Research Explorer

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Researcher

Mohamed Lamkanfi

Awards & Distinctions

166 Results

2024

Drugging the NLRP3 inflammasome : from signalling mechanisms to therapeutic targets

Lieselotte Vande WalleMohamed Lamkanfi

A1 Journal Article in NATURE REVIEWS DRUG DISCOVERY

Dual neutrophil subsets exacerbate or suppress inflammation in tuberculosis via IL-1β or PD-L1

Emilie Doz-DeblauweBadreddine BounabFlorence CarrerasJulia S FahelSergio C OliveiraMohamed LamkanfiYves Le VernPierre GermonJulien PichonFlorent Kempf et al.

A1 Journal Article in LIFE SCIENCE ALLIANCE

Infection history imprints prolonged changes to the epigenome, transcriptome and function of Kupffer cells

Mohamed Amer MusratiBenoit StijlemansAbdulkader AzouzDaliya KanchevaSarah MesbahiEva HadadiEls LebeggeLeen AliKaren De VlaminckIsabelle Scheyltjens et al.

A1 Journal Article in JOURNAL OF HEPATOLOGY

Inflammasome signaling is dispensable for ß-amyloid-induced neuropathology in preclinical models of Alzheimer's disease

Sahana SrinivasanDaliya KanchevaSofie De RenTakashi SaitoMaude JansFleur BooneCharysse VandendriesscheIne PaesmansHerve MaurinRoosmarijn Vandenbroucke et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

NLRP3 inflammasome activation and pyroptosis are dispensable for tau pathology

Ine PaesmansKristof Van KolenMarc VandermeerenPei-Yu ShihDirk WuytsFleur BooneSergio Garcia SanchezKarolien GrauwenFilip Van HauwermeirenNina Van Opdenbosch et al.

U Journal Article in FRONTIERS IN AGING NEUROSCIENCE

Nlrp2 deletion ameliorates kidney damage in a mouse model of cystinosis

Marianna Nicoletta RossiValentina MatteoFrancesca Diomedi-CamasseiEster De LeoOlivier DevuystMohamed LamkanfiIvan CaielloElena LoricchioFrancesco BellomoAnna Taranta et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Novel chemotype NLRP3 inhibitors that target the CRID3-binding pocket with high potency

Lieselotte Vande WalleMadhukar SaidOonagh PaerewijckArinna BertoniMarco GattornoBruno LinclauMohamed Lamkanfi

A1 Journal Article in LIFE SCIENCE ALLIANCE

Oxylipins and metabolites from pyroptotic cells act as promoters of tissue repair

Parul MehrotraSophia MaschalidiLaura BoeckaertsChristian MaueröderRochelle TixeiraJonathan PinneyJavier BurgoaVladimir SukhovYunus IncikChristopher Anderson et al.

A1 Journal Article in NATURE

2023

Comment on : effective ex vivo inhibition of cryopyrin-associated periodic syndrome (CAPS)-associated mutant NLRP3 inflammasome by MCC950/CRID3

Lieselotte Vande WalleMohamed Lamkanfi

A1 Journal Article in RHEUMATOLOGY

Complex regulation of alarmins S100A8/A9 and secretion via gasdermin D pores exacerbates autoinflammation in familial Mediterranean fever

Selina K. JorchAnnika McNallyPhilipp BergerJonas WolfKim KaiserAndrian Chetrusca CovashStefanie RobeckIsabell PastauOlesja FehlerSaskia-L. Jauch-Speer et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice

Karel Van DammePieter HertensArne MartensElisabeth GilisDario PriemInge BruggemanAmelie FossoulJozefien DeclercqHelena Catharine AegerterAndy Wullaert et al.

A1 Journal Article in SCIENTIFIC REPORTS

Regulated cell death in neutrophils : from apoptosis to NETosis and pyroptosis

Léonie DejasKarin SantoniEtienne MeunierMohamed Lamkanfi

A1 Journal Article in SEMINARS IN IMMUNOLOGY

The autoinflammation-associated NLRC4<SUP>V341A</SUP> mutation increases microbiota-independent IL-18 production but does not recapitulate human autoinflammatory symptoms in mice

Elien EeckhoutTomoko AsaokaHanne Van GorpDieter DemonCharlotte Girard-Guyonvarc'hVanessa AndriesLars VereeckeCem GabayMohamed LamkanfiGeert van Loo et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Tuberculosis : the tug of war between pathogen and inflammasome

Filip Van HauwermeirenMohamed Lamkanfi

Editorial material

2022

Bacillus anthracis induces NLRP3 inflammasome activation and caspase-8-mediated apoptosis of macrophages to promote lethal anthrax

Filip Van HauwermeirenNina Van OpdenboschHanne Van GorpNathalia de VasconcelosGeert van LooPeter VandenabeeleThirumala-Devi KannegantiMohamed Lamkanfi

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-1-driven neutrophil pyroptosis and its role in host susceptibility to Pseudomonas aeruginosa

Karin SantoniDavid PericatLeana GorseJulien BuyckMiriam PinillaLaure ProuvensierSalimata BagayokoAudrey HesselStephen Adonai Leon-IcazaElisabeth Bellard et al.

