Karolien De Bosscher

Characterization of the PPARα-ERRα interaction and crosstalk in non-alcoholic fatty liver disease

Combining lower doses of glucocorticoids with mineralocorticoid receptor antagonists as a novel drug repurposing strategy in multiple myeloma

Exploiting novel GR biology as an opportunity to develop safer anti-inflammatory drugs

Exploring the immune-regulatory role of a combination of GR and PPAR agonists in the house dust mite model for asthma

Genome-wide transcription factor-DNA recruitment and surrounding cofactorprofiling at combined GRα- and PPARα-based transcriptional cross-talk mechanisms.

Impact of the nutritional status on the transcriptional cross-talk between PPARalpha and GRalpha in healthy versus inflamed primary hepatocytes.

Multiple myeloma tumor microenvironment characterization in relation to its response to glucocorticoid therapy: from biomarkers to an improved therapy

Nuclear receptor-based molecular mechanisms in the fight against inflammation and cancer

Regulation and mechanisms of resistance to anti-inflammatoire mediators in a mouse model of malaria-associated acute respiratory distress syndrome

Role of the bone marrow microenvironment in the development of glucocorticoid resistance in lymphoid malignancies

Role of the nuclear peroxisome proliferator-activated receptors (PPAR) in the intestinal immune response against the protozoan parasites Giardia duodenalis and Giardia muris

Selective glucocorticoid receptor mediated gene regulation mechanisms in mature adipocytes

Study of nuclear receptor-based cross-talk mechanisms in the combat against inflammation

Study of the plasticity of the Glucocorticoid Receptor using selective modulators.

Study of the transcriptional cross-talk between PPARalfa and ERRalfa

Study of the transcriptional cross-talk between PPARα and ERRα

The study of the therapeutic potential of PPARa-ERRa ligand combinations in non-alcoholic fatty liver disease

Circumventing the Biological Obstacles of anti-inflammatory Glucocorticoid Therapy

Exploration of HDAC6 inhibitors as anti-inflammatory agents – linking HDAC6 chemistry with inflammation biology

In-depth study of structure/activity relations of the glucocorticoid receptor and its ligands via an extreme mutation scan.

Investigation of anti-inflammatory and cytotoxic guaianolide lactones: isolation and characterisation of naturally occuring NF-B inhibitors from Laserpitium L. species and their structural modification in order to enhance their activity

Out of limbo: a toolbox to eliminate ambiguity around HDAC6, offering a novel therapeutic opportunity against multiple myeloma.

Study of the immune-regulatory role of a combination of GR and PPAR agonists in the house dust mite model for asthma

Study of the molecular mechanism of corticosteroids and non-steroidal anti-inflammatory drugs.

Nuclear receptor-based molecular mechanisms in the fight against inflammation and cancer

Study of nuclear receptor-based cross-talk mechanisms in the combat against inflammation

The impact of glucocorticoid receptor-mediated signaling on the functioning of metabolically stressed mature human adipocytes