Research Explorer

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Researcher

Bart Vandekerckhove

Awards & Distinctions

181 Results

2024

Development and clinical evaluation of a dendritic cell vaccine targeting patient-individual neoantigens in lung cancer

Joline IngelsBart VandekerckhoveKarim Vermaelen

From thymus to periphery : unraveling the complexity of human polyclonal unconventional αβ T cells

Lore BillietBart VandekerckhoveTessa Kerre

Gene editing-based targeted integration for correction of Wiskott-Aldrich syndrome

Melissa PilleJohn M. AvilaSo Hyun ParkCuong Q. LeHaipeng XueFilomeen HaerynckLavanya SaxenaCiaran LeeElizabeth J. ShpallGang Bao et al.

A1 Journal Article in MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT

HES6 knockdown in human hematopoietic precursor cells reduces their in vivo engraftment potential and their capacity to differentiate into erythroid cells, B cells, T cells and plasmacytoid dendritic cells

Tamara De VosNicole OatmanLena BoehmeTom PuttemanImke VelgheYana Van DroogenbroeckStijn De MunterMichaela CesnekovaFilip Van NieuwerburghBart Vandekerckhove et al.

A1 Journal Article in HAEMATOLOGICA

Knocking out CD70 rescues CD70-specific nanoCAR T cells from antigen-induced exhaustion

Stijn De MunterJuliane L. BuhlLaurenz De CockAlexander Van ParysWillem DaneelsEva PascalLucas DeseinsJoline IngelsGlenn GoetgelukHanne Jansen et al.

A1 Journal Article in CANCER IMMUNOLOGY RESEARCH

Neoantigen-targeted dendritic cell vaccination in lung cancer patients induces long-lived T cells exhibiting the full differentiation spectrum

Joline IngelsLaurenz De CockDieter StevensRupert MayerFabien Henri TheryGuillem Sanchez SanchezDavid VermijlenKarin WeeningSaskia De SmetNele Lootens et al.

A1 Journal Article in CELL REPORTS MEDICINE

Photoporation of NK-92MI cells with biodegradable polydopamine nanosensitizers as a promising strategy for the generation of engineered NK cell therapies

Charlotte HinnekensAranit HarizajDominika BerdeckaIlke AernoutMolood ShariatiStefanie PeetersEva LionStefaan De SmedtBart VandekerckhoveKevin Braeckmans et al.

A1 Journal Article in APPLIED MATERIALS TODAY

ThymoSpheres culture : a model to study human polyclonal unconventional T cells

Lore BillietHanne JansenMelissa PilleLena BoehmeGuillem Sanchez SanchezLaurenz De CockGlenn GoetgelukEva PascalStijn De MunterLucas Deseins et al.

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Wiskott Aldrich syndrome : novel insights and strategies towards a cure : the story of WASp

Melissa PilleBart VandekerckhoveTessa Kerre

2023

Delivery of macromolecules in unstimulated T cells by photoporation with polydopamine nanoparticles

Dominika BerdeckaAranit HarizajIlia GoemaereDeep PunjGlenn GoetgelukStijn De MunterHerlinde De KeersmaeckerVeerle BoterbergPeter DubruelBart Vandekerckhove et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Immunotherapy : towards engineered NK cell therapy : mRNA transfection of NK92 cells by photoporation with biodegradable polydopamine nanosensitizersHOTOPORATION WITH BIODEGRADABLE POLYDOPAMINE NANOSENSITIZERS

Charlotte HinnekensAranit HarizajIlia GoemaereStefaan De SmedtBart VandekerckhoveJuan FraireKevin Braeckmans

Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF

Kai Ling LiangJuliette RoelsMarieke LavaertTom PuttemanLena BoehmeLaurentijn TillemanImke VelgheValentina PegorettiInge Van de WalleStephanie Sontag et al.

A1 Journal Article in NATURE IMMUNOLOGY

Knocking out CD70 rescues CD70-specific nanoCAR T cells from antigen induced exhaustion

Stijn De MunterJuliane BuhlLaurenz De CockAlexander Van ParysWillem DaneelsEva PascalLucas DeseinsJoline IngelsGlenn GoetgelukLore Billiet et al.

MIDRIXNEO-LUNG : safety and immunogenicity of a neoantigen-presenting autologous dendritic cell therapy in resected NSCLC patients

Joline IngelsLaurenz De CockDieter StevensKarin WeeningVeerle SurmontJo Van DorpeFrancis ImpensBjörn MentenKarim VermaelenBart Vandekerckhove

Optimization of VHH-based chimeric antigen receptor T cells for the treatment of solid and liquid malignancies

Stijn De MunterBart VandekerckhoveTessa Kerre

Single-cell profiling identifies a novel human polyclonal unconventional T cell lineage

Lore BillietLaurenz De CockGuillem Sanchez SanchezRupert MayerGlenn GoetgelukStijn De MunterMelissa PilleJoline IngelsHanne JansenKarin Weening et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

The Wiskott–Aldrich syndrome protein is required for positive selection during T-cell lineage differentiation

Melissa PilleJohn AvilaGuillem Sanchez SanchezGlenn GoetgelukStijn De MunterHanne JansenLore BillietKarin WeeningHaipeng XueSarah Bonte et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2022

IRF2 is required for development and functional maturation of human NK cells

Eva PersynSigrid WahlenLaura KiekensWouter Van LoockeHannah SiweEls Van AmmelZenzi De VosFilip Van NieuwerburghPatrick MatthysTom Taghon et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes

Rupert MayerRein VerbekeCaroline AsselmanIlke AernoutAdillah GulDenzel EggermontKatie BoucherFabien Henri TheryTeresa MaiaHans Demol et al.

A1 Journal Article in NATURE COMMUNICATIONS

Small-scale manufacturing of neoantigen-encoding messenger RNA for early-phase clinical trials

Joline IngelsLaurenz De CockRupert MayerPam DevrekerKarin WeeningKelly HeynsNele LootensSaskia De SmetMarieke BrusseelStijn De Munter et al.

A1 Journal Article in CYTOTHERAPY

T-BET drives the conversion of human type 3 innate lymphoid cells into functional NK cells

Laura KiekensSigrid WahlenEva PersynZenzi De VosTom TaghonBart VandekerckhoveGeorges Leclercq

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

TXNIP promotes human NK cell development but is dispensable for NK cell functionality

Eva PersynSigrid WahlenLaura KiekensSylvie TaveirneWouter Van LoockeEls Van AmmelFilip Van NieuwerburghTom TaghonBart VandekerckhovePieter Van Vlierberghe et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency

Sigrid WahlenFilip MatthijssensWouter Van LoockeSylvie TaveirneLaura KiekensEva PersynEls Van AmmelZenzi De VosStijn De MunterPatrick Matthys et al.

