor ETS1 is an important regulator of human NK cell development and terminal differentiation
Sylvie Taveirne
Sigrid Wahlen
Wouter Van Loocke
Laura Kiekens
Eva Persyn
Els Van Ammel
Katrien De Mulder
Juliette Roels
Laurentijn Tilleman
Marc Aumercier
et al.
A1
Journal Article
in
BLOOD
2020
hsa-miR-20b-5p and hsa-miR-363-3p affect expression of PTEN and BIM tumor suppressor genes and modulate survival of T-ALL cells in vitro
Monika Drobna
Bronisława Szarzyńska
Roman Jaksik
Łukasz Sędek
Anna Kuchmiy
Tom Taghon
Pieter Van Vlierberghe
Tomasz Szczepański
Michał Witt
Małgorzata Dawidowska
A1
Journal Article
in
CELLS
2020
2019
PHF6loss drives IL7R oncogene addiction in TLX1 driven T-ALL
Siebe Loontiens
Kaat Durinck
Suzanne Vanhauwaert
Lisa Depestel
Mariana L Oliveira
Givani Dewyn
Charles De Bock
Joao T Barata
David Langenau
Jan Cools
et al.
C3
Conference
2019
Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition
Roger A. Habets
Charles E. de Bock
Lutgarde Serneels
Inge Lodewijckx
Delphine Verbeke
David Nittner
Rajeshwar Narlawar
Sofie Demeyer
James Dooley
Adrian Liston
et al.
A1
Journal Article
in
SCIENCE TRANSLATIONAL MEDICINE
2019
Stellate cells, hepatocytes, and endothelial cells imprint the Kupffer cell identity on monocytes colonizing the liver macrophage niche
Johnny Bonnardel
Wouter T'Jonck
Djoere Gaublomme
Robin Browaeys
Charlotte Scott
Liesbet Martens
Bavo Vanneste
Sofie De Prijck
Sergei A Nedospasov
Anna Kremer
et al.
A1
Journal Article
in
IMMUNITY
2019
T-cell acute lymphoblastic leukemias express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development
Charles E de Bock
Michelle Down
Kinsha Baidya
Bram Sweron
Andrew W Boyd
Mark Fiers
Gordon F Burns
Timothy J Molloy
Richard B Lock
Jean Soulier
et al.
A1
Journal Article
in
HAEMATOLOGICA
2019
The RNA Atlas, a single nucleotide resolution map of the human transcriptome
Lucia Lorenzi
Hua-Sheng Chiu
Francisco Avila Cobos
Stephen Gross
Pieter-Jan Volders
Robrecht Cannoodt
Justine Nuytens
Katrien Vanderheyden
Jasper Anckaert
Steve Lefever
et al.
Preprint
2019
ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms
Steven Goossens
Jueqiong Wang
Cedric Tremblay
Jelle De Medts
Sara T'Sas
Thao Nguyen
Jesslyn Saw
Katharina Haigh
David J Curtis
Pieter Van Vlierberghe
et al.
A1
Journal Article
in
HAEMATOLOGICA
2019
ZEB2 in T-cells and T-ALL
Stien De Coninck
Geert Berx
Tom Taghon
Pieter Van Vlierberghe
Steven Goossens
A2
Journal Article
in
ADVANCES IN BIOLOGICAL REGULATION
2019
2018
A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA+ and total RNA sequencing
Karen Verboom
Wouter Van Loocke
Pieter-Jan Volders
Bieke Decaesteker
Francisco Avila Cobos
Simon Bornschein
Charles E de Bock
Zeynep Kalender Atak
Emmanuelle Clappier
Stein Aerts
et al.
A1
Journal Article
in
HAEMATOLOGICA
2018
Deletion 6q drives T-cell leukemia progression by ribosome modulation
Stéphanie Gachet
Tiama El-Chaar
David Avran
Eulalia Genesca
Frédéric Catez
Samuel Quentin
Marc Delord
Gabriel Thérizols
Delphine Briot
Godelieve Meunier
et al.
A1
Journal Article
in
CANCER DISCOVERY
2018
Generation of adult human T-cell progenitors for immunotherapeutic applications
Laura Simons
Kuiying Ma
Corinne de Chappedelaine
Ranjita Devi Moiranghtem
Elodie Elkaim
Juliette Olivré
Sandrine Susini
Kevin Appourchaux
Christian Reimann
Hanem Sadek
et al.
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2018
SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival
Hexiu Su
Juncheng Hu
Liang Huang
Yang Yang
Morgan Thénoz
Anna Kuchmiy
Yufeng Hu
Peng Li
Hui Feng
Yu Zhou
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2018
Scrutinizing PHF6 regulatory networks in T-ALL and normal hematopoiesis using zebrafish
Siebe Loontiens
Kaat Durinck
Inge Van de Walle
Finola Moore
Suzanne Vanhauwaert
Els Janssens
Givani Dewyn
Lisa Depestel
Christophe Van Neste
David Langenau
et al.