A1 Journal Article in PLOS PATHOGENS

GSDMD drives canonical inflammasome-induced neutrophil pyroptosis and is dispensable for NETosis

Dhruv ChauhanDieter DemonLieselotte Vande WalleOonagh PaerewijckAnnalisa ZecchinLeslie BosselerKarin SantoniRemi PlanesSilvia Ribó GenéAmelie Fossoul et al.

A1 Journal Article in EMBO REPORTS

How to dodge pyroptosis : lessons from Shigella flexneri

Filip Van HauwermeirenMohamed Lamkanfi

A1 Journal Article in CELL RESEARCH

Nonredundancy of IL-1 alpha and IL-1 beta is defined by distinct regulation of tissues orchestrating resistance versus tolerance to infection

Kevin EislmayrAnnika BestehornLuisa MorelliMartina BorroniLieselotte Vande WalleMohamed LamkanfiPavel Kovarik

A1 Journal Article in SCIENCE ADVANCES

The human inflammasomes

Oonagh PaerewijckMohamed Lamkanfi

A1 Journal Article in MOLECULAR ASPECTS OF MEDICINE

2021

Characterizing the role of microglial inflammation in neurodegeneration

Sahana SrinivasanGeert van LooMohamed Lamkanfi

Escherichia coli Rho GTPase-activating toxin CNF1 mediates NLRP3 inflammasome activation via p21-activated kinases-1/2 during bacteraemia in mice

Oceane DufiesAnne DoyeJohan CourjonCedric TorreGregory MichelCeline LoubatierArnaud JacquelPaul ChaintreuilAlissa MajoorRodolphe R. Guinamard et al.

A1 Journal Article in NATURE MICROBIOLOGY

IL1 beta promotes immune suppression in the tumor microenvironment independent of the inflammasome and gasdermin D

Mate KissLieselotte Vande WallePedro Henrique Viana SaavedraEls LebeggeHelena Van DammeAleksandar MurgaskiJunbin QianManuel EhlingSamantha PrettoEvangelia Bolli et al.

A1 Journal Article in CANCER IMMUNOLOGY RESEARCH

Nanoparticle-sensitized photoporation enables inflammasome activation studies in targeted single cells dagger

Aranit HarizajFilip Van HauwermeirenStephan StremerschRiet De RyckeHerlinde De KeersmaeckerToon BransJuan FraireKarolien GrauwenStefaan De SmedtIne Lentacker et al.

A1 Journal Article in NANOSCALE

2020

An apoptotic caspase network safeguards cell death induction in pyroptotic macrophages

Nathalia Moraes de VasconcelosNina Van OpdenboschHanne Van GorpRosa Martin-PerezAnnalisa ZecchinPeter VandenabeeleMohamed Lamkanfi

A1 Journal Article in CELL REPORTS

Blood-based test for diagnosis and functional subtyping of familial Mediterranean fever

Hanne Van GorpLinyan HuangPedro Henrique Viana SaavedraMarnik VuylstekeTomoko AsaokaGiusi PrencipeAntonella InsalacoBenson OgunjimiJerold JeyaratnamIlaria Cataldo et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Familial mediterranean fever and COVID-19 : friends or foes?

Alessandro StellaMohamed LamkanfiPiero Portincasa

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Recent insights on inflammasomes, gasdermin pores, and pyroptosis

Nathalia Moraes de VasconcelosMohamed Lamkanfi

A1 Journal Article in COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY

Snapshot of a deadly embrace : the caspase-1-GSDMD interface

Lieselotte Vande WalleMohamed Lamkanfi

Editorial material

Therapeutic modulation of inflammasome pathways

Dhruv ChauhanLieselotte Vande WalleMohamed Lamkanfi

A1 Journal Article in IMMUNOLOGICAL REVIEWS

Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities

Arne MartensDario PriemEsther HosteJessica VettersSofie RennenLeen CatrysseSofie VoetLaura DeelenMozes SzeHanna-Kaisa Vikkula et al.

A1 Journal Article in NATURE IMMUNOLOGY

2019

A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation

Simon TavernierV AthanasopoulosPATRICK VERLOOG BehrensJens StaalDelfien BogaertLeslie NaesensMarieke De BruyneSofie Van GassenEef Parthoens et al.

