Research Explorer

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Researcher

Savvas Savvides

Awards & Distinctions

154 Results

2024

Activation of goblet-cell stress sensor IRE1β is controlled by the mucin chaperone AGR2

Eva ClootsPhaedra GuilbertMathias ProvostLisa NeidhardtEvelien Van De VeldeFarzaneh FayazpourDelphine De SutterSavvas SavvidesSven EyckermanSophie Janssens

A1 Journal Article in EMBO JOURNAL

Clostridium perfringens chitinases, key enzymes during early stages of necrotic enteritis in broiler chickens

Evelien DierickChana CallensYehudi BlochSavvas SavvidesSarah HarkStefan PelzerRichard DucatelleFilip Van ImmerseelEvy Goossens

A1 Journal Article in PLOS PATHOGENS

Structural and functional studies of receptor complexes mediated by Interleukin-19 and Interleukin-26

Maria KaramolegkouSavvas SavvidesKenneth Verstraete

Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23

Yehudi BlochJan FélixRomain MerceronMathias ProvostRoyan Alipour SymakaniRobin De BackerElisabeth LambertAhmadreza MehdipourSavvas Savvides

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY

The pros and confs of IL-18 activation

Danielle ClancyJulie AndriesSavvas Savvides

Editorial material

Ym1 protein crystals promote type 2 immunity

Ines HeyndrickxKim DeswarteKenneth VerstraeteKoen VerschuerenUrsula SmoleHelena Catharine AegerterAnn DansercoerHamida HammadSavvas SavvidesBart Lambrecht

A1 Journal Article in ELIFE

2023

EGOC inhibits TOROID polymerization by structurally activating TORC1

Manoël ProuteauClélia BourgointJan FélixLenny BonadeiYashar SadianCaroline GabusSavvas SavvidesIrina GutscheAmbroise DesfossesRobbie Loewith

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY

Improving de novo protein binder design with deep learning

Nathaniel R. BennettBrian CoventryInna GoreshnikBuwei HuangAza AllenDionne VafeadosYing Po PengJustas DauparasMinkyung BaekLance Stewart et al.

A1 Journal Article in NATURE COMMUNICATIONS

Mechanism of receptor assembly via the pleiotropic adipokine Leptin

Alexandra TsirigotakiAnn DansercoerKoen VerschuerenIva MarkovićChristoph PollmannMaximillian HaferJan FélixCatherine BirckWouter Van PutteDominiek Catteeuw et al.

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pore-forming proteins as drivers of membrane permeabilization in cell death pathways

Peter VandenabeeleGeert BultynckSavvas Savvides

A1 Journal Article in NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice

Karel Van DammePieter HertensArne MartensElisabeth GilisDario PriemInge BruggemanAmelie FossoulJozefien DeclercqHelena Catharine AegerterAndy Wullaert et al.

A1 Journal Article in SCIENTIFIC REPORTS

Rare antagonistic leptin variants and severe, early-onset obesity

Jan-Bernd FunckeBarbara MoeppsJulian RoosJulia von SchnurbeinKenneth VerstraeteElke Fröhlich-ReitererKatja KohlsdorfAdriana NunziataStephanie BrandtAlexandra Tsirigotaki et al.

A1 Journal Article in NEW ENGLAND JOURNAL OF MEDICINE

Unexpected complexity of the ammonia monooxygenase in archaea

Logan H. HodgskissMichael MelcherMelina KerouWeiqiang ChenRafael I. Ponce-ToledoSavvas SavvidesStefanie WienkoopMarkus HartlChrista Schleper

A1 Journal Article in ISME JOURNAL

2022

Design of protein-binding proteins from the target structure alone

Longxing CaoBrian CoventryInna GoreshnikBuwei HuangWilliam ShefflerJoon Sung ParkKevin M. JudeIva MarkovićRameshwar U. KadamKoen Verschueren et al.

A1 Journal Article in NATURE

Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding

Steven TimmermansNicolette J.D. VerhoogKelly Van LooverenSylviane DewaeleTino HochepiedMelanie EggermontBarbara GilbertAnne Boerema-de MunckTineke VanderhaeghenJoke Vanden Berghe et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27

Katarzyna SkladanowskaYehudi BlochJamie StrandKerry F. WhiteJing HuaDaniel AldridgeMartin WelinDerek T. LoganArne SoeteRomain Merceron et al.

A1 Journal Article in CELL REPORTS

Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity

Sammy DetryJulie AndriesYehudi BlochCem GabayDanielle ClancySavvas Savvides

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The Charcot-Leyden crystal protein Galectin-10 is not a major determinant of human regulatory T-cell function

Rebeca Arroyo-HorneroHelena Catharine AegerterIbrahim HamadBeatriz Corte-RealKatrien StaesBas van Der WoningKenneth VerstraeteSavvas SavvidesBart LambrechtMarkus Kleinewietfeld

A1 Journal Article in ALLERGY

The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement

Maximilian BrinkhausErwin PannecouckeElvera J. van der KooiArthur E. H. BentlageNinotska I. L. DerksenJulie AndriesBianca BalbinoMagdalena SipsPeter UlrichtsPeter Verheesen et al.

