Disentangling the complexity and diversity of glucocorticoid receptor signaling

Biophysical characterization and targeting of nuclear receptor crosstalk

Disentangling the COmplexity and DIversity of Glucocorticoid receptor signaling [DeCODInG]

Doctoral project Bert Luyckx

Doctoral project Dariusz Ratman

Doctoral project Dorien Clarisse

Doctoral project Sofie Desmet

Doctoral project Yunkun Li

The quest for improved ligands: a study of the functional plasticity of the glucocorticoid receptor

Therapeutic potential of PPARα-ERRα crosstalk in mitigating metabolic dysfunction-associated steatotic liver disease progression

The study of novel GR-MR bivalent ligands for multiple myeloma therapy

The transcription factor HNF4α and its role in sepsis via selected OMICs approaches

Curcumin-inspired benzothiazepane derivatives: Synthesis and cancer cell cytotoxicity study.

Detailed research into the role of HNF4a in sepsis.

Development of hybrid molecules targeting glucocorticoid receptor-based heterodimers to combat inflammation

Doctoral project Céline Van Dender

Doctoral project Chloé Van Leene

Doctoral project Kelly Van Looveren

Doctoral project Nick Deploey

PPAR and ERR as dual targets for combinational treatment of steatotic liver disease-associated cancer

Synthesis and biological assessment of novel GR-MR bivalent ligands for multiple myeloma therapy

The role of glucocorticoid resistance and TNFR1 signaling in sepsis

The role of hemolysis in sepsis. Mechanisms and therapeutic possibilities.

A study of the therapeutic potential of PPARa-ERRa ligand combinations in non-alcoholic fatty liver disease

BOF-ZAP professorship in biochemistry

Characterization of the PPARα-ERRα interaction and crosstalk in non-alcoholic fatty liver disease

Combining lower doses of glucocorticoids with mineralocorticoid receptor antagonists as a novel drug repurposing strategy in multiple myeloma

Exploiting novel GR biology as an opportunity to develop safer anti-inflammatory drugs

Exploring the immune-regulatory role of a combination of GR and PPAR agonists in the house dust mite model for asthma

Genome-wide transcription factor-DNA recruitment and surrounding cofactorprofiling at combined GRα- and PPARα-based transcriptional cross-talk mechanisms.

Glucocorticoid receptor-centered heterodimer formation under physiological and pathophysiological conditions

Impact of the nutritional status on the transcriptional cross-talk between PPARalpha and GRalpha in healthy versus inflamed primary hepatocytes.

Integrative interactome and protein modification analysis of HNF4α in sepsis

Leveraging nuclear receptor based research

Market oriented validation of bivalent ligands: towards an improved treatment for multiple myeloma

Multiple myeloma tumor microenvironment characterization in relation to its response to glucocorticoid therapy: from biomarkers to an improved therapy

Regulation and mechanisms of resistance to anti-inflammatoire mediators in a mouse model of malaria-associated acute respiratory distress syndrome

Role of the bone marrow microenvironment in the development of glucocorticoid resistance in lymphoid malignancies

Role of the nuclear peroxisome proliferator-activated receptors (PPAR) in the intestinal immune response against the protozoan parasites Giardia duodenalis and Giardia muris

Selective glucocorticoid receptor mediated gene regulation mechanisms in mature adipocytes

Study of novel bivalent ligands targeting glucocorticoid and mineralocorticoid receptor heterodimers: towards an improved glucocorticoid-based multiple myeloma therapy"

Study of nuclear receptor-based cross-talk mechanisms in the combat against inflammation

Study of the plasticity of the Glucocorticoid Receptor using selective modulators.

Study of the transcriptional cross-talk between PPARalfa and ERRalfa

Study of the transcriptional cross-talk between PPARα and ERRα

The Best Of Both Worlds: Nuclear Receptor Heterodimers To Battle Against Rheumatoid Arthritis.

The study of the therapeutic potential of PPARa-ERRa ligand combinations in non-alcoholic fatty liver disease

The study of the therapeutic potential of PPARα-ERRα ligand combinations in metabolic dysfunction-associated steatotic liver disease

Validation of a small molecule system for a safer treatment of chronic inflammation

Circumventing the Biological Obstacles of anti-inflammatory Glucocorticoid Therapy

Development of hybrid molecules targeting glucocorticoid and peroxisome proliferator-activated receptor-based heterodimers to combat inflammation

Development of steroid-based GR-PPARα conjugates for the treatment of chronic inflammatory diseases

Exploration of HDAC6 inhibitors as anti-inflammatory agents – linking HDAC6 chemistry with inflammation biology

In-depth study of structure/activity relations of the glucocorticoid receptor and its ligands via an extreme mutation scan

In-depth study of structure/activity relations of the glucocorticoid receptor and its ligands via an extreme mutation scan.

Investigation of anti-inflammatory and cytotoxic guaianolide lactones: isolation and characterisation of naturally occuring NF-B inhibitors from Laserpitium L. species and their structural modification in order to enhance their activity

Out of limbo: a toolbox to eliminate ambiguity around HDAC6, offering a novel therapeutic opportunity against multiple myeloma.

PPAR and ERR as dual targets for combinational treatment of steatotic liver disease-associated cancer

SpatialConnect: linking tissue biology to the new era of single-cell spatial transcriptomics

STOP_SEPSIS: investigation into a new concept of sepsis, the greatest unmet medical need of our times.

Study of the immune-regulatory role of a combination of GR and PPAR agonists in the house dust mite model for asthma

Study of the molecular mechanism of corticosteroids and non-steroidal anti-inflammatory drugs.

BOF-ZAP professorship in biochemistry

Study of nuclear receptor-based cross-talk mechanisms in the combat against inflammation

The impact of glucocorticoid receptor-mediated signaling on the functioning of metabolically stressed mature human adipocytes