Research Explorer

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Researcher

Geert van Loo

Awards & Distinctions

162 Results

2024

A20 : a jack of all trades

Pieter HertensGeert van Loo

A1 Journal Article in TRENDS IN CELL BIOLOGY

Inflammasome signaling is dispensable for ß-amyloid-induced neuropathology in preclinical models of Alzheimer's disease

Sahana SrinivasanDaliya KanchevaSofie De RenTakashi SaitoMaude JansFleur BooneCharysse VandendriesscheIne PaesmansHerve MaurinRoosmarijn Vandenbroucke et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Regulation of inflammasome signaling by the linear deubiquitinase OTULIN

Maria Giulia DoglioAndy WullaertGeert van Loo

2023

A20 regulates lymphocyte adhesion in murine neuroinflammation by restricting endothelial ICOSL expression in the CNS

Lisa JohannSasha SoldatiKristin MüllerJosephine LampeFederico MariniMatthias KleinEva SchrammNathalie RiesCarsten SchelmbauerIlaria Palagi et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Autophagy critically controls skin inflammation and apoptosis-induced stem cell activation

Lisette Van HoveAnnagiada TonioloMohammad GhiaslooKim LecomteFleur BooneMaarten CiersKris RaaijmakersNiels VandammeJana RoelsSophia Maschalidi et al.

A1 Journal Article in AUTOPHAGY

Death by TNF : a road to inflammation

Geert van LooMathieu Bertrand

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression

Emily Van SanAngela DebruyneGeraldine VeeckmansYulia Y. Y. TyurinaVladimir A. A. TyurinHao ZhengSze Men ChoiKoen AugustynsGeert van LooBernhard Michalke et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Gasdermin D independent canonical inflammasome responses cooperate with caspase-8 to establish host defense against gastrointestinal Citrobacter rodentium infection

Elien EeckhoutLisa HamerlinckVeronique JonckheerePetra Van DammeGeert van LooAndy Wullaert

A1 Journal Article in CELL DEATH & DISEASE

Glycyrrhizin-based hydrogels accelerate wound healing of normoglycemic and diabetic mouse skin

Maarten A. MeesFleur BooneThomas BouwenFrederik VanaerschotCharlotte TitecaHanna-Kaisa VikkulaLeen CatrysseAnja VananroyeErin KoosStelios Alexandris et al.

A1 Journal Article in PHARMACEUTICS

Myeloid OTULIN deficiency couples RIPK3-dependent cell death to Nlrp3 inflammasome activation and IL-1β secretion

Maria Giulia DoglioLien VerboomEmily Ruilova SosorangaUlrika FrisingTomoko AsaokaYannick GansemansFilip Van NieuwerburghGeert van LooAndy Wullaert

A1 Journal Article in SCIENCE IMMUNOLOGY

OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection

Lien VerboomChristopher AndersonMaude JansIoanna PettaGillian BlanckeArne MartensMozes SzeTino HochepiedKodi RavichandranLars Vereecke et al.

A1 Journal Article in CELL DEATH & DISEASE

Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice

Karel Van DammePieter HertensArne MartensElisabeth GilisDario PriemInge BruggemanAmelie FossoulJozefien DeclercqHelena Catharine AegerterAndy Wullaert et al.

A1 Journal Article in SCIENTIFIC REPORTS

Sterile triggers drive joint inflammation in TNF‐ and IL-1β‐dependent mouse arthritis models

Alexandra ThiranIoanna PettaGillian BlanckeMarie ThorpGuillaume PlanckaertMaude JansVanessa AndriesKorneel BarbryElisabeth GilisJulie Coudenys et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

The autoinflammation-associated NLRC4<SUP>V341A</SUP> mutation increases microbiota-independent IL-18 production but does not recapitulate human autoinflammatory symptoms in mice

Elien EeckhoutTomoko AsaokaHanne Van GorpDieter DemonCharlotte Girard-Guyonvarc'hVanessa AndriesLars VereeckeCem GabayMohamed LamkanfiGeert van Loo et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Unravelling the role of OTULIN in liver and intestinal pathology

Lien VerboomGeert van Loo

2022

A20 controls RANK-dependent osteoclast formation and bone physiology

Arne MartensPieter HertensDario PriemVagelis RinotasTheodore MeletakosMeropi GennadiLisette Van HoveEls LouagieJulie CoudenysAmélie De Muynck et al.

A1 Journal Article in EMBO REPORTS

ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation

Richard de ReuverSimon VerdonckEvelien DierickJosephine NemegeerEline HessmannSadeem AhmadMaude JansGillian BlanckeFilip Van NieuwerburghAlexander Botzki et al.

A1 Journal Article in NATURE

ATG9A prevents TNF cytotoxicity by an unconventional lysosomal targeting pathway.

Jon HuygheDario PriemLisette Van HoveBarbara GilbertJ FritschY UchiyamaEsther HosteGeert van LooMathieu Bertrand

A1 Journal Article in SCIENCE

Bacillus anthracis induces NLRP3 inflammasome activation and caspase-8-mediated apoptosis of macrophages to promote lethal anthrax

Filip Van HauwermeirenNina Van OpdenboschHanne Van GorpNathalia de VasconcelosGeert van LooPeter VandenabeeleThirumala-Devi KannegantiMohamed Lamkanfi

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NF-κB-inducing kinase (NIK) is activated in pancreatic β-cells but does not contribute to the development of diabetes

P XiaoT TakiishiNM ViolatoG LicataF DottaG SebastianiL MarselliSP SinghMozes SzeGeert van Loo et al.

