Research Explorer

Your browser does not support JavaScript or JavaScript is not enabled. Without JavaScript some functions of this webapplication may be disabled or cause error messages. To enable JavaScript, please consult the manual of your browser or contact your system administrator.

Researcher

Claude Libert

Publications & Research Data

Awards & Distinctions

349 Results

2026

Balancing metabolism and regeneration in liver diseases through HNF4α targeting

Céline Van DenderJolien VandewalleClaude Libert

A1 Journal Article in TRENDS IN ENDOCRINOLOGY AND METABOLISM

Biologically younger individuals, as identified by MARK-AGE biological age scores, display a distinct favourable blood chemistry profile regardless of age

Maria Moreno-villanuevaMichael JunkGrazyna MosieniakEwa SikoraMiriam CapriPaolo GaragnaniChiara PirazziniNicolle BreusingJurgen BernhardtChristiane Schon et al.

A1 Journal Article in AGING CELL

2025

A crucial role of the malate aspartate shuttle in metabolic reprogramming in TNF-induced SIRS

Louise NuyttensMarah HeyerickMaxime RoesElise MoensCéline Van DenderCharlotte WallaeysTino HochepiedSteven TimmermansJolien VandewalleClaude Libert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

CARD14 signaling in intestinal epithelial cells induces intestinal inflammation and intestinal transit delay

Aigerim AidarovaMarieke CarelsMira HaegmanYasmine DriegeSteven TimmermansEline Van DammeJavier Aguilera-LizarragaMaria Francesca ViolaRita de Cassia de Oliveira CollacoJoan Manils et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Cytochrome P450 activity in sepsis : insights into gene expression and enzymatic dysfunction

Fëllanza HalimiJolien VandewalleTineke VanderhaeghenCharlotte CuypersBruna AlonsoBruno GarciaAntoine HerpainSteven TimmermansClaude LibertStijn Schauvliege et al.

Cytochrome P450 activity in sepsis : insights into multilevel disruption of hepatic drug metabolism

Fëllanza HalimiJolien VandewalleTineke VanderhaeghenCharlotte CuypersBruna AlonsoBruno GarciaAntoine HerpainSteven TimmermansClaude LibertStijn Schauvliege et al.

Cytochrome P450 Activity in Sepsis: Insights into Gene Expression and Enzymatic Dysfunction

Fëllanza HalimiJolien VandewalleTineke VanderhaeghenCharlotte CuypersBruna AlonsoBruno Garcia [missing]Antoine Herpain [missing]Steven TimmermansClaude LibertStijn Schauvliege et al.

Detection of chimeric alpha-defensin transcripts and peptides in mouse Paneth cells

Steven TimmermansCharlotte WallaeysSomara De BeulNatalia Garcia GonzalezClaude Libert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Generation of a new Paneth cell-specific Cre-recombinase transgenic mouse line

Natalia Garcia GonzalezCharlotte WallaeysWendy ToussaintTino HochepiedSylviane DewaeleSomara De BeulRobin Van LokeJolien VandewalleSteven TimmermansRichard S. Blumberg et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Gradual DNA methylation changes reveal transcription factors implicated in metabolic dysfunction-associated steatotic liver disease progression and epigenetic age acceleration

Evelien Van DijckSteven Van LaereEmilie LogieSteven TimmermansErik FransenJoe IbrahimTimothy J. KendallJonathan A. FallowfieldLigia M. MateiuClaude Libert et al.

A1 Journal Article in CLINICAL EPIGENETICS

Hepatic HNF4a and CAR in sepsis : investigating the mechanisms of their loss-of-function and impact on liver metabolism

Céline Van DenderClaude LibertKarolien De Bosscher

HNF4α contributes to hepatic CAR dysfunction in polymicrobial sepsis

Céline Van DenderSteven TimmermansMaxime RoesMadeleine HellemansElise MoensLouise NuyttensMaarten ClaesBart RomanKarolien De BosscherJolien Vandewalle et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Metabolic alterations in sepsis and SIRS : exploring mitochondrial pyruvate metabolism and the role of the malate aspartate shuttle

Louise NuyttensClaude Libert

Modulation of glucocorticoid receptor function under iron overload

Wanting ZhuTineke VanderhaeghenSteven TimmermansJolien VandewalleMelanie EggermontNicolette J. D. VerhoogClaude Libert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Unraveling mitochondrial pyruvate dysfunction to mitigate hyperlactatemia and lethality in sepsis

Louise NuyttensMarah HeyerickGeike HeremansElise MoensMaxime RoesCéline Van DenderLiesbet De BusJohan DecruyenaereJan De WaeleJolien Vandewalle et al.

A1 Journal Article in CELL REPORTS

2024

A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death

Céline Van DenderSteven TimmermansVille PaakinahoTineke VanderhaeghenJolien VandewalleMaarten ClaesBruno GarciaBart RomanJan De WaeleSiska Croubels et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Comparative analysis of hepatic gene expression profiles in murine and porcine sepsis models

Fëllanza HalimiTineke VanderhaeghenSteven TimmermansSiska CroubelsClaude LibertJolien Vandewalle

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression

Sofie DesmetJonathan ThommisTineke VanderhaeghenEdmee VandenboornDorien ClarisseYunkun LiSteven TimmermansDaria FijalkowskaDariusz RatmanEvelien Van Hamme et al.

A1 Journal Article in MOLECULAR METABOLISM

Identification and characterization of multiple Paneth cell types in the mouse small intestine

Steven TimmermansCharlotte WallaeysNatalia Garcia GonzalezLotte PollarisYvan SaeysClaude Libert

A1 Journal Article in CELLS

Immunomodulation by glucocorticoid-induced leucine zipper in macrophages : enhanced phagocytosis, protection from pyroptosis, and altered mitochondrial function

Thierry M. LegrouxHanna S. SchymikGilles GasparoniSaeed MohammadiJoern WalterClaude LibertBritta DieselJessica HoppstaedterAlexandra K. Kiemer

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in metabolic dysfunction associated Steatotic liver disease (MASLD)

Claudia TheysTineke VanderhaeghenEvelien Van DijckCedric PelemanAnne ScheepersJoe IbrahimLigia MateiuSteven TimmermansTom Vanden BergheSven M. Francque et al.

A2 Journal Article in FRONTIERS IN MOLECULAR MEDICINE

MeCP2 binds to methylated DNA independently of phase separation and heterochromatin organisation

Raphael PantierMegan BrownSicheng HanKatie PatonStephen MeekThomas MontavonNicholas ShukeirToni MchughDavid A. KellyTino Hochepied et al.

A1 Journal Article in NATURE COMMUNICATIONS

Microbial metabolome in septic shock : bridging bench to bedside

Jolien VandewalleClaude Libert

Editorial material

Paneth cell TNF signaling induces gut bacterial translocation and sepsis

Charlotte WallaeysNatalia Garcia GonzalezSteven TimmermansJolien VandewalleTineke VanderhaeghenSomara De BeulHester DufoorMelanie EggermontElise MoensVictor Bosteels et al.

A1 Journal Article in CELL HOST & MICROBE

Polo-like kinase 1 (PLK1) is a novel CARD14-binding protein in keratinocytes

Stella IliakiMarja KreikeNatalia Ferreras MorenoFemke De MeyerAigerim AidarovaHarald BraunClaude LibertInna AfoninaRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Sepsis-induced changes in pyruvate metabolism : insights and potential therapeutic approaches

Louise NuyttensJolien VandewalleClaude Libert

A1 Journal Article in EMBO MOLECULAR MEDICINE

2023

Circulating cell-free DNA in health and disease : the relationship to health behaviours, ageing phenotypes and metabolomics

Laura KananenMikko HurmeAlexander BürkleMaria Moreno-VillanuevaJürgen BernhardtFlorence Debacq-ChainiauxBeatrix Grubeck-LoebensteinMarco MalavoltaAndrea BassoFrancesco Piacenza et al.

A1 Journal Article in GEROSCIENCE

Exploring Paneth cells : uncovering their homeostatic diversity and role in TNF-induced SIRS

Charlotte WallaeysClaude Libert

Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF

Kai Ling LiangJuliette RoelsMarieke LavaertTom PuttemanLena BoehmeLaurentijn TillemanImke VelgheValentina PegorettiInge Van de WalleStephanie Sontag et al.

A1 Journal Article in NATURE IMMUNOLOGY

Mousepost 2.0, a major expansion of the resource

Steven TimmermansJolien VandewalleClaude Libert

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Paneth cells as the cornerstones of intestinal and organismal health : a primer

Charlotte WallaeysNatalia Garcia GonzalezClaude Libert

A1 Journal Article in EMBO MOLECULAR MEDICINE

Spns2/S1P : it takes two to tango with inflammation and metabolic rewiring during sepsis

Tineke VanderhaeghenJolien VandewalleClaude Libert

Editorial material

The impact of hepatocyte-specific deletion of hypoxia-inducible factors on the development of polymicrobial sepsis with focus on GR and PPARα function

Tineke VanderhaeghenSteven TimmermansMelanie EggermontDeepika WattsJolien VandewalleCharlotte WallaeysLouise NuyttensJoyca De TemmermanTino HochepiedSylviane Dewaele et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

The pig as a translational animal model to explore a new concept in the treatment of sepsis, today's largest unmet medical need

Fëllanza HalimiCharlotte CuypersBruna AlonsoEline HermansDiethard ReckelbusJolien VandewalleB. GarciaA. HerpainTineke VanderhaeghenCéline Van Dender et al.

The pig as a translational animal to explore a new concept in the treatment of sepsis, today's largest unmet medical need

Fëllanza HalimiCharlotte CuypersBruna AlonsoEline HermansDiethard ReckelbusJolien VandewalleBruno GarciaAntoine HerpainTineke VanderhaeghenCéline Van Dender et al.

2022

Acute endotoxemia-induced respiratory and intestinal dysbiosis

Evy GoossensJianhui LiChana CallensNathalie Van RysselbergheHannele KettunenJuhani VuorenmaaNatalia Garcia GonzalezClaude LibertRichard DucatelleFilip Van Immerseel

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Coding variants in mouse and rat model organisms : mousepost and ratpost

Steven TimmermansClaude Libert

A1 Journal Article in MAMMALIAN GENOME

Dimerization of the glucocorticoid receptor and its importance in (patho)physiology : a primer

Steven TimmermansJolien VandewalleClaude Libert

A1 Journal Article in CELLS

Engineering a highly sensitive biosensor for abscisic acid in mammalian cells

Seo Woo KimKûbra AlciFemke Van GaeverYasmine DriegeKeylla BicalhoGeert GoeminneClaude LibertAlain GoossensRudi BeyaertJens Staal

A1 Journal Article in FEBS LETTERS

Hepatic peroxisome proliferator-activated receptor alpha dysfunction in porcine septic shock

Jolien VandewalleBruno GarciaSteven TimmermansTineke VanderhaeghenLise Van WyngeneMelanie EggermontHester DufoorCéline Van DenderFëllanza HalimiSiska Croubels et al.