C3
Conference
2018
2017
A murine intestinal intraepithelial NKp46-negative innate lymphoid cell population characterized by group 1 properties
Aline Van Acker
Konrad Gronke
Aindrila Biswas
Liesbet Martens
Yvan Saeys
Jessica Filtjens
Sylvie Taveirne
Els Van Ammel
Tessa Kerre
Patrick Matthys
et al.
A1
Journal Article
in
CELL REPORTS
2017
Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities
Yasmine Van Caeneghem
Stijn De Munter
Paola Tieppo
Glenn Goetgeluk
Karin Weening
Greet Verstichel
Sarah Bonte
Tom Taghon
Georges Leclercq
Tessa Kerre
et al.
A1
Journal Article
in
ONCOIMMUNOLOGY
2017
Comprehensive miRNA expression profiling in human T-cell acute lymphoblastic leukemia by small RNA-sequencing
Annelynn Wallaert
Wouter Van Loocke
Lucie Hernandez
Tom Taghon
Franki Speleman
Pieter Van Vlierberghe
A1
Journal Article
in
SCIENTIFIC REPORTS
2017
Human T cell development notched up a level
Anne-Catherine Dolens
Tom Taghon
Editorial material
2017
T-ALL and thymocytes : a message of noncoding RNAs
Annelynn Wallaert
Kaat Durinck
Tom Taghon
Pieter Van Vlierberghe
Franki Speleman
A1
Journal Article
in
JOURNAL OF HEMATOLOGY & ONCOLOGY
2017
The TLX1 oncogene modulates the enhancer RNA landscape in T-ALL
Karen Verboom
Kaat Durinck
Matthias De Decker
Wouter Van Loocke
Filip Matthijssens
Jean-Jacques Soulier
Wouter De Laat
Tom Taghon
Pieter Van Vlierberghe
Franki Speleman
C3
Conference
2017
The checkpoint for agonist selection precedes conventional selection in human thymus
Greet Verstichel
David Vermijlen
Liesbet Martens
Glenn Goetgeluk
Margreet Brouwer
Nicolas Thiault
Yasmine Van Caeneghem
Stijn De Munter
Karin Weening
Sarah Bonte
et al.
A1
Journal Article
in
SCIENCE IMMUNOLOGY
2017
2016
A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network
Ashwin Unnikrishnan
Yi Fang Guan
Yizhou Huang
Dominik Beck
Julie AI Thoms
Sofie Peirs
Kathy Knezevic
Shiyong Ma
Inge Van de Walle
Ineke de Jong
et al.
A1
Journal Article
in
NUCLEIC ACIDS RESEARCH
2016
Approaches to study human T cell development
Anne-Catherine Dolens
Inge Van de Walle
Tom Taghon
Bookchapter
in
T-Cell development : methods and protocols
2016
CRISPR-Cas9 modeling of cell lines and zebrafish to study the TLX1-PHF6 cooperative interrelationship in T-cell acute lymphoblastic leukemia
Siebe Loontiens
Kaat Durinck
Nina De Rocker
Annekatrien Boel
Els Janssens
Suzanne Vanhauwaert
Pieter Rondou
Charles De Bock
Inge Van de Walle
Finola Moore
et al.
C3
Conference
2016
Characterization and isolation of human T cell progenitors
Inge Van de Walle
Karin Davids
Tom Taghon
Bookchapter
in
T-Cell development : methods and protocols
2016
Expanding the TLX1 regulome in T-cell acute lymphoblastic leukemia towards long noncoding RNAs
Kaat Durinck
Wouter Van Loocke
Inge Van de Walle
Joni Van der Meulen
Pieter-Jan Volders
Nadine Van Roy
Yves Benoit
Bruce Poppe
Pieter Mestdagh
Jo Vandesompele
et al.
C3
Conference
2016
Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours
Jessica Filtjens
Jiri Keirsse
Els Van Ammel
Sylvie Taveirne
Aline Van Acker
Tessa Kerre
Tom Taghon
Bart Vandekerckhove
Jean Plum
Jo A Van Ginderachter
et al.
A1
Journal Article
in
SCIENTIFIC REPORTS
2016
Functional dissection of transcriptional regulation during normal and malignant T-cell development : an integrative (epi)genomic approach
Kaat Durinck
Franki Speleman
Pieter Van Vlierberghe
Tom Taghon
Dissertation
2016
GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate
Inge Van de Walle
Anne-Catherine Dolens
Kaat Durinck
Katrien De Mulder
Wouter Van Loocke
Sagar Damle
Els Waegemans
Jelle De Medts
Imke Velghe
Magda De Smedt
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2016
Humanized mice to study human T cell development
Sarah Bonte
SYLVIA SNAUWAERT
Stijn Vanhee
Anne-Catherine Dolens
Tom Taghon
Bart Vandekerckhove
Tessa Kerre
Bookchapter
in
T-Cell development : methods and protocols
2016
Long noncoding RNA signatures define oncogenic subtypes in T-cell acute lymphoblastic leukemia
Annelynn Wallaert
Kaat Durinck
Wouter Van Loocke
Inge Van de Walle
Filip Matthijssens
Pieter-Jan Volders
Francisco Avila Cobos
Dries Rombaut
Pieter Rondou
Pieter Mestdagh
et al.
