Research Explorer

Project

Cell type specific functional analysis of inflammasome signalling in the colon, and its role in IBD
Code
3E020113
Duration
01 October 2013 → 30 September 2019
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Gastro-enterology and hepatology
    • Immunology
    • Gastro-enterology and hepatology
    • Immunology
    • Gastro-enterology and hepatology
    • Immunology
Keywords
inflammasomes intestinal inflammation gut microbiome
 
Project description
 

Defects in inflammasome signalling are linked to IBD development in humans. Moreover, inflammasome signalling influences the composition of the gut microbiome. As inflammasome activity depends on the enzymatic function of either caspase-1 or caspase-11, we will investigate wich of these caspase units is involved in these connections and in which intestinal cell type(s) this acts to influence intestinal inflammation.