Investigating itaconic acid as a critical immunometabolite in Influenza and RSV infections

Characterizing the role of microglial inflammation in neurodegeneration

Doctoral project Arne Martens

Doctoral project Brecht Rogiers

Doctoral project Leen Catrysse

Doctoral project Maude Jans

Doctoral project Maude Jans

Doctoral project Sofie Voet

Investigating critical mediators of inflammatory disease

OTULIN in neuroinflammation, multiple sclerosis and Alzheimer pathology

OTULIN in neuroinflammation, multiple sclerosis and Alzheimer pathology

studie van de mechanismen die de darmhomeostase en pathologie controleren

Unravelling molecular mechanisms mediating skin inflammation and tumour formation

Unravelling the role of OTULIN in liver and intestinal pathology.

Doctoral project Lise Van Wyngene

OTULIN as a crucial regulator of keratinocyte death, stem cell identity and WNT signaling

A20 as a tool to dissect the crosstalk between chronic inflammation and ER stress

Afwerkersbeurs Emmanuel Van der Schueren Karolina: Characterization of an aggressive and microbiota-dependent colon cancer model

BOF-ZAP professorship in biomedical molecular biology

BOF-ZAP-professorship in inflammatory pathologies

Cell type specific functional analysis of inflammasome signalling in the colon, and its role in IBD

Characterizing the in vivo importance of OTULIN in liver through mouse gene targeting studies

Characterizing the in vivo importance of OTULIN through mouse gene targeting studies

Charcot Stichting - Fund 2022: Investigating itaconic acid as a critical immunometabolite in multiple sclerosis

Endoplasmic reticulum stress in autoimmune central nervous system inflammation and demyelination.

Host-microbe interaction in intestinal homeostasis: unravelling the mechanisms involved in the onset of multiple inflammation-related diseases

Identification of molecular cues mediating inflammation and tumorpromoting properties of skin fibroblasts

Investigating microglia inflammasome activation and regulation in Alzheimer disease

Investigating the molecular mechanisms and therapeutic use of A20 and MYSM1 in inflammatory signaling and pathology

Investigating the role and molecular mechanisms of two distinct cell death modalities in cutaneous regenerative and neoplastic inflammation

: In vivo study of optineurin in inflammation and autophagy

Manipulation of fibroblast-mediated proteolytic events in the cutaneous wound and tumour microenvironment

Microglia, inflammasomes and multiple sclerosis

Molecular mechanisms of cellular crosstalk in skin regeneration and cancer

Molecular mechanisms of cellular crosstalk in skin regeneration and cancer

NF-kB, autophagy and ER stress in homeostasis and pathology of the intestine.

Novel mechanisms of inflammation and cell death regulation in autoinflammatory and infectious diseases

OTULIN in neuroinflammation an Alzheimer pathology

OTULIN in neuroinflammation, multiple sclerosis and Alzheimer pathology

Regulation of inflammatory signalling in homeostasis and disease

Study of host-microbiota interactions in colon cancer

Study of microbiota-host interactions during colon cancer development using a unique microbiome dependent mouse model

Study of molecular mechanisms driving inflammation-induced intestinal cancer

Study of the impact of chronic intestinal inflammation on stem cell function and its consequences for epithelial transformation and cancer development

Study of the molecular mechanisms by which chronic intestinal inflammation affects stem cell function leading to epithelial inflammation and cancer development

Study of the molecular pathways through which linear (de)ubiquitination governs skin inflammation and aberrant epidermal stem cell activation

Study of the NF-kB inhibitory protein A20 in the liver and liver pathologies like hepatocellular carcinoma

Study of the (patho)physiological role of NF-kB inhibitors A20 and ABINs through genetic

Study of the role of A20 in intestinal homeostasis and pathology by means of conditional knockout mice

Study of the role of the endoplasmic reticulum stress in the pathology of multiple sclerosis

Study of the role of the NF-B regulatory protein A20 in autoimmune central nervous system inflammation

Study of the role of the NF-kB-inhibiting protein A20 in diabetes

Study of the role of the NF-kB inhibitory protein A20 in inflammation-associated cancer

Study of the role of the NF-kB-inhibitory protein A20 in inflammation-associated cancer

Targeting the mevalonate pathway to treat inflammatory diseases

The impact of cell death on the cancer stem cell niche in non-melanoma skin cancer

The unfolded protein response in intestinal physiology and inflammatory pathology

Characterisation of the physiological role of the NF-kB inhibitor A20 via genetic modification in mice

Characterization of the physiological role of the NF-kB and IFN regulatory proteins A20 and DUBA by genetic modification in the mouse.

Integrated proteome-centric analysis of immune regulation

Negative regulation of NF-kB in the pathophysiology of rheumatoid arthritis and systemic lupus erythermatosus

Study of the role of NF-kB regulatory signalling molecules involved in multiple sclerosis through gene targeting in the mouse

BOF-ZAP professorship in biomedical molecular biology

BOF-ZAP-professorship in inflammatory pathologies

Investigating the effects of regulatory phosphorylation and linear ubiquitination on Pyrin-mediated auto-inflammatory disorders.