A1
Journal Article
in
LEUKEMIA
2016
Modeling the TLX1-PHF6 cooperative interrelationship in T-cell acute lymphoblastic leukemia in zebrafish
Siebe Loontiens
Kaat Durinck
ELS JANSSENS
Suzanne Vanhauwaert
Pieter Rondou
Jan Cools
Charles De Bock
Inge Van de Walle
Finola Moore
David Langenau
et al.
C3
Conference
2016
NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNF AIP3/A20
Michael Drennan
Srinath Govindarajan
Eveline Verheugen
Jonathan Coquet
Jens Staal
Conor Mc Guire
Tom Taghon
Georges Leclercq
Rudi Beyaert
Geert van Loo
et al.
A1
Journal Article
in
JOURNAL OF EXPERIMENTAL MEDICINE
2016
Persistent rotavirus diarrhea post-transplant in a novel JAK3-SCID patient after vaccination
Delfien Bogaert
Kristof Van Schil
Tom Taghon
Maria Bordon Cueto De Braem
Carolien Bonroy
Melissa Dullaers
Elfride De Baere
Filomeen Haerynck
A1
Journal Article
in
PEDIATRIC ALLERGY AND IMMUNOLOGY
2016
The European Hematology Association Roadmap for European hematology research: a consensus document
Andreas Engert
Carlo Balduini
Anneke Brand
Bertrand Coiffier
Catherine Cordonnier
Hartmut Döhner
Thom Duyvené de Wit
Sabine Eichinger
Willem Fibbe
Tony Green
et al.
A1
Journal Article
in
HAEMATOLOGICA
2016
The Ly49E receptor inhibits the immune control of acute Trypanosoma cruzi infection
Jessica Filtjens
Nicolas Coltel
Sabrina Cencig
Sylvie Taveirne
Els Van Ammel
Aline Van Acker
Tessa Kerre
Patrick Matthys
Tom Taghon
Bart Vandekerckhove
et al.
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2016
The T-ALL oncogene TLX1 controls enhancer lncRNA expression
Karen Verboom
Kaat Durinck
Wouter Van Loocke
Filip Matthijssens
Inge Van de Walle
Annelynn Wallaert
Pieter-Jan Volders
Nadine Van Roy
Yves Benoit
Bruce Poppe
et al.
C3
Conference
2016
The role of Ly49E receptor expression on murine intraepithelial lymphocytes in intestinal cancer development and progression
Aline Van Acker
Els Louagie
Jessica Filtjens
Sylvie Taveirne
Els Van Ammel
Tessa Kerre
Dirk Elewaut
Tom Taghon
Bart Vandekerckhove
Jean Plum
et al.
A1
Journal Article
in
CANCER IMMUNOLOGY IMMUNOTHERAPY
2016
2015
A novel Janus kinase 3 (JAK3) mutation in a patient with severe combined immunodeficiency
Delfien Bogaert
Kristof Van Schil
Tom Taghon
Maria Bordon Cueto De Braem
Melissa Dullaers
Elfride De Baere
Filomeen Haerynck
C3
Conference
2015
Characterization of the genome-wide TLX1 binding profile in T-cell acute lymphoblastic leukemia
Kaat Durinck
Wouter Van Loocke
Joni Van der Meulen
Inge Van de Walle
Maté Ongenaert
Pieter Rondou
Annelynn Wallaert
CE de Bock
Nadine Van Roy
Bruce Poppe
et al.
A1
Journal Article
in
LEUKEMIA
2015
Chimeric antigen receptor transgenic, T cell receptor/CD3 negative monospecific T cells generated from cord blood CD34 positive cells
Yasmine Van Caeneghem
Glenn Goetgeluk
Karin Weening
Greet Verstichel
Sarah Bonte
Tom Taghon
Georges Leclercq
Fritz Offner
Hinrich Abken
Tessa Kerre
et al.
C3
Conference
2015
Epigenetics in T-cell acute lymphoblastic leukemia
Sofie Peirs
Joni Van der Meulen
Inge Van de Walle
Tom Taghon
Franki Speleman
Bruce Poppe
Pieter Van Vlierberghe
A1
Journal Article
in
IMMUNOLOGICAL REVIEWS
2015
In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis
Stijn Vanhee
Katrien De Mulder
Yasmine Van Caeneghem
Greet Verstichel
Nadine Van Roy
Björn Menten
Imke Velghe
Jan Philippé
Dominique De Bleser
Bart Lambrecht
et al.