A1 Journal Article in NATURE COMMUNICATIONS

The STE20 kinase TAOK3 controls the development of house dust mite-induced asthma in mice

Bastiaan MaesUrsula SmoleMatthias VanderkerkenKim DeswarteJustine Van MoorleghemKarl VergoteManon VanheerswynghelsCaroline De WolfSofie De PrijckNincy Debeuf et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

2021

A recombinant antibody fragment directed to the thymic stromal lymphopoietin receptor (CRLF2) efficiently targets pediatric Philadelphia chromosome-like acute lymphoblastic leukemia

Sara M. A. MohamedAndreas WohlmannPeter SchofieldKeith C. S. SiaHannah McCalmontSavvas SavvidesKenneth VerstraeteMaria KavallarisDaniel ChristKarl-Heinz Friedrich et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase

Kenneth VerstraeteKoen VerschuerenAnn DansercoerSavvas Savvides

Editorial material

Attenuated CSF-1R signalling drives cerebrovascular pathology

Conor DelaneyMichael FarrellColin P. DohertyKiva BrennanEoin O'KeeffeChris GreeneKieva ByrneEoin KellyNiamh BirminghamPaula Hickey et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

CRISPR-SID : identifying EZH2 as a druggable target for desmoid tumors via in vivo dependency mapping

Thomas NaertDieter TulkensTom Van NieuwenhuysenJoanna PrzybylSuzan DemuynckMatt van de RijnMushriq Al-JazraweBenjamin A. AlmanPaul CouckeKim De Leeneer et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-penetrating Alphabody protein scaffolds for intracellular drug targeting

Erwin PannecouckeMaaike Van TrimpontJohan DesmetTim PietersLindy ReunesLisa DemoenMarnik VuylstekeStefan LoverixKaren VandenbrouckePhilippe Alard et al.

A1 Journal Article in SCIENCE ADVANCES

Charcot-Leyden crystals and other protein crystals driving type 2 immunity and allergy

Helena Catharine AegerterUrsula SmoleInes HeyndrickxKenneth VerstraeteSavvas SavvidesHamida HammadBart Lambrecht

A1 Journal Article in CURRENT OPINION IN IMMUNOLOGY

Distinct EH domains of the endocytic TPLATE complex confer lipid and protein binding

Klaas YpermanAnna PapageorgiouRomain MerceronSteven De MunckYehudi BlochDominique EeckhoutQihang JiangPieter TackRosa GrigoryanThomas Evangelidis et al.

A1 Journal Article in NATURE COMMUNICATIONS

Engineering and crystal structure of a monomeric FLT3 ligand variant

Erwin PannecouckeLaurens RaesSavvas Savvides

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS

Hapin1b, a central organizer of the ECM, modulates kit signaling to control developmental hematopoiesis in zebrafish

Christopher B. MahonyPietro CacialliCorentin PascheRui MonteiroSavvas SavvidesJulien Y. Bertrand

A1 Journal Article in BLOOD ADVANCES

Minimal epitope for Mannitou IgM on paucimannose-carrying glycoproteins.

Stefania RobakiewiczClarisse BridotSonia SernaAna GimenoBegoña EcheverriaSandra DelgadoJérôme de RuyckShubham SemwalDiego CharroAnn Dansercoer et al.

A1 Journal Article in GLYCOBIOLOGY

Molecular architecture of the endocytic TPLATE complex

Klaas YpermanJie WangDominique EeckhoutJoanna WinklerLam Dai VuMichaël VandorpePeter GronesEvelien MylleMichael KrausRomain Merceron et al.

A1 Journal Article in SCIENCE ADVANCES

Natural antibodies : protecting role of IgM in glioblastoma and brain tumours

Shubham SemwalRabah BoukherroubSavvas SavvidesJulie Bouckaert

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

Rational design and development of HDAC inhibitors for breast cancer treatment

Deepansh ModyJulie BouckaertSavvas SavvidesVibha Gupta

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

Structural basis for the activation and antagonism of the IL-9 signaling complex

Tatjana De VosSavvas Savvides

Structural basis of cytokine-mediated activation of ALK family receptors

Steven De MunckMathias ProvostMichiko KurikawaIkuko OmoriJunko MukohyamaJan FélixYehudi BlochOmar Abdel-WahabJ. Fernando BazanAkihide Yoshimi et al.

A1 Journal Article in NATURE

Structure and mechanism of cytokine mediated activation of ALK family receptor tyrosine kinases

Steven De MunckSavvas Savvides

Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors

Lijun SongRomain MerceronFabian HulpiaAinhoa LuciaBegona GraciaYanlin JianMartijn RisseeuwToon VerstraelenPaul CosJose A. Ainsa et al.