A1 Journal Article in ELIFE

Transcriptional dynamics and epigenetic regulation of E and ID protein encoding genes during human T cell development

Juliette RoelsJolien Van HulleMarieke LavaertAnna KuchmiySteven StrubbeTom PuttemanBart VandekerckhoveGeorges LeclercqFilip Van NieuwerburghLena Boehme et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2021

A novel non-coding variant in DCLRE1C results in deregulated splicing and induces SCID through the generation of a truncated ARTEMIS protein that fails to support V(D)J recombination and DNA damage repair

Steven StrubbeMarieke De BruyneUlrich PannickeElien BeylsBart VandekerckhoveGeorges LeclercqElfride De BaereVictoria BordonAnne VralKlaus Schwarz et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Cas9 RNP transfection by vapor nanobubble photoporation for ex vivo cell engineering

Laurens RaesMelissa PilleAranit HarizajGlenn GoetgelukJelter Van HoeckStephan StremerschJuan FraireToon BransOlivier Gerrit de JongRoel Maas-Bakker et al.

A1 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

Dendritic cell-based immunotherapy in lung cancer

Dieter StevensJoline IngelsSandra Van LintBart VandekerckhoveKarim Vermaelen

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

HES1 and HES4 have non-redundant roles downstream of Notch during early human T-cell development

Matthias De DeckerMarieke LavaertJuliette RoelsLaurentijn TillemanBart VandekerckhoveGeorges LeclercqFilip Van NieuwerburghPieter Van VlierbergheTom Taghon

A1 Journal Article in HAEMATOLOGICA

Hydrogel-induced cell membrane disruptions enable direct cytosolic delivery of membrane-impermeable cargo

Jelter Van HoeckThijs Van de VyverAranit HarizajGlenn GoetgelukPieterjan MerckxJing LiuMike WelsFélix SauvageHerlinde De KeersmaeckerChristian Vanhove et al.

A1 Journal Article in ADVANCED MATERIALS

In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality

Sarah BonteStijn De MunterLore BillietGlenn GoetgelukJoline IngelsHanne JansenMelissa PilleLaurenz De CockKarin WeeningTom Taghon et al.

A1 Journal Article in ONCOIMMUNOLOGY

Photoporation with biodegradable polydopamine nanosensitizers enables safe and efficient delivery of mRNA in human T cells

Aranit HarizajMike WelsLaurens RaesStephan StremerschGlenn GoetgelukToon BransBart VandekerckhoveFélix SauvageStefaan De SmedtIne Lentacker et al.

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Photothermal nanofibres enable safe engineering of therapeutic cells

Ranhua XiongDawei HuaJelter Van HoeckDominika BerdeckaLaurens LégerStijn De MunterJuan FraireLaurens RaesAranit HarizajFélix Sauvage et al.

A1 Journal Article in NATURE NANOTECHNOLOGY

T-BET and EOMES accelerate and enhance functional differentiation of human natural killer cells

Laura KiekensWouter Van LoockeSylvie TaveirneSigrid WahlenEva PersynEls Van AmmelZenzi De VosPatrick MatthysFilip Van NieuwerburghTom Taghon et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

TCR-based T cell immunotherapy for AML : multidimensional aids in optimizing treatment and patient identification

Sarah BonteTessa KerreBart Vandekerckhove

Treatment of a patient with severe cytomegalovirus (CMV) infection after haploidentical stem cell transplantation with donor-derived CMV-specific T cells

Joline IngelsSaskia De SmetKelly HeynsNele LootensJonas SegaertTom TaghonGeorges LeclercqKarim VermaelenEvelyne WillemsEtienne Baudoux et al.

A1 Journal Article in ACTA CLINICA BELGICA

2020

Clinical significance of TARP expression in pediatric acute myeloid leukemia

B. DepreterBarbara De MoerlooseKarl VandepoeleA. UyttebroeckA. Van DammeB. DenysL. DedekenM. -F. DresseJ. Van der Werff Ten BoschM. Hofmans et al.

Clinical significance of TARP expression in pediatric acute myeloid leukemia

Barbara DepreterBarbara De MoerlooseKarl VandepoeleAnne UyttebroeckAn Van DammeBarbara DenysLaurence DedekenMarie-Françoise DresseJutte Van Der Werff Ten BoschMattias Hofmans et al.

A1 Journal Article in HEMASPHERE

Conventional and computational flow cytometry analyses reveal sustained human intrathymic T cell development from birth until puberty

Marieke LavaertBrecht ValckeBart VandekerckhoveGeorges LeclercqKai Ling LiangTom Taghon

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development

Anne-Catherine DolensKaat DurinckMarieke LavaertJoni Van der MeulenImke VelgheJelle De MedtsKarin WeeningJuliette RoelsKatrien De MulderPieter-Jan Volders et al.

A1 Journal Article in EMBO REPORTS

Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development

Juliette RoelsAnna KuchmiyMatthias De DeckerSteven StrubbeMarieke LavaertKai Ling LiangGeorges LeclercqBart VandekerckhoveFilip Van NieuwerburghPieter Van Vlierberghe et al.

A1 Journal Article in NATURE IMMUNOLOGY

Human thymic CD10+ PD-1+ intraepithelial lymphocyte precursors acquire interleukin-15 responsiveness at the CD1a– CD95+ CD28– CCR7– developmental stage

Lore BillietGlenn GoetgelukSarah BonteStijn De MunterLaurenz De CockMelissa PilleJoline IngelsHanne JansenKarin WeeningFilip Van Nieuwerburgh et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Integrated scRNA-seq identifies human postnatal thymus seeding progenitors and regulatory dynamics of differentiating immature thymocytes

Marieke LavaertKai Ling LiangNiels VandammeJong-Eun ParkJuliette RoelsMonica S. KowalczykBo LiOrr AshenbergMarcin TabakaDanielle Dionne et al.

A1 Journal Article in IMMUNITY

Intracellular delivery of mRNA in adherent and suspension cells by vapor nanobubble photoporation

Laurens RaesStephan StremerschJuan FraireToon BransGlenn GoetgelukStijn De MunterLien Van HoeckeRein VerbekeJelter Van HoeckRanhua Xiong et al.

