BACLiPs – Biology, Chemistry and Biophysics of BACterial LipoPeptideS

Cofunding core facility - NMR Expertise Centre

High resolution NMR Centre – a centre of expertise for structure characterization and molecular analysis in chemical, biochemical, biomedical and materials sciences at Ghent University)

ReHiFiNMR - Rejuvenation of High-Field NMR equipment for the continued and enhanced characterization of complex molecular architectures and their interactions

An integrated approach towards increasing aptamer robustness by incorporation of an imidazolium modified thymine

Combined NMR and <i>ab initio</i> analysis of fluorinated prolines for their application in peptides and proteins

Creating clarity in the structural diversity of <i>Pseudomonas</i> lipopeptides and in their associated membrane perturbing effect

Doctoral project Gert-Jan Hofman

Doctoral project Matthias De Vleeschouwer

Doctoral project Niels Geudens

Doctoral project Tim Van Kersavond

Downsizing the Downsized: Nanobody Complementarity-Determining Region Peptidomimicry

Exploration of the importance of acyl chains for the bioactivity of Cyclic Lipodepsipeptides from Pseudomonas bacteria

<i>Pseudomonas</i> Cyclic Lipopeptides as Cytotoxic Agents for Cancer Cells: Structure-Function Analysis

Structure, Function and Interaction of Tolaasin

Towards an atlas of conformations for Pseudomonas cyclic lipodepsipeptides using unlabeled and isotope-labeled NMR methodologies

Unravelling the secrets of aptamer−small molecule complexes with NMR spectroscopy - the TESS.1 aptamer case

A combined structure-activity and biophysical investigation of the cyclic lipopeptide tolaasin, the virulence factor causing brown blotch disease

Cyclodextrin-Nanobody Conjugates: A Peptide Delivery System to Harness the Anticancer Potential of Cyclic Lipopeptides

Dearomative Spiroannulations for Nucleoside Synthesis and Derivatization

Doctoral project Jan Elskens

Doctoral project Lars Verdonck

Doctoral project Paolo Sabatino

Doctoral project Pieter Schiettecatte

Investigation of the influence of aliphatic fluorination on lipophilicity

500 MHz two-channel spectrometer electronics for molecular structure analysis in fundamental and applied chemical research.

Alliance Research Group: Interuniversity High Resolution NMR Center

Application of advanced and diffusion based Magnetic Resonance techniques as a new tool to investigate nanoparticles and brain biochemistry

Combined NMR and ab initio analysis of new fluorinated prolines for their application as structural modulators and NMR probes in disordered proline-rich peptide sequences 

Design and optimisation of synthetic DNAzymes: development of an integrated structure analysis approach

Development and application of NMR-based tools to inorganic nanocarriers for effective vaccine delivery

Development and application of NMR diffusion and relaxation techniques for the characterisation of supramolecular structures and self-assembly

Development of synthetic selective receptors for the enrichment and trace determination of endocrine disrupting chemicals in water samples

Exploration of the importance of acyl chains for the bioactivity of Cyclic Lipodepsipeptides from Pseudomonas bacteria

Harvesting the potential of fluorine labels and NMR spectroscopy to study the conformation of polyproline sequences and their interaction with biomolecular targets

High resolution 500 Mhz Nuclear Magnetic Resonance platform for the chemistry of single molecules, nanostructures, supramolecular objects and macromolecules.

Infusing Structure in Pseudomonas Lipopeptide and Small Molecule Aptamer Research with NMR spectroscopy

In-situ observation and manipulation of ligands of colloidal quantum dots using liquid NMR

LC-'Single Quadrupole MS' for analysis of reaction mixtures and organic compounds with determination of their molecular mass and purity.

Magnetic resonance equipment for advanced materials research: molecular characterization of solid, soft, homogeneous and heterogeneous matter in the development of advanced functional materials and chemical catalysis

MEMCLIP: A comprehensive chemical-biology approach to understand the bioactivity of Pseudomonas cyclic lipopeptides on eukaryotic membranes

Molecular design of imidazole enhanced nucleic acid aptamers and DNAzymes based upon a modeling-synthesis-analysis toolbox

New NMR methods to study supramolecular self-assemblies - application to the structure-function relation of cyclic lipodepsipeptides

NMR and molecular modelling investigations of hydroxyl apatite – DNA immunestimulator nanoplatforms for improved vaccine delivery

Polymer Additives from Lignin Building Blocks

Probing the molecular and nanoscale structure of covalent adaptable networks with solid state NMR and X-Ray techniques for improved material design (RESONANCE)

Relation between molecular structure and liposomal sorption of moderately soluble compounds: a high resolution and pfg-NMR study

Sensitivity Upgrade at High Magnetic Field for NMR Based Science in the Next Decade.

Structure-function study with NMR of and insight into the supramolecular assembly of lipopeptide antibiotics from the viscosin group.

Structure, self-assembly and function of cyclic lipodepsipeptides from Pseudomonads by drafting their bacterial biosynthetic machinery for NMR spectroscopic duty

Studying molecular recognition of natural and derivatised peptidoglycans by innate immune receptors for the design of improved immunomodulators

Supramolecular structure-function relationship of naturally occurring antimicrobial peptides.

Supramolecular structure-function relationships of antimicrobial peptides from the viscosin group: a combined approach via synthesis and advanced NMR structure analysis

Supramolecular structure-function relationships of naturally occurring antimicrobial peptides

A combined structure-activity and biophysical investigation of the cyclic lipopeptide tolaasin, the virulence factor causing brown blotch disease

A combined structure-activity and biophysical investigation of the cyclic lipopeptide tolaasin, the virulence factor causing brown blotch disease

A multifaceted approach to boost the biosynthesis of bioactive mycin- and peptin-type cyclic lipopeptides in Pseudomonas

Characterization of multidomain enzymes to enable microbial production of specialty carbohydrates

Colloidal Transition Metal Chalcogenide Nanosheets and Quantum Dots, a New Class of Nanomaterials, from Synthesis towards Application.

Development of methods for enrichment and analysis for trace analysis of endocrine disrupting chemicals in water samples mediated by synthetic selective receptors

Ecological roles of cyclic lipopeptides from plant-beneficial rhizobacteria: a chemical-biology approach to decipher primary functions of secondary metabolites.

Fluorinations with implications: enhancing the potential of biologically and medicinally interesting molecules through targeted fluorine introduction

MOLECULAR DESIGN OF ‘FROZEN’ APTAMERS: Aptamers with enhanced properties by covalent and non-covalent stabilization using functionalized nucleotides: a combined modelling, NMR and electrochemistry approach

Surface chemistry unlocks the nanocrystal library for catalysis

all35 – III-V core/shell quantum dots for emission and amplification of infrared light