A1 Journal Article in NATURE COMMUNICATIONS

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

Melanie FritschSaskia D GuntherRobin SchwarzerMarie-Christine AlbertFabian SchornJ Paul WerthenbachLars M SchiffmannNeil StairHannah StocksJens M Seeger et al.

A1 Journal Article in NATURE

Caspases in cell death, inflammation, and disease

Nina Van OpdenboschMohamed Lamkanfi

A1 Journal Article in IMMUNITY

Characterisation of innate immune responses associated with gastrointestinal norovirus infection

Hanne DuboisAndy WullaertMohamed Lamkanfi

DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages

Nathalia Moraes de VasconcelosGwendolyn VliegenAmanda GonçalvesEmilie De HertRosa Martín-PérezNina Van OpdenboschAnvesh JallapallyRuth Geiss-FriedlanderAnne-Marie LambeirKoen Augustyns et al.

A2 Journal Article in LIFE SCIENCE ALLIANCE

El Tor biotype Vibrio cholerae activates the caspase-11-independent canonical Nlrp3 and Pyrin inflammasomes

Michail MamantopoulosUlrika FrisingTomoko AsaokaGeert van LooMohamed LamkanfiAndy Wullaert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Inflammasome-dependent cytokines at the crossroads of health and autoinflammatory disease

Hanne Van GorpNina Van OpdenboschMohamed Lamkanfi

A1 Journal Article in COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY

Inflammasomes in neuroinflammatory and neurodegenerative diseases

Sofie VoetSahana SrinivasanMohamed LamkanfiGeert van Loo

A1 Journal Article in EMBO MOLECULAR MEDICINE

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

Lieselotte Vande WalleIrma B StowePavel SachaBettina L LeeDieter DemonAmelie FossoulFilip Van HauwermeirenPedro Henrique Viana SaavedraPetr SimonVladimir Subrt et al.

A1 Journal Article in PLOS BIOLOGY

Monitoring of fluconazole and caspofungin activity against in vivo Candida glabrata biofilms by bioluminescence imaging

Aranka PersynOna RogiersMatthias BrockGreetje Vande VeldeMohamed LamkanfiIlse D JacobsenUwe HimmelreichKatrien LagrouPatrick Van DijckSofia Kuchadkova

A1 Journal Article in ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection

Hanne DuboisFrederic SorgeloosSoroush T. SarvestaniLiesbet MartensYvan SaeysJason M. MackenzieMohamed LamkanfiGeert van LooIan GoodfellowAndy Wullaert

A1 Journal Article in PLOS PATHOGENS

Prdx4 limits caspase-1 activation and restricts inflammasome-mediated signaling by extracellular vesicles

Simone LipinskiSteffen PfeufferPhilipp ArnoldChristian TreitzKonrad AdenHenriette EbsenMaren Falk-PaulsenNicolas GischAntonella FazioJan Kuiper et al.

A1 Journal Article in EMBO JOURNAL

Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture

Nathalia Moraes de VasconcelosNina Van OpdenboschHanne Van GorpEef ParthoensMohamed Lamkanfi

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Structure of S-layer protein Sap reveals a mechanism for therapeutic intervention in anthrax

Antonella FioravantiFilip Van HauwermeirenSander E Van der VerrenWim JonckheereAmanda GonçalvesEls PardonJan SteyaertHenri De GreveMohamed LamkanfiHan Remaut

A1 Journal Article in NATURE MICROBIOLOGY

The emerging roles of inflammasome-dependent cytokines in cancer development

Hanne Van GorpMohamed Lamkanfi

A1 Journal Article in EMBO REPORTS

2018

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

Sofie VoetConor Mc GuireNora HagemeyerArne MartensAnna SchroederPeter WieghoferCarmen DaemsOri StaszewskiLieselotte Vande WalleMarta Joana Costa Jordao et al.

A1 Journal Article in NATURE COMMUNICATIONS

Anidulafungin increases the antibacterial activity of tigecycline in polymicrobial Candida albicans/Staphylococcus aureus biofilms on intraperitoneally innplanted foreign bodies

Ona RogiersMichelle HoltappelsWafi SialaMohamed LamkanfiFrancoise Van BambekeKatrien LagrouPatrick Van DijckSona Kucharikova

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis

Pedro Henrique Viana SaavedraLinyan HuangFarzaneh GhazaviStephanie KourulaTom Vanden BergheNozomi TakahashiPeter VandenabeeleMohamed Lamkanfi

A1 Journal Article in NATURE COMMUNICATIONS

Cell death signaling at the crossroads of inflammasome activation

Nathalia Moraes de VasconcelosAndy WullaertMohamed Lamkanfi

GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever

Apurva KannegantiRK Subbarao MalireddiPedro Henrique Viana SaavedraLieselotte Vande WalleHanne Van GorpHiroto KambaraHeather TillmanPeter VogelHongbo R LuoRamnik J Xavier et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Inflammasomes in intestinal host-microbe interactions