A1 Journal Article in NANO-MICRO LETTERS

Rapid and effective generation of nanobody based CARs using PCR and Gibson Assembly

Stijn De MunterAlexander Van ParysLayla BralJoline IngelsGlenn GoetgelukSarah BonteMelissa PilleLore BillietKarin WeeningAnnick Verhee et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Safe eradication of large established tumors using neovasculature-targeted tumor necrosis factor-based therapies

Leander HuygheAlexander Van ParysAnje CauwelsSandra Van LintStijn De MunterJennyfer BultinckLennart ZabeauJeroen HostensAn GoethalsNele Vanderroost et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources

Sarah BonteStijn De MunterGlenn GoetgelukJoline IngelsMelissa PilleLore BillietTom TaghonGeorges LeclercqBart VandekerckhoveTessa Kerre

A1 Journal Article in ONCOIMMUNOLOGY

TARP is an immunotherapeutic target in acute myeloid leukemia expressed in the leukemic stem cell compartment

Barbara DepreterKarin WeeningKarl VandepoeleMagnus EssandBarbara De MoerlooseMaria ThemeliJacqueline CloosDiana HanekampIne MoorsINGE D'HONT et al.

A1 Journal Article in HAEMATOLOGICA

The human fetal thymus generates invariant effector γδ T cells

Paola TieppoMaria PapadopoulouDeborah GattiNaomi McGovernJerry K. Y. ChanFrancoise GosselinGlenn GoetgelukKarin WeeningLing MaNicolas Dauby et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

The transcription factor ETS1 is an important regulator of human NK cell development and terminal differentiation

Sylvie TaveirneSigrid WahlenWouter Van LoockeLaura KiekensEva PersynEls Van AmmelKatrien De MulderJuliette RoelsLaurentijn TillemanMarc Aumercier et al.

A1 Journal Article in BLOOD

iPSC-based modeling of RAG2 severe combined immunodeficiency reveals multiple T cell developmental arrests

Maria ThemeliAmiet ChhattaHester BoersmaHenk Jan PrinsMartijn CordesEdwin de WiltAida Shahrabi FarahaniBart VandekerckhoveMirjam van der BurgRob C. Hoeben et al.

A1 Journal Article in STEM CELL REPORTS

2019

TARP as immunotherapeutic target in AML expressed in the LSC compartment

Barbara DepreterKarin WeeningKarl VandepoeleM EssandBarbara De MoerlooseM ThemeliJ CloosD HanekampIne MoorsINGE D'HONT et al.

Tcr sequencing reveals the distinct development of fetal and adult human vγ9vδ2 t cells

M PapadopoulouP TieppoN McGovernF GosselinChan JKYGlenn GoetgelukN DaubyA CoganC DonnerF Ginhoux et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

2018

An accelerated, clinical-grade protocol to generate high yields of type 1-polarizing messenger RNA loaded dendritic cells for cancer vaccination

Elisabeth BrabantsKelly HeynsS De SmetPam DevrekerJoline IngelsNancy De CabooterVeronique DebackerMelissa DullaersJP Van MeerbeeckBart Vandekerckhove et al.

A1 Journal Article in CYTOTHERAPY

Comprehensive mapping of the antigenic peptide repertoire during bacterial infection

Rupert MayerTeresa MaiaKatie BoucherBart VandekerckhoveFrancis Impens

Delivering type I interferon to dendritic cells empowers tumor eradication and immune combination treatments

Anje CauwelsSandra Van LintFranciane PaulGenevieve GarcinStefaan De KokerAlexander Van ParysThomas WüestSarah GerloJosé Van Der HeydenYan Bordat et al.

A1 Journal Article in CANCER RESEARCH

Nanobody based dual specific CARs

Stijn De MunterJoline IngelsGlenn GoetgelukSarah BonteMelissa PilleKarin WeeningTessa KerreHinrich AbkenBart Vandekerckhove

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2017

A murine intestinal intraepithelial NKp46-negative innate lymphoid cell population characterized by group 1 properties

Aline Van AckerKonrad GronkeAindrila BiswasLiesbet MartensYvan SaeysJessica FiltjensSylvie TaveirneEls Van AmmelTessa KerrePatrick Matthys et al.

A1 Journal Article in CELL REPORTS

A new transcript in the TCRB locus unveils the human ortholog of the mouse pre-Dß1 promoter

Bernard LethéSYLVIA SNAUWAERTOrian BricardDavid SchröderTiphanie GomardGérald HamesCatherine MullerChristophe LurquinEmilie GauthyAhmed Essaghir et al.

A1 Journal Article in IMMUNITY INFLAMMATION AND DISEASE

Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities

Yasmine Van CaeneghemStijn De MunterPaola TieppoGlenn GoetgelukKarin WeeningGreet VerstichelSarah BonteTom TaghonGeorges LeclercqTessa Kerre et al.

A1 Journal Article in ONCOIMMUNOLOGY

In vitro generation of tumor antigen-specific T cells from patient and healthy donor stem cells

Sarah BonteSYLVIA SNAUWAERTGlenn GoetgelukBart VandekerckhoveTessa Kerre

The checkpoint for agonist selection precedes conventional selection in human thymus

Greet VerstichelDavid VermijlenLiesbet MartensGlenn GoetgelukMargreet BrouwerNicolas ThiaultYasmine Van CaeneghemStijn De MunterKarin WeeningSarah Bonte et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

Thymic development of a new innate CD8+ T cell population

Greet VerstichelBart VandekerckhoveTessa Kerre

2016

Early TCRA rearrangements favor development of agonist selected CD8ααhi T cells in human

Greet VerstichelGlenn GoetgelukLiesbet MartensYvan SaeysTessa KerreHilde CheroutreDavid VermijlenBart Vandekerckhove

Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours

Jessica FiltjensJiri KeirsseEls Van AmmelSylvie TaveirneAline Van AckerTessa KerreTom TaghonBart VandekerckhoveJean PlumJo A Van Ginderachter et al.

A1 Journal Article in SCIENTIFIC REPORTS

GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate

Inge Van de WalleAnne-Catherine DolensKaat DurinckKatrien De MulderWouter Van LoockeSagar DamleEls WaegemansJelle De MedtsImke VelgheMagda De Smedt et al.

