Code
01G00511
Duration
01 January 2011 → 31 October 2015
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Natural sciences
- Genetics
-
Medical and health sciences
- Gynaecology and obstetrics
- Immunology
- Molecular and cell biology
- Morphological sciences
- Gynaecology and obstetrics
- Immunology
- Molecular and cell biology
- Morphological sciences
- Gynaecology and obstetrics
- Immunology
- Molecular and cell biology
- Morphological sciences
Keywords
immunity
gene targeting
immune deficiency
embryonic stem cells
induced pluripotent stem cells
human
hematopoiesis
Project description
Pluripotent stem cells will be generated from patients with an inborn immune (T/NK) deficiency. In addition, gene modified human embryonic stem cells will be generated for lineage tracing and deletion mutants. Using these cell lines T and NK differentiation will be studied and the effect of the targeted genes on differentiation will be analyzed.