Elucidating the details of the interaction between specific nutrients-microbiota-intestinal health and the consequences for inflammatory diseases

Promoting intestinal health by modulating the Zinc-microbiome axis at the Paneth cell level (acronym: ZIPAM)

De role of autophagy in the endothelium durig sepsis

Detailed research into the role of HNF4a in sepsis.

Doctoral project Céline Van Dender

Doctoral project Ioanna Petta

Doctoral project Iris Pinheiro

Doctoral project Jolien Souffriau

Doctoral project Karen Dendoncker

Doctoral project Kelly Van Looveren

Doctoral project Leen Puimège

Doctoral project Lindsy Aelbrecht

Doctoral project Lise Van Wyngene

Doctoral project Louise Nuyttens

Doctoral project Lynda Grine

Doctoral project Marlies Ballegeer

Doctoral project Sofie Vandevyver

Doctoral project Sofie Vandevyver

Doctoral project Sophie Steeland

Exploring Paneth cells: Uncovering their homeostatic diversity and role in TNF-induced SIRS

Research into the role of HNF4a and heptocyte de-differentiation in human sepsis.

Research into the role of HNF4a in Paneth cells in mice and men.

Research into the role of Paneth cells in Inflammatory bowel disease

The Effect of Hypoxia and Hypoxia Inducible Factors on the Glucocorticoid Receptor Function and their Role during Sepsis

The role of enteroendrocrine cells in the gut in inflammatory bowel disease.

The role of glucocorticoid resistance and TNFR1 signaling in sepsis

The role of hemolysis in sepsis. Mechanisms and therapeutic possibilities.

Doctoral project Marjana Brkic

Functional characterization of novel IBD candidate genes in intestinal epithelial cells

The pig as translational animal model to explore a new concept in the treatment of sepsis, today's largest unmet medical need

The transcription factor HNF4α and its role in sepsis via selected OMICs approaches

A detailed study of the role of SRC-1A and SRC-2 (GRP-1) in TNF-induced Glucocorticoid Resistance

Analysis of the effect of caloric restriction on the choroid plexus epithelial (CPE) cells that form the blood-cerebrospinal fluid barrier (BCSFB).

Application of novel tools and insights to understand the exact role of TNF in polymicrobial sepsis and to develop an efficient therapy.

A profound study of the anti-inflammatory condition of the mouse strain SPRET/Ei, with emphasis on the glucocorticoidreceptor and the X chromosome

A profound study of the mechanism and field of application of the increase of Glucocorticoid Receptor transcriptional activity by zinc. 

A profound study of the pro-inflammatory activities of MMPs 

A profound study of the pro-inflammatory activities of MMPs

Autophagy in inflammation and inflammatory disorders (ATLANTIS), from basic insights to experimental therapy

Circumventing the Biological Obstacles of anti-inflammatory Glucocorticoid Therapy

Deatailed analysis of the resistance against inflammation of Mus spretus by means of genomic techniques

Derivation of embryonic stem cells from SPRET/Ei, an inbred strain from the wild species Mus spretus

Detailed studie of the role of type-I IFN in TNF-induced and TNF-mediated pathologies

Detailed study of the molecular basis of TNF-induced glucocorticoid resistance

Developing a broadly protecting vaccine against polymicrobial sepsis.

Development of alphaVBeta3 nanobodies as novel cancer therapy

Development of TNF as a drastic and safe anti-cancer therapy

Endotoxemia and gram-nagative sepsis: fundamental research to identify new mediators and new therapeutic targets

Generation and detailed analysis of novel tools to study the importance of dimerization of the Glucocorticoid Receptor in inflammation.

Generation and detailed analysis of novel tools to study the importance of dimerization of the Glucocorticoid Receptor in inflammation. 

Generation, characterization and use of immortalized Paneth cells, to elucidate and mimic the therapeutic mechanism of Zinc against infections.