A1
Journal Article
in
HAEMATOLOGICA
2015
MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia
Evelien Mets
Joni Van der Meulen
Gert Van Peer
Michael Boice
Pieter Mestdagh
Inge Van de Walle
Tim Lammens
Steven Goossens
Barbara De Moerloose
Yves Benoit
et al.
A1
Journal Article
in
LEUKEMIA
2015
The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia
Joni Van der Meulen
Viraj Sanghvi
Konstantinos Mavrakis
Kaat Durinck
Fang Fang
Filip Matthijssens
Pieter Rondou
Monica Rosen
Tim Pieters
Peter Vandenberghe
et al.
A1
Journal Article
in
BLOOD
2015
Transcriptional antagonism between the cooperative oncogenes TLX1 and NOTCH1 in T-cell acute lymphoblastic leukemia.
Kaat Durinck
Wouter Van Loocke
Joni Van der Meulen
Inge Van de Walle
Pieter Rondou
Charles E De Bock
Bruce Poppe
Jan Cools
Jean Soulier
Tom Taghon
et al.
C3
Conference
2015
ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling
Steven Goossens
Enrico Radaelli
Odile Blanchet
Kaat Durinck
Joni Van der Meulen
Sofie Peirs
Tom Taghon
Cedric S Tremblay
Magdaline Costa
Morvarid Farhang Ghahremani
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2015
2014
ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia
Sofie Peirs
Filip Matthijssens
Steven Goossens
Inge Van de Walle
Katia Ruggero
Charles E de Bock
Sandrine Degryse
Kirsten Canté-Barrett
Delphine Briot
Emmanuelle Clappier
et al.
A1
Journal Article
in
BLOOD
2014
ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in early immature T-cell acute lymphoblastic leukemia
Sofie Peirs
Filip Matthijssens
Steven Goossens
Kirsten Canté-Barrett
Tim Lammens
Barbara De Moerloose
Yves Benoit
Jean Soulier
Bruce Poppe
Tom Taghon
et al.
C3
Conference
2014
ABT-199 mediated inhibition of BCL2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia
Sofie Peirs
Filip Matthijssens
Steven Goossens
Charles De Bock
Kirsten Canté-Barrett
Tim Lammens
Inge Van de Walle
Barbara De Moerloose
Yves Benoit
Bruce Poppe
et al.
C3
Conference
2014
Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia
Viraj R Sanghvi
Konstantinos J Mavrakis
Joni Van der Meulen
Michael Boice
Andrew L Wolfe
Mark Carty
Prathibha Mohan
Pieter Rondou
Nicholas D Socci
Yves Benoit
et al.
A1
Journal Article
in
SCIENCE SIGNALING
2014
Contribution of the Ly49E natural killer receptor in the immune response to Plasmodium berghei infection and control of hepatic parasite development
Jessica Filtjens
Lander Foquet
Sylvie Taveirne
Els Van Ammel
Mandy Vanhees
Aline Van Acker
Tessa Kerre
Tom Taghon
Bart Vandekerckhove
Jean Plum
et al.
A1
Journal Article
in
PLOS ONE
2014
In vitro generation of mature, naive antigen-specific CD8⁺ T cells with a single T-cell receptor by agonist selection
SYLVIA SNAUWAERT
Greet Verstichel
Sarah Bonte
Glenn Goetgeluk
Stijn Vanhee
Yasmine Van Caeneghem
Katrien De Mulder
Carlo Heirman
Hans Stauss
Miriam HM Heemskerk
et al.
A1
Journal Article
in
LEUKEMIA
2014
In vitro human embryonic stem cell hematopoiesis mimics MYB independent yolk sac hematopoiesis
Stijn Vanhee
Katrien De Mulder
Yasmine Van Caeneghem
Nadine Van Roy
Björn Menten
Imke Velghe
Jan Philippé
Tom Taghon
Georges Leclercq
Tessa Kerre
et al.
C3
Conference
2014
Integrative analysis of the NOTCH1 regulatory network identifies key downstream lncRNAs in acute T-cell lymphoblastic leukemia and normal T-cell development
Annelynn Wallaert
Kaat Durinck
Pieter Rondou
Inge Van de Walle
Wouter Van Loocke
Pieter-Jan Volders
Maté Ongenaert
Nadine Van Roy
Bruce Poppe
Yves Benoit
et al.
C3
Conference
2014
Integrative genomic and transcriptomic analysis identified candidate genes implicated in the pathogenesis of hepatosplenic T-cell lymphoma
Julio Finalet Ferreiro
Leila Rouhigharabaei
Helena Urbankova
Jo-Anne van der Krogt
Lucienne Michaux
Shashirekha Shetty
Laszlo Krenacs
Thomas Tousseyn
Pascale De Paepe
Anne Uyttebroeck
et al.
A1
Journal Article
in
PLOS ONE
2014
Ly49E Expression on CD8αα-expressing intestinal intraepithelial lymphocytes plays no detectable role in the development and progression of experimentally induced inflammatory bowel diseases
Aline Van Acker
Jessica Filtjens
Sophie Van Welden
Sylvie Taveirne
Els Van Ammel
Mandy Vanhees
Lindsey Devisscher
Tessa Kerre
Tom Taghon
Bart Vandekerckhove
et al.