Michail MamantopoulosAndy WullaertMohamed Lamkanfi

Mechanism and functions of the cytosolic receptor Pyrin

Pedro Henrique Viana SaavedraAndy WullaertMohamed Lamkanfi

Towards mulitplexed SERS-based on-chip detection on protease activity

Nina TurkPieter WuytensHans DemolKris GevaertAndre SkirtachMohamed LamkanfiRoel Baets

2017

A new lead to NLRP3 inhibition

Mohamed LamkanfiVishva M Dixit

Editorial material

Carboxylate isosteres for caspase inhibitors : the acylsulfonamide case revisited

Y AdriaenssensDaniel Jiménez FernandezLieselotte Vande WalleF ElvasJ JoossensA LambeirK AugustynsMohamed LamkanfiP Van der Veken

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Caspase-1 engagement and TLR-induced c-FLIP expression suppress ASC/caspase-8-dependent apoptosis by inflammasome sensors NLRP1b and NLRC4

Nina Van OpdenboschHanne Van GorpMaarten VerdoncktPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosAmanda GonçalvesLieselotte Vande WalleDieter DemonMagdalena MatusiakFilip Van Hauwermeiren et al.

A1 Journal Article in CELL REPORTS

Flagellin-mediated protection against intestinal Yersinia pseudotuberculosis infection does not require interleukin-22

Rémi PorteLaurye Van MaeleNatalia Muñoz-WolfBenoit FolignéLaure DumoutierJulien TabareauDelphine CayetPierre GossetNicolas JonckheereIsabelle Van Seuningen et al.

A1 Journal Article in INFECTION AND IMMUNITY

Gold nanodome SERS platform for label-free detection of protease activity

Pieter WuytensHans DemolNina TurkKris GevaertAndre SkirtachMohamed LamkanfiRoel Baets

A1 Journal Article in FARADAY DISCUSSIONS

Gut sensor halts viral attack

Pedro Henrique Viana SaavedraMohamed Lamkanfi

Editorial material

Neutrophilic NLRP3 inflammasome-dependent IL-1β secretion regulates the γδT17 cell response in respiratory bacterial infections

M HassaneDieter DemonD SoulardJ FontaineLE KellerEC PatinR PorteI PrinzB RyffelA Kadioglu et al.

A1 Journal Article in MUCOSAL IMMUNOLOGY

Nlrp6-and ASC-dependent inflammasomes do not shape the commensal gut microbiota composition

Michail MamantopoulosFrancesca RonchiFilip Van HauwermeirenSara Vieira-SilvaBahtiyar YilmazLiesbet MartensYvan SaeysStefan K DrexlerAmir S YazdiJeroen Raes et al.

A1 Journal Article in IMMUNITY

The inflammasome turns 15

Mohamed LamkanfiVishva M Dixit

Editorial material

2016

Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection

Xiaopeng QiSi Ming ManRK Subbarao MalireddiRajendra KarkiChristopher LupferPrajwal GurungGeoffrey NealeClifford S GuyMohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Complementarity and redundancy of IL-22-producing innate lymphoid cells

Lucille C RankinMathilde JH Girard-MadouxCyril SeilletLisa A MielkeYann KerdilesAurore FenisElisabeth WieduwildTracy PutoczkiStanislas MondotOlivier Lantz et al.

A1 Journal Article in NATURE IMMUNOLOGY

Does caspase-12 suppress inflammasome activation?

Lieselotte Vande WalleDaniel Jiménez FernandezDieter DemonNaomi Van LaethemFilip Van HauwermeirenHanne Van GorpNina Van OpdenboschNobuhiko KayagakiMohamed Lamkanfi

A1 Journal Article in NATURE

Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

Hanne Van GorpPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosNina Van OpdenboschLieselotte Vande WalleMagdalena MatusiakGiusi PrencipeAntonella InsalacoFilip Van HauwermeirenDieter Demon et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional characterization of inflammatory caspases

Daniel Jiménez FernandezMohamed LamkanfiKris Gevaert

General strategies in inflammasome biology

Hanne DuboisAndy WullaertMohamed Lamkanfi

A1 Journal Article in Current Topics in Microbiology and Immunology

Inflammasomes as polyvalent cell death platforms

Nathalia Moraes de VasconcelosNina Van OpdenboschMohamed Lamkanfi

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Inflammasomes in inflammatory disease

Hanne Van GorpPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosNina Van OpdenboschLieselotte Vande WalleMagdalena MatusiakFilip Van HauwermeirenG. PrencipeDelfien BogaertMelissa Dullaers et al.