A1 Journal Article in CELLS

MiR-511 deficiency protects mice from experimental colitis by reducing TLR3 and TLR4 responses via WD repeat and FYVE-domain-containing protein 1

Shafaque RahmanJolien VandewallePatricia H. P. van HamersveldCaroline VerseijdenOlaf WeltingAldo JongejanPierina CasanovaSybren L. MeijerClaude LibertTheodorus B. M. Hakvoort et al.

A1 Journal Article in CELLS

N/C interactions are dispensable for normal in vivo functioning of the androgen receptor in male mice

Sarah El KharrazVanessa DuboisKaisa-Mari LaunonenLaura HelminenJorma J PalvimoClaude LibertElien SmeetsLisa MorisRoy EerlingsDirk Vanderschueren et al.

A1 Journal Article in ENDOCRINOLOGY

Novel assays monitoring direct glucocorticoid receptor protein activity exhibit high predictive power for ligand activity on endogenous gene targets

Laura Van MoortelJonathan ThommisBrecht MaertensAn StaesDorien ClarisseDelphine De SutterClaude LibertOnno C. MeijerSven EyckermanKris Gevaert et al.

A1 Journal Article in BIOMEDICINE & PHARMACOTHERAPY

Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding

Steven TimmermansNicolette J.D. VerhoogKelly Van LooverenSylviane DewaeleTino HochepiedMelanie EggermontBarbara GilbertAnne Boerema-de MunckTineke VanderhaeghenJoke Vanden Berghe et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Reprogramming of glucocorticoid receptor function by hypoxia

Tineke VanderhaeghenSteven TimmermansDeepika WattsVille PaakinahoMelanie EggermontJolien VandewalleCharlotte WallaeysLise Van WyngeneKelly Van LooverenLouise Nuyttens et al.

A1 Journal Article in EMBO REPORTS

Sepsis : a failing starvation response

Jolien VandewalleClaude Libert

A1 Journal Article in TRENDS IN ENDOCRINOLOGY AND METABOLISM

Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements

Lovelace J. LuquetteMichael B. MillerZinan ZhouCraig L. BohrsonYifan ZhaoHu JinDoga GulhanJavier GanzSara BizzottoSamantha Kirkham et al.

A1 Journal Article in NATURE GENETICS

2021

Bidirectional crosstalk between hypoxia inducible factors and glucocorticoid signalling in health and disease

Tineke VanderhaeghenRudi BeyaertClaude Libert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis

Jolien VandewalleSteven TimmermansVille PaakinahoLies VancraeynestLiza DewyseTineke VanderhaeghenCharlotte WallaeysLise Van WyngeneKelly Van LooverenLouise Nuyttens et al.

A1 Journal Article in CELL METABOLISM

Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation

Federico VirgaFederica CappellessoBenoit StijlemansAnne-Theres HenzeRosa TrottaJonas Van AudenaerdeAnanda S. MirchandaniManuel A. Sanchez-GarciaJolien VandewalleFrancesca Orso et al.

A1 Journal Article in SCIENCE ADVANCES

Ratpost : a searchable database of protein-inactivating sequence variations in 40 sequenced rat-inbred strains

Steven TimmermansClaude Libert

A1 Journal Article in MAMMALIAN GENOME

Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains

L. KananenL. EnrothJ. RaitanenJ. JylhavaA. BuerkleM. Moreno-VillanuevaJ. BernhardtO. ToussaintB. Grubeck-LoebensteinM. Malavolta et al.

A1 Journal Article in SCIENTIFIC REPORTS

The androgen receptor depends on ligand-binding domain dimerization for transcriptional activation

Sarah El KharrazVanessa DuboisMartin E. van RoyenAdriaan B. HoutsmullerEkatarina PavlovaNina AtanassovaTien NguyenArnout VoetRoy EerlingsFlorian Handle et al.

A1 Journal Article in EMBO REPORTS

The effect of hypoxia and hypoxia inducible factors on the glucocorticoid receptor function and their role during sepsis

Tineke VanderhaeghenClaude LibertRudi Beyaert

The role of glucocorticoid resistance and TNFR1 signaling in sepsis

Jolien VandewalleClaude LibertKarolien De Bosscher

Turning a pathogen protein into a therapeutic tool for sepsis

Tineke VanderhaeghenCharlotte WallaeysClaude Libert

Editorial material

ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation

Lise Van WyngeneTineke VanderhaeghenIoanna PettaSteven TimmermansKatrien CorbeelsBart Van der SchuerenJolien VandewalleKelly Van LooverenCharlotte WallaeysMelanie Eggermont et al.

A1 Journal Article in ISCIENCE

2020

An extracellular microRNA can rescue lives in sepsis

Kelly Van LooverenLise Van WyngeneClaude Libert

Editorial material

GILZ in sepsis : 'poor is the pupil who does not surpass his master'

Jolien VandewalleClaude Libert

Editorial material

Glucocorticoids in sepsis : to be or not to be

Jolien VandewalleClaude Libert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Glucocorticoids limit lipopolysaccharide-induced lethal inflammation by a double control system

Kelly Van LooverenSteven TimmermansTineke VanderhaeghenCharlotte WallaeysMarlies BallegeerJolien SouffriauMelanie EggermontJolien VandewalleLise Van WyngeneKarolien De Bosscher et al.

A1 Journal Article in EMBO REPORTS

Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis

Lise Van WyngeneTineke VanderhaeghenSteven TimmermansJolien VandewalleKelly Van LooverenJolien SouffriauCharlotte WallaeysMelanie EggermontSam ErnstEvelien Van Hamme et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Hypoxia-inducible factors in metabolic reprogramming during sepsis

Tineke VanderhaeghenJolien VandewalleClaude Libert

A1 Journal Article in FEBS JOURNAL

Phytohormones : multifunctional nutraceuticals against metabolic syndrome and comorbid diseases

Seo Woo KimAlain GoossensClaude LibertFilip Van ImmerseelJens StaalRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Potential of glucocorticoids to treat intestinal inflammation during sepsis

Kelly Van LooverenCharlotte WallaeysClaude Libert

A1 Journal Article in CURRENT OPINION IN PHARMACOLOGY

Taking the STING out of sepsis?

Jolien VandewalleTineke VanderhaeghenRudi BeyaertClaude Libert

Editorial material

The glucocorticoid receptor in acute inflammation : new molecular insights and development of a new GR dimerization mutant

Kelly Van LooverenClaude LibertKarolien De Bosscher

The role of hepatic PPARa in sepsis and ZBTB32 in metabolic homeostasis

Lise Van WyngeneClaude LibertGeert van Loo

Zinc inhibits lethal inflammatory shock by preventing microbe-induced interferon signature in intestinal epithelium

Jolien SouffriauSteven TimmermansTineke VanderhaeghenCharlotte WallaeysKelly Van LooverenLindsy AelbrechtSylviane DewaeleJolien VandewalleEvy GoossensSerge Verbanck et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

2019

A general introduction to glucocorticoid biology

Steven TimmermansJolien SouffriauClaude Libert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

A study of cecal ligation and puncture-induced sepsis in tissue-specific tumor necrosis factor receptor 1-deficient mice

Jolien VandewalleSophie SteelandSara Van RyckeghemMelanie EggermontElien Van WonterghemRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Cognitive dysfunction in mice lacking proper glucocorticoid receptor dimerization

Kelly Van LooverenMichiel Van BoxelaereZsuzsanna Callaerts-VeghClaude Libert

A1 Journal Article in PLOS ONE

Do people living with HIV experience greater age advancement than their HIV-negative counterparts?

Davide De FrancescoFerdinand W WitAlexander BürkleSebastian OehlkeNeeltje A KootstraAlan WinstonClaudio FranceschiPaolo GaragnaniChiara PirazziniClaude Libert et al.

A1 Journal Article in AIDS

Mechanisms underlying the functional cooperation between PPARα and GRα to attenuate inflammatory responses

Nadia BougarneViacheslav MylkaDariusz RatmanIlse BeckJonathan ThommisLode De CauwerJan TavernierBart StaelsClaude LibertKarolien De Bosscher

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Overexpression of Gilz protects mice against lethal septic peritonitis

Marlies BallegeerJolien VandewalleMelanie EggermontGert Van IsterdaelLien DejagerLiesbet De BusJohan DecruyenaereRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in SHOCK

Part II: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for types of infections and organ dysfunction endpoints

Claude LibertAlfred AyalaMichael BauerJean-Marc CavaillonClifford DeutschmanClaes FrostellSylvia KnappAndrey V KozlovPing WangMarcin F Osuchowski et al.

A1 Journal Article in SHOCK

Studies on structural and functional changes of mouse choroid plexus in the initiation of neuroinflammation

Marjana BrkićRoosmarijn VandenbrouckeSelma KanazirClaude Libert

The response to the letter to the editor titled: 'Is triple self-plagiarism 'OK' if only made transparent?'' by Volker R Jacobs, MD, MBA

Marcin F OsuchowskiJudith HellmanMarkus Huber-LangClaude LibertDaniel G RemickChristoph ThiemermannBasilia Zingarelli

A1 Journal Article in SHOCK

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile

Karen DendonckerSteven TimmermansJolien VandewalleMelanie EggermontJoanna LempiäinenVille PaakinahoEvelien Van HammeSylviane DewaeleSofie VandevyverMarlies Ballegeer et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Validation of a novel multivariate method of defining HIV-associated cognitive impairment

Jonathan UnderwoodDavide de FrancescoJames H ColeMatthan WA CaanRosan A van ZoestBen A SchmandDavid J SharpCaroline A SabinPeter ReissAlan Winston et al.

A1 Journal Article in OPEN FORUM INFECTIOUS DISEASES

2018

A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8

Delphine BouhyManisha JunejaIstvan KatonaAnne HolmgrenBob AsselberghVicky De WinterTino HochepiedSteven GoossensJody J HaighClaude Libert et al.

A1 Journal Article in ACTA NEUROPATHOLOGICA

A new venue of TNF targeting

Sophie SteelandClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A screening assay for Selective Dimerizing Glucocorticoid Receptor Agonists and Modulators (SEDIGRAM) that are effective against acute inflammation

Jolien SouffriauMelanie EggermontSara Van RyckeghemKelly Van LooverenLise Van WyngeneEvelien Van HammeMarnik VuylstekeRudi BeyaertKarolien De BosscherClaude Libert

A1 Journal Article in SCIENTIFIC REPORTS

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

Sofie VoetConor Mc GuireNora HagemeyerArne MartensAnna SchroederPeter WieghoferCarmen DaemsOri StaszewskiLieselotte Vande WalleMarta Joana Costa Jordao et al.