A1 Journal Article in NATURE COMMUNICATIONS

Gene correction of iPSCs from a Wiskott-Aldrich syndrome patient normalizes the lymphoid developmental and functional defects

Tamara J LaskowskiYasmine Van CaeneghemRasoul PourebrahimChao MaZhenya NiZita GarateAna M CraneXuan Shirley LiWei LiaoManuel Gonzalez-Garay et al.

A1 Journal Article in STEM CELL REPORTS

Humanized mice to study human T cell development

Sarah BonteSYLVIA SNAUWAERTStijn VanheeAnne-Catherine DolensTom TaghonBart VandekerckhoveTessa Kerre

Bookchapter in T-Cell development : methods and protocols

Radiation sensitivity of human CD34+ cells versus peripheral blood T lymphocytes of newborns and adults: DNA repair and mutagenic effects

Charlot VandevoordeAnne VralBart VandekerckhoveJan PhilippéHubert Thierens

A1 Journal Article in RADIATION RESEARCH

The Ly49E receptor inhibits the immune control of acute Trypanosoma cruzi infection

Jessica FiltjensNicolas ColtelSabrina CencigSylvie TaveirneEls Van AmmelAline Van AckerTessa KerrePatrick MatthysTom TaghonBart Vandekerckhove et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

The checkpoint for agonist selection precedes conventional selection in human thymus

Greet VerstichelDavid VermijlenLiesbet MartensGlenn GoetgelukYvan SaeysHilde CheroutreBart Vandekerckhove

The role of Ly49E receptor expression on murine intraepithelial lymphocytes in intestinal cancer development and progression

Aline Van AckerEls LouagieJessica FiltjensSylvie TaveirneEls Van AmmelTessa KerreDirk ElewautTom TaghonBart VandekerckhoveJean Plum et al.

A1 Journal Article in CANCER IMMUNOLOGY IMMUNOTHERAPY

2015

A candidate agonist selected CD8SP subpopulation in the human thymus and cord blood

Greet VerstichelAline Van AckerGeorges LeclercqBart Vandekerckhove

Chimeric antigen receptor transgenic, T cell receptor/CD3 negative monospecific T cells generated from cord blood CD34 positive cells

Yasmine Van CaeneghemGlenn GoetgelukKarin WeeningGreet VerstichelSarah BonteTom TaghonGeorges LeclercqFritz OffnerHinrich AbkenTessa Kerre et al.

In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis

Stijn VanheeKatrien De MulderYasmine Van CaeneghemGreet VerstichelNadine Van RoyBjörn MentenImke VelgheJan PhilippéDominique De BleserBart Lambrecht et al.

A1 Journal Article in HAEMATOLOGICA

In vitro studies on human hematopoiesis

Stijn VanheeBart VandekerckhoveTessa Kerre

Pluripotent stem cell based gene therapy for hematological diseases

Stijn VanheeBart Vandekerckhove

A1 Journal Article in CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

2014

Contribution of the Ly49E natural killer receptor in the immune response to Plasmodium berghei infection and control of hepatic parasite development

Jessica FiltjensLander FoquetSylvie TaveirneEls Van AmmelMandy VanheesAline Van AckerTessa KerreTom TaghonBart VandekerckhoveJean Plum et al.

A1 Journal Article in PLOS ONE

Functional evaluation of T-cells generated from WT1-TCR transduced human hematopoietic stem cells using the OP9-DL1 coculture system

Sarah BonteSYLVIA SNAUWAERTG GoetgelukM HeemskerkH StaussBart VandekerckhoveTessa Kerre

In vitro and in vivo functional evaluation of T-cells generated from WT1-TCR transduced human hematopoietic stem cells using the OP9-DL1 coculture system

Sarah BonteSYLVIA SNAUWAERTGlenn GoetgelukH StaussR StripeckeM HeemskerkYasmine Van CaeneghemGreet VerstichelStijn VanheeBart Vandekerckhove et al.

In vitro generation of AML-specific T cells from human hematopoietic progenitor cells : a step towards curing acute myeloid leukemia?

SYLVIA SNAUWAERTTessa KerreBart Vandekerckhove

In vitro generation of mature, naive antigen-specific CD8⁺ T cells with a single T-cell receptor by agonist selection

SYLVIA SNAUWAERTGreet VerstichelSarah BonteGlenn GoetgelukStijn VanheeYasmine Van CaeneghemKatrien De MulderCarlo HeirmanHans StaussMiriam HM Heemskerk et al.

A1 Journal Article in LEUKEMIA

In vitro human embryonic stem cell hematopoiesis mimics MYB independent yolk sac hematopoiesis

Stijn VanheeKatrien De MulderYasmine Van CaeneghemNadine Van RoyBjörn MentenImke VelgheJan PhilippéTom TaghonGeorges LeclercqTessa Kerre et al.

Ly49E Expression on CD8αα-expressing intestinal intraepithelial lymphocytes plays no detectable role in the development and progression of experimentally induced inflammatory bowel diseases

Aline Van AckerJessica FiltjensSophie Van WeldenSylvie TaveirneEls Van AmmelMandy VanheesLindsey DevisscherTessa KerreTom TaghonBart Vandekerckhove et al.

A1 Journal Article in PLOS ONE

Notch3 activation is sufficient but not required for inducing human T-lineage specification

Els WaegemansInge Van de WalleJelle De MedtsMagda De SmedtTessa KerreBart VandekerckhoveGeorges LeclercqTao WangJean PlumTom Taghon

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Polyfunctional tumor antigen-specific T cells generated in vitro from human CD34 positive precursor cells transduced to express T cell receptor alpha beta chains fused to CD28-CD3 zeta signaling cassette

Yasmine Van CaeneghemGlenn GoetgelukSYLVIA SNAUWAERTFritz OffnerReno DebetsTessa KerreBart Vandekerckhove

2013

Abundant stage-dependent Ly49E expression by liver NK cells is not essential for their differentiation and function

Jessica FiltjensSylvie TaveirneAline Van AckerEls Van AmmelMandy VanheesTessa KerreTom TaghonBart VandekerckhoveJean PlumGeorges Leclercq

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

CMYB expression during human in vitro hematopoiesis

Stijn VanheeYasmine Van CaeneghemKatrien De MulderImke VelgheSylvie TaveirneNadine Van RoyBjörn MentenSYLVIA SNAUWAERTGreet VerstichelMelissa Dullaers et al.

Can immunotherapy specifically target acute myeloid leukemic stem cells?