NLRP2 controls age-associated maternal fertility

Anna KuchmiyJinke D'HontTino HochepiedMohamed Lamkanfi

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

NOD-like receptor Nlrp2 is dispensable for immune signaling, but critical for efficient early embryonic development in aged oocytes

Anna KuchmiyJinke D’HontTino HochepiedMohamed Lamkanfi

Lieselotte Vande WalleMohamed Lamkanfi

Editorial material

The NEK-sus of the NLRP3 inflammasome

Filip Van HauwermeirenMohamed Lamkanfi

Editorial material

2015

An NLRP3 inflammasome-triggered Th2-biased adaptive immune response promotes leishmaniasis

Prajwal GurungRajendra KarkiPeter VogelMakiko WatanabeMark BixMohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

CARD- and pyrin-only proteins regulating inflammasome activation and immunity

Magdalena MatusiakNina Van OpdenboschMohamed Lamkanfi

A1 Journal Article in IMMUNOLOGICAL REVIEWS

Chronic TLR stimulation controls NLRP3 inflammasome activation through IL-10 mediated regulation of NLRP3 expression and caspase-8 activation

Prajwal GurungBofeng LiRK Subbarao MalireddiMohamed LamkanfiTerrence L GeigerThirumala-Devi Kanneganti

A1 Journal Article in SCIENTIFIC REPORTS

Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection

Rajendra KarkiSi Ming ManRK Subbarao MalireddiPrajwal GurungPeter VogelMohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in CELL HOST & MICROBE

Cutting edge: SHARPIN is required for optimal NLRP3 inflammasome activation

Prajwal GurungMohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Escherichia coli α-hemolysin counteracts the anti-virulence innate immune response triggered by the Rho GTPase activating toxin CNF1 during bacteremia

Mamady DiabatePatrick MunroElsa GarciaArnaud JacquelGregory MichelSandrine ObbaDiogo GoncalvesCarmelo LuciSandrine MarchettiDieter Demon et al.

A1 Journal Article in PLOS PATHOGENS

Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5

Magdalena MatusiakNina Van OpdenboschLieselotte Vande WalleJean-Claude SirardThirumala-Devi KannegantiMohamed Lamkanfi

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory caspases : key regulators of inflammation and cell death

Daniel Jiménez FernandezMohamed Lamkanfi

A1 Journal Article in BIOLOGICAL CHEMISTRY

NAIP and CARD-only proteins in inflammasome signaling

Magdalena MatusiakMohamed Lamkanfi

Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes

Elke YdensDieter DemonGuillaume LornetVicky De WinterVincent TimmermanMohamed LamkanfiSophie Janssens

A1 Journal Article in JOURNAL OF NEUROINFLAMMATION

Protective and detrimental roles of inflammasomes in disease

Pedro Henrique Viana SaavedraDieter DemonHanne Van GorpMohamed Lamkanfi

A1 Journal Article in SEMINARS IN IMMUNOPATHOLOGY

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection

Si Ming ManRajendra KarkiRK Subbarao MalireddiGeoffrey NealePeter VogelMasahiro YamamotoMohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in NATURE IMMUNOLOGY

2014

Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation

Nina Van OpdenboschPrajwal GurungLieselotte Vande WalleAmelie FossoulThirumala-Devi KannegantiMohamed Lamkanfi

A1 Journal Article in NATURE COMMUNICATIONS

Airway structural cells regulate TLR5-mediated mucosal adjuvant activity

L Van MaeleD FougeronL JanotA DidierlaurentD CayetJ TabareauM RumboS Corvo-ChamaillardS BoulenouarS Jeffs et al.

A1 Journal Article in MUCOSAL IMMUNOLOGY

Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulfate-induced colitis

Dieter DemonAnna KuchmiyAmelie FossoulQ ZhuT-D KannegantiMohamed Lamkanfi

A1 Journal Article in MUCOSAL IMMUNOLOGY

Critical role for inflammasome-independent IL-1β production in osteomyelitis

John R LukensJordan M GrossChristopher CalabreseYoichiro IwakuraMohamed LamkanfiPeter VogelThirumala-Devi Kanneganti

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cutting edge: STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation

Qifan ZhuSi Ming ManPrajwal GurungZhiping LiuPeter VogelMohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Dietary modulation of the microbiome affects autoinflammatory disease

John R LukensPrajwal GurungPeter VogelGordon R JohnsonRobert A CarterDaniel J McGoldrickSrinivasa Rao BandiChristopher R CalabreseLieselotte Vande WalleMohamed Lamkanfi et al.