A1 Journal Article in NATURE COMMUNICATIONS

Alterations of the serum N-glycan profile in female patients with Major Depressive Disorder

Christina BoeckSophia PfisterAlexander BuerkleValerie VanhoorenClaude LibertJuan Salinas-ManriqueDetlef E DietrichIris-Tatjana KolassaAlexander Karabatsiakis

A1 Journal Article in JOURNAL OF AFFECTIVE DISORDERS

Counteracting the effects of TNF receptor-1 has therapeutic potential in Alzheimer's disease

Sophie SteelandNina GorléCharysse VandendriesscheSriram BalusuMarjana BrkićCaroline Van CauwenbergheGriet Van ImschootElien Van WonterghemRiet De RyckeAnna Kremer et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Easy access to and applications of the sequences of all protein-coding genes of all sequenced mouse strains

Steven TimmermansClaude Libert

Editorial material

Genetic mapping of species differences via in vitro crosses in mouse embryonic stem cells

Stefano LazzaranoMarek KuckaJoao PL CastroRonald NaumannPaloma MedinaMichael NC FletcherRebecka WombacherJoost GribnauTino HochepiedMarc Van Montagu et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice

Marlies BallegeerKelly Van LooverenSteven TimmermansMelanie EggermontSofie VandevyverFabien Henri TheryKaren DendonckerJolien SouffriauJolien VandewalleLise Van Wyngene et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

How good roommates can protect against microbial sepsis

Rudi BeyaertClaude Libert

Editorial material

Identifying and classifying protein coding gene polymorphisms between laboratory mouse strains and investigating glucocorticoid actions in sepsis models

Steven TimmermansClaude LibertYvan Saeys

IFN-γ stimulates CpG-induced IL-10 production in Bcells via p38 and JNK signalling pathways

Maya ImbrechtsKaren De SamblancxKarlien FierensEllen BrisseJessica VandenhauteTania MiteraClaude LibertIde SmetsAn GorisCarine Wouters et al.

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Inhibition of MALT1 decreases neuroinflammation and pathogenicity of virulent rabies virus in mice

Elodie KipJens StaalHG TimaLynn VerstrepenM RomanoKelly LemeireV SuinA HamoudaM BaensClaude Libert et al.

A1 Journal Article in JOURNAL OF VIROLOGY

Learning lessons in sepsis from the children

Steven TimmermansClaude Libert

Editorial material

Mechanistic insights into the protective impact of zinc on sepsis

Jolien SouffriauClaude Libert

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS) : an international expert consensus initiative for improvement of animal modeling in sepsis

Marcin F. OsuchowskiAlfred AyalaSoheyl BahramiMichael BauerMihaly BorosJean-Marc CavaillonIrshad H. ChaudryCraig M. CoopersmithClifford DeutschmanSusanne Drechsler et al.

A2 Journal Article in INTENSIVE CARE MEDICINE EXPERIMENTAL

Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS) : an international expert consensus initiative for improvement of animal modeling in sepsis

Marcin F OsuchowskiAlfred AyalaSoheyl BahramiMichael BauerMihaly BorosJean-Marc CavaillonIrshad H ChaudryCraig M CoopersmithClifford DeutschmanSusanne Drechsler et al.

A1 Journal Article in INFECTION

Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS) : an international expert consensus initiative for improvement of animal modeling in sepsis

Marcin F OsuchowskiAlfred AyalaSoheyl BahramiMichael BauerMihaly BorosJean-Marc CavaillonIrshad H ChaudryCraig M CoopersmithClifford S DeutschmanSusanne Drechsler et al.

A1 Journal Article in SHOCK

Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J

Steven TimmermansClaude Libert

A1 Journal Article in JCI INSIGHT

Reprogramming of basic metabolic pathways in microbial sepsis : therapeutic targets at last?

Lise Van WyngeneJolien VandewalleClaude Libert

A1 Journal Article in EMBO MOLECULAR MEDICINE

Should we target TNF receptors in the intestinal epithelium with glucocorticoids during systemic inflammation?

Kelly Van LooverenClaude Libert

A1 Journal Article in EXPERT OPINION ON THERAPEUTIC TARGETS

Simultaneous inhibition of tumor necrosis factor receptor 1 and matrix metalloproteinase 8 completely protects against acute inflammation and sepsis

Sophie SteelandSara Van RyckeghemJolien VandewalleMarlies BallegeerElien Van WonterghemMelanie EggermontJohan DecruyenaereLiesbet De BusClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in CRITICAL CARE MEDICINE

Strategies and compounds to circumvent glucocorticoid-induced side effects

Astrid LuypaertWim Vanden BergheJan TavernierClaude LibertKarolien De Bosscher

Bookchapter in Immunopharmacology and inflammation

Structural brain abnormalities in successfully treated HIV infection : associations with disease and cerebrospinal fluid biomarkers

Rosan A van ZoestJonathan UnderwoodDavide De FrancescoCaroline A SabinJames H ColeFerdinand W WitMatthan WA CaanNeeltje A KootstraDietmar FuchsHenrik Zetterberg et al.

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Targeting TNF-induced acute inflammation by making use of SEDIGRAM or zinc

Jolien SouffriauClaude Libert

The 'COmorBidity in Relation to AIDS' (COBRA) cohort : design, methods and participant characteristics

Davide De FrancescoFerdinand W WitJames H ColeNeeltje A KootstraAlan WinstonCaroline A SabinJonathan UnderwoodRosan A van ZoestJudith SchoutenKatherine W Kooij et al.

A1 Journal Article in PLOS ONE

The autophagy receptor SQSTM1/p62 mediates anti-inflammatory actions of the selective NR3C1/glucocorticoid receptor modulator compound A (CpdA) in macrophages

Viacheslav MylkaJulie DeckersDariusz RatmanLode De CauwerJonathan ThommisRiet De RyckeFrancis ImpensClaude LibertJan TavernierWim Vanden Berghe et al.

A1 Journal Article in AUTOPHAGY

The choroid plexus epithelium as a novel player in the stomach-brain axis during Helicobacter infection

Nina GorléCaroline BlaecherEva BauwensCharysse VandendriesscheSriram BalusuJolien VandewalleCaroline Van CauwenbergheElien Van WonterghemGriet Van ImschootCheng Liu et al.

A1 Journal Article in BRAIN BEHAVIOR AND IMMUNITY

The E3 ubiquitin ligases HOIP and cIAP1 are recruited to the TNFR2 signaling complex and mediate TNFR2-induced canonical NF-κB signaling

Alice BorghiMira HaegmanRoman FischerIsabelle CarpentierMathieu BertrandClaude LibertInna AfoninaRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Therapeutic mechanisms of glucocorticoids

Jolien VandewalleAstrid LuypaertKarolien De BosscherClaude Libert

A1 Journal Article in TRENDS IN ENDOCRINOLOGY AND METABOLISM

Using the inbred mouse strain SPRET/EiJ to provide novel insights in inflammation and infection research

Steven TimmermansJolien SouffriauJolien VandewalleLise Van WyngeneKelly Van LooverenTineke VanderhaeghenClaude Libert

A1 Journal Article in MAMMALIAN GENOME

2017

Airway epithelial cells are crucial targets of glucocorticoids in a mouse model of allergic asthma

Carina KlassenAnna KarabinskayaLien DejagerSabine VettorazziJustine Van MoorleghemFred LuehderSebastiaan H MeijsingJan P TuckermannHanibal BohnenbergerClaude Libert et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains

Steven TimmermansMarc Van MontaguClaude Libert

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual-specificity phosphatase 3 deletion protects female, but not male, mice from endotoxemia-induced and polymicrobial-induced septic shock

Maud M VandereykenPratibha SinghCaroline P WathieuSophie JacquesTinatin ZurashvilliLien DejagerMathieu AmandLucia MusumeciManeesh SinghMichel P Moutschen et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Effect of a gastral infection with zoonotic Helicobacter species on brain barrier integrity

Eva BauwensCaroline BlaecherHelena BerlamontNina GorléRichard DucatelleClaude LibertRoosmarijn VandenbrouckeAnnemieke SmetFreddy Haesebrouck

Elucidating the mechanism behind TNF-induced glucocorticoid resistance and strategies to overcome this resistance

Karen DendonckerClaude Libert

Glucocorticoid receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor

Ioanna PettaNadia BougarneJolien VandewalleLien DejagerSofie VandevyverMarlies BallegeerSofie DesmetJonathan ThommisLode De CauwerSam Lievens et al.

A1 Journal Article in SCIENTIFIC REPORTS

Glucocorticoid resistance as a major drive in sepsis pathology

Karen DendonckerClaude Libert

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

High cellular monocyte activation in people living with human immunodeficiency virus on combination antiretroviral therapy and lifestyle-matched controls is associated with greater inflammation in cerebrospinal fluid

Thijs BooimanFerdinand W WitIrma MaurerDavide De FrancescoCaroline A SabinAgnes M HarskampMaria PrinsPaolo GaragnaniChiara PirazziniClaudio Franceschi et al.

A1 Journal Article in OPEN FORUM INFECTIOUS DISEASES

Increased brain-predicted aging in treated HIV disease

James H ColeJonathan UnderwoodMatthan WA CaanDavide De FrancescoRosan A van ZoestRobert LeechFerdinand WNM WitPeter PortegiesGert J GeurtsenBen A Schmand et al.

A1 Journal Article in NEUROLOGY

Novel insights into the choroid plexus' response to systemic inflammation and Alzheimer's disease

Sriram BalusuRoosmarijn VandenbrouckeClaude LibertKris Gevaert

The nature of the GRE influences the screening for GR-activity enhancing modulators

Karen DendonckerSteven TimmermansKelly Van LooverenLode De CauwerKarolien De BosscherClaude Libert

A1 Journal Article in PLOS ONE

Therapeutic targeting of inflammatory mediators in sepsis and neurodegenerative diseases

Sophie SteelandClaude LibertRoosmarijn Vandenbroucke

TNFR1 inhibition with a nanobody protects against EAE development in mice

Sophie SteelandSara Van RyckeghemGriet Van ImschootRiet De RyckeWendy ToussaintLeen VanhoutteChristian VanhoveFilip De VosRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in SCIENTIFIC REPORTS

2016

A study of inflammatory mechanisms involved in systemic inflammation and brain trauma

Delphine DemeestereRoosmarijn VandenbrouckeClaude Libert

Activation of the glucocorticoid receptor in acute inflammation : the SEDIGRAM concept

Karolien De BosscherIlse BeckDariusz RatmanWim Vanden BergheClaude Libert

A1 Journal Article in TRENDS IN PHARMACOLOGICAL SCIENCES

Caloric restriction: beneficial effects on brain aging and Alzheimer's disease

Caroline Van CauwenbergheCharysse VandendriesscheClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in MAMMALIAN GENOME

Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARα

Dariusz RatmanViacheslav MylkaNadia BougarneMichal PawlakSandrine CaronNathalie HennuyerRéjane PaumelleLode De CauwerJonathan ThommisMark H Rider et al.

