Histology is the study of human or animal tissue at the cellular level and is the basis of fundamental and translational biomedical research. The Core Facility Histology, part of the recognized Core ARTH, has basic equipment for the preparation and evaluation of tissue samples in the context of histo(patho)logical and immunohistochemical research. This currently includes equipment for tissue preparation, embedding, sectioning, staining and simple microscopy. Given that research into the physiology and pathophysiology of tissues and organs involves a complex network of different cells, there is need for a system that allows identification of different markers within the same tissue sample. With this application, we wish to supplement the Core Facility Histology with a spatial multiplex imaging device, based on fluorescence and spectral imaging, that is affordable and user-friendly for everyone and with which research can be performed at a competitive level.