A1 Journal Article in CELL DEATH & DISEASE

Nlrp3 inflammasome activation in macrophages suffices for inducing autoinflammation in mice

Ulrika FrisingSilvia Ribó GenéMaria Giulia DoglioBernard MalissenGeert van LooAndy Wullaert

A1 Journal Article in EMBO REPORTS

Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes

Sophia MaschalidiParul MehrotraBurcu Nur KeçeliHannah De CleeneKim LecomteRenée Van der CruyssenPauline JanssenJonathan PinneyGeert van LooDirk Elewaut et al.

A1 Journal Article in NATURE

2021

A20 deficiency in myeloid cells protects mice from diet-induced obesity and insulin resistance due to increased fatty acid metabolism

Leen CatrysseBastiaan MaesParul MehrotraArne MartensEsther HosteLiesbet MartensChristian MaueröderAnneleen RemmerieAnna BujkoKarolina Slowicka et al.

A1 Journal Article in CELL REPORTS

Central role of dendritic cells in pulmonary arterial hypertension in human and mice

Denise van UdenThomas KoudstaalJennifer A. C. van HulstIngrid M. BergenChelsea GootjesNicholas W. MorrellGeert van LooJan H. von der ThusenThierry P. P. van den BoschMaria-Rosa Ghigna et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characterizing the role of microglial inflammation in neurodegeneration

Sahana SrinivasanGeert van LooMohamed Lamkanfi

Fibrotic enzymes modulate wound-induced skin tumorigenesis

Lisette Van HoveKim LecomteJana RoelsNiels VandammeHanna-Kaisa VikkulaIsabelle HoorensKatia OngenaeTino HochepiedGiacomo DonatiYvan Saeys et al.

A1 Journal Article in EMBO REPORTS

IL1 beta promotes immune suppression in the tumor microenvironment independent of the inflammasome and gasdermin D

Mate KissLieselotte Vande WallePedro Henrique Viana SaavedraEls LebeggeHelena Van DammeAleksandar MurgaskiJunbin QianManuel EhlingSamantha PrettoEvangelia Bolli et al.

A1 Journal Article in CANCER IMMUNOLOGY RESEARCH

Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients

Marion PicardSatoru YonekuraKarolina SlowickaIoanna PettaConrad RauberBertrand RoutyCorentin RichardValerio IebbaMaryam Tidjani AlouSonia Becharef et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Microbes exploit death-induced nutrient release by gut epithelial cells

Christopher AndersonChristopher B. MedinaBrady J. BarronLaura KarvelyteTania Love AaesIrina LambertzJustin S. A. PerryParul MehrotraAmanda GonçalvesKelly Lemeire et al.

A1 Journal Article in NATURE

OTULIN in NF-κB signaling, cell death, and disease

Lien VerboomEsther HosteGeert van Loo

A1 Journal Article in TRENDS IN IMMUNOLOGY

OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity

Esther HosteKim LecomteKarl AnnusverNiels VandammeJana RoelsSophia MaschalidiLien VerboomHanna-Kaisa VikkulaMozes SzeLisette Van Hove et al.

A1 Journal Article in NATURE COMMUNICATIONS

The hepatocyte IKK:NF-kB axis promotes liver steatosis by stimulating de novo lipogenesis and cholesterol synthesis

Andries HeidaNanda GrubenLeen CatrysseMartijn KoehorstMirjam KosterNiels J. KloosterhuisAlbert GerdingRick HavingaVincent W. BloksLaura Bongiovanni et al.

A1 Journal Article in MOLECULAR METABOLISM

Unravelling molecular mechanisms mediating skin inflammation and tumour formation

Lisette Van HoveGeert van LooEsther Hoste

ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation

Lise Van WyngeneTineke VanderhaeghenIoanna PettaSteven TimmermansKatrien CorbeelsBart Van der SchuerenJolien VandewalleKelly Van LooverenCharlotte WallaeysMelanie Eggermont et al.

A1 Journal Article in ISCIENCE

2020

A20 and cell death-driven inflammation

Dario PriemGeert van LooMathieu Bertrand

A1 Journal Article in TRENDS IN IMMUNOLOGY

A20 at the crossroads of cell death, inflammation, and autoimmunity

Arne MartensGeert van Loo

A1 Journal Article in COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY

A20/TNFAIP3 heterozygosity predisposes to behavioral symptoms in a mouse model for neuropsychiatric lupus

C DaemsMirna SekulićV VulstekeGeert van LooR D’HoogeZ Callaerts-VéghP Callaerts

A2 Journal Article in BRAIN BEHAVIOR AND IMMUNITY - HEALTH

DNGR1-Cre-mediated deletion of Tnfaip3/A20 in conventional dendritic cells induces pulmonary hypertension in mice

Thomas KoudstaalJennifer A. C. van HulstTridib DasStefan F. H. NeysDaphne MerkusIngrid M. BergenMichiel A. de RaafHarm Jan BogaardLouis BoonGeert van Loo et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Mechanistic insights into the regulation of inflammatory pathology by A20

Arne MartensGeert van Loo

OTULIN prevents liver inflammation and hepatocellular carcinoma by inhibiting FADD- and RIPK1 kinase-mediated hepatocyte apoptosis

Lien VerboomArne MartensDario PriemEsther HosteMozes SzeHanna-Kaisa VikkulaLisette Van HoveSofie VoetJana RoelsJonathan Maelfait et al.