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Comment on 'Tumour necrosis factor-α plays a significant role in the Aldara-induced skin inflammation in mice'

Lynda GrineClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in BRITISH JOURNAL OF DERMATOLOGY

Development and validation of a small single-domain antibody that effectively inhibits matrix metalloproteinase 8

Delphine DemeestereEline DejonckheereSophie SteelandPaco HulpiauJurgen HaustraeteNick DevoogdtRielana WichertChristoph Becker-PaulyElien Van WonterghemSylviane Dewaele et al.

A1 Journal Article in MOLECULAR THERAPY

Efficient analysis of mouse genome sequences reveal many nonsense variants

Sophie SteelandSteven TimmermansSara Van RyckeghemPaco HulpiauYvan SaeysMarc Van MontaguRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles

Sriram BalusuElien Van WonterghemRiet De RyckeKoen RaemdonckStephan StremerschKris GevaertMarjana BrkićDelphine DemeestereValerie VanhoorenAn Hendrix et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

MMP-3 deficiency alleviates endotoxin-induced acute inflammation in the posterior eye segment

Inge Van HoveEvy LefevereLies De GroefJurgen SergeysManuel Salinas-NavarroClaude LibertRoosmarijn VandenbrouckeLieve Moons

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modulation of protein-protein interactions for the development of novel therapeutics

Ioanna PettaSam LievensClaude LibertJan TavernierKarolien De Bosscher

A1 Journal Article in MOLECULAR THERAPY

Nanobodies as therapeutics: big opportunities for small antibodies

Sophie SteelandRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in DRUG DISCOVERY TODAY

Overexpression of glucocorticoid-induced leucine zipper (GILZ) increases susceptibility to imiquimod-induced psoriasis and involves cutaneous activation of TGF-β1

Elena CarcellerMarlies BallegeerJulie DeckersCarlo RiccardiStefano BruscoliTino HochepiedClaude LibertPaloma Perez

A1 Journal Article in SCIENTIFIC REPORTS

Preeclampsia transforms membrane N-glycome in human placenta

Dragana RobajacValerie VanhoorenRomana MasnikosaŽeljko MikovićVesna MandićClaude LibertOlgica Nedić

A1 Journal Article in EXPERIMENTAL AND MOLECULAR PATHOLOGY

Proteome-scale binary interactomics in human cells

Sam LievensJosé Van Der HeydenDelphine MasschaeleLeentje De CeuninckIoanna PettaSurya GuptaVeronic De PuysseleyrVirginie VauthierIrma LemmensDries De Clercq et al.

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

Sizing nanomaterials in bio-fluids by cFRAP enables protein aggregation measurements and diagnosis of bio-barrier permeability

Ranhua XiongRoosmarijn VandenbrouckeKatleen BroosToon BransElien Van WonterghemClaude LibertJo DemeesterStefaan De SmedtKevin Braeckmans

A1 Journal Article in NATURE COMMUNICATIONS

Study of the role and regulation of glucocorticoid induced leucine zipper (GILZ) and GR dimers in acute inflammation

Marlies BallegeerClaude LibertRoosmarijn Vandenbroucke

The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease : more than just a barrier

Sriram BalusuMarjana BrkićClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in NEURAL REGENERATION RESEARCH

The effect of aging on brain barriers and the consequences for Alzheimer's disease development

Nina GorléCaroline Van CauwenbergheClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in MAMMALIAN GENOME

The interactome of the glucocorticoid receptor and its influence on the actions of glucocorticoids in combatting inflammatory and infectious diseases

Ioanna PettaLien DejagerMarlies BallegeerSam LievensJan TavernierKarolien De BosscherClaude Libert

A2 Journal Article in MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Topical imiquimod yields systemic effects due to unintended oral uptake

Lynda GrineSophie SteelandSara Van RyckeghemMarlies BallegeerStefan LienenklausSiegfried WeissNiek SandersRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in SCIENTIFIC REPORTS

Transient hepatic overexpression of insulin-like growth factor 2 induces free cholesterol and lipid droplet formation

Sonja M KesslerStephan LaggaiElien Van WonterghemKatja GemperleinRolf MüllerJohannes HaybaeckRoosmarijn VandenbrouckeManfred OgrisClaude LibertAlexandra K Kiemer

A1 Journal Article in FRONTIERS IN PHYSIOLOGY

2015

Amyloid β oligomers disrupt blood-CSF barrier integrity by activating matrix metalloproteinases

Marjana BrkićSriram BalusuElien Van WonterghemNina GorléIryna BenilovaAnna KremerInge Van HoveLieve MoonsBart De StrooperSelma Kanazir et al.

A1 Journal Article in JOURNAL OF NEUROSCIENCE

An inflammatory triangle in psoriasis: TNF, type I IFNs and IL-17

Lynda GrineLien DejagerClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

Clinical implications of leukocyte infiltration at the choroid plexus in (neuro)inflammatory disorders

Delphine DemeestereClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in DRUG DISCOVERY TODAY

Decreased TNF levels and improved retinal ganglion cell survival in MMP-2 Null mice suggest a role for MMP-2 as TNF sheddase

Lies De GroefManuel Salinas-NavarroGriet Van ImschootClaude LibertRoosmarijn VandenbrouckeLieve Moons

A1 Journal Article in MEDIATORS OF INFLAMMATION

Determining differentially expressed miRNAs and validating miRNA-target relationships using the SPRET/Ei mouse strain

Steven TimmermansFilip Van HauwermeirenLeen PuimègeLien DejagerElien Van WonterghemValerie VanhoorenPieter MestdaghClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in MAMMALIAN GENOME

Dual inhibition of TNFR1 and IFNAR1 in imiquimod-induced psoriasiform skin inflammation in mice

Lynda GrineLien DejagerClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in JOURNAL OF IMMUNOLOGY

DUSP3 genetic deletion confers M2-like macrophage-dependent tolerance to septic shock

Pratibha SinghLien DejagerMathieu AmandEmilie TheatreMaud VandereykenTinatin ZurashviliManeesh SinghMatthias MackSteven TimmermansLucia Musumeci et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Friends or foes: matrix metalloproteinases and their multifaceted roles in neurodegenerative diseases

Marjana BrkićSriram BalusuClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in MEDIATORS OF INFLAMMATION

Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1

Sophie SteelandLeen PuimègeRoosmarijn VandenbrouckeFilip Van HauwermeirenJurgen HaustraeteNick DevoogdtPaco HulpiauGeert Leroux-RoelsDebby LaukensPhilip Meuleman et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1

Leen PuimègeFilip Van HauwermeirenSophie SteelandSara Van RyckeghemJolien VandewalleSofie LodensLien DejagerSofie VandevyverJan StaelensSteven Timmermans et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1

Sabine VettorazziConstantin BodeLien DejagerLucien FrappartEkaterina ShelestCarina KlaßenAlpaslan TasdoganHolger M ReichardtClaude LibertMarion Schneider et al.

A1 Journal Article in NATURE COMMUNICATIONS

Hematopoietic plakophilin-3 regulates acute tissue-specific and systemic inflammation in mice

Tatyana SklyarovaJolanda van HengelElien Van WonterghemClaude LibertFrans Van RoyRoosmarijn Vandenbroucke

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Identification of striatin-3 and ZBTB32 as two novel modulators of glucocorticoid receptor activity

Ioanna PettaClaude LibertJan Tavernier

Influence of the stomach-brain axis in relation to an experimental Helicobacter suis infection in mice

Caroline BlaecherNina GorléEva BauwensBram FlahouRichard DucatelleClaude LibertR VandenbrouckeFreddy HaesebrouckAnnemieke Smet

MARK-AGE biomarkers of ageing

Alexander BürkleMaría Moreno-VillanuevaJürgen BernhardMaría BlascoGerben ZondagJan HJ HoeijmakersOlivier ToussaintBeatrix Grubeck-LoebensteinEugenio MocchegianiSebastiano Collino et al.

A1 Journal Article in MECHANISMS OF AGEING AND DEVELOPMENT

N-glycome profile levels relate to silent brain infarcts in a cohort of hypertensives

Andrea Vilar-BerguaIolanda Riba-LlenaValerie VanhoorenSylviane DewaeleClaude LibertAnna PenalbaJoan MontanerPilar Delgado

A1 Journal Article in JOURNAL OF THE AMERICAN HEART ASSOCIATION

N-Glycomic changes in serum proteins in type 2 diabetes mellitus correlate with complications and with metabolic syndrome parameters

Roberto TestaValerie VanhoorenAnna Rita BonfigliMassimo BoemiFabiola OlivieriAntonio CerielloStefano GenoveseLiana SpazzafumoVincenzo BorelliMaria Giulia Bacalini et al.

A1 Journal Article in PLOS ONE

Neutralizing TNFα restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation

Lien DejagerKaren DendonckerMelanie EggermontJolien SouffriauFilip Van HauwermeirenMonique WillartElien Van WonterghemThomas NaessensMarlies BallegeerSofie Vandevyver et al.

A1 Journal Article in MUCOSAL IMMUNOLOGY

Passenger mutations confound interpretation of all genetically modified congenic mice

Tom Vanden BerghePaco HulpiauLiesbet MartensRoosmarijn VandenbrouckeElien Van WonterghemSeth W PerryInge BruggemanTatyana DivertSze Men ChoiMarnik Vuylsteke et al.