A1
Journal Article
in
PLOS ONE
2014
MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia
Evelien Mets
Gert Van Peer
Joni Van der Meulen
Michael Boice
Tom Taghon
Steven Goossens
Pieter Mestdagh
Yves Benoit
Barbara De Moerloose
Nadine Van Roy
et al.
A1
Journal Article
in
HAEMATOLOGICA
2014
Notch3 activation is sufficient but not required for inducing human T-lineage specification
Els Waegemans
Inge Van de Walle
Jelle De Medts
Magda De Smedt
Tessa Kerre
Bart Vandekerckhove
Georges Leclercq
Tao Wang
Jean Plum
Tom Taghon
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2014
The NOTCH1 driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia
Annelynn Wallaert
Kaat Durinck
Pieter Rondou
Inge Van de Walle
Wouter Vanloocke
Pieter-Jan Volders
Suzanne Vanhauwaert
Ellen Geerdens
Maté Ongenaert
Nadine Van Roy
et al.
C3
Conference
2014
The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia
Kaat Durinck
Annelynn Wallaert
Inge Van de Walle
Wouter Van Loocke
Pieter-Jan Volders
Suzanne Vanhauwaert
Ellen Geerdens
Yves Benoit
Nadine Van Roy
Bruce Poppe
et al.
A1
Journal Article
in
HAEMATOLOGICA
2014
The first lncRNA landscape of major genetic T-ALL subsets and guilt-by-association analysis for ETP-ALL specific lncRNAs
Annelynn Wallaert
Kaat Durinck
Wouter Van Loocke
Pieter-Jan Volders
Inge Van de Walle
Yves Benoit
Bruce Poppe
Jo Vandesompele
Tom Taghon
Jean Soulier
et al.
C3
Conference
2014
The role of Notch3 at discrete developmental stages of early human T cell development
Els Waegemans
Tom Taghon
Jean Plum
Dissertation
2014
2013
Abundant stage-dependent Ly49E expression by liver NK cells is not essential for their differentiation and function
Jessica Filtjens
Sylvie Taveirne
Aline Van Acker
Els Van Ammel
Mandy Vanhees
Tessa Kerre
Tom Taghon
Bart Vandekerckhove
Jean Plum
Georges Leclercq
A1
Journal Article
in
JOURNAL OF LEUKOCYTE BIOLOGY
2013
CMYB expression during human in vitro hematopoiesis
Stijn Vanhee
Yasmine Van Caeneghem
Katrien De Mulder
Imke Velghe
Sylvie Taveirne
Nadine Van Roy
Björn Menten
SYLVIA SNAUWAERT
Greet Verstichel
Melissa Dullaers
et al.
C3
Conference
2013
Differential Ly49e expression pathways in resting versus TCR-activated intraepithelial γδ T cells
Tina Van Den Broeck
Els Van Ammel
Maarten Delforche
Sylvie Taveirne
Tessa Kerre
Bart Vandekerckhove
Tom Taghon
Jean Plum
Georges Leclercq
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2013
MiR-128 is a novel PHF6 targeting regulatory non-coding RNA acting as a T-ALL oncogene
Evelien Mets
Joni Van der Meulen
Gert Van Peer
Michael Boice
Pieter Mestdagh
Tom Taghon
David Avran
Barbara De Moerloose
Yves Benoit
Bruce Poppe
et al.
C3
Conference
2013
Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms
Anouk Van Nuffel
Kevin Ariën
Veronique Stove
Michael Schindler
Eduardo O'Neill
Jan Schmökel
Inge Van de Walle
Evelien Naessens
Hanne Vanderstraeten
Kathleen Van Landeghem
et al.
A1
Journal Article
in
RETROVIROLOGY
2013
Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength
Inge Van de Walle
Els Waegemans
Jelle De Medts
Greet De Smet
Magda De Smedt
SYLVIA SNAUWAERT
Bart Vandekerckhove
Tessa Kerre
Georges Leclercq
Jean Plum
et al.
A1
Journal Article
in
JOURNAL OF EXPERIMENTAL MEDICINE
2013
2012
Notch induces human T-cell receptor γδ+ thymocytes to differentiate along a parallel, highly proliferative and bipotent CD4 CD8 double-positive pathway
Stefanie Van Coppernolle
Stijn Vanhee
Greet Verstichel
SYLVIA SNAUWAERT
A van der Spek
Imke Velghe
Mieke Sinnesael
MH Heemskerk
Tom Taghon
Georges Leclercq
et al.
A1
Journal Article
in
LEUKEMIA
2012
Notch ligands control the human alpha beta/gamma delta lineage choice through receptor-specific induction of differential Notch signal strength
Tom Taghon
Inge Van de Walle
Els Waegemans
Jelle De Medts
Greet De Smet
Magda De Smedt
Bart Vandekerckhove
Tessa Kerre
Georges Leclercq
Tao Wang
et al.