A1 Journal Article in CELL REPORTS

Publisher correction : Zeb2 drives invasive and microbiota-dependent colon carcinoma

Karolina SlowickaIoanna PettaGillian BlanckeEsther HosteEmilie DumasMozes SzeHanna-Kaisa VikkulaEnrico RadaelliJody J. HaighSven Jonckheere et al.

The role of hepatic PPARa in sepsis and ZBTB32 in metabolic homeostasis

Lise Van WyngeneClaude LibertGeert van Loo

Tnfaip3 expression in pulmonary conventional type 1 Langerin‐expressing dendritic cells regulates T helper 2‐mediated airway inflammation in mice

Heleen VromanDenise van UdenIngrid M. BergenJennifer A.C. van HulstMelanie LukkesGeert van LooBjörn E. ClausenLouis BoonBart LambrechtHamida Hammad et al.

A1 Journal Article in ALLERGY

Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities

Arne MartensDario PriemEsther HosteJessica VettersSofie RennenLeen CatrysseSofie VoetLaura DeelenMozes SzeHanna-Kaisa Vikkula et al.

A1 Journal Article in NATURE IMMUNOLOGY

Zeb2 drives invasive and microbiota-dependent colon carcinoma

Karolina SlowickaIoanna PettaGillian BlanckeEsther HosteEmilie DumasMozes SzeHanna-Kaisa VikkulaEnrico RadaelliJody J. HaighSven Jonckheere et al.

A1 Journal Article in NATURE CANCER

2019

A20 phosphorylation controls A20 function

Arne MartensGeert van Loo

Editorial material

A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain

Apostolos PolykratisArne MartensRemzi Onur ErenYoshitaka ShirasakiMai YamagishiYoshifumi YamaguchiSotaro UemuraMasayuki MiuraBernhard HolzmannGeorge Kollias et al.

A1 Journal Article in NATURE CELL BIOLOGY

A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms

Dario PriemMichael DevosSarah DruwéArne MartensKarolina SlowickaAdrian T TingManolis PasparakisWim DeclercqPeter VandenabeeleGeert van Loo et al.

A1 Journal Article in CELL DEATH & DISEASE

Candidalysin crucially contributes to Nlrp3 inflammasome activation by Candida albicans hyphae

Ona RogiersUlrika FrisingSoňa KucharíkováMary Ann Jabra-RizkGeert van LooPatrick Van DijckAndy Wullaert

A1 Journal Article in MBIO

DNGR1-mediated deletion of A20/Tnfaip3 in dendritic cells alters T and B-cell homeostasis and promotes autoimmune liver pathology

Tridib DasIngrid M BergenThomas KoudstaalJennifer AC van HulstGeert van LooAndre BoonstraThomas VanwolleghemPatrick SC LeungM Eric GershwinRudi W Hendriks et al.

A1 Journal Article in JOURNAL OF AUTOIMMUNITY

El Tor biotype Vibrio cholerae activates the caspase-11-independent canonical Nlrp3 and Pyrin inflammasomes

Michail MamantopoulosUlrika FrisingTomoko AsaokaGeert van LooMohamed LamkanfiAndy Wullaert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Epithelial HMGB1 delays skin wound healing and drives tumor initiation by priming neutrophils for NET formation

Esther HosteChristian MaueröderLisette Van HoveLeen CatrysseHanna-Kaisa VikkulaMozes SzeBastiaan MaesDyah KarjosukarsoLiesbet MartensAmanda Gonçalves et al.

A1 Journal Article in CELL REPORTS

Inflammasomes in neuroinflammatory and neurodegenerative diseases

Sofie VoetSahana SrinivasanMohamed LamkanfiGeert van Loo

A1 Journal Article in EMBO MOLECULAR MEDICINE

Keratinocyte expression of A20/TNFAIP3 controls skin inflammation associated with atopic dermatitis and psoriasis

Michael DevosDenis A MogilenkoSébastien FleuryBarbara GilbertCoralie BecquartSandrine QuemenerHélène DehondtPeter TougaardBart StaelsClaus Bachert et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Microglia in central nervous system inflammation and multiple sclerosis pathology

Sofie VoetMarco PrinzGeert van Loo

A1 Journal Article in TRENDS IN MOLECULAR MEDICINE

Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection

Hanne DuboisFrederic SorgeloosSoroush T. SarvestaniLiesbet MartensYvan SaeysJason M. MackenzieMohamed LamkanfiGeert van LooIan GoodfellowAndy Wullaert

A1 Journal Article in PLOS PATHOGENS

Nucleic acid induced interferon and inflammasome responses in regulating host defense to gastrointestinal viruses

Hanne DuboisGeert van LooAndy Wullaert

A1 Journal Article in INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY

Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis

Karolina SlowickaInmaculada Serramito-GómezEmilio Boada-RomeroArne MartensMozes SzeIoanna PettaHanna-Kaisa VikkulaRiet De RyckeEef ParthoensSaskia Lippens et al.