SYLVIA SNAUWAERTBart VandekerckhoveTessa Kerre

A1 Journal Article in ONCOIMMUNOLOGY

Differential Ly49e expression pathways in resting versus TCR-activated intraepithelial γδ T cells

Tina Van Den BroeckEls Van AmmelMaarten DelforcheSylvie TaveirneTessa KerreBart VandekerckhoveTom TaghonJean PlumGeorges Leclercq

A1 Journal Article in JOURNAL OF IMMUNOLOGY

In vitro generation of antigen-specific T-cells from CD34+haematopoietic progenitor cells: a new and promising immunotherapeutic strategy

SYLVIA SNAUWAERTS Van CoppernolleGreet VerstichelGlenn GoetgelukYasmine Van CaeneghemStijn VanheeImke VelgheJean PlumTessa KerreBart Vandekerckhove

Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength

Inge Van de WalleEls WaegemansJelle De MedtsGreet De SmetMagda De SmedtSYLVIA SNAUWAERTBart VandekerckhoveTessa KerreGeorges LeclercqJean Plum et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2012

Evaluation of the receptor for hyaluronic acid mediated motility as a tumour-specific antigen in AML

SYLVIA SNAUWAERTStijn VanheeYasmine Van CaeneghemGreet VerstichelGlenn GoetgelukImke VelgheBart VandekerckhoveTessa Kerre

Notch induces T cell receptor gamma delta thymocytes to differentiate along a bipotent CD4 CD8 double positive pathway

Bart VandekerckhoveStefanie Van CoppernolleGreet VerstichelSYLVIA SNAUWAERTAnton LangerakTessa Kerre

Notch induces human T-cell receptor γδ+ thymocytes to differentiate along a parallel, highly proliferative and bipotent CD4 CD8 double-positive pathway

Stefanie Van CoppernolleStijn VanheeGreet VerstichelSYLVIA SNAUWAERTA van der SpekImke VelgheMieke SinnesaelMH HeemskerkTom TaghonGeorges Leclercq et al.

A1 Journal Article in LEUKEMIA

Notch ligands control the human alpha beta/gamma delta lineage choice through receptor-specific induction of differential Notch signal strength

Tom TaghonInge Van de WalleEls WaegemansJelle De MedtsGreet De SmetMagda De SmedtBart VandekerckhoveTessa KerreGeorges LeclercqTao Wang et al.

RHAMM/HMMR (CD168) is not an ideal target antigen for immunotherapy of acute myeloid leukemia

SYLVIA SNAUWAERTStijn VanheeGlenn GoetgelukGreet VerstichelYasmine Van CaeneghemImke VelgheJan PhilippéZwi N BernemanJean PlumTom Taghon et al.

A1 Journal Article in HAEMATOLOGICA-THE HEMATOLOGY JOURNAL

TCR-dependency of in vitro T cell maturation in OP9-DL1 cocultures

Greet VerstichelSYLVIA SNAUWAERTTessa KerreBart Vandekerckhove

2011

CD27-deficient mice show normal NK-cell differentiation but impaired function upon stimulation

Veerle De ColvenaerSylvie TaveirneMaarten DelforcheMagda De SmedtBart VandekerckhoveTom TaghonLouis BoonJean PlumGeorges Leclercq

A1 Journal Article in IMMUNOLOGY AND CELL BIOLOGY

Double positive and double negative TCR gamma delta plus cells independently generate mature functional TCR gamma delta plus cells in the human thymus

Stefanie Van CoppernolleStijn VanheeGreet VerstichelSYLVIA SNAUWAERTImke VelgheMieke SinnesaelA van der SpekTom TaghonGeorges LeclercqJean Plum et al.

Hemato-endothelial development : an in vitro study

Frank TimmermansBart VandekerckhoveThierry Gillebert

In vitro generation of immune cells from pluripotent stem cells

Bart VandekerckhoveStijn VanheeStefanie Van CoppernolleSYLVIA SNAUWAERTImke VelgheTom TaghonGeorges LeclercqTessa KerreJean Plum

A1 Journal Article in FRONTIERS IN BIOSCIENCE-LANDMARK

Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8αα intestinal intraepithelial T lymphocytes

Sylvie TaveirneJessica FiltjensEls Van AmmelVeerle De ColvenaerTessa KerreTom TaghonBart VandekerckhoveJean PlumWerner HeldGeorges Leclercq

A1 Journal Article in BLOOD

Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions

Inge Van de WalleGreet De SmetMartina GärtnerMagda De SmedtEls WaegemansBart VandekerckhoveGeorges LeclercqJean PlumJon C AsterIrwin D Bernstein et al.

A1 Journal Article in BLOOD

Langerhans cells are not required for epidermal Vγ3 T cell homeostasis and function

Sylvie TaveirneVeerle De ColvenaerTina Van Den BroeckEls Van AmmelClare L BennettTom TaghonBart VandekerckhoveJean PlumBjörn E ClausenDaniel H Kaplan et al.

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

Study of human T cell differentiation using the OP9-DL1 co-culture system as a model

Stefanie Van CoppernolleBart VandekerckhoveTessa Kerre

T-lymphoid differentiation potential measured in vitro is higher in CD34+CD38-/lo hematopoietic stem cells from umbilical cord blood than from bone marrow and is an intrinsic property of the cells

Magda De SmedtGeorges LeclercqBart VandekerckhoveTessa KerreTom TaghonJean Plum

A1 Journal Article in HAEMATOLOGICA-THE HEMATOLOGY JOURNAL

2010

Continuous CD27 triggering in vivo strongly reduces NK cell numbers

Veerle De ColvenaerSylvie TaveirneJörg HamannAlex M de BruinMagda De SmedtTom TaghonBart VandekerckhoveJean PlumRené van LierGeorges Leclercq

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

2009

An early decrease in Notch activation is required for human TCR-αβ lineage differentiation at the expense of TCR-γδ T cells

Inge Van de WalleGreet De SmetMagda De SmedtBart VandekerckhoveGeorges LeclercqJean PlumTom Taghon

A1 Journal Article in BLOOD

CD4 and CD8 TCR alpha beta cells are selected on MHC expressed on thymocyte precursors in OP9-DL1 cultures

Stefanie Van CoppernolleBart VandekerckhoveGreet VerstichelImke VelgheTom TaghonGeorges LeclercqJean PlumTessa Kerre

Endothelial progenitor cells : identity defined?

