Chronic inflammation reactions can give rise to the formation and growth of tumors. The transcription factor NF-kB plays a decisive role. Transcription factors are proteins that play a role in the mechanisms that control gene expression. The cell mechanisms which are controlled by NF-kB (expression of cytokines, growth factors, and survival proteins), characteristic of inflammatory reactions, are an ideal breeding ground for the development of tumors. A possible therapy for the treatment of such "inflammation-associated" cancers regard, therefore, the intervention at the level of the NF-kB. An important regulatory protein (protein A20) protects against excessive NF-kB activation. Recent evidence, however, suggests that A20 is not only crucial in the control of NF-kB, but also could be crucial in the control of various mechanisms that trigger the cell death. In our studies, we want also the importance of these mechanisms and the specific contribution of A20 herein, consider the control of inflammation involved in the development of inflammation-associated cancers.