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Medical and health sciences
- Immunology not elsewhere classified
- Cell death
- Cancer diagnosis
- Cancer therapy
- Applied immunology
- Cell therapy
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Engineering and technology
- Other electrical and electronic engineering not elsewhere classified
The CARTAGENA project aims to develop a highly innovative platform and associated assays for complex screenings of single cells. Initial assay development will focus on encapsulation of cells in nanoliter-sized droplets, their manipulation and visualization, and the use of this technology to study tumor-lytic properties of individual CAR-T cells. Subsequent assay development will focus on development of droplet-based assays to additionally assess secretome and phenotype. Ultimately, the platform will enable multi-parametric assessment of single cells with unprecedented high throughput. Following screening, selective and live retrieval of the desired cells enables further downstream use. The project aims to add a new dimention to the single cell research besides flow cytometry, single cell transcriptomics,...