A1 Journal Article in IMMUNITY

Plasma N-glycome signature of Down syndrome

Vincenzo BorelliValerie VanhoorenEmanuela LonardiKarli R ReidingMiriam CapriClaude LibertPaolo GaragnaniStefano SalvioliClaudio FranceschiManfred Wuhrer

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

Predominant contribution of cis-regulatory divergence in the evolution of mouse alternative splicing

Qingsong GaoWei SunMarlies BallegeerClaude LibertWei Chen

A1 Journal Article in MOLECULAR SYSTEMS BIOLOGY

Protein modification and maintenance systems as biomarkers of ageing

Valerie VanhoorenAlexander Navarrete SantosKonstantinos VoutetakisIsabelle PetropoulosClaude LibertAndreas SimmEfstathios S GonosBertrand Friguet

A1 Journal Article in MECHANISMS OF AGEING AND DEVELOPMENT

Selective glucocorticoid receptor modulation : new directions with non-steroidal scaffolds

Nora SundahlJolien BridelanceClaude LibertKarolien De BosscherIlse Beck

A1 Journal Article in PHARMACOLOGY & THERAPEUTICS

Synthesis and validation of a hydroxypyrone-based, potent, and specific matrix metalloproteinase-12 inhibitor with anti-inflammatory activity in vitro and in vivo

J AertsRoosmarijn VandenbrouckeR DeraSriram BalusuElien Van WonterghemL MoonsClaude LibertW DehaenL Arckens

A1 Journal Article in MEDIATORS OF INFLAMMATION

The glucocorticoid receptor in inflammatory processes : transrepression is not enough

Sabine HübnerLien DejagerClaude LibertJan P Tuckermann

A1 Journal Article in BIOLOGICAL CHEMISTRY

Therapeutic implications of the choroid plexus-cerebrospinal fluid interface in neuropsychiatric disorders

Delphine DemeestereClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in BRAIN BEHAVIOR AND IMMUNITY

TNF trailblazers five centuries apart

A1 Journal Article in NATURE

TNFR1-induced lethal inflammation is mediated by goblet and Paneth cell dysfunction

Filip Van HauwermeirenRoosmarijn VandenbrouckeLynda GrineSofie LodensElien Van WonterghemRiet De RyckeN De GeestB HassanClaude Libert

A1 Journal Article in MUCOSAL IMMUNOLOGY

2014

An acute phase protein ready to go therapeutic for sepsis

Sofie VandevyverLien DejagerRoosmarijn VandenbrouckeClaude Libert

Editorial material

Antisense oligonucleotides against TNFR1 prevent toxicity of TNF/IFNγ treatment in mouse tumor models

Filip Van HauwermeirenRoosmarijn VandenbrouckeLynda GrineLeen PuimègeElien Van WonterghemHong ZhangClaude Libert

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Choose your models wisely: how different murine bone marrow-derived dendritic cell protocols influence the success of nanoparticulate vaccines in vitro

Heleen DewitteRein VerbekeKarine BreckpotRoosmarijn VandenbrouckeClaude LibertStefaan De SmedtIne Lentacker

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Cofactor profiling of the glucocorticoid receptor from a cellular environment

Sofie DesmetLien DejagerDorien ClarisseJonathan ThommisDiana MelchersNiek BastiaensenRob RuijtenbeekIlse BeckClaude LibertRenée Houtman et al.

Bookchapter in Steroid receptors : methods and protocols

Comprehensive overview of the structure and regulation of the glucocorticoid receptor

Sofie VandevyverLien DejagerClaude Libert

A1 Journal Article in ENDOCRINE REVIEWS

Dominance of the strongest: inflammatory cytokines versus glucocorticoids

Lien DejagerSofie VandevyverIoanna PettaClaude Libert

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

How steroids steer T cells

Claude LibertLien Dejager

A1 Journal Article in CELL REPORTS

Is there new hope for therapeutic matrix metalloproteinase inhibition?

Roosmarijn VandenbrouckeClaude Libert

A1 Journal Article in NATURE REVIEWS DRUG DISCOVERY

Magnetic layer-by-layer coated particles for efficient MRI of dendritic cells and mesenchymal stem cells

Marie-Luce De TemmermanStefaan SoenenNathalie SymensBart LucasRoosmarijn VandenbrouckeClaude LibertJo DemeesterStefaan De SmedtUwe HimmelreichJoanna Rejman

A1 Journal Article in NANOMEDICINE

Pharmacological inhibition of type I interferon signaling protects mice against lethal sepsis

Lien DejagerSofie VandevyverMarlies BallegeerElien Van WonterghemLing-Ling AnJeffrey RiggsRoland KolbeckClaude Libert

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Pro-inflammatory effects of matrix metalloproteinase 7 in acute inflammation

Roosmarijn VandenbrouckeIneke VanlaereFilip Van HauwermeirenElien Van WonterghemC WilsonClaude Libert

A1 Journal Article in MUCOSAL IMMUNOLOGY

Regulation and dysregulation of tumor necrosis factor receptor-1

Leen PuimègeClaude LibertFilip Van Hauwermeiren

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

Selective modulation of the glucocorticoid receptor can distinguish between transrepression of NF-κB and AP-1

Karolien De BosscherIlse BeckLien DejagerNadia BougarneAnthoula GaigneauxSebastien ChateauvieuxDariusz RatmanMarc BrackeJan TavernierWim Vanden Berghe et al.

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Study of the role of type I interferons in TNF-mediated inflammation

Lynda GrineClaude LibertRoosmarijn Vandenbroucke

Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death

Debby LaukensLindsey DevisscherLien Van den BosschePieter HindryckxRoosmarijn VandenbrouckeYves-Paul VandewynckelClaude CuvelierBrigitta BrinkmanClaude LibertPeter Vandenabeele et al.

A1 Journal Article in LABORATORY INVESTIGATION

The N-glycan profile of placental membrane glycoproteins alters during gestation and aging

Pragana RobajacRomana MasnikosaValerie VanhoorenClaude LibertŽeljko MikovićOlgica Nedić

A1 Journal Article in MECHANISMS OF AGEING AND DEVELOPMENT

2013

A molecular genetic analysis of TNFR1 regulation in SPRET/Ei and generation of new TNFR1 inhibitory tools

Leen PuimègeClaude Libert

Controlling complexity: the clinical relevance of mouse complex genetics

Klaus SchughartClaude LibertMartien J Kas

Editorial material

Direct effect of dsRNA mimetics on cancer cells induces endogenous IFN-beta production capable of improving dendritic cell function

Gerardo GattiNicolás Gonzalo NuñezDavid Andrés NoceraLien DejagerClaude LibertConstancio GiraudoMariana Maccioni

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

How glucocorticoid receptors modulate the activity of other transcription factors: a scope beyond tethering

Dariusz RatmanWim Vanden BergheLien DejagerClaude LibertJan TavernierIlse BeckKarolien De Bosscher

A1 Journal Article in MOLECULAR AND CELLULAR ENDOCRINOLOGY

LPS resistance of SPRET/Ei mice is mediated by Gilz, encoded by the Tsc22d3 gene on the X chromosome

Iris PinheiroLien DejagerIoanna PettaSofie VandevyverLeen PuimègeTina MahieuMarlies BallegeerFilip Van HauwermeirenCarlo RiccardiMarnik Vuylsteke et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF

Roosmarijn VandenbrouckeEline DejonckheereFilip Van HauwermeirenSofie LodensRiet De RyckeElien Van WonterghemAn StaesKris GevaertCarlos López-OtinClaude Libert

A1 Journal Article in EMBO MOLECULAR MEDICINE

Mice overexpressing β-1,4-galactosyltransferase I are resistant to TNF-induced inflammation and DSS-induced colitis

Valerie VanhoorenRoosmarijn VandenbrouckeSylviane DewaeleEvelien Van HammeJody HaighTino HochepiedClaude Libert

A1 Journal Article in PLOS ONE

N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder

M Moreno-VillanuevaJ MorathValerie VanhoorenT ElbertS KolassaClaude LibertA BürkleI-T Kolassa

A1 Journal Article in TRANSLATIONAL PSYCHIATRY

New insights into the anti-inflammatory mechanisms of glucocorticoids : an emerging role for glucocorticoid-receptor-mediated transactivation

Sofie VandevyverLien DejagerJan TuckermannClaude Libert

A1 Journal Article in ENDOCRINOLOGY

Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium

Filip Van HauwermeirenMarietta ArmakaNiki KaragianniKsanthi KranidiotiRoosmarijn VandenbrouckeSonja LogesMaarten Van RoyenJan StaelensLeen PuimègeAjay Palagani et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Study of the molecular mechanisms of glucocorticoid receptor function and resistance in TNF-induced toxicity

Sofie VandevyverClaude Libert

The mouse as a model organism in aging research: usefulness, pitfalls and possibilities

Valerie VanhoorenClaude Libert

A1 Journal Article in AGEING RESEARCH REVIEWS

2012

Alteration of liver N-glycome in patients with hepatocellular carcinoma

Ling WangValerie VanhoorenSylviane DewaeleXue-En LiuClaude LibertFeng-Min LuHui ZuangCuiying Chen

A2 Journal Article in OPEN JOURNAL OF GASTROENTEROLOGY

Altered desialylated plasma N-glycan profile in patients with non-small cell lung carcinoma

Babett BartlingValerie VanhoorenSylviane DewaeleClaude LibertHans-Stefan HofmannJohannes HaertingSebastian NudingRolf-Edgar SilberAndreas SimmCuiying Chen

A1 Journal Article in CANCER BIOMARKERS

Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation

Sofie VandevyverLien DejagerTom Van BogaertAnna KleymanYusen LiuJan TuckermannClaude Libert

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages

Anna KleimanSabine HübnerJan M Rodriguez ParkitnaAnita NeumannStefan HoferMarkus A WeigandMichael BauerWolfgang SchmidGünter SchützClaude Libert et al.

A1 Journal Article in FASEB JOURNAL

IFNβ produced by TLR4-activated tumor cells is involved in improving the antitumoral immune response

Nicolás Gonzalo NúñezVirginia AndreaniMaría Inés CrespoDavid Andrés NoceraMaría Laura BreserGabriel MorónLien DejagerClaude LibertVirginia RiveroMariana Maccioni

A1 Journal Article in CANCER RESEARCH

Matrix metalloprotease 8-dependent extracellular matrix cleavage at the blood-CSF barrier contributes to lethality during systemic inflammatory diseases

Roosmarijn VandenbrouckeEline DejonckheerePhilippe Van LintDelphine DemeestereElien Van WonterghemIneke VanlaereLeen PuimègeFilip Van HauwermeirenRiet De RyckeConor Mc Guire et al.

A1 Journal Article in JOURNAL OF NEUROSCIENCE

Modulation of dendritic cells by lipid grafted polyelectrolyte microcapsules

Marie-Luce De TemmermanJoanna RejmanBart LucasRoosmarijn VandenbrouckeClaude LibertJo DemeesterStefaan De Smedt

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

Nozomi TakahashiLinde DuprezSasker GrootjansAnje CauwelsWim NerinckxJB DuHadawayVera GoossensRia RoelandtFilip Van HauwermeirenClaude Libert et al.

A1 Journal Article in CELL DEATH & DISEASE

On the trail of the glucocorticoid receptor: into the nucleus and back

Sofie VandevyverLien DejagerClaude Libert

A1 Journal Article in TRAFFIC

Polyelectrolyte LbL microcapsules versus PLGA microparticles for immunization with a protein antigen

Marie-Luce De TemmermanJoanna RejmanRoosmarijn VandenbrouckeStefaan De KokerClaude LibertJohan GrootenJo DemeesterBruno GanderStefaan De Smedt

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Strength to strength for mouse models

Klaus SchughartClaude LibertMartien J Kas

A1 Journal Article in NATURE

2011

A therapeutic role for matrix metalloproteinase inhibitors in lung diseases?