Generation, validation and application of nanobodies directed against the neovascular integrins alpha V and Beta 3 in cancer therapie

Glycomics monitoring of HCC, fibrosis and cirrhossis in chinese patients infected with hepatitis

Identification of novel therapeutic targets for the prevention of epithelial blood-CSF barrier disruption in systemic inflammatory diseases

Inhibition of TNF-induced inflammation by glucocorticoids via induction of microRNAs

Inhibition of TNFR1 for the treatment of TNF mediated diseases

Inhibition of TNFR1 for the treatment of TNF-mediated pathologies

Investigating the protective role of the glucocorticoid receptor against lactate-mediated lethal shock in sepsis

Investigating the role of hemolysis in polymicrobial sepsis.

Investigating the role of hemolysis in polymicrobial sepsis.

Investigating the role of lactate-mediated lethal shock in sepsis.

Investigation of the mechanism of the loss of function of HNF4a-PPARa axis in polymicrobial sepsis.

Matrix metalloproteinases in inflammatory diseases: therapeutic and functional study.

Matrix Metalloproteinases (MMP’s) in inflammatory diseases: therapeuytic and functional studies

Novel anti-inflammatory mechanisms of glucocorticoids – towards a higher safety and efficacy

Optimisation of a aVB3 targeted Nanobodies for cancer therapy, cancer imaging and targeted delivery.

Profound study of blood-brain and blood-CSF barrier disruption in systemic inflammatory disorders

Profound study of the anti-inflammatory mechanism and therapeutic significance of GILZ in endotocemia ans sepsis.

Profound study of the function of several matrix metalloproteinases (MMPs) in innate immunity, amongst others against bacterial infections

Profound study of the molecular basis of TNF-induced glucocorticoid resistance

Profound study on the molecular basis of TNF-induced glucocorticoid resistance

Research into the role of the matrix metalloproteinases, and more specifically, MMP7, endotoxemia in

Resolving the glucocorticoid resistance of severe asthma

Role of non-coding RNAs in the anti-inflammatory actions of glucocorticoids

Search for new therapeutic strategies to treat Alzheimer's disease: development of an in vitro system for high throughput compound screening based on choroid plexus epithelium. 

STOP SEPSIS

STOP_SEPSIS: investigation into a new concept of sepsis, the greatest unmet medical need of our times.

Study for the role of type I and III interferons in endotoxemia and sepsis

Study of the aging process: the role of N-glycosylation, hormones and the Klotho gene.

Study of the involvement of the choroid plexus during SIRS

Study of transversal ompuls and spin degrees of freedom in ucleon structure with semi-inclusive deep inelastic scattering in HERMES. Study of high energy cosmic rays through the observation v.atmosferische neutrinos in Icecube.

Study on the effects of HDAC inhibitors on the transcriptional activity of the glucocorticoid receptor.

Taking IBD Genes from GWAS to Function to Drug Target

The development of a robust and safe anticancer therapy based on TNF and interferon

The development of strong specific, efficient, flexible and safe TNF-receptor inhibitors for treatment of acute and chronic inflammatory diseases.

The interactions between the brain and MMP8 and MMP3 in systemic inflammation

The role of HNF4α and hepatocyte de-differentiation in sepsis

The role of RNA in the TNF-induced reduced DNA binding of the glucocorticoid Receptor

The role of TNF Receptor-1 regulating microRNA's in inflammation

Towards a substantial increase in therapeutic index of TNF 

Understanding the anti-diarrhea effects of zinc at the Paneth cell level.

Understanding the role of nuclear receptor HNF4a in sepsis and unravel the mechanisms of its loss-of-function in relation to PPARa failure.

Unraveling the effect of caloric restriction on gene expression in the choroid plexus and correlation with extracellular vesicle production and cognition in mouse models of age-related Alzheimer’ disease

Effect of Helicobacter suis infection to the onset of neurodegenerative diseases in humans.

FullPicture: Combining Spectral Flow Cytometry with High-Speed Cell Imaging to enable comprehensive profiling of plant and animal cells and their components in real time.

Integrative interactome and protein modification analysis of HNF4α in sepsis

Replacement and extension of basic infrastructure in the histology core facility.