A1 Journal Article in NATURE COMMUNICATIONS

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

Takahiro MasudaRoman SankowskiOri StaszewskiChotima BoettcherLukas AmannChristian ScheiweStefan NesslerPatrik KunzGeert van LooVolker Arnd Coenen et al.

A1 Journal Article in NATURE

Study of inflammatory signaling and microglia activation in central nervous system pathology

Sofie VoetGeert van Loo

The anti-inflammatory protein TNFAIP3/A20 binds the WD40 domain of ATG16L1 to control the autophagic response, NFKB/NF-κB activation and intestinal homeostasis

Inmaculada Serramito-GomezEmilio Boada-RomeroKarolina SlowickaLars VereeckeGeert van LooFelipe X Pimentel-Muinos

Editorial material

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF

Jessica VettersMary van HeldenSigrid WahlenSimon TavernierArne MartensFarzaneh FayazpourKarl VergoteManon VanheerswynghelsKim DeswarteJustine Van Moorleghem et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2018

A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway

Emmy Van QuickelbergheDelphine De SutterGeert van LooSven EyckermanKris Gevaert

A1 Journal Article in SCIENTIFIC DATA

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

Sofie VoetConor Mc GuireNora HagemeyerArne MartensAnna SchroederPeter WieghoferCarmen DaemsOri StaszewskiLieselotte Vande WalleMarta Joana Costa Jordao et al.

A1 Journal Article in NATURE COMMUNICATIONS

Adipose tissue macrophages and their polarization in health and obesity

Leen CatrysseGeert van Loo

A1 Journal Article in CELLULAR IMMUNOLOGY

Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1

Thaneas PrabakaranChiranjeevi BoddaChristian KrappBao-cun ZhangMaria H ChristensenChenglong SunLine ReinertYujia CaiSoren B JensenMorten K Skouboe et al.

A1 Journal Article in EMBO JOURNAL

BACE2 distribution in major brain cell types and identification of novel substrates

Iryna VoytyukStephan A MuellerJulia HerberAn SnellinxDieder MoecharsGeert van LooStefan F LichtenthalerBart De Strooper

A1 Journal Article in LIFE SCIENCE ALLIANCE

House dust mite-driven neutrophilic airway inflammation in mice with TNFAIP3-deficient myeloid cells is IL-17-independent

Heleen VromanTridib DasIngrid M BergenJennifer AC van HulstFatemeh AhmadiGeert van LooErik LubbertsRudi W HendriksMirjam Kool

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Identification of immune-responsive gene 1 (IRG1) as a target of A20

Emmy Van QuickelbergheArne MartensLudger GoeminneLieven ClementGeert van LooKris Gevaert

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

Optineurin functions for optimal immunity

Karolina SlowickaGeert van Loo

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Study of intestinal homeostasis and pathology through mouse gene targeting

Karolina SlowickaGeert van LooLars Vereecke

Studying the double-faced A20 protein by contemporary proteomics

Emmy Van QuickelbergheKris GevaertGeert van Loo

TNF-α-induced protein 3 levels in lung dendritic cells instruct TH2 or TH17 cell differentiation in eosinophilic or neutrophilic asthma

Heleen VromanIngrid M BergenJennifer AC van HulstMenno van NimwegenDenise van UdenMartijn SchuijsSaravanan Y PillaiGeert van LooHamida HammadBart Lambrecht et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

2017

A20 deletion in T cells modulates acute graft-versus-host disease in mice

Julius C FischerVera OttenKatja SteigerMartina SchmicklJulia Slotta-HuspeninaRudi BeyaertGeert van LooChristian PeschelHendrik PoeckTobias Haas et al.

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

A20 inhibition of STAT1 expression in myeloid cells : a novel endogenous regulatory mechanism preventing development of enthesitis

Katelijne De WildeArne MartensStijn LambrechtPeggy JacquesMichael DrennanKarlijn DebusschereSrinath GovindarajanJulie CoudenysEveline VerheugenFien Windels et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1

Ji-Hyung LeeSu Myung JungKyung-Min YangEunjin BaeSung Gwe AhnJin Seok ParkDongyeob SeoMinbeom KimJihoon HaJaewon Lee et al.

A1 Journal Article in NATURE CELL BIOLOGY

A20 restrains thymic regulatory T cell development

Julius Clemens FischerVera OttenMaike KoberChristoph DreesMarc RosenbaumMartina SchmicklSimon HeideggerRudi BeyaertGeert van LooXian Chang Li et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Absence of system xc⁻ on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis

Ellen MerckxGiulia AlbertiniMagdalena PaterkaCathy JensenPhilipp AlbrechtMichael DietrichJoeri Van LiefferingeEduard BenteaLise VerbruggenThomas Demuyser et al.