A1 Journal Article in NATURE

FADD and Caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes

Prajwal GurungParas K AnandRK Subbarao MalireddiLieselotte Vande WalleNina Van OpdenboschChristopher P DillonRicardo WeinlichDouglas R GreenMohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Inflammasomes in respiratory disease: from bench to bedside

Guy BrusselleSharen ProvoostKen BrackeAnna KuchmiyMohamed Lamkanfi

A1 Journal Article in CHEST

Mechanisms and functions of inflammasomes

Mohamed LamkanfiVishva M Dixit

A1 Journal Article in CELL

NOD-like receptors interfacing the immune and reproductive systems

Hanne Van GorpAnna KuchmiyFilip Van HauwermeirenMohamed Lamkanfi

A1 Journal Article in FEBS JOURNAL

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

Lieselotte Vande WalleNina Van OpdenboschPeggy JacquesAmelie FossoulEveline VerheugenPeter VogelRudi BeyaertDirk ElewautThirumala-Devi KannegantiGeert van Loo et al.

A1 Journal Article in NATURE

Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection

Christopher R LupferParas K AnandZhiping LiuKate L StokesPeter VogelMohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in PLOS PATHOGENS

Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection

Md Hasan ZakiSi Ming ManPeter VogelMohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensing the enemy within: how macrophages detect intracellular Gram-negative bacteria

Dieter DemonLieselotte Vande WalleMohamed Lamkanfi

Editorial material

Targeted sequencing by proximity ligation for comprehensive variant detection and local haplotyping

Paula JP de VreeElzo de WitMehmet YilmazMonique van de HeijningPetra KlousMarjon JAM VerstegenYi WanHans TeunissenPeter HL KrijgerGeert Geeven et al.

A1 Journal Article in NATURE BIOTECHNOLOGY

The small GTPase Arf6 is essential for the Tram/Trif pathway in RLR4 signaling

Tim Van AckerSven EyckermanLieselotte Vande WalleSarah GerloMarc GoethalsMohamed LamkanfiCelia BovijnJan TavernierFrank Peelman

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2013

K⁺ drops tilt the NLRP3 inflammasome

Thirumala-Devi KannegantiMohamed Lamkanfi

Editorial material

RIP1-driven autoinflammation targets IL-1 alpha independently of inflammasomes and RIP3

John R LukensPeter VogelGordon R JohnsonMichelle A KelliherYoichiro IwakuraMohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in NATURE

Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection

Christopher LupferPaul G ThomasParas K AnandPeter VogelSandra MilastaJennifer MartinezGonghua HuangMaggie GreenMondira KunduHongbo Chi et al.

A1 Journal Article in NATURE IMMUNOLOGY

2012

Defective Dock2 expression in a subset of ASC-deficient mouse lines

Sirish K IppaguntaRK Subbarao MalireddiPatrick J ShawGeoffrey A NealeLieselotte Vande WalleYoshinori FukuiDouglas R GreenMohamed LamkanfiThirumala-Devi Kanneganti

Editorial material

Inflammasomes and their roles in health and disease

Mohamed LamkanfiVishva M Dixit

A1 Journal Article in Annual Review of Cell and Developmental Biology

Innate immune pathways in host defense

Thirumala-Devi KannegantiMohamed LamkanfiAmal O Amer

Editorial material

NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens

Paras K AnandRK Subbarao MalireddiJohn R LukensPeter VogelJohn BertinMohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in NATURE

Phosphorylation of NLRC4 is critical for inflammasome activation

Yan QuShahram MisaghiAnita Izrael-TomasevicKim NewtonLaurie L GilmourMohamed LamkanfiSalina LouieNobuhiko KayagakiJinfeng LiuLászló Kömüves et al.

A1 Journal Article in NATURE

Regulation of immune pathways by the NOD-like receptor NLRC5

Mohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in IMMUNOBIOLOGY

Role of inflammasomes in host defense against Citrobacter rodentium infection

Zhiping LiuMd Hasan ZakiPeter VogelPrajwal GurungB Brett FinlayWanyin DengMohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The inflammasome: a remote control for metabolic syndrome

Mohamed LamkanfiThirumala-Devi Kanneganti

Editorial material

Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-β (TRIF)-mediated caspase-11 protease production integrates toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome-mediated host defense against enteropathogens

Prajwal GurungRK Subbarao MalireddiParas K AnandDieter DemonLieselotte Vande WalleZhiPing LiuPeter VogelMohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2011

Deregulated inflammasome signaling in disease

Mohamed LamkanfiLieselotte Vande WalleThirumala-Devi Kanneganti

A1 Journal Article in IMMUNOLOGICAL REVIEWS

Emerging inflammasome effector mechanisms

Mohamed Lamkanfi

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

HMGB1 release by inflammasomes

Lieselotte Vande WalleThirumala-Devi KannegantiMohamed Lamkanfi

A1 Journal Article in VIRULENCE

Inflammasomes: caspase-1-activating platforms with critical roles in host defense