C3
Conference
2012
Notch signaling during human T cell development
Tom Taghon
Els Waegemans
Inge Van de Walle
A1
Journal Article
in
Current Topics in Microbiology and Immunology
2012
Quantification of reverse transcriptase activity by real-time PCR as a fast and accurate method for titration of HIV, lenti- and retroviral vectors
JOLIEN VERMEIRE
Evelien Naessens
Hanne Vanderstraeten
Alessia Landi
Veronica Iannucci
Anouk Van Nuffel
Tom Taghon
Massimo Pizzato
Bruno Verhasselt
A1
Journal Article
in
PLOS ONE
2012
RHAMM/HMMR (CD168) is not an ideal target antigen for immunotherapy of acute myeloid leukemia
SYLVIA SNAUWAERT
Stijn Vanhee
Glenn Goetgeluk
Greet Verstichel
Yasmine Van Caeneghem
Imke Velghe
Jan Philippé
Zwi N Berneman
Jean Plum
Tom Taghon
et al.
A1
Journal Article
in
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
2012
2011
A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)
Konstantinos J Mavrakis
Joni Van der Meulen
Andrew L Wolfe
Xiaoping Liu
Evelien Mets
Tom Taghon
Aly A Khan
Manu Setty
Pieter Rondou
Peter Vandenberghe
et al.
A1
Journal Article
in
NATURE GENETICS
2011
A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)
Evelien Mets
Joni Van der Meulen
Konstantinos J Mavrakis
Andrew L Wolfe
Tom Taghon
Aly A Khan
Manu Setty
Xiaoping Liu
Pieter Rondou
Peter Vandenberghe
et al.
C3
Conference
2011
A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia
Apostolos Klinakis
Camille Lobry
Omar Abdel-Wahab
Philmo Oh
Hiroshi Haeno
Silvia Buonamici
Inge van De Walle
Severine Cathelin
Thomas Trimarchi
Elisa Araldi
et al.
A1
Journal Article
in
NATURE
2011
CD27-deficient mice show normal NK-cell differentiation but impaired function upon stimulation
Veerle De Colvenaer
Sylvie Taveirne
Maarten Delforche
Magda De Smedt
Bart Vandekerckhove
Tom Taghon
Louis Boon
Jean Plum
Georges Leclercq
A1
Journal Article
in
IMMUNOLOGY AND CELL BIOLOGY
2011
Cooperative miRNA mediated FBXW7 suppression contributes to T-cell lymphoblastic leukemogenesis
Evelien Mets
Joni Van der Meulen
Konstantinos J Mavrakis
Andrew L Wolfe
Tom Taghon
Aly A Khan
Manu Setty
Xiaoping Liu
Peter Vandenberghe
Eric Delabesse
et al.
C3
Conference
2011
Double positive and double negative TCR gamma delta plus cells independently generate mature functional TCR gamma delta plus cells in the human thymus
Stefanie Van Coppernolle
Stijn Vanhee
Greet Verstichel
SYLVIA SNAUWAERT
Imke Velghe
Mieke Sinnesael
A van der Spek
Tom Taghon
Georges Leclercq
Jean Plum
et al.
C3
Conference
2011
EVI1-mediated down regulation of MIR449A is essential for the survival of EVI1 positive leukaemic cells
An De Weer
Joni Van der Meulen
Pieter Rondou
Tom Taghon
Torsten A Konrad
Katleen De Preter
Pieter Mestdagh
Tom Van Maerken
Nadine Van Roy
Marta Jeison
et al.
A1
Journal Article
in
BRITISH JOURNAL OF HAEMATOLOGY
2011
In vitro generation of immune cells from pluripotent stem cells
Bart Vandekerckhove
Stijn Vanhee
Stefanie Van Coppernolle
SYLVIA SNAUWAERT
Imke Velghe
Tom Taghon
Georges Leclercq
Tessa Kerre
Jean Plum
A1
Journal Article
in
FRONTIERS IN BIOSCIENCE-LANDMARK
2011
Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8αα intestinal intraepithelial T lymphocytes
Sylvie Taveirne
Jessica Filtjens
Els Van Ammel
Veerle De Colvenaer
Tessa Kerre
Tom Taghon
Bart Vandekerckhove
Jean Plum
Werner Held
Georges Leclercq
A1
Journal Article
in
BLOOD
2011
Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions
Inge Van de Walle
Greet De Smet
Martina Gärtner
Magda De Smedt
Els Waegemans
Bart Vandekerckhove
Georges Leclercq
Jean Plum
Jon C Aster
Irwin D Bernstein
et al.
