Good Manufacturing Practices (GMP) Cell and Gene Therapy Facility for manufacturing first-in-human (FIH) investigational Advanced Therapy Medicinal Products (iaTMP)

The nature of the T cell Receptor ligands of the KIR+Helios+ unconventional T cell lineage in humans

CARTAGENA- Development of an innovative platform and complementary assays for screening and selection of CAR-T cells

Characterization of a novel innate CD8 PD1 positive thymic T cell population and its progeny in cord blood

Chimeric antigen receptor unconventional T cell therapy (CAR-uT) for the treatment of solid tumors

Chimeric antigen receptor unconventional T cell therapy (CAR-uT) for the treatment of solid tumors

Chromatography for the purification of in vitro transcribed RNA as part of the production process of lipid nanoparticle vaccines and cancer immunotherapeutics for use in clinical trials (C-puRNA)

Development and functional validation of a gene editing approach in hematopoietic precursor cells for Wiskott-Aldrich Syndrome

Generation and expansion of hematopoietic stem cells from human pluripotent stem cells

Generation of autologous T cells against acute myeloid leukemia by transduction of hematopoietic stem cells with T cell receptor genes and subsequent differentiation to T cells

Generation of autologous T cells against acute myeloid leukemia by transduction of hematopoietic stem cells with T cell receptor genes and subsequent differentiation to T cells

Generation of chimeric antigen receptor expressing, T cell receptor negative CD4 helper and CD8 cytotoxic cells starting from cord blood hematopoietic precursor cells that are optimized for in vivo tumor eradication.

Generation of "off the shelf" nano-chimeric antigen receptor tranduced cell lines

Generation of tumor-specific, single receptor CD4 helper and CDS cytotoxic cells from cord blood hematopoietic stem cells transgenic for a chimeric antigen receptor (CAR) incorporating a cytoplasmic costimulator domain

Immunomonitoring of patients with non-small cell lung carcinoma treated with a tumor mutanome-targeted dendritic cell vaccine

Immunotherapies for cancer

Improving Neo-epitope Identification in lung cancer patients using Mass spectrometry and next generation sequencing (INI-M&N)

Improving outcome of immune checkpoint blockade in lung cancer by combination with a tumor mutanome-targeted dendritic cell vaccine

In vitro generation of AML specific T cells from gematopoietic stem cells and functional characterization of these cells in an in vivo animal model

In vitro generation of cytotoxic T cells from CD34+ hematopoietic precursor cells

Optimisation of CD70-targeted adoptive cell therapy

Optimising CD70-specific T cell therapy for solitary and haematological malignancies

Patient-friendly tumor sampling for the design, and reduction of the production time of a neoepitope dendritic cell vaccine for patients presenting with inoperable non small cell lung carcinoma (NEO4LUNG)

Proteomics-derived epitopes for dramatically improved anticancer and antibacterial vaccine development

Study of human lymphoid cell differentiation using gene-modified embryonic stem cells and induced pluripotent stem cells from immunodeficiency patients

Study of the stimuli required for the generation and maintenance of hematopoietic stem cells from humanpluripotent stem cells

The role of endothelium hemogeen in the in vitro generation of hematopoietic stem cells from human pluripotent stem cells

The role of the Wiskott-Aldrich Syndrome protein (WASp) in human T cell development and on the development of the T cell repertoire.

T lymphocytes: from basic biology to immunotherapy

Vaccination with nucleoside-modified mRNA-ceramide lipoplexes: a phase I trial in stage IV lung carcinoma patients

ABSL3 mice housing system to develop new therapies against virulent pathogens

A flow cytometer to perform multiparameter sorting, including single-cell deposition under biohazard conditions L2

A patient derived xenograft (PDX) platform for in vivo evaluation of novel anticancer therapies

Humanized Immune Liver Mouse and 3D in vitro models for the study and therapy of liver disease (HILIM-3D)

Improving outcome of immune checkpoint blockade in lung cancer by combination with a tumor mutanome-targeted dendritic cell vaccine

Improving outcome of immune checkpoint blockade in lung cancer by combination with a tumor mutanome-targeted dendritic cell vaccine

In-depth comparison and feasibility assessment of an integrated pipeline for neoantigen identification and HLA ligandome sequencing in a clinical setting

Light-triggered self-assembled nanostructures for efficient and safe production of engineered therapeutic immune cells

Regucyte : Bringing Regenerative Medicine to the Clinic

Study of human lymphoid cell differentiation using gene-modified embryonic stem cells and induced pluripotent stem cells from immunodeficiency patients

Study of inducible glycome manipulation of CAR-T cells upon antigen exposure in the tumor environment

White light laser-based confocal fluorescence lifetime imaging microscope for multi-parameter 3D live imaging

Yellow/Green laser upgrade for LSRII analyser and FACSARIAII sorter flow cytometers

Combining photoporation with electrophoresis for improved transfection of hard-to-transfect cells