Frank TimmermansJean PlumMervin YoderDavid IngramBart VandekerckhoveJamie Case

A1 Journal Article in JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Functionally mature CD4 and CD8 TCRαβ cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells

Stefanie Van CoppernolleGreet VerstichelFrank TimmermansImke VelgheDavid VermijlenMagda De SmedtGeorges LeclercqJean PlumTom TaghonBart Vandekerckhove et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Generation of T cells from human embryonic stem cell-derived hematopoietic zones

Frank TimmermansImke VelgheLieve VanwalleghemMagda De SmedtStefanie Van CoppernolleTom TaghonHarry MooreGeorges LeclercqAnton LangerakTessa Kerre et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Notch signaling is required for proliferation but not for differentiation at a well-defined β-selection checkpoint during human T-cell development

Tom TaghonInge Van de WalleGreet De SmetMagda De SmedtGeorges LeclercqBart VandekerckhoveJean Plum

A1 Journal Article in BLOOD

2008

GUIDELINES FOR THE USE OF FRESH FROZEN PLASMA

D. De BackerBart VandekerckhoveS. StanworthL. WilliamsonC. HermansP. Van der LindenR. HubnerP. BaeleK. JochmansA. Ferrant et al.

A1 Journal Article in ACTA CLINICA BELGICA

Generation of T cells from human embryonic stem cells

Frank TimmermansImke VelgheLieve VanwalleghemMagda De SmedtStefanie Van CoppernolleGeorges LeclercqTom TaghonHarry MooreAnton W LangerakTessa Kerre et al.

Human intrathymic development: a selective approach

Jean PlumMagda De SmedtGeorges LeclercqTom TaghonTessa KerreBart Vandekerckhove

A1 Journal Article in SEMINARS IN IMMUNOPATHOLOGY

Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator

Tina Van Den BroeckFrederick StevenaertSylvie TaveirneVeronique DebackerCHRISTEL VANGESTELBart VandekerckhoveTom TaghonPatrick MatthysJean PlumWerner Held et al.

A1 Journal Article in Blood

OP9-DL1 Cell Line Supports the Development of Phenotypically and Functionally Mature Tcr alpha beta And Tcr gamma delta T Cells, through Both Conventional and Aberrant Developmental Pathways

Tessa KerreGreet VerstichelStefanie Van CoppernolleImke VelgheFrank TimmermansJean PlumBart Vandekerckhove

2007

Bone-marrow-derived cells for cardiac stem cell therapy: safe or still under scrutiny?

J. BartunekM. VanderheydenW. WijnsFrank TimmermansBart VandekerckhoveA. VillaP. SanchezR. ArnoldJ. San RomanGuy Heyndrickx et al.

Differentiation assays of bone marrow-derived Multipotent Adult Progenitor Cell (MAPC)-like cells towards neural cells cannot depend on morphology and a limited set of neural markers

Robrecht RaedtJ PINXTERENAnnelies Van DyckeAnouk WaeytensD CRAEYEFrank TimmermansKristl VonckBart VandekerckhoveJean PlumPaul Boon

A1 Journal Article in EXPERIMENTAL NEUROLOGY

Endothelial outgrowth cells are not derived from CD133(+) cells or CD45(+) hematopoietic precursors

Frank TimmermansFilip Van HauwermeirenMagda De SmedtRobrecht RaedtFRANK PLASSCHAERTMarc De BuyzereThierry GillebertJean PlumBart Vandekerckhove

A1 Journal Article in ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Experimental study to improve hematopoietic recovery after umbilical cord blood transplantation

Katrien VanheusdenBart VandekerckhoveJean Plum

In vitro expanded cells contributing to rapid severe combined Immunodeficient repopulation activity are CD34(+)38(-)33(+)90(+)45RA(-)

Katrien VanheusdenStefanie Van CoppernolleMagda De SmedtJean PlumBart Vandekerckhove

A1 Journal Article in STEM CELLS

Time-dependent effects on coronary remodeling and epicardial conductance after intracoronary injection of enriched hematopoietic bone marrow stem cells in patients with previous myocardial infarction

M VANDERHEYDENS VERCAUTERENS MANSOURL DELRUEBart VandekerckhoveGR HEYNDRICKXI VAN HAUTEB DE BRUYNEFrank TimmermansW WIJNS et al.

A1 Journal Article in CELL TRANSPLANTATION

2006

Endothelial cells are not derived from hematopoietic precursor cells

Frank TimmermansMagda De SmedtRobrecht RaedtJean PlumBart Vandekerckhove

Intracoronary delivery of hematopoietic bone marrow stem cells and luminal loss of the infarct-related artery in patients with recent myocardial infarction

S MANSOURM VANDERHEYDENB DE BRUYNEBart VandekerckhoveL DELRUEI VAN HAUTEG HEYNDRICKXS CARLIERG RODRIGUEZ-GRANILLOW WIJNS et al.

A1 Journal Article in JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Therapeutic efficacy and safety of transfusion of pathogen-inactivated platelets tot pediatric patients

Inge Van hauteYves BenoitMaria Bordon Cueto De BraemBarbara De MoerlooseEls VandecruysSophie Van LanckerMURIEL VAN VOORENBart Vandekerckhove

2005

Can mesenchymal-like stem differentiate towards neurons: the validity of neural gene expression as a proof for neural differentiation?

Robrecht RaedtJef PinxterenAnnelies Van DyckeAnouk WaeytensDavid CraeyeBart VandekerckhoveJean PlumPaul Boon

Intracoronary injection of CD133-positive enriched bone marrow progenitor cells promotes cardiac recovery after recent myocardial infarction - Feasibility and safety

J BARTUNEKM VANDERHEYDENBart VandekerckhoveS MANSOURB DE BRUYNEP DE BONDTI VAN HAUTEN LOOTENSG HEYNDRICKXW WIJNS

A1 Journal Article in CIRCULATION

Selecting cord blood units for storage by CD34+cell counts

I VAN HAUTEN LOOTENSK DE BUCKL VERDEGENVV STEENES DESMETDavid CraeyeBart Vandekerckhove

A1 Journal Article in TRANSFUSION

Synovial intracellular citrullinated proteins colocalizing with peptidyl arginine deiminase as pathophysiologically relevant antigenic determinants of rheumatoid arthritis-specific humoral autoimmunity

Leen De RyckeAP NICHOLASTineke CantaertElli KruithofJD ECHOLSBart VandekerckhoveEric VeysFilip De KeyserDominique Baeten

A1 Journal Article in ARTHRITIS AND RHEUMATISM

Towards a cell therapy for temporal lobe epilepsy (TLE)?