A1
Journal Article
in
BLOOD
2011
Langerhans cells are not required for epidermal Vγ3 T cell homeostasis and function
Sylvie Taveirne
Veerle De Colvenaer
Tina Van Den Broeck
Els Van Ammel
Clare L Bennett
Tom Taghon
Bart Vandekerckhove
Jean Plum
Björn E Clausen
Daniel H Kaplan
et al.
A1
Journal Article
in
JOURNAL OF LEUKOCYTE BIOLOGY
2011
Regulatory networks governed by microRNAs in T-ALL oncogenesis and normal T-cell development
Joni Van der Meulen
Evelien Mets
Pieter Mestdagh
Peter Pipelers
Tom Taghon
David Camacho Trujillo
David Avran
Gert Van Peer
Nadine Van Roy
Olivier Thas
et al.
C3
Conference
2011
T-lymphoid differentiation potential measured in vitro is higher in CD34+CD38-/lo hematopoietic stem cells from umbilical cord blood than from bone marrow and is an intrinsic property of the cells
Magda De Smedt
Georges Leclercq
Bart Vandekerckhove
Tessa Kerre
Tom Taghon
Jean Plum
A1
Journal Article
in
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
2011
2010
Continuous CD27 triggering in vivo strongly reduces NK cell numbers
Veerle De Colvenaer
Sylvie Taveirne
Jörg Hamann
Alex M de Bruin
Magda De Smedt
Tom Taghon
Bart Vandekerckhove
Jean Plum
René van Lier
Georges Leclercq
A1
Journal Article
in
EUROPEAN JOURNAL OF IMMUNOLOGY
2010
PHF6 mutations in T-cell acute lymphoblastic leukemia
Pieter Van Vlierberghe
Teresa Palomero
Hossein Khiabanian
Joni Van der Meulen
Mireia Castillo
Nadine Van Roy
Barbara De Moerloose
Jan Philippé
Sara Gonzalez-Garcia
Maria L Toribio
et al.
A1
Journal Article
in
NATURE GENETICS
2010
2009
An early decrease in Notch activation is required for human TCR-αβ lineage differentiation at the expense of TCR-γδ T cells
Inge Van de Walle
Greet De Smet
Magda De Smedt
Bart Vandekerckhove
Georges Leclercq
Jean Plum
Tom Taghon
A1
Journal Article
in
BLOOD
2009
CD4 and CD8 TCR alpha beta cells are selected on MHC expressed on thymocyte precursors in OP9-DL1 cultures
Stefanie Van Coppernolle
Bart Vandekerckhove
Greet Verstichel
Imke Velghe
Tom Taghon
Georges Leclercq
Jean Plum
Tessa Kerre
C3
Conference
2009
Functionally mature CD4 and CD8 TCRαβ cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells
Stefanie Van Coppernolle
Greet Verstichel
Frank Timmermans
Imke Velghe
David Vermijlen
Magda De Smedt
Georges Leclercq
Jean Plum
Tom Taghon
Bart Vandekerckhove
et al.
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2009
Generation of T cells from human embryonic stem cell-derived hematopoietic zones
Frank Timmermans
Imke Velghe
Lieve Vanwalleghem
Magda De Smedt
Stefanie Van Coppernolle
Tom Taghon
Harry Moore
Georges Leclercq
Anton Langerak
Tessa Kerre
et al.
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2009
MICRORNA SIGNATURES IN GENETIC SUBTYPES OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
Joni Van der Meulen
Pieter Van Vlierberghe
Pieter Mestdagh
Jo Vandesompele
Bruce Poppe
Nadine Van Roy
Tom Taghon
Jean Plum
B. Cauwelier
DLD Selleslag
et al.
C3
Conference
2009
Notch signaling is required for proliferation but not for differentiation at a well-defined β-selection checkpoint during human T-cell development
Tom Taghon
Inge Van de Walle
Greet De Smet
Magda De Smedt
Georges Leclercq
Bart Vandekerckhove
Jean Plum
A1
Journal Article
in
BLOOD
2009
Regulation of early T cell development in mouse and human by Notch
Tom Taghon
A4
Journal Article
in
VERHANDELINGEN VAN DE KONINKLIJKE ACADEMIE VOOR GENEESKUNDE VAN BELGIË
2009
2008
Generation of T cells from human embryonic stem cells
Frank Timmermans
Imke Velghe
Lieve Vanwalleghem
Magda De Smedt
Stefanie Van Coppernolle
Georges Leclercq
Tom Taghon
Harry Moore
Anton W Langerak
Tessa Kerre
et al.
C3
Conference
2008
Human intrathymic development: a selective approach
Jean Plum
Magda De Smedt
Georges Leclercq
Tom Taghon
Tessa Kerre
Bart Vandekerckhove
A1
Journal Article
in
SEMINARS IN IMMUNOPATHOLOGY
2008
Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator
Tina Van Den Broeck
Frederick Stevenaert
Sylvie Taveirne
Veronique Debacker
CHRISTEL VANGESTEL
Bart Vandekerckhove
Tom Taghon
Patrick Matthys
Jean Plum
Werner Held
et al.
