Research Explorer

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Project

Investigating the effects of regulatory phosphorylation and linear ubiquitination on Pyrin-mediated auto-inflammatory disorders.

Outputs and Outcomes

Code

01J09219

Duration

01 October 2019 → 30 July 2024

Funding

Regional and community funding: Special Research Fund

Promotor

Andy Wullaert

Research disciplines

Medical and health sciences
- Medical proteomics

Keywords

Inflammasome Auto-inflammatory diseases Phosphorylation Ubiquitination

Project description

Enhanced inflammasome signaling due to Pyrin mutations underlie auto-inflammation in Familial Mediterranean Fever (FMF). We obtained evidence that also Otulin-related auto-inflammatory syndrome (ORAS) involves enhanced Pyrin signaling. In this project, we will investigate the mechanisms by which Pyrin signaling is regulated by phosphorylation and linear ubiquitination, and how this modulates Pyrin-mediated auto-inflammation in FMF and ORAS mouse models.

English

Dutch

English

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