Accelerating the lysin hit-to-lead pipeline through metagenomic lysin identification, modular engineering, and ultrahigh-throughput screening.

AgroFUNzymes: Boosting AGROBODIES with fungal cell wall-degrading enzymes

A pipeline for the development of lysins as decolonizing agents against vancomycin-resistant enterococci.

Approaches to the development of designer cellulosomes for biorefinery applications.

A technological chain for the development of antibacterial lysins against fermentation contaminants and infectious diseases

Back to the future: specificity determinant evolution of Klebsiella bacteriophage depolymerases

Bacteriophage-derived Proteins as Antimicrobials

De novo designed phage lysins to innovate antibiotic development

Doctoral project Bjorn Criel

Doctoral project Dorien Dams

Doctoral project Vincent De Maesschalck

Function, organization, dynamics and evolution of hyperbranched receptor-binding protein in Klebsiella jumbo bacteriophages

Harnessing phage tailspike modularity to reprogram phages and phage tail-like bacteriocins towards Shiga-toxin producing <i>Escherichia coli</i>.

Scaffoldomics for product yield maximization of fine chemicals in microbial cell factories

Synthetic bacteriophages and their synergies with antibiotics

Doctoral project Lenny De Staercke

Engineering of bacteriophage-derived endolysins to treat streptococcal mammary gland infections

Innovating phage therapy through computational mutagenesis: a machine learning framework for evolution-aware treatment design

Predicting and understanding phage-host interactions with machine learning tools based on phage receptor-binding proteins.

The role of the skin microbiome in mosquito attraction

A digital phagogram for personalized phage therapy

A discovery and engineering platform for lysins as a novel class of antibiotics

A discovery and engineering platform for lysins as a novel class of antibiotics

A market-fit and scalable pipeline for VersaTile antibodies

AntiFUNzymen II

A pipeline for phage lysins targeting multidrug-resistant Staphylococcus pseudintermedius in canine pyoderma and bacterial otitis externa

A pipeline for the development of lysins as decolonizing agents against vancomycin-resistant enterococci.

A pipeline for the development of lysins as decolonizing agents against vancomycin-resistant enterococci.

A technological chain for the development of antibacterial lysins against fermentation contaminants and infectious diseases

Burnzymes

Cofunding core facility - HTS for SynBio

Customized phages and tailocins targeting Shiga-toxin producing Escherichia coli

Depolymerases for the prevention and treatment of neonatal sepsis in low- and middle-income countries

Designer cellulosomics for a customized conversion of lignocellulosic biomass to bioethanol

Designer cellulosomics for customized solutions towards sustainable bioethanol production

Designer enzybiotics against bacterial pathogens

Development of the next generatation Artilysins, enzyme-based antibiotics against multidrug-resistant bacteria

Directed evolution of modular proteins driven by machine learning: the VersaTile Platform 2.0

Directed evolution of modular proteins driven by machine learning: the VersaTile Platform 2.0

Engineered phages and tailocins targeting Shiga toxin-producing Escherichia coli (STEC)

Enzyme-based fungicides with a dual mode-of-action - AntiFUNzymes

Function, organization, dynamics and evolution of hyperbranched receptor-binding protein systems in Klebsiella jumbo phages and their interactions with bacteria

Horizontal and vertical evolution of receptor-binding proteins in mono- and bivalent Klebsiella bacteriophages

Novel enzyme engineering methodology: VersaTile Shuffling

Scaffoldomics for product yield maximization of fine chemicals in microbial cell factories

Scaffoldomics for product yield maximization of fine chemicals in microbial cell factories

Synthetic biology of modular phage proteins

The organization and evolution of receptor binding proteins in Klebsiella phages by exploiting novel tools in synthetic biology

The role of capsular exopolysaccharide depolymerases as host determinant for Klebsiella pneumoniae phages, and their enzymatic properties.

Understanding the evolutionary dynamics of phage lysin configurations as a driver for new enzyme-based antibiotics

Valorisation of industrial bio-based side streams with designer cellulosomics

VersaTile antibodies

VersaTile Platform: innovating modular proteins by combinatorial design

A high-throughput electroporation system for rapid strain development for industrial biotechnology purposes

A MALDI-TOF/TOF MS instrument for (bio)polymer characterization and imaging.

Automated protein purification: an essential step towards further analyses and new applications.

Engineered lysines as innovative antimicrobial strategy for the treatment of coliform mastitis

Engineering of chimeric bacteriophage-derived endolysins and selection of staphylolytic and streptolytic candidates for the treatment of Gram-positive mammary gland infections in cows.

Microfluidics for the synthetic biology of modular endolysins