Project

Interactome and degradome analysis of signaling pathways leading to activation of the inflammasome complexes.

Duration
01 October 2009 → 30 September 2012
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Immunology
    • Orthopaedics
    • Physiology
    • Immunology
    • Microbiology
    • Orthopaedics
    • Physiology
    • Immunology
    • Orthopaedics
    • Physiology
Keywords
inflammasome
 
Project description

Ipaf, Nalp1 and Cryopyrin/Nalp3 zijn cytosolic Nod-like (NLRs) that are implicated in the stimulus-dependent assembly of large caspase-1-activating protein complexes called ' inflammasomes'. We will characterize the upstream signaling pathways that lead to activation of the inflammasomes by making use of making use of mass spectrometry-and MAPPIT-based degradomics and interactome analysis.