Project

OTULIN in neuroinflammation, multiple sclerosis and Alzheimer pathology

Code
01D11022
Duration
01 January 2023 → 31 December 2026
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Animal immunology
    • Cell signalling
  • Medical and health sciences
    • Inflammation
    • Neurological and neuromuscular diseases
Keywords
Neuroinflammation multiple sclerosis Alzheimer
 
Project description

Inflammatory signaling pathways are subjected to tight regulation to avoid chronic inflammation and the development of inflammatory pathology. One of the proteins involved in such regulation is the deubiquitinating enzyme OTULIN. In my PhD, I aim to investigate the role of OTULIN in central
nervous system inflammation and in models of multiple sclerosis and Alzheimer pathology.