Novel mechanisms of inflammation and cell death regulation in autoinflammatory and infectious diseases

Mechanisms and regulation of inflammasome-associated programmed cell death

Targeting NLRP3-mediated inflammation with novel chemotypes

Doctoral project Léonie Dejas

Molecular Mechanisms of Cell Death and Inflammation regulation in Host-Pathogen Interactions with the Human Immune System

Characterizing the role of microglial inflammation in neurodegeneration

BOF staff support in the framework of an ERC-Grant

BOF-ZAP professorship in medical biochemistry

Caspase-12 in regulation of immune responses during bacterial infection

Cell Death Regulation and Role in Infection and Inflammatory Diseases

Cell type specific functional analysis of inflammasome signalling in the colon, and its role in IBD

Combined chemotherapy and inflammasome neutralization for the treatment of non-small cell lung carcinoma

Development and functional characterization of inhibitors targeting specific inflammatory caspases

Exploring the Nlrp6 interactome and its role in immune signaling

Functional analysis of inflammasome and immune signaling in conditionally targeted NLRP2-deficient mice

Human Brain Project Specific Grant Agreement 1

Inhibition of TNFR1 for the treatment of TNF mediated diseases

Regulation of inflammasome and inflammatory cell death signaling

Regulation of the Nlrp1a inflammasome in cutaneous and systemic autoinflammation

Role of caspase-11 in inflammasome and innate immune signaling

Role of caspase-12 in immune signaling and bacterial infection

Role of NOD-like receptors in cytokine and chemokine production

Signalling mechanisms of the NLRP1b inflammasome in innate immunity

Single cell analysis of inflammasome-mediated IL-1ß secretion in primary human monocytes

The IL-18/IFN signaling axis in NLRC4-dependent inflammatory disease

A MESO QuickPlex SQ system to measure single or multiple immunotargets in biofluids

HIGH-THROUGHPUT, HIGH-SENSITIVITY AND COST-EFFECTIVE MONITORING OF INNATE AND ADAPTIVE IMMUNE RESPONSES AT SINGLE CELL LEVEL

Integrated proteome-centric analysis of immune regulation

Investigating microglia inflammasome activation and regulation in Alzheimer disease

BOF-ZAP professorship in medical biochemistry

Interactome and degradome analysis of signaling pathways leading to activation of the inflammasome complexes.

Targeting the Tumor Microenvironment in Colorectal Peritoneal Metastases