Lieselotte Vande WalleMohamed Lamkanfi

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

Interaction patches of procaspase-1 caspase recruitment domains (CARDs) are differently involved in procaspase-1 activation and receptor-interacting protein 2 (RIP2)-dependent nuclear factor κB signaling

Kristof KersseMohamed LamkanfiMathieu BertrandTom Vanden BerghePeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of inflammasome pathways by bacterial and viral pathogens

Mohamed LamkanfiVishva M Dixit

A1 Journal Article in JOURNAL OF IMMUNOLOGY

NOD-like receptors and the innate immune system: coping with danger, damage and death

Kristof KersseMathieu BertrandMohamed LamkanfiPeter Vandenabeele

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

Non-canonical inflammasome activation targets caspase-11

Nobuhiko KayagakiSoren WarmingMohamed LamkanfiLieselotte Vande WalleSalina LouieJennifer DongKim NewtonYan QuJinFeng LiuSherry Heldens et al.

A1 Journal Article in NATURE

TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation

Paras K AnandStephen WG TaitMohamed LamkanfiAmal O AmerGabriel NunezGilles PagèsJacques PouysségurMaureen A McGargillDouglas R GreenThirumala-Devi Kanneganti

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The NIrp3 inflammasome: contributions to intestinal homeostasis

MH ZakiMohamed LamkanfiTD Kanneganti

A1 Journal Article in TRENDS IN IMMUNOLOGY

The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis

Md Hasan ZakiPeter VogelRK Subbarao MalireddiMathilde Body-MalapelParas K AnandJohn BertinDouglas R GreenMohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in CANCER CELL

The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization

Sirish K IppaguntaRK Subbarao MalireddiPatrick J ShawGeoffrey A NealeLieselotte Vande WalleDouglas R GreenYoshinori FukuiMohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in NATURE IMMUNOLOGY

2010

Caspase-7: a protease involved in apoptosis and inflammation

Mohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cutting edge: proteolytic inactivation of poly(ADP-ribose) polymerase 1 by the Nlrp3 and Nlrc4 inflammasomes

RK Subbarao MalireddiSirish IppaguntaMohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in JOURNAL OF IMMUNOLOGY

IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation

Mohammad Hasan ZakiPeter VogelMathilde Body-MalapelMohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia

Mohamed LamkanfiAnasuya SarkarLieselotte Vande WalleAlberto C Vitarimal AO AmerMark D WewersKevin J TraceyThirumala-Devi KannegantiVishva M Dixit

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Inflammasome-independent role of apoptosis-associated speck-like protein containing a CARD (ASC) in T cell priming is critical for collagen-induced arthritis

Sirish K IppaguntaDavid D BrandJiWen LuoKelli L BoydChristopher CalabreseRinke StienstraFrank L Van de VeerdonkMihai G NeteaLeo AB JoostenMohamed Lamkanfi et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Manipulation of host cell death pathways during microbial infections

Mohamed LamkanfiVishva M Dixit

A1 Journal Article in CELL HOST & MICROBE

NOD-like receptor (NLR) signaling beyond the inflammasome

Patrick J ShawMohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Nlrp3: an immune sensor of cellular stress and infection

Mohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella

Petr BrozKim NewtonMohamed LamkanfiSanjeev MariathasanVishva M DixitDenise M Monack

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis

Md Hasan ZakiKelli L BoydPeter VogelMichael B KastanMohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in IMMUNITY

The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal

Lieselotte Vande WalleEllen WirawanMohamed LamkanfiNele FestjensJelle VerspurtenXavier SaelensTom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL RESEARCH

2009

Association of C-Terminal Ubiquitin Hydrolase BRCA1-Associated Protein 1 with Cell Cycle Regulator Host Cell Factor 1

S MisaghiS OttosenA Izrael-TomasevicD ArnottMohamed LamkanfiJ LeeJF LiuK O'RourkeVM DixitAC Wilson

A1 Journal Article in MOLECULAR AND CELLULAR BIOLOGY

Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival

Mohamed LamkanfiLO MoreiraP MakenaDCJ SpieringsK BoydPJ MurrayDR GreenTD Kanneganti

A1 Journal Article in BLOOD

Fungal Zymosan and Mannan Activate the Cryopyrin Inflammasome

Mohamed LamkanfiRKS MalireddiTD Kanneganti

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

Mohamed LamkanfiJL MuellerAC VitariS MisaghiA FedorovaK DeshayesWP LeeHM HoffmanVM Dixit

A1 Journal Article in JOURNAL OF CELL BIOLOGY

IL-33 Raises Alarm

Mohamed LamkanfiVM Dixit

Editorial material

Inflammasomes: guardians of cytosolic sanctity

Mohamed LamkanfiVishva Dixit

A1 Journal Article in IMMUNOLOGICAL REVIEWS

The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

PG ThomasP DashJR AldridgeAH EllebedyC ReynoldsAJ FunkWJ MartinMohamed LamkanfiRJ WebbyKL Boyd et al.