A1 Journal Article in JOURNAL OF NEUROINFLAMMATION

Diabetes and inflammation : how A20 regulates tissue homeostasis in metabolic tissues

Leen CatrysseGeert van LooRudi Beyaert

Inflammation and the metabolic syndrome : the tissue-specific functions of NF-κB

Leen CatrysseGeert van Loo

A1 Journal Article in TRENDS IN CELL BIOLOGY

2016

A20 deficiency in lung epithelial cells protects against influenza A virus infection

Jonathan MaelfaitKenny RooseLars VereeckeConor Mc GuireMozes SzeMartijn SchuijsMonique WillartLorena IbanezHamida HammadBart Lambrecht et al.

A1 Journal Article in PLOS PATHOGENS

A20 inhibits β-cell apoptosis by multiple mechanisms and predicts residual β-cell function in type 1 diabetes

Makiko FukayaCaroline A BrorssonKira MeyerovichLeen CatrysseDiane DelarocheEmerielle C VanzelaFernanda OrtisRudi BeyaertLotte B NielsenMarie L Andersen et al.

A1 Journal Article in MOLECULAR ENDOCRINOLOGY

A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death

Leen CatrysseMorvarid Farhang GhahremaniLars VereeckeSA YoussefConor Mc GuireMozes SzeA WeberM HeikenwalderA de BruinRudi Beyaert et al.

A1 Journal Article in CELL DEATH & DISEASE

Cellular functions of optineurin in health and disease

Karolina SlowickaLars VereeckeGeert van Loo

A1 Journal Article in TRENDS IN IMMUNOLOGY

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNF AIP3/A20

Michael DrennanSrinath GovindarajanEveline VerheugenJonathan CoquetJens StaalConor Mc GuireTom TaghonGeorges LeclercqRudi BeyaertGeert van Loo et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling

Karolina SlowickaLars VereeckeConor Mc GuireMozes SzeJonathan MaelfaitAnnasaheb KolpeXavier SaelensRudi BeyaertGeert van Loo

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

TLR-independent anti-inflammatory function of intestinal epithelial TRAF6 signalling prevents DSS-induced colitis in mice

Katerina VlantisApostolos PolykratisPatrick-Simon WelzGeert van LooManolis PasparakisAndy Wullaert

A1 Journal Article in GUT

The prosurvival IKK-related kinase IKKε integrates LPS and IL17A signaling cascades to promote Wnt-dependent tumor development in the intestine

Serkan Ismail GöktunaKateryna ShostakTieu-Lan ChauLukas C HeukampBenoit HennuyHong-Quan DuongAurélie LadangPierre CloseIva KlevernicFabrice Olivier et al.

A1 Journal Article in CANCER RESEARCH

2015

A20 deficiency sensitizes pancreatic beta cells to cytokine-induced apoptosis in vitro but does not influence type 1 diabetes development in vivo

Leen CatrysseM FukayaMozes SzeK MeyerovichRudi BeyaertAK CardozoGeert van Loo

A1 Journal Article in CELL DEATH & DISEASE

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

Martijn SchuijsMonique WillartKarl VergoteDelphine GrasKim DeswarteMarkus J EgeFilipe Branco MadeiraRudi BeyaertGeert van LooFranz Bracher et al.

A1 Journal Article in SCIENCE

Leptin's metabolic and immune functions can be uncoupled at the ligand/receptor interaction level

Lennart ZabeauCathy J JensenSylvie SeeuwsKoen VenkenAnnick VerheeDominiek CatteeuwGeert van LooHui ChenKen WalderJacob Hollis et al.

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

MicroRNA let-7 modulates the immune response to Mycobacterium tuberculosis infection via control of A20, an inhibitor of the NF-κB pathway

Manish KumarSanjaya Kumar SahuRanjeet KumarArijita SubuddhiRanjan Kumar MajiKuladip JanaPushpa GuptaJohanna RaffetsederMaria LermZhumur Ghosh et al.

A1 Journal Article in CELL HOST & MICROBE

Regulation of macrophage motility by the water channel aquaporin-1 : crucial role of M0/M2 phenotype switch

Donatienne TytecaTomoya NishinoHuguette DebaixPatrick Van Der SmissenFrancisca N'KuliDelia HoffmannYvette CnopsVirginie RabolliGeert van LooRudi Beyaert et al.

A1 Journal Article in PLOS ONE

2014

A20 controls intestinal homeostasis through cell-specific activities

Lars VereeckeSara Vieira-SilvaThomas BillietJohan H van EsConor Mc GuireKarolina SlowickaMozes SzeMaaike van den BornGert De HertoghHans Clevers et al.

A1 Journal Article in NATURE COMMUNICATIONS

A20 in inflammation and autoimmunity

Leen CatrysseLars VereeckeRudi BeyaertGeert van Loo

A1 Journal Article in TRENDS IN IMMUNOLOGY

A20-Deficient mast cells exacerbate inflammatory responses in vivo

Klaus HegerKaat FierensJ Christoph VahlAttila AszodiKatrin PeschkeDominik SchentenHamida HammadRudi BeyaertDieter SaurGeert van Loo et al.

A1 Journal Article in PLOS BIOLOGY

A20: attractive without showing cleavage

Kelly VerhelstGeert van LooRudi Beyaert

Editorial material

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

Lieselotte Vande WalleNina Van OpdenboschPeggy JacquesAmelie FossoulEveline VerheugenPeter VogelRudi BeyaertDirk ElewautThirumala-Devi KannegantiGeert van Loo et al.