Tine WyckhuysRobrecht RaedtPieter ClaeysTim De SmedtJozef PinxterenDavid CraeyeKaatje SmitsKristl VonckStefanie DedeurwaerdereAnouk Waeytens et al.

2004

Selective apheresis using glycosorb AB (R) daclizumab and mycophenolate mofetil induction without splenectomy in ABO-incompatible living donor liver transplantations in adults

Roberto TroisiLucien NoensBart VandekerckhoveR MONTALTISALVATORE RICCIARDIJ PHILIPPEBernard de Hemptinne

Viable CD34+ stem cell content of a cord blood graft: which measurement performed before transplantation is most representative?

I VAN HAUTEN LOOTENSS DE SMETC DE BUCKL VERDEGEMKatrien VanheusdenJozef PinxterenBart Vandekerckhove

A1 Journal Article in TRANSFUSION

2002

Active form of notch imposes T cell fate in human progenitor cells

Magda De SmedtKatia ReynvoetTessa KerreTom TaghonBruno VerhasseltBart VandekerckhoveGeorges LeclercqJean Plum

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Adapted NOD/SCID model supports development of phenotypically and functionally mature T cells from human umbilical cord blood CD34(+) cells.

Tessa KerreG DE SMETM DE SMEDTA ZIPPELIUSMJ PITTETAW LANGERAKJ DE BOSSCHERFritz OffnerBart VandekerckhoveJean Plum

A1 Journal Article in BLOOD

Cytokine deprivation improves the homing of long-term cultured human hematopoietic stem cells after intravenous injection into NOD/SCID mice

Tessa KerreKatrien VanheusdenFritz OffnerJean PlumBart Vandekerckhove

Cytokine deprivation improves the homing of long-term cultured human hematopoietic stem cells after transplantation int NOD/SCID mice

Tessa KerreBart VandekerckhoveFritz OffnerJean Plum

Long term culture of human hematopoietic stem cells influence on homing, organ selectivity, survival and proliferation early after transplantation into NOD/SCID mice

Tessa KerreBart VandekerckhoveFritz OffnerJean Plum

2001

An adapted NOD/SCID model supports the development of phenotypically and functionally mature T cells from human umbilical cord blood CD34(+) cells

Tessa KerreBart VandekerckhoveFritz OffnerJean Plum

Both CD34(+)38(+) and CD34(+)38(-) cells home specifically to the bone marrow of NOD/LtSZ scid/scid mice but show different kinetics in expansion.

Tessa KerreG DE SMETM DE SMEDTFritz OffnerJ DE BOSSCHERJean PlumBart Vandekerckhove

A1 Journal Article in JOURNAL OF IMMUNOLOGY

The behavior of long-term cultured human hematopoietic stem cells early after transplantation into NOD/SCID mice provides explanations for their impaired long-term engraftment in this model

Tessa KerreBart VandekerckhoveFritz OffnerJean Plum

2000

Both human CD34(+)38(+) and CD34(+)38(-) cells home specifically to the bone marrow, but show different kinetics in take and proliferation

Tessa KerreG DE SMETMagda De SmedtFritz OffnerJean PlumBart Vandekerckhove

Human T lymphopoiesis - In vitro and in vivo study models.

Jean PlumM DE SMEDTBruno VerhasseltTessa KerreDominique VanheckeBart VandekerckhoveGeorges Leclercq

A1 Journal Article in NEUROIMMUNOMODULATION

1999

In vitro intrathymic differentiation kinetics of human fetal liver CD34(+)CD38(-) progenitors reveals a phenotypically defined dendritic/T-NK precursor split

Jean PlumMagda De SmedtBruno VerhasseltFritz OffnerTessa KerreD VANHECKEGeorges LeclercqBart Vandekerckhove

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Thymic repopulation by CD34+ human cord blood cells after expansion in stroma-free culture

Bruno VerhasseltTessa KerreEvelien NaessensDominique VanheckeMagda De SmedtBart VandekerckhoveJean Plum

A1 Journal Article in BLOOD

1998

Abnormal thymocyte development and generation of autoreactive T cells in mixed and cortical thymomas.

R NENNINGERA SCHULTZV HOFFACKERM HELMREICHA WILISCHBart VandekerckhoveT HUNIGB SCHALKEC SCHNEIDERS TZARTOS et al.

A1 Journal Article in LABORATORY INVESTIGATION

Passive particle agglutination test for screening of Treponema pallidum antibodies in blood bank routine.

D DE BLESERL VAN RENTERGHEMBart Vandekerckhove

A1 Journal Article in ACTA CLINICA BELGICA

1997

Human thymocytes become lineage committed at an early postselection CD69(+) stage, before the onset of functional maturation.

Dominique VanheckeBruno VerhasseltM DE SMEDTGeorges LeclercqJean PlumBart Vandekerckhove

A1 Journal Article in JOURNAL OF IMMUNOLOGY

MHC class II molecules are required for initiation of positive selection but not during terminal differentiation of human CD4 single positive thymocytes

Dominique VanheckeBruno VerhasseltM DESMEDTB DEPAEPEGeorges LeclercqJean PlumBart Vandekerckhove

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Phenotypic and functional maturation of TCR gamma delta cells in the human thymus.

Fritz OffnerKatrien Van BenedenV DEBACKERDominique VanheckeBart VandekerckhoveJean PlumGeorges Leclercq

A1 Journal Article in JOURNAL OF IMMUNOLOGY

T cell development in the human thymus

Bart VandekerckhoveDominique VanheckeJean Plum

1996

Interleukin-7 is a critical growth factor in early human T-cell development.

Jean PlumM DESMEDTGeorges LeclercqBruno VerhasseltBart Vandekerckhove

A1 Journal Article in BLOOD

1995

CHARACTERIZATION OF DISTINCT STAGES DURING THE DIFFERENTIATION OF HUMAN CD69(+)CD3(+) THYMOCYTES AND IDENTIFICATION OF THYMIC EMIGRANTS.

