Project

A pipeline for the development of lysins as decolonizing agents against vancomycin-resistant enterococci.

Code
01D19621
Duration
01 October 2021 → 31 October 2021
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
  • Natural sciences
    • Infectious diseases
    • Microbiomes
  • Medical and health sciences
    • Drug discovery and development not elsewhere classified
Keywords
Antibiotics microfluidics protein engineering vancomycin-resistant enterococci
 
Project description

Lysins are bacteriophage-encoded peptidoglycan degrading enzymes with proven clinical potential as alternative for broad-spectrum antibiotics. In this project, I will develop a pipeline for discovery, engineering and delivery of lysins in the gut environment for pathogenic decolonization. A generic
approach will be elaborated for lysins, here specifically acting against vancomycin-resistant enterococci (VRE).