A1 Journal Article in NATURE

Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis

Conor Mc GuireLynn EltonPeter WieghoferJens StaalSofie VoetAnnelies DemeyerDaniel NagelDaniel KrappmannMarco PrinzRudi Beyaert et al.

A1 Journal Article in JOURNAL OF NEUROINFLAMMATION

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

Nozomi TakahashiLars VereeckeMathieu BertrandLinde DuprezScott B BergerTatyana DivertAmanda GonçalvesMozes SzeBarbara GilbertStephanie Kourula et al.

A1 Journal Article in NATURE

The tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) imposes a brake on antitumor activity of CD8 T cells

Marilyn GiordanoRomain RoncagalliPierre BourdelyLionel ChassonMichel BuferneSho YamasakiRudi BeyaertGeert van LooNathalie Auphan-AnezinAnne-Marie Schmitt-Verhulst et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2013

Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology

Conor Mc GuireMarco PrinzRudi BeyaertGeert van Loo

A1 Journal Article in TRENDS IN MOLECULAR MEDICINE

Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination

Conor Mc GuirePeter WieghoferLynn EltonDavid MuylaertMarco PrinzRudi BeyaertGeert van Loo

A1 Journal Article in JOURNAL OF IMMUNOLOGY

The study of signaling pathways controlling central nervous system inflammation and pathology

Conor Mc GuireGeert van LooRudi Beyaert

The ubiquitin editing enzyme A20 (TNFAIP3) is upregulated during permanent middle cerebral artery occlusion but does not influence disease outcome

Conor Mc GuireM RahmanM SchwaningerRudi BeyaertGeert van Loo

A1 Journal Article in CELL DEATH & DISEASE

2012

A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection

Jonathan MaelfaitKenny RoosePieter BogaertMozes SzeXavier SaelensManolis PasparakisIsabelle CarpentierGeert van LooRudi Beyaert

A1 Journal Article in PLOS PATHOGENS

A20 and CYLD do not share significant overlapping functions during B cell development and activation

Yuanyuan ChuValeria SoberonLaura GlocknerRudi BeyaertRamin MassoumiGeert van LooDaniel KrappmannMarc Schmidt-Supprian

A1 Journal Article in JOURNAL OF IMMUNOLOGY

CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair

Sebastian WillenborgTina LucasGeert van LooJohanna A KnipperThomas KriegIngo HaaseBent BrachvogelMatthias HammerschmidtAndras NagyNapoleone Ferrara et al.

A1 Journal Article in BLOOD

Conditional targeting of tumor necrosis factor receptor-associated factor 6 reveals opposing functions of toll-like receptor signaling in endothelial and myeloid cells in a mouse model of atherosclerosis

Apostolos PolykratisGeert van LooSofia XanthouleaMartin HellmichManolis Pasparakis

A1 Journal Article in CIRCULATION

Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway

Monika Julia WolfAlexandra HoosJudith BauerSteffen BoettcherMarkus KnustAchim WeberNicole SimonaviciusChristoph SchneiderMatthias LangMichael Sturzl et al.

A1 Journal Article in CANCER CELL

2011

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

Mourad MatmatiPeggy JacquesJonathan MaelfaitEveline VerheugenMirjam KoolMozes SzeLies GeboesEls LouagieConor Mc GuireLars Vereecke et al.

A1 Journal Article in NATURE GENETICS

A20 (TNFAIP3) deficiency in myeloid cells triggers rheumatoid arthritis

Dirk ElewautMourad MatmatiPeggy JacquesJonathan MaelfaitEveline VerheugenMirjam KoolMozes SzeLies GeboesEls LouagieConor Mc Guire et al.

B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice

Yuanyuan ChuJ Christoph VahlDilip KumarKlaus HegerArianna BertossiEdyta WojtowiczValeria SoberonDominik SchentenBrigitte MackMiriam Reutelshofer et al.

A1 Journal Article in BLOOD

Controlling inflammation and cell death at the intestinal epithelial interface and beyond: lessons from conditional A20 knockout mice

Lars VereeckeRudi BeyaertGeert van Loo

Death receptor signalling in central nervous system inflammation and demyelination

Conor Mc GuireRudi BeyaertGeert van Loo

A1 Journal Article in TRENDS IN NEUROSCIENCES

Enterocyte death and intestinal barrier maintenance in homeostasis and disease

Lars VereeckeRudi BeyaertGeert van Loo

A1 Journal Article in TRENDS IN MOLECULAR MEDICINE

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

Patrick-Simon WelzAndy WullaertKaterina VlantisVangelis KondylisVanesa Fernandez-MajadaMaria ErmolaevaPetra KirschAnja Sterner-KockGeert van LooManolis Pasparakis

A1 Journal Article in NATURE

Genetic relationships between A20/TNFAIP3, chronic inflammation and autoimrnune disease

Lars VereeckeRudi BeyaertGeert van Loo

A1 Journal Article in BIOCHEMICAL SOCIETY TRANSACTIONS

I kappa B kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappa B in the central nervous system

Jenni RaaschNicolas ZellerGeert van LooDoron MerklerAlexander MildnerDaniel ErnyKlaus-Peter KnobelochJohn R BetheaAri WaismanMarkus Knust et al.