Roosmarijn VandenbrouckeEline DejonckheereClaude Libert

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Alteration in N-glycomics during mouse aging: a role for FUT8

Valerie VanhoorenSylviane DewaeleMakoto Kuro-oNaoyuki TaniguchiLaurent DolléLeo A van GrunsvenEvgenia MakrantonakiChristos C ZouboulisCuiying ChenClaude Libert

A1 Journal Article in AGING CELL

Cecal ligation and puncture: the gold standard model for polymicrobial sepsis?

Lien DejagerIris PinheiroEline DejonckheereClaude Libert

A1 Journal Article in TRENDS IN MICROBIOLOGY

Introduction to the session 'Mechanisms of pathological and therapeutic effects of the TNF family'

A1 Journal Article in Advances in Experimental Medicine and Biology

Matrix metalloproteinase8 has a central role in inflammatory disorders and cancer progression

Eline DejonckheereRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

Matrix metalloproteinases as drug targets in ischemia/reperfusion injury

Eline DejonckheereRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in DRUG DISCOVERY TODAY

Molecular cloning of the X-chromosome located LPS-resistance gene of SPRET/Ei mice : Tsc22d3/Gilz as a candidate gene

Iris PinheiroClaude LibertMarnik Vuylsteke

mRNA-Lipoplex loaded microbubble contrast agents for ultrasound-assisted transfection of dendritic cells

Marie-Luce De TemmermanHeleen DewitteRoosmarijn VandenbrouckeBart LucasClaude LibertJo DemeesterStefaan De SmedtIne LentackerJoanna Rejman

A1 Journal Article in BIOMATERIALS

New strategies to prevent TNF-induced toxicity in TNF/IFNγ-based anti-tumor models

Filip Van HauwermeirenClaude Libert

RIP Kinase-dependent necrosis drives lethal systemic inflammatory response syndrome

Linde DuprezNozomi TakahashiFilip Van HauwermeirenBenjamin VandendriesscheVera GoossensTom Vanden BergheWim DeclercqClaude LibertAnje CauwelsPeter Vandenabeele

A1 Journal Article in IMMUNITY

Strategies to inhibit the toxicity of systemic TNF treatment

Filip Van HauwermeirenLeen PuimègeSofie VandevyverTom Van BogaertIneke VanlaereLiesbeth HuysLien DejagerClaude Libert

A1 Journal Article in Advances in Experimental Medicine and Biology

The first MMP in sepsis

Roosmarijn VandenbrouckeLien DejagerClaude Libert

Editorial material

The role of MMP8 in TLR4-mediated acute systemic inflammation

Eline DejonckheereClaude Libert

Treatment of TNF mediated diseases by selective inhibition of soluble TNF or TNFR1

Filip Van HauwermeirenRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

Tumor necrosis factor Inhibits glucocorticoid receptor function in mice a strong signal toward lethal shock

Tom Van BogaertSofie VandevyverLien DejagerFilip Van HauwermeirenIris PinheiroIoanna PettaDavid EngblomAnna KleymanGuenther SchutzJan Tuckermann et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

X-chromosome-located microRNAs in immunity: might they explain male/female differences?: the X chromosome-genomic context may affect X-located miRNAs and downstream signaling, thereby contributing to the enhanced immune response of females

Iris PinheiroLien DejagerClaude Libert

A1 Journal Article in BIOESSAYS

2010

Alteration of N-glycome in diethylnitrosamine-induced hepatocellular carcinoma mice: a non-invasive monitoring tool for liver cancer

Xue-en LiuSylviane DewaeleValerie VanhoorenYe-Dong FanLing WangJacques Van HuysseHui ZhuangRoland ContrerasClaude LibertCuiying Chen

A1 Journal Article in LIVER INTERNATIONAL

Altered serum glycomics in Alzheimer disease: a potential blood biomarker?

Cuiying ChenSebastiaan EngelborghsSylviane DewaeleNathalie Le BastardJean-Jacques MartinValerie VanhoorenClaude LibertPeter Paul De Deyn

A1 Journal Article in REJUVENATION RESEARCH

Altered serum N-glycomics in chronic hepatitis B patients

Hong-Lian GuiChung-Fang GaoHui WangXue-En LiuQing XieSylviane DewaeleLing WangHui ZhuangRoland ContrerasClaude Libert et al.

A1 Journal Article in LIVER INTERNATIONAL

Crosstalk between TNF and glucocorticoid receptor signaling pathways

Tom Van BogaertKarolien De BosscherClaude Libert

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

Increased glucocorticoid receptor expression and activity mediate the LPS resistance of SPRET/EI mice

Lien DejagerIris PinheiroLeen PuimègeYe-Dong FanLies GremeauxHugo VankelecomClaude Libert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action

F Thomas WunderlichPeter StröhleA Christine KönnerSabine GruberSulay TovarHella S BrönnekeLisa Juntti-BerggrenLuo-Sheng LiNico van RooijenClaude Libert et al.

A1 Journal Article in CELL METABOLISM

Molecular and genetic analysis of the resistance of the mouse strain SPRET/Ei to endotoxemia and Gram-negative sepsis

Lien DejagerClaude Libert

Role for neutrophils in host immune responses and genetic factors that modulate resistance to Salmonella enterica serovar Typhimurium in the inbred mouse strain SPRET/Ei

Lien DejagerIris PinheiroPieter BogaertLiesbeth HuysClaude Libert

A1 Journal Article in INFECTION AND IMMUNITY

Serum N-glycan profile shift during human ageing

Valerie VanhoorenSylviane DewaeleClaude LibertSebastiaan EngelborghsPeter Paul De DeynOlivier ToussaintFlorence Debacq-ChainiauxMichel PoulainYouri GlupczynskiClaudio Franceschi et al.

A1 Journal Article in EXPERIMENTAL GERONTOLOGY

Serum N-glycome biomarker for monitoring development of DENA-induced hepatocellular carcinoma in rat

Meng FangSylviane DewaeleYun-peng ZhaoPeter StarkelValerie VanhoorenYue-ming ChenXin JiMing LuoBao-mu SunYves Horsmans et al.

A1 Journal Article in MOLECULAR CANCER

Study of the molecular mechanism of glucocorticoid resistance in tumor necrosis factor-induced systemic inflammation

Tom Van BogaertClaude Libert

The X chromosome in immune functions: when a chromosome makes the difference

Claude LibertLien DejagerIris Pinheiro

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

2009

Hop bitter acids efficiently block inflammation independent of GRα, PPARα, or PPARγ

Marjan Van CleemputArne HeyerickClaude LibertKatrien SwertsJan PhilippéDenis De KeukeleireGuy HaegemanKarolien De Bosscher

A1 Journal Article in MOLECULAR NUTRITION & FOOD RESEARCH

In vitro and in vivo protein-bound tyrosine nitration characterized by diagonal chromatography

Bart GhesquièreNiklaas ColaertKenny HelsensLien DejagerCaroline VanhauteKatleen VerleysenKoen KasEvy TimmermanMarc GoethalsClaude Libert et al.

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

Increased rat serum corticosterone suggests immunomodulation by stimulation of the vagal nerve

Veerle De HerdtLeen PuimègeJan De WaeleRobrecht RaedtTine WyckhuysRIEM EL TAHRYClaude LibertWytse WadmanPaul BoonKristl Vonck

A1 Journal Article in JOURNAL OF NEUROIMMUNOLOGY

Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17

Melba MunozMarkus M HeimesaatKerstin DankerDaniela StruckUwe LohmannRita PlickertStefan BereswillAndre FischerIldiko Rita DunayKerstin Wolk et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Loss of matrix metalloproteinase 2 in platelets reduces arterial thrombosis in vivo

S MomiE FalcinelliS GianniniL RuggeriL CecchettiT CorazziClaude LibertP Gresele

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Matrix metalloproteinases as drug targets in infections caused by gram-negative bacteria and in septic shock

Ineke VanlaereClaude Libert

A1 Journal Article in CLINICAL MICROBIOLOGY REVIEWS

N-glycan profiles as tools in diagnosis of hepatocellular carcinoma and prediction of healthy human ageing

Valerie VanhoorenXue-En LiuClaudio FranceschiChun-Fang GaoClaude LibertRoland ContrerasCuiying Chen

A1 Journal Article in MECHANISMS OF AGEING AND DEVELOPMENT

Serum protein N-glycans profiling for the discovery of potential biomarkers for nonalcoholic steatohepatitis

Cuiying ChenHemda Schmilovtz-WeissXue-en LiuOrit PappoMarisa HalpernJacqueline SulkesMarius BraunMaya CohenNir BarakRan Tur-Kaspa et al.

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

Spray-dried powders of starch and crosslinked poly(acrylic acid) as carriers for nasal delivery of inactivated influenza vaccine

Delphine CouckeMichael SchotsaertClaude LibertEveline PringelsChris VervaetP ForemanXavier SaelensJean Paul Remon

A1 Journal Article in Vaccine

Thirty years of Mus spretus: a promising future

Lien DejagerClaude LibertXavier Montagutelli

A1 Journal Article in TRENDS IN GENETICS

Type I interferon drives tumor necrosis factor-induced lethal shock

Liesbeth HuysFilip Van HauwermeirenLien DejagerEline DejonckheereStefan LienenklausSiegfried WeissGeorges LeclercqClaude Libert

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2008

A heat shock protein gene (Hsp70.1) is critically involved in the generation of the immune response to myelin antigen

MA MYCKOH CWIKLINSKAA WALCZAKClaude LibertCS RAINEKW SELMAJ

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways

Zeynep DogusanMonica GarcíaDaisy FlamezLena AlexopouiouMichel GoldmanConny GysemansChantal MathieuClaude LibertDécio L EizirikJoanne Rasschaert

A1 Journal Article in DIABETES

IL-17 produced by Paneth cells drives TNF-induced shock

N TAKAHASHIIneke VanlaereRiet De RyckeAnje CauwelsLAB JOOSTENE LUBBERTSWB VAN DEN BERGClaude Libert

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

In-vitro and in-vivo evidence for the anti-inflammatory activity of hop bitter acids in mouse

Marjan Van CleemputArne HeyerickClaude LibertDenis De KeukeleireGuy HaegemanKarolien De Bosscher

Modeling lymphangiogenesis in a three-dimensional culture system

F BRUYEREL MELEN-LAMALLES BLACHERG ROLANDM THIRYL MOONSF FRANKENNEP CARMELIETK ALITALOClaude Libert et al.

A1 Journal Article in NATURE METHODS

Mx1 causes resistance against influenza A viruses in the Mus spretus-derived inbred mouse strain SPRET/Ei

Ineke VanlaereAnanza VanderrijstJL GUENETMarina De FiletteClaude Libert

A1 Journal Article in CYTOKINE

N-Glycan profiling in the study of human aging

Valerie VanhoorenWouter LaroyClaude LibertCuiying Chen

A1 Journal Article in BIOGERONTOLOGY

Over-expression of heat shock protein 70 in mice is associated with growth retardation, tumor formation, and early death

Valerie VanhoorenXue-En LiuLiesbeth DesmyterYe-Dong FanLieve VanwalleghemWim Van MolleSylviane DewaeleMarleen PraetRoland ContrerasClaude Libert et al.

