Project

Study of the aging process: the role of N-glycosylation, hormones and the Klotho gene.

Code
01P12110
Duration
01 October 2010 → 30 September 2013
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Systems biology
  • Medical and health sciences
    • Gerontology and geriatrics
    • Gerontology and geriatrics
    • Nursing
    • Gerontology and geriatrics
  • Engineering and technology
    • Biomaterials engineering
    • Biological system engineering
    • Biomaterials engineering
    • Biomechanical engineering
    • Other (bio)medical engineering
    • Environmental engineering and biotechnology
    • Industrial biotechnology
    • Other biotechnology, bio-engineering and biosystem engineering
Keywords
N-glycosylation aging mice
 
Project description

N-glycosylation is altered during aging and specific glyco-genes are responsible for this process. We will analyze the regulation of involved glyco-genes by in silico analysis and functional promoter studies. Next, we will study the influence of alterations of the N-glycosylation pattern on the aging process itself as well as on aging-related signaling pathways. This will be done both in vitro and in vivo.