A1 Journal Article in BRAIN

Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis

Saskia LippensS LefebvreBarbara GilbertMozes SzeMichael DevosKelly VerhelstLars VereeckeConor Mc GuireChris GuerinPeter Vandenabeele et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Negative regulation of NF-κB and its involvement in rheumatoid arthritis

Geert van LooRudi Beyaert

A1 Journal Article in ARTHRITIS RESEARCH & THERAPY

Signaling in antiviral immunity and its regulation by the ubiquitin-editing protein A20

Jonathan MaelfaitRudi BeyaertGeert van Loo

The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation

Marion C BonnetDaniela PreukschatPatrick-Simon WelzGeert van LooMaria A ErmolaevaWilhelm BlochIngo HaaseManolis Pasparakis

A1 Journal Article in IMMUNITY

The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity

Mirjam KoolGeert van LooWim WaelputSofie De PrijckFemke MuskensMozes SzeJens Van PraetFilipe Branco MadeiraSophie JanssensBoris Reizis et al.

A1 Journal Article in IMMUNITY

2010

Antiinflammatory Properties of a Plant-Derived Nonsteroidal, Dissociated Glucocorticoid Receptor Modulator in Experimental Autoimmune Encephalomyelitis

Geert van LooMozes SzeNadia BougarneJelle PraetConor Mc GuireAndrea UllrichGuy HaegemanMarco PrinzRudi BeyaertKarolien De Bosscher

A1 Journal Article in MOLECULAR ENDOCRINOLOGY

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis

Lars VereeckeMozes SzeConor Mc GuireBrecht RogiersYuanyuan ChuMarc Schmidt-SupprianManolis PasparakisRudi BeyaertGeert van Loo

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Expression, biological activities and mechanisms of action of A20 (TNFAIP3)

Lynn VerstrepenKelly VerhelstGeert van LooIsabelle CarpentierSteven C LeyRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Oligodendrocyte-specific FADD deletion protects mice from autoimmune-mediated demyelination

Conor Mc GuireThomas VolckaertUta WolkeMozes SzeRiet De RyckeAri WaismanMarco PrinzRudi BeyaertManolis PasparakisGeert van Loo

A1 Journal Article in JOURNAL OF IMMUNOLOGY

2009

Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappa B signals

Emmanuel DerudderEmily J. CaderaJ. Christoph ValJing WangCasey J. FoxShan ZhaGeert van LooManolis PasparakisMark S. SchlisselMarc Schmidt-Supprian et al.

A1 Journal Article in NATURE IMMUNOLOGY

The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology

Lars VereeckeRudi BeyaertGeert van Loo

A1 Journal Article in TRENDS IN IMMUNOLOGY

2008

Identification of oxidative stress and toll-like receptor 4 signaling as a key pathway of acute lung injury

Yumiko ImaiKeiji KubaG Greg NeelyRubina Yaghubian-MalhamiThomas PerkmannGeert van LooMaria ErmolaevaRuud VeldhuizenYH Connie LeungHongliang Wang et al.

A1 Journal Article in CELL

2007

A novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappa B activation by API2 center dot MALT1 fusions

H NOELSGeert van LooS HAGENSV BROECKXRudi BeyaertP MARYNENM BAENS

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of NEMO/IKKγ in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma

Tom LueddeNaiara BerazaVasileios KotsikorisGeert van LooArianna NenciRita De VosTania RoskamsChristian TrautweinManolis Pasparakis

A1 Journal Article in CANCER CELL

Epithelial NEMO links innate immunity to chronic intestinal inflammation

Arianna NenciChristoph BeckerAndy WullaertRalph GareusGeert van LooSilvio DaneseMarion HuthAlexei NikolaevClemens NeufertBlair Madison et al.

A1 Journal Article in NATURE

Hepatic tumor necrosis factor signaling and nuclear factor-kappa B: Effects on liver homeostasis and beyond

Andy WullaertGeert van LooKaren HeyninckRudi Beyaert

A1 Journal Article in ENDOCRINE REVIEWS

Identification and evaluation of protein-protein interactions involved in NF-kB signaling using MAPPIT technology

Lars VereeckeSam LievensJan TavernierGeert van LooMozes SzeRudi Beyaert

Study of the role of FAS-associated death domain protein FADD in brain pathology by conditional gene inactivation

Geert van LooRudi BeyaertA WAISMANM PRINZM PASPARAKIS

2006

Inhibition of transcription factor NF-κB in the central nervous system ameliorates autoimmune encephalomyelitis in mice

Geert van LooRossana De LorenziHauke SchmidtMarion HuthAlexander MildnerMarc Schmidt-SupprianHans LassmannMarco R PrinzManolis Pasparakis

A1 Journal Article in NATURE IMMUNOLOGY

2005

Apoptosis of hematopoietic cells induced by growth factor withdrawal is associated with caspase-9 mediated cleavage of Raf-1

Sigrid CornelisYanik BruynoogheGeert van LooXavier SaelensPeter VandenabeeleRudi Beyaert

A1 Journal Article in ONCOGENE

Induction of apoptosis by TNF receptor 2 in a T-cell hybridoma is FADD dependent and blocked by caspase-8 inhibitors

