Antibodies against Tumour Associated Carbohydrate Antigen

CYTOKINE-AGNOSTIC, NANOBODY®-BASED INTERLEUKIN-20 RECEPTOR AGONISTS WITH BIASED SIGNALING

De structurele basis voor de interactie van THEMIS proteïnen door adaptor-moleculen in immuniteit

Doctoral project Aleksandra Fulara

Doctoral project Daniel Bruznican

Doctoral project Delaney Smith

Doctoral project Erwin Pannecoucke

Doctoral project Ioanna Ramou

Doctoral project Jan Félix

Doctoral project Jonathan Elegheert

Doctoral project Julie Andries

Doctoral project Katarzyna Skladanowska

Doctoral project Kedar Moharana

Doctoral project Ruben Van der Meeren

Doctoral project Sammy Detry

Doctoral project Wouter Van Putte

In situ structure and dynamics of Anaplastic Lymphoma Kinase in complex with cytokines via integrative structural biology

Structural and functional studies of receptor complexes mediated by Interleukin-19 and Interleukin-26.

Structural basis for the activation and antagonism of the IL-9 signaling complex

Structure and mechanism of cytokine mediated activation of ALK family receptor tyrosine kinases

Structure-driven design of PROTAC drugs against protein complexes central to leukemia

Structure, mechanism and antagonism of protein complexes in immunity, inflammation and cancer.

Doctoral project Agata Goza

Doctoral project Qiaozhi Yu

Enlarging the toolbox for cysteine selective protein modification

3D Structural Platform for Chemical Excellence.

An integrated approach to unravel eosinophil function in chronic eosinophilic disorders

Deciphering the role of PI3K in JAK2-mediated Th17 immunity

Development of small-molecule inhibitors targeting pro-inflammatory and pruritogenic IL-31

Dissection of the interleukin-9 signalling assembly fundamental to Th9 immunity

Dissection of the molecular basis of bacterial type II secretion in pathogenic bacteria

Dissection of the molecular basis of bacterial type II secretion in pathogenic bacteria

Interleukin-34: an exciting new twist in the activation of the human Colony Stimulating Factor 1 Receptor

Intracellular therapeutic alphabodies

Molecular and evolutionary insights into the structure and mechanism of ATP citrate lyase

Molecular and structural basis of type-II secretion systems of pathogenic Gram-negative bacteria.

Molecular and structural basis of type-II secretion systems of pathogenic Gram-negative bacteria

Molecular and structural study of standard and pathological FLT3 receptor activation

Molecular study and characterization of the agglutination protein from Shewanella oneidensis

Rational design of biologics for therapeutic development (FoldCo)

Role of protein crystals in asthma?

Structural and biophysical characterisation of XcpP and XcpQ of the bacterial type 2 secretion system from Pseudomonas aeruginosa.

Structural and biophysical characterization of extracellular assemblies of the anaplastic lymphoma kinase receptor

Structural and functional insights into the role of Themis1 and Themis2 in inflammation.

Structural and functional insights into the role of Themis:SHP-1 complexes in inflammation

Structural and molecular basis for the cooperative assembly of the pro-inflammatory TSLP:TSLPR:IL- 7Ralpha signaling complex.

Structural and molecular basis of the inflammatory TSLP:TSLPR:IL7-Ralpha assembly

Structural and thermodynamic characterization of hematopoietic cytokine/receptor interactions: towards the rational development of agonists with improved binding characteristics

Structural basis of regulation of pro-inflammatory IL-17RA by TAOK1 and Act1

Structural biology of Interleukin-34, a novel cytokine ligand for colony stimulating factor 1 receptor (CSF-1R)

Structural insights into the assembly of the inflammatory IL-23 signaling complexes

Structural, kinetic, and biophysical analysis and engineering of KIT.METRNL signalling to boost heart tissue regeneration after myocardial infarction

Structural, thermodynamic, and kinetic characterization of CSF-1/CSF-1R cytokine/receptor interaction

Structure-function studies on Interleukin-26, a pro-inflammatory and antimicrobial cytokine.

Structure, mechanism, and modulation of protein assemblies in immunity, inflammation, and cancer

'Take 1' on TAOK2: structural insights into TAOK2 and its complexes with TRIM4 and viral dsRNA

The molecular and structural basis of GM-CSF and IL-2 by viral GIF to achieve immunomodulation.

The molecular and structural basis of pro- and anti-inflammatory signalling assemblies mediated by IL-27 and IL-35. 

The structural biology of Interleukin-34, a novel cytokine-ligand for the colony stimulating factor 1 receptor (CSF1R)

The T2SS, an anti-virulence drug-target against Pseudomonas aeruginosa infections

Towards the structural and molecular basis of pro-inflammatory signalling assemblies mediated by IL-23 and IL-12

Towards the structural and molecular basis of signaling assemblies mediated by the pruritogenic Interleukin-31.

Unraveling the structural and mechanistic principles of IL-35 signaling complexes pivotal to inflammation and auto-immune diseases

Validation of the hematopoietic Flt3-D3 ectodomain as a novel drug target for cancer and immunostimu

Chemical and enzymatic bioconjugation for the site-specific decoration of proteins with therapeutic property enhancing moieties

Engineering and study of peptide-based hydrogels for the sustained release of therapeutic proteins.

Glutathiontransport and - metabolism in bacteria and evaluation of a disruption of the cofactordieet the central metabolism of yeast.

Purchase steam autoclave central kitchen Department of Biomedical Molecular Biology

Structural and molecular basis of proinflammatory assemblies mediated by thymic stromal lymphopoietin (TSLP).

Targeting transcription factor addiction in acute leukemia (TaTFAL)

Unravelling the pharmaceutical potential of receptor heterodimers for therapeutic intervention in CNS disorders.

Understanding the immunological basis of persistent airway obstruction in asthma