A1 Journal Article in REJUVENATION RESEARCH

Tumor necrosis factor alpha mediates the lethal hepatotoxic effects of poly(I: C) in D-galactosamine-sensitized mice

Lien DejagerClaude Libert

A1 Journal Article in CYTOKINE

2007

A role for type I interferons in endotoxemia and sepsis?

Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage

L TIANM STEFANIDAKISL NINGPhilippe Van LintH NYMAN-HUTTUNENClaude LibertS ITOHARAM MISHINAH RAUVALACG GAHMBERG

A1 Journal Article in JOURNAL OF CELL BIOLOGY

Caspase-14 protects against epidermal UVB photo-damage and water loss

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensC VAN DEN BROUCKEPetra Van DammeKatharina D'HerdeJ HACHEM et al.

Caspase-14 protects against epidermal UVB photo-damage and water loss.

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensC VAN DEN BROUCKEPetra Van DammeKatharina D'HerdeJ HACHEM et al.

Caspase-14 protects against epidermal UVB photodamage and water loss

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensCaroline Van den broeckePetra Van DammeKatharina D'HerdeJP HACHEM et al.

A1 Journal Article in NATURE CELL BIOLOGY

Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation

Philippe Van LintClaude Libert

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

Description and mapping of the resistance of DBA/2 mice to TNF-induced lethal shock

Ben WielockxJan StaelensLeen PuimègeIneke VanlaereMaarten Van RoyPhilippe Van LintFrans Van RoyClaude Libert

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Early mediators and downstream effectors of dsRNA-induced beta cell apoptosis: the role of IRF-3 and ER stress

Joanne RasschaertZeynep DogusanMonica GarcíaDaisy FlamezLena AlexopoulouMichele GoldmanConny GysemansChantal MathieuClaude LibertDécio L Eizirik

Involvement of specific matrix metalloproteinases during tumor necrosis factor/IFN gamma-based cancer therapy in mice

Maarten Van RoyPhilippe Van LintI VAN LAEREBen WielockxC WILSONC LOPEZ-OTINS SHAPIROClaude Libert

A1 Journal Article in MOLECULAR CANCER THERAPEUTICS

N-glycomic changes in hepatocellular carcinoma patients with liver cirrhosis induced by hepatitis B virus

Xueen LiuLiesbeth DesmyterCF GAOWouter LaroySylviane DewaeleValerie VanhoorenL WANGH ZHUANGNico CallewaertClaude Libert et al.

A1 Journal Article in HEPATOLOGY

N-glycomic changes in serum proteins during human aging

Valerie VanhoorenLiesbeth DesmyterXueen LiuM CARDELLIC FRANCESCHIA FEDERICOClaude LibertWouter LaroySylviane DewaeleRoland Contreras et al.

A1 Journal Article in REJUVENATION RESEARCH

Nonclassical export pathway: overexpression of NCE102 reduces protein and DNA damage and prolongs lifespan in an SGS1 deficient Saccharomyces cerevisiae

Liesbeth DesmyterJan VerstraelenSylviane DewaeleClaude LibertRoland ContrerasCuiying Chen

A1 Journal Article in BIOGERONTOLOGY

Protection of zinc against tumor necrosis factor-induced lethal inflammation depends on heat shock protein 70 and allows safe antitumor therapy

Wim Van MolleMaarten Van RoyTom Van BogaertLien DejagerPhilippe Van LintIneke VanlaereK SEKIKAWAG KOLLIASClaude Libert

A1 Journal Article in CANCER RESEARCH

Should we inhibit type I interferons in sepsis?

Tina MahieuClaude Libert

A1 Journal Article in INFECTION AND IMMUNITY

The use of tissue inhibitors of matrix metalloproteinases to increase the efficacy of a tumor necrosis factor/interferon gamma antitumor therapy

Maarten Van RoyBen WielockxA BAKERClaude Libert

A1 Journal Article in CANCER GENE THERAPY

Vagus nerve stimulation induced changes in corticosterone in rats

Veerle De HerdtClaude LibertJan De WaeleT DE SMEDTL WATERSCHOOTTine WyckhuysRIEM EL TAHRYAnnelies Van DyckeRobrecht RaedtKristl Vonck et al.

Withaferin A strongly elicits I kappa B kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity

Mary KailehWim Vanden BergheArne HeyerickJ HORIONJ PIETTEClaude LibertDenis De KeukeleireT ESSAWIGuy Haegeman

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2006

Matrix metalloproteinase-8: Cleavage can be decisive

Philippe Van LintClaude Libert

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

The secret life of caspase-14

Geertrui DeneckerEsther HosteT HOCHPIEDBarbara GilbertPetra OvaereKatharina D'HerdeCaroline VandenbrouckeSaskia LippensLore SchoonjansClaude Libert et al.

The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production

Tina MahieuJM PARKH REVETSB PASCHEA LENGELINGJan StaelensAndy WullaertIneke VanlaereTino HochepiedFrans Van Roy et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2005

A fully dissociated compound of plant origin for inflammatory gene repression

Karolien De BosscherWim Vanden BergheIlse BeckWim Van MolleN HENNUYERJ HAPGOODClaude LibertB STAELSA LOUWGuy Haegeman

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adenoviral gene transfer of ABIN-1 protects mice from TNF/galactosamine-induced acute liver failure and lethality

Andy WullaertBen WielockxSofie Van HuffelVeerle BogaertB DE GEESTP PAPELEUPeter SchotteKarim El BakkouriKaren HeyninckClaude Libert et al.

A1 Journal Article in HEPATOLOGY

Glycoprofiling of N-linked serum protein: an aging biomarker?

Cuiying ChenL DESMYTERW VAN MOLLEWouter LaroyAnnelies Van HeckeSylviane DewaeleA FEDERICOClaude LibertRoland Contreras

How glucocorticoids control their own strength and the balance between pro- and anti-inflammatory mediators

Wim Van MolleClaude Libert

Editorial material

Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis

Philippe Van LintBen WielockxLeen PuimègeAgnès NoëlCarlos López-OtinClaude Libert

A1 Journal Article in JOURNAL OF IMMUNOLOGY

The liver stage of Plasmodium berghei inhibits host cell apoptosis

C VAN DE SANDS HORSTMANNA SCHMIDTA STURMS BOLTEA KRUEGERM LUTGEHETMANNJM POLLOKClaude LibertVT HEUSSLER

A1 Journal Article in MOLECULAR MICROBIOLOGY

2004

Breaking the species barrier: derivation of germline-competent embryonic stem cells from Mus spretus x C57BL/6 hybrids

Tino HochepiedLuc SchoonjansJan StaelensVeerle KreemersSophie DanloyLeen PuimègeDésiré CollenFrans Van RoyClaude Libert

A1 Journal Article in STEM CELLS

Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes

V MASSONLR DE LA BALLINAC MUNAUTBen WielockxM JOSTC MAILLARDS BLACHERK BAJOUT ITOHS ITOHARA et al.

A1 Journal Article in FASEB JOURNAL

Deficiency of matrix metalloproteinase-2 (MMP-2) protects mice against platelet-dependent thrombosis

S MOMIE FALCINELLIClaude LibertP GRESELE

Exogenous alpha-1-acid glycoprotein protects against renal ischemia-reperfusion injury by inhibition of inflammation and apoptosis

B DE VRIESSJ WALTERTGAM WOLFSTino HochepiedJ RABINAP HEERINGAJ PARKKINENClaude LibertWA BUURMAN

A1 Journal Article in TRANSPLANTATION

Matrilysin (matrix metalloproteinase-7): a new promising drug target in cancer and inflammation?

Ben WielockxClaude LibertC WILSON

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders

Jan StaelensLeen PuimègeTina MahieuGwenda PynaertTino HochepiedAnnelies VandenabeeleJohan GrootenDimitris KontoyiannisFrans Van RoyGeorge Kollias et al.

A1 Journal Article in MAMMALIAN GENOME

2003

alpha(1)-Acid glycoprotein: an acute phase protein with inflammatory and immunomodulating properties

Tino HochepiedFG BERGERH BAUMANNClaude Libert

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

Bilirubin release induced by tumor necrosis factor in combination with galactosamine is toxic to mice

Wim Van MolleClaude Libert

A1 Journal Article in CYTOKINE

Inflammation - A nervous connection

Editorial material

MMP-2 and MMP-9 synergize in promoting choroidal neovascularization

V LAMBERTBen WielockxC MUNAUTC GALOPINM JOSTT ITOHZ WERBA BAKERClaude LibertHW KRELL et al.

A1 Journal Article in FASEB JOURNAL

Serine proteases of the fibrinolysis pathway are not involved in lethal hepatitis and fibrinogen breakdown induced by tumor necrosis factor

Ben WielockxClaude Libert

A1 Journal Article in CYTOKINE

2002

HSP70 protects against TNF-induced lethal inflammatory shock.

Wim Van MolleBen WielockxTina MahieuM TAKADAT TANIGUCHIK SEKIKAWAClaude Libert

A1 Journal Article in IMMUNITY

Hyporesponsiveness of SPRET/Ei mice to lethal shock induced by tumor necrosis factor and implications for a TNF-based antitumor therapy

Jan StaelensBen WielockxLeen PuimègeFrans Van RoyJean-Louis GuénetClaude Libert

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mice lacking a 2-macroglobulin show an increased host defense against Gram-negative bacterial sepsis, but are more susceptible to endotoxic shock.

Tino HochepiedF VAN LEUVENClaude Libert

A1 Journal Article in EUROPEAN CYTOKINE NETWORK

Overexpression of alpha(1)-acid glycoprotein in transgenic mice leads to sensitisation to acute colitis.

Tino HochepiedAndy WullaertFG BERGERH BAUMANNPeter BrouckaertLothar SteidlerClaude Libert

A1 Journal Article in GUT

TNF-Mediated toxicity after massive induction of specific CD8(+) T cells following immunization of mice with a tumor-specific peptide.

J BILSBOROUGHC UYTTENHOVED COLAUP BOUSSOClaude LibertB WEYNANDT BOONBenedicte Van Den Eynde

A1 Journal Article in JOURNAL OF IMMUNOLOGY

2001

A mediator role for metallothionein in tumor necrosis factor-induced lethal shock

Wim WaelputDaniël BroekaertJoël VandekerckhovePeter BrouckaertJan TavernierClaude Libert

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Antisense knockdown of inducible nitric oxide synthase inhibits the relaxant effect of VIP in isolated smooth muscle cells of the mouse gastric fundus.