Bart DepuydtGeert van LooPeter VandenabeeleWim Declercq

A1 Journal Article in JOURNAL OF CELL SCIENCE

2004

Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD

Tom Vanden BergheGeert van LooXavier SaelensMarjan Van GurpGreet BrouckaertMichaël KalaiWim DeclercqPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Toxic proteins released from mitochondria in cell death

Xavier SaelensNele FestjensLieselotte Vande WalleMarjan Van GurpGeert van LooPeter Vandenabeele

A1 Journal Article in ONCOGENE

2003

A Bcl-2 transgene expressed in hepatocytes does not protect mice from fulminant liver destruction induced by Fas ligand

Geert van LooSaskia LippensM HAHNEFilip MatthijssensWim DeclercqXavier SaelensPeter Vandenabeele

A1 Journal Article in CYTOKINE

Bcl-2 family members as sentinels of cellular integrity and role of mitochondrial intermembrane space proteins in apoptotic cell death

Nele FestjensMarjan Van GurpGeert van LooXavier SaelensPeter Vandenabeele

A1 Journal Article in ACTA HAEMATOLOGICA

Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis

Tom Vanden BergheMichaël KalaiGeert van LooWim DeclercqPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial intermembrane proteins in cell death

Marjan Van GurpNele FestjensGeert van LooXavier SaelensPeter Vandenabeele

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

2002

A matrix-assisted laser desorption ionization post-source decay (MALDI-PSD) analysis of proteins released from isolated liver mitochondria treated with recombinant truncated Bid

Geert van LooHans DemolMarjan Van GurpB HoorelbekePeter SchotteRudi BeyaertB ZhivotovskyKris GevaertWim DeclercqJoël Vandekerckhove et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Caspases are not localized in mitochondria during life or death

Geert van LooXavier SaelensFilip MatthijssensPeter SchotteRudi BeyaertWim DeclercqPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Signaling to gene activation and cell death by tumor necrosis factor receptors and Fas

Rudi BeyaertGeert van LooKaren HeyninckPeter Vandenabeele

A1 Journal Article in International Review of Cytology : a Survey of Cell Biology

The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet.

Geert van LooXavier SaelensMarjan Van GurpM MACFARLANESJ MARTINPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity.

Geert van LooMarjan Van GurpBart DepuydtSM SRINIVASULAI RODRIGUEZES ALNEMRIKris GevaertJoël VandekerckhoveWim DeclercqPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA

Michaël KalaiGeert van LooTom Vanden BergheAnn MeeusWilhelmina BurmXavier SaelensPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2001

Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria.

Geertrui DeneckerD VERCAMMENMargino SteemansTom Vanden BergheGreet BrouckaertGeert van LooB ZHIVOTOVSKYWalther FiersJohan GrootenWim Declercq et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspaseindependent DNA degradation

Geert van LooPeter SchotteMarjan Van GurpHans DemolB HOORELBEKEKris GevaertI RODRIGUEZA RUIZ-CARRILLOJoël VandekerckhoveWim Declercq et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Lithium sensitizes tumor cells in an NF-kappa B-independent way to caspase activation and apoptosis induced by tumor necrosis factor (TNF) - Evidence for a role of the TNF receptor-associated death domain protein.

Peter SchotteGeert van LooIsabelle CarpentierPeter VandenabeeleRudi Beyaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2000

Phosphatidyl serine exposure during apoptosis precedes release of cytochrome c and decrease in mitochondrial transmembrane potential.

Geertrui DeneckerHans DoomsGeert van LooD VERCAMMENJohan GrootenWalther FiersWim DeclercqPeter Vandenabeele

A1 Journal Article in FEBS LETTERS

Structure/function analysis of p55 tumor necrosis factor receptor and Fas-associated death domain : effect on necrosis in L929sA cells.

Elke BooneTom Vanden BergheGeert van LooGert De WildeN DE WAELD VERCAMMENWalther FiersGuy HaegemanPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1998

Cathepsin B-mediated activation of the proinflammatory caspase-11

Peter SchotteWim Van CriekingeMarc Van De CraenGeert van LooMarjory DesmedtJohan GrootenMaria CornelissenLeo De RidderJoël VandekerckhoveWalther Fiers et al.

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of a new caspase homologue: caspase-14.

Marc Van De CraenGeert van LooS PYPEWim Van CriekingeI VAN DEN BRANDEFrancis MolemansWalther FiersWim DeclercqPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

Dominique VercammenRudi BeyaertGeertrui DeneckerVera GoossensGeert van LooWim DeclercqJohan GrootenWalther FiersPeter Vandenabeele

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Molecular cloning and identification of murine caspase-8.

M VAN DE CRAENGeert van LooWim DeclercqP SCHOTTEI VAN DEN BRANDES MANDRUZZATOP VAN DER BRUGGENWalther FiersPeter Vandenabeele

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

1997

Characterization of seven murine caspase family members

Marc Van de CraenPeter VandenabeeleWim DeclercqIlse Van den BrandeGeert van LooFrancis MolemansPeter SchotteWim Van CriekingeRudi BeyaertWalther Fiers

A1 Journal Article in FEBS LETTERS