Research Explorer

Project

A detailed study of the role of SRC-1A and SRC-2 (GRP-1) in TNF-induced Glucocorticoid Resistance
Code
01J00511
Duration
01 July 2011 → 30 April 2016
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Immunology
    • Morphological sciences
    • Oncology
    • Respiratory medicine
    • Immunology
    • Morphological sciences
    • Oncology
    • Respiratory medicine
    • Immunology
    • Morphological sciences
    • Oncology
    • Respiratory medicine
Keywords
mice liver inflammation biology sepsis
 
Project description

It is our hypothesis that the reduced glucocorticoid response of many patients suffering from inflammation, is due to effects of TNF on the biology of the glucocorticoid receptor. In this project, we will investigate whether the effects of TNF are located at the level or activity of the GR-cofactors SCR1 and SRC2.