A1 Journal Article in IMMUNITY

The inflammasomes

Mohamed LamkanfiVishva M Dixit

A1 Journal Article in PLOS PATHOGENS

2008

Increased Inflammatory Gene Expression in ABC Transporter-Deficient Macrophages Free Cholesterol Accumulation, Increased Signaling via Toll-Like Receptors, and Neutrophil Infiltration of Atherosclerotic Lesions

L Yvan-CharvetC WelchTA PaglerM RanallettaMohamed LamkanfiS HanM IshibashiR LiN WangAR Tall

A1 Journal Article in CIRCULATION

Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes

Mohamed LamkanfiThirumala-Devi KannegantiPetra Van DammeTom Vanden BergheIsabel VanoverbergheJoël VandekerckhovePeter VandenabeeleKris GevaertGabriel Nuñez

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

The mitochondrial serine protease HtrA2/Omi: an overview

Lieselotte Vande WalleMohamed LamkanfiPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2007

A phylogenetic and functional overview of inflammatory caspases and caspase-1-related CARD-only proteins

Kristof KersseTom Vanden BergheMohamed LamkanfiPeter Vandenabeele

A1 Journal Article in BIOCHEMICAL SOCIETY TRANSACTIONS

Caspase-1 inflammasomes in infection and inflammation

Mohamed LamkanfiTD KannegantiL FranchiG Nunez

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

Caspases in cell survival, proliferation and differentiation

Mohamed LamkanfiNele FestjensWim DeclercqTom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Inflammatory caspases : targets for novel therapies

Sigrid CornelisKristof KersseNele FestjensMohamed LamkanfiPeter Vandenabeele

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

Intracellular NOD-like receptors in host defense and disease

Thirumala-Devi KannegantiMohamed LamkanfiGabriel Nunez

A1 Journal Article in IMMUNITY

Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling

TD KANNEGANTIMohamed LamkanfiYG KIMG CHENJH PARKL FRANCHIPeter VandenabeeleG NUNEZ

A1 Journal Article in IMMUNITY

Proteome-wide identification of HtrA2/Omi substrates

Lieselotte Vande WallePetra Van DammeMohamed LamkanfiXavier SaelensJoël VandekerckhoveKris GevaertPeter Vandenabeele

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation

Mohamed LamkanfiA AMERTD KANNEGANTIR MUNOZ-PLANILLOG CHENPeter VandenabeeleA FORTIERP GROSG NUNEZ

A1 Journal Article in JOURNAL OF IMMUNOLOGY

2006

Caspase-containing complexes in the regulation of cell death and inflammation

Nele FestjensSigrid CornelisMohamed LamkanfiPeter Vandenabeele

A1 Journal Article in BIOLOGICAL CHEMISTRY

Caspases leave the beaten track: caspase-mediated activation of NF-kappa B

Mohamed LamkanfiWim DeclercqTom Vanden BerghePeter Vandenabeele

A1 Journal Article in JOURNAL OF CELL BIOLOGY

2005

A novel caspase-2 complex containing TRAF2 and RIP1

Mohamed LamkanfiKathleen D'HondtLieselotte Vande WalleMarjan Van GurpGeertrui DeneckerJill DemeulemeesterMichaël KalaiWim DeclercqXavier SaelensPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2004

Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity

Mohamed LamkanfiMichaël KalaiXavier SaelensWim DeclercqPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-12: an overview

Mohamed LamkanfiMichaël KalaiPeter Vandenabeele

Editorial material

INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1 beta generation

Mohamed LamkanfiGeertrui DeneckerMichaël KalaiKathleen D'HondtAnn MeeusWim DeclercqXavier SaelensPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2003

Regulation of the expression and processing of caspase-12

Michaël KalaiMohamed LamkanfiGeertrui DeneckerM BoogmansSaskia LippensAnn MeeusWim DeclercqPeter Vandenabeele

A1 Journal Article in JOURNAL OF CELL BIOLOGY

The caspase family

Mohamed LamkanfiWim DeclercqBart DepuydtMichaël KalaiXavier SaelensPeter Vandenabeele

Bookchapter in Caspases-Their Role in Cell Death and Cell Survival

2002

Alice in caspase land. A phylogenetic analysis of caspases from worm to man.

Mohamed LamkanfiWim DeclercqMichaël KalaiXavier SaelensPeter Vandenabeele

Editorial material