D VANHECKEGeorges LeclercqJean PlumBart Vandekerckhove

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Characterization of distinct stages during the differentiation of human CD69+CD3+thymocytes ad identification of thymic emigrants

Dominique VanheckeGeorges LeclercqJean PlumBart Vandekerckhove

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Differentiation to T helper cells in the thymus : gradual acquisition of T helper cell function by CD3⁺CD4⁺ cells

Dominique VanheckeBruno VerhasseltVeronique DebackerGeorges LeclercqJean PlumBart Vandekerckhove

A1 Journal Article in JOURNAL OF IMMUNOLOGY

INFLUENCE OF TGF-BETA ON MURINE THYMOCYTE DEVELOPMENT IN FETAL THYMUS ORGAN-CULTURE.

Jean PlumM DESMEDTGeorges LeclercqBart Vandekerckhove

A1 Journal Article in JOURNAL OF IMMUNOLOGY

1994

Human CD34+ Fetal Liver Stem Cells Differentiate to T Cells in a Mouse Thymic Microenvironment.

Jean PlumM DESMEDTMP DEFRESNEGeorges LeclercqBart Vandekerckhove

A1 Journal Article in BLOOD

Human Fetal Liver Cells differentiate into thymocytes in chemeric mouse Fetal Thymus Organ Culture

M DE SMEDTGeorges LeclercqBart VandekerckhoveJean Plum

Human fetal liver cells differentiate into thymocytes in chimeric mouse fetal thymus organ culture

Magda De SmedtGeorges LeclercqBart VandekerckhoveJean Plum

IL-2 reverses human T-cell unresponsiveness induced by thymic epithelium in SCID-HU mice

D ScholsBart VandekerckhoveD JonesM Roncarolo

A1 Journal Article in JOURNAL OF IMMUNOLOGY

In-vivo cytokine expression in the thymus CD3(high) human thymocytes are activated and already functionally differentiated in helper and cytotoxic-cells

Bart VandekerckhoveA BarcenaD ScholsS MohanpetersonH SpitsM Roncarolo

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Stem cell differentiation into mature lymphocytes using the SCID mouse thymus chimera model

Magda De SmedtGeorges LeclercqBart VandekerckhoveJean Plum

Bookchapter in Hematopoietic stem cells : the Mulhouse manual

Thymocyte Differentiation is accompanied by modulation of multiple human adhesion antigens

D VAN HECKEGeorges LeclercqJean PlumBart Vandekerckhove

1993

Bacterial superantigens mediate T-cell deletions in the mouse severe combined immunodeficiency human liver thymus model

R BaccalaBart VandekerckhoveD JonesD KonoM RoncaroloAn Theofilopoulos

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Chimerism and tolerance to host and donor in severe combined immunodeficiencies transplanted with fetal liver stem-cells

R BacchettaBart VandekerckhoveJ TouraineM BiglerS MartinoL GebuhrerJ DevriesH SpitsM Roncarolo

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Human IG production and isotype switching in severe combined immunodeficient: human mice

Bart VandekerckhoveD JonesJ PunnonenD ScholsH LinB DuncanR BachettaJ DevriesM Roncarolo

A1 Journal Article in JOURNAL OF IMMUNOLOGY

1992

Human hematopoietic-cells and thymic epithelial-cells induce tolerance via different mechanisms in the SCID-HU mouse thymus

Bart VandekerckhoveR NamikawaR BacchettaM Roncarolo

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Induction of isotype switching and IG production by CD5+ and CD10+ human fetal B-cells

J PunnonenG AversaBart VandekerckhoveM RoncaroloJ De Vries

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Thymic selection of the human T-cell receptor V-Beta repertoire in SCID-HU mice

Bart VandekerckhoveR BaccalaD JonesD KonoA TheophylopoulosMG Roncarolo

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

1991

Clonal analysis of the peripheral T-Cell compartment of the SCID-HU mouse

Bart VandekerckhoveJ KrowkaJ MccuneJ DevriesH SpitsM Roncarolo

A1 Journal Article in JOURNAL OF IMMUNOLOGY

1990

An increase of donor-specific T-helper precursors resulting from blood-transfusions

Bart VandekerckhoveG DatemaF ZaantvoortF Claas

A1 Journal Article in TRANSPLANTATION

Analysis of the donor-specific cytotoxic lymphocyte-T repertoire in a patient with a long-term surviving allograft-frequency, specificity, and phenotype of donor-reactive T-cell receptor (TCR)-Alpha-Beta and TCR-Gamma-Delta+ clones

Bart VandekerckhoveG DatemaF KoningE GoulmyG PersijnJ VanroodF ClaasJ Devries

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Gamma-delta T-cell receptor positive T-cell clones derived from human heart-transplants do not show donor-specific cytotoxicity

N JutteBart VandekerckhoveL VaessenA OuwehandC BaanE BosF ClaasW Weimar

A1 Journal Article in HUMAN IMMUNOLOGY

Immunological-unresponsiveness induced by ultraviolet-B irradiated and nonirradiated skin-grafts

Bart VandekerckhoveG DatemaF Claas

A1 Journal Article in TRANSPLANTATION

1989

A novel T-cell-defined HLA-DR polymorphism not predicted from the linear amino acid sequence

Annemarie TermijtelenPeter van den ElsenFrits KoningSaskia de KosterWilleke SchroeijersBart Vandekerckhove

A1 Journal Article in HUMAN IMMUNOLOGY

Analysis of cytotoxic T cell precursor frequencies directed against individual HLA-A and -B alloantigens

Li ZhangShu Guang LiBart VandekerckhoveAnnemarie TermijtelenJoh J Van RoodFrans HJ Claas

A1 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS

Cytotoxic lymphocytes- T are the prime mediators of suppression of the mixed lymphocyte-reaction by alloactivated cells

Bart VandekerckhoveE Timmermans-De JongG DatemaF Claas

A1 Journal Article in SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Increase of donor-specific cyto-toxic lymphocyte-T precursors after transfusion

Bart VandekerckhoveS Van BreeZ LiG DatemaF ZantvoortF Claas

A1 Journal Article in TRANSPLANTATION

Specific suppression of mixed lymphocyte reactions by alloactivated cells is correlated with cyto-toxicity

Bart VandekerckhoveEJ Timmermans-de JongA TermijtelenFHJ Claas

A1 Journal Article in HUMAN IMMUNOLOGY

1988

Differential immune-response of congenic mice to ultraviolet-treated major histocompatibility complex class-II incompatible skin-grafts

BJ VermeerB SanterseBart VandekerckhoveAA SchothorstFHJ Claas

A1 Journal Article in TRANSPLANTATION