JMC DICKWim Van MolleClaude LibertRomain Lefebvre

A1 Journal Article in BRITISH JOURNAL OF PHARMACOLOGY

Detection, characterisation and purification of a murine liver factor capable of desensitising towards the lethal activity of tumour necrosis factor.

Ben WielockxTino HochepiedJan StaelensWim Van MollePeter BrouckaertClaude Libert

A1 Journal Article in CYTOKINE

Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene activation in the liver

T AlonziD MaritanoB GorgoniG RizzutoClaude LibertV Poli

A1 Journal Article in MOLECULAR AND CELLULAR BIOLOGY

Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy.

Ben WielockxK LANNOYSD SHAPIROT ITOHS ITOHARAJoël VandekerckhoveClaude Libert

A1 Journal Article in NATURE MEDICINE

Involvement of a serine protease, but not of neutrophil elastase, in tumor necrosis factor-induced lethal hepatitis and induction of platelet-activating factor.

Ben WielockxF BUSSOLINOSD SHAPIROClaude Libert

A1 Journal Article in JOURNAL OF HEPATOLOGY

2000

Differential response of alpha(2)-macroglobulin-deficient mice in models of lethal TNF-induced inflammation.

Tino HochepiedPaul AmelootPeter BrouckaertF VAN LEUVENClaude Libert

A1 Journal Article in EUROPEAN CYTOKINE NETWORK

Involvement of the acute phase protein alpha(1)-acid glycoprotein in nonspecific resistance to a lethal Gram-negative infection.

Tino HochepiedWim Van MolleFG BERGERH BAUMANNClaude Libert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The major acute-phase protein, serum amyloid P component, in mice is not involved in endogenous resistance against tumor necrosis factor alpha-induced lethal hepatitis, shock, and skin necrosis.

Wim Van MolleTino HochepiedPeter BrouckaertClaude Libert

A1 Journal Article in INFECTION AND IMMUNITY

Tumor necrosis factor-induced lethal hepatitis: pharmacological intervention with verapamil, tannic acid, picotamide and K76COOH.

Wim Van MolleJ VANDEN BERGHEPeter BrouckaertClaude Libert

A1 Journal Article in FEBS LETTERS

1999

Activation of caspases in lethal experimental hepatitis and prevention by acute phase proteins.

Wim Van MolleGeertrui DeneckerI RODRIGUEZPeter BrouckaertPeter VandenabeeleClaude Libert

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Caspase-1 is not involved in experimental hepatitis in mouse.

Wim Van MollePeter BrouckaertClaude Libert

A1 Journal Article in FEBS LETTERS

Identification of a locus on distal mouse chromosome 12 that controls resistance to tumor necrosis factor-induced lethal shock.

Claude LibertBen WielockxGL HAMMONDPeter BrouckaertWalter FiersRW ELLIOTT

A1 Journal Article in GENOMICS

Onderzoek naar de mechanismen leidend tot Tumor Necrosis Factor-geïnduceerde leverschade en hypotensie

Wim Van MollePeter BrouckaertClaude Libert

The role of complement activation in tumour necrosis factor-induced lethal hepatitis.

Claude LibertBen WielockxB GRIJALBAWim Van MolleE KREMMERHR COLTENWalter FiersPeter Brouckaert

A1 Journal Article in CYTOKINE

1998

High-level constitutive expression of alpha(1)-acid glycoprotein and lack of protection against tumor necrosis factor-induced lethal shock in transgenic mice.

Claude LibertTino HochepiedFG BERGERH BAUMANNWalter FiersPeter Brouckaert

A1 Journal Article in TRANSGENIC RESEARCH

Interleukin 6 dependence of anti-DNA antibody production: evidence for two pathways of autoantibody formation in pristane-induced lupus

HB RichardsM SatohM ShawClaude LibertV PoliWH Reeves

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

1997

al-Acid glycoprotein and al-antitrypsin inhibit TNF-induced but not anti-Fas-induced apoptosis of hepatocytes in mice

Wim Van MolleClaude LibertWalter FiersPeter Brouckaert

A2 Journal Article in J. Immunol. 159, 3555-3564, 1997

alpha(1)-acid glycoprotein and alpha(1)-antitrypsin inhibit TNF-induced but not anti-Fas-induced apoptosis of hepatocytes in mice.

W VANMOLLEClaude LibertWalter FiersPeter Brouckaert

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Defective development of pristane-oil-induced plasmacytomas in interleukin-6-deficient BALB/c mice

G. LattanzioClaude LibertM. AquilinaM. CappellettiG. CilibertoP. MusianiV. Poli

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

1996

al-Antitrypsin inhibits the lethal response to TNF in mice

Claude LibertWim Van MollePeter BrouckaertWalter Fiers

A2 Journal Article in J. Immunol. 157, 5126-5129, 1996

alpha(1)-antitrypsin inhibits the lethal response to TNF in mice.

Claude LibertWim Van MollePeter BrouckaertWalter Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

C/EBP beta is required for the late phases of acute phase genes induction in the liver and for tumour necrosis factor-alpha, but not Interleukin-6, regulation

M CAPPELLETTIT ALONZIE FATTORIClaude LibertV POLI

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Inhibition of and sensitization to the lethal effects of tumor necrosis factor

Peter BrouckaertClaude LibertAnje CauwelsBart EveraerdtWim Van MollePaul AmelootYannick GansemansBernardo GrijalbaNozomi TakahashiMarie-José Truong et al.

A1 Journal Article in JOURNAL OF INFLAMMATION

Platelet-activating factor is a mediator in tumor necrosis factor galactosamine-induced lethality.

Claude LibertWim Van MollePeter BrouckaertWalter Fiers

A1 Journal Article in JOURNAL OF INFLAMMATION

1994

Protection by alpha(1)-acid glycoprotein against tumor necrosis factor-induced lethality.

Claude LibertPeter BrouckaertWalter Fiers

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Receptor-selective mutants of tumour necrosis factor in the therapy of cancer : preclinical studies

Peter BrouckaertPaul AmelootAnje CauwelsBart EveraerdtClaude LibertNozomi TakahashiWim Van MolleWalter Fiers

A1 Journal Article in CIRCULATORY SHOCK

Response of interleukin-6-deficient mice to tumor necrosis factor-induced metabolic changes and lethality.

Claude LibertNozomi TakahashiAnje CauwelsPeter BrouckaertH BLUETHMANNWalter Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

1993

Protection against tumor necrosis factor-induced lethality

Claude LibertBart EveraerdtNozomi TakahashiAnje CauwelsPeter BrouckaertWalter Fiers

Relations between tumor necrosis factor, interleukin-6 and the liver in a murine model

Claude LibertWalter Fiers

Strategies to broaden the therapeutic margin of tumor necrosis factor

Peter BrouckaertBart EveraerdtClaude LibertNozomi TakahashiAnje CauwelsWalter Fiers

Tumor necrosis factor

Peter BrouckaertClaude Libert

Bookchapter in Acute Phase Proteins. Molecular Biology, Biochemistry, and Clinical Applications

TUMOR-NECROSIS-FACTOR, ITS RECEPTORS AND THE CONNECTION WITH INTERLEUKIN-1 AND INTERLEUKIN-6.

Peter BrouckaertClaude LibertB EVERAERDTNozomi TakahashiAnje CauwelsWalter Fiers

A1 Journal Article in IMMUNOBIOLOGY

Two pathways of tumor necrosis factor signal transduction: in vitro and in vivo implications

Walter FiersRudi BeyaertPeter BrouckaertAnje CauwelsWim DeclercqDirk De ValckB EveraerdtVera GoossensJohan GrootenGuy Haegeman et al.

1992

Limited involvement of interleukin-6 in the pathogenesis of lethal septic shock as revealed by the effect of monoclonal antibodies against interleukin-6 or its receptor in various murine models

Claude LibertAnne VinkPierre CouliePeter BrouckaertBart EveraerdtJacques Van SnickWalter Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Selective species specificity of tumor-necrosis-factor for toxicity in the mouse.

Peter BrouckaertClaude LibertBart EveraerdtWalter Fiers

A1 Journal Article in LYMPHOKINE AND CYTOKINE RESEARCH

Tumor necrosis factor : mechanism of action and its potential for anticancer therapy

W HersRudi BeyaertPeter BrouckaertEls DecosterDirk De ValckB EveraerdtJohan GrootenAnne LenaertsClaude LibertK Schulze-Osthoff et al.

Tumor-necrosis-factor : mechanism of action at the molecular, cellular and in vivo level

Walter FiersRudi BeyaertPeter BrouckaertEls DecosterDirk De ValckBart EveraerdtJohan GrootenAnne LenaertsClaude LibertK. Schulzeosthoff et al.

1991

Interleukin-6 enhances the expression of tumor necrosis factor receptors on hepatoma cells and hepatocytes

Sigrid Van BladelClaude LibertWalter Fiers

A1 Journal Article in CYTOKINE

Involvement of the liver, but not of IL-6, in IL-1-induced desensitization to the lethal effects of tumor necrosis factor

Claude LibertSigrid Van BladelPeter BrouckaertAlan ShawWalter Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

The influence of modulating substances on tumor necrosis factor and interleukin-6 levels after injection of murine tumor necrosis factor or lipopolysaccharide in mice

Claude LibertSigrid Van BladelPeter BrouckaertWalter Fiers

A1 Journal Article in JOURNAL OF IMMUNOTHERAPY

1990

Development of a simple, sensitive and specific bioassay for interleukin-1 based on the proliferation of RPMI 1788 cells: comparison with other bioassays for IL-1

Peter VandenabeeleWim DeclercqClaude LibertWalter Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS

In vitro and in vivo action of tumor necrosis factor

Walter FiersRudi BeyaertPeter BrouckaertBart EveraerdtGuy HaegemanClaude LibertPhilip SuffysNozomi TakahashiJan TavernierSigrid Van Bladel et al.

Induction of interleukin 6 by human and murine recombinant interleukin 1 in mice

Claude LibertPeter BrouckaertAlan ShawWalter Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor-necrosis-factor : mechanism of action at the molecular, cellular and in vivo level

Walter FiersRudi BeyaertPeter BrouckaertBart EveraerdtJohan GrootenAnne LenaertsClaude LibertP. SuffysNozomi TakahashiJan Tavernier et al.

A1 Journal Article in SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

1989

A role for Interleukin-1 in the invivo actions of tumor necrosis factor

Peter BrouckaertClaude LibertBart EveraerdtNozomi TakahashiWalter Fiers

A1 Journal Article in LYMPHOKINE RESEARCH

Species specificity and involvement of other cytokines in endotoxic shock action of recombinant tumour necrosis factor in mice

Peter BrouckaertBart EveraerdtClaude LibertNozomi TakahashiWalter Fiers

A1 Journal Article in AGENTS AND ACTIONS