A1
Journal Article
in
Blood
2008
MicroRNA signatures in genetic subtypes of T-cell acute lymphoblastic leukemia.
Pieter Van Vlierberghe
Bruce Poppe
Nadine Van Roy
Tom Taghon
Jean Plum
B Cauwelier
D Selleslag
P Heimann
P Vandenberghe
N Dastugue
et al.
C3
Conference
2008
Molecular mechanisms that control mouse and human TCR-alpha beta and TCR-gamma delta T cell development
Tom Taghon
Ellen V. Rothenberg
A1
Journal Article
in
SEMINARS IN IMMUNOPATHOLOGY
2008
Stage-dependent molecular changes in Notch signaling are critical for normal human T cell development
Tom Taghon
Inge Van de Walle
Greet De Smet
Magda De Smedt
Jean Plum
C3
Conference
2008
2007
Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3
Tom Taghon
MA YUI
EV ROTHENBERG
A1
Journal Article
in
NATURE IMMUNOLOGY
2007
Molecular dissection of prethymic progenitor entry into the T lymphocyte developmental pathway
CC TYDELL
ES DAVID-FUNG
JE MOORE
L ROWEN
Tom Taghon
EV ROTHENBERG
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2007
Notch signaling induces cytoplasmic CD3 epsilon expression in human differentiating NK cells
Magda De Smedt
Tom Taghon
Inge Van de Walle
Greet De Smet
Georges Leclercq
Jean Plum
A1
Journal Article
in
BLOOD
2007
Tumor necrosis factor promotes T-cell at the expense of B-cell lymphoid development from cultured human CD34(+) cord blood cells
K SMITS
Magda De Smedt
Evelien Naessens
Greet De Smet
Veronique Stove
Tom Taghon
Jean Plum
Bruno Verhasselt
A1
Journal Article
in
EXPERIMENTAL HEMATOLOGY
2007
2006
Developmental and molecular characterization of emerging beta- and gamma delta-selected pre-T cells in the adult mouse thymus
Tom Taghon
MA YUI
R PANT
RA DIAMOND
EV ROTHENBERG
A1
Journal Article
in
IMMUNITY
2006
Notch/Delta signaling constrains reengineering of pro-T cells by PU.1
CB FRANCO
DD SCRIPTURE-ADAMS
I PROEKT
Tom Taghon
AH WEISS
MA YUI
SL ADAMS
RA DIAMOND
EV ROTHENBERG
A1
Journal Article
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2006
Progression of regulatory gene expression states in fetal and adult pro-T-cell development
ES DAVID-FUNG
MA YUI
M MORALES
H WANG
Tom Taghon
RA DIAMOND
EV ROTHENBERG
A1
Journal Article
in
IMMUNOLOGICAL REVIEWS
2006
2005
Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling
Tom Taghon
ES DAVID
JC ZUNIGA-PFLUCKER
EV ROTHENBERG
A1
Journal Article
in
GENES & DEVELOPMENT
2005
Molecular genetics of T cell development
EV ROTHENBERG
Tom Taghon
A1
Journal Article
in
ANNUAL REVIEW OF IMMUNOLOGY
2005
2003
Homeobox gene expression profile in human hematopoietic multipotent stem cells and T-cell progenitors: implications for human T-cell development
Tom Taghon
K THYS
Magda De Smedt
F WEERKAMP
FJT STAAL
Jean Plum
Georges Leclercq
A1
Journal Article
in
LEUKEMIA
2003
2002
Active form of notch imposes T cell fate in human progenitor cells
Magda De Smedt
Katia Reynvoet
Tessa Kerre
Tom Taghon
Bruno Verhasselt
Bart Vandekerckhove
Georges Leclercq
Jean Plum
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2002
Enforced expression of HOX-A10 drives human hematopoietic precursor cells toward the monocytic lineage
Tom Taghon
F Stolz
Magda De Smedt
M Cnockaert
Bruno Verhasselt
Jean Plum
Georges Leclercq
C3
Conference
2002
HOX en GATA : molecular control of human hematopoiesis
Tom Taghon
Georges Leclercq
Jean Plum
Dissertation
2002
HOX-A10 regulates hematopoietic lineage commitment: evidence for a monocyte-specific transcription factor
Tom Taghon
Frank Stolz
Magda De Smedt
M CNOCKAERT
Bruno Verhasselt
Jean Plum
Georges Leclercq
A1
Journal Article
in
BLOOD
2002
2001
Enforced expression of GATA-3 severely reduces human thymic cellularity
Tom Taghon
Magda De Smedt
Frank Stolz
M CNOCKAERT
Jean Plum
Georges Leclercq
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2001
2000
Langerhans cells that have matured in vivo in the absence of T cells are fully capable of inducing a helper CD4 as well as a cytotoxic CD8 response
An De Creus
Katrien Van Beneden
Tom Taghon
Frank Stolz
Veronique Debacker
Jean Plum
Georges Leclercq
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2000