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2020

Charcot-Leyden crystals promote neutrophilic inflammation in patients with nasal polyposis

Elien GevaertTim DelemarreJoyceline De VolderNan ZhangGabriële HoltappelsNatalie De RuyckEmma PerssonInes HeyndrickxKenneth VerstraeteHelena Catharine Aegerter et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance

Flora D'AnnaLaurien Van DyckJieyi XiongHui ZhaoV Berrens, RebeccaJunbin QianPawel Bieniasz-KrzywiecVikas ChandraLuc SchoonjansJason Matthews et al.

A1 Journal Article in GENOME BIOLOGY

Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents

Yanlin JianRomain MerceronSteven De MunckHe Eun ForbesFabian HulpiaMartijn RisseeuwKristof Van HeckeSavvas SavvidesHélène Munier-LehmannHelena I. M. Boshoff et al.

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Homogeneously N-glycosylated proteins derived from the GlycoDelete HEK293 cell line enable diffraction-quality crystallogenesis

Sandra KozakYehudi BlochSteven De MunckAleksandra MikulaIsabel BentoSavvas SavvidesRob Meijers

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY

Modulation of signaling mediated by TSLP and IL-7 in inflammation, autoimmune diseases, and cancer

Iva MarkovićSavvas Savvides

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Mouse strain-dependent difference toward the staphylococcus aureus allergen serine protease-like protein D reveals a novel regulator of IL-33

Andrea Renate TeufelbergerSharon Van NevelPaco HulpiauMaria NordengrünSavvas SavvidesSarah De GraeveSrinivas AkulaGabriële HoltappelsNatalie De RuyckWim Declercq et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Single-chain soluble receptor fusion proteins as versatile cytokine inhibitors

Aurora Holgado MuñozHarald BraunKenneth VerstraeteDomien VannesteNico CallewaertSavvas SavvidesInna AfoninaRudi Beyaert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Small-molecule inhibitors get pro-inflammatory TNF into shape

Savvas SavvidesDirk Elewaut

Editorial material

Structure and assembly mechanism of the signaling complex mediated by human CSF-1 (vol 23, pg 1621, 2015)

Jan FélixSteven De MunckKenneth VerstraeteLeander MeurisNico CallewaertJonathan ElegheertSavvas Savvides

2019

Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms

Benjamin H DurhamEstibaliz Lopez RodrigoJennifer PicarsicDavid AbramsonVeronica RotembergSteven De MunckErwin PannecouckeSydney X LuAlessandro PastoreAkihide Yoshimi et al.

A1 Journal Article in NATURE MEDICINE

An integrative approach towards unraveling the activation of oncogenic FLT3

Erwin PannecouckeSavvas Savvides

Disruption of endocytosis through chemical inhibition of clathrin heavy chain function

Wim DejongheIsha SharmaBram DenooSteven De MunckQing LuKiril MishevHaydar BulutEvelien MylleRiet De RyckeMina Vasileva et al.

A1 Journal Article in NATURE CHEMICAL BIOLOGY

IL-33trap is a novel IL-33-neutralizing biologic that inhibits allergic airway inflammation

Aurora Holgado MuñozHarald BraunElien Van NuffelSammy DetryMartijn SchuijsKim DeswarteKarl VergoteMira HaegmanGriet BaudeletJurgen Haustraete et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Pathophysiology and inhibition of IL-23 signaling in psoriatic arthritis : a molecular insight

Cuong Thach NguyenYehudi BlochKatarzyna SkladanowskaSavvas SavvidesIannis E Adamopoulos

A1 Journal Article in CLINICAL IMMUNOLOGY

Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis

Karolina SlowickaInmaculada Serramito-GómezEmilio Boada-RomeroArne MartensMozes SzeIoanna PettaHanna-Kaisa VikkulaRiet De RyckeEef ParthoensSaskia Lippens et al.

A1 Journal Article in NATURE COMMUNICATIONS

Protein crystallization promotes type 2 immunity and is reversible by antibody treatment

Emma PerssonKenneth VerstraeteInes HeyndrickxElien GevaertHelena Catharine AegerterJean-Michel PercierKim DeswarteKoen VerschuerenAnn DansercoerDelphine Gras et al.

A1 Journal Article in SCIENCE

Revisiting the combinatorial potential of cytokine subunits in the IL-12 family

Sammy DetryKatarzyna SkladanowskaMarnik VuylstekeSavvas SavvidesYehudi Bloch

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation

Yves DondelingerTom DelangheDario PriemMeghan A Wynosky-DolfiDaniel SorobeteaDiego Rojas RiveraPiero GiansantiRia RoelandtJulia GropengiesserKlaus Ruckdeschel et al.

A1 Journal Article in NATURE COMMUNICATIONS

Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle

Koen VerschuerenClement BlanchetJan FelixAnn DansercoerDirk De VosYehudi BlochJozef Van BeeumenDmitri SvergunIrina GutscheSavvas Savvides et al.

A1 Journal Article in NATURE

Unraveling and targeting of molecular signaling mechanisms of IL-12 family, IL-18 and IL-33 cytokines using integrative structural biology

Sammy DetrySavvas SavvidesYehudi Bloch

2018

A CARD9 founder mutation disrupts NF-κB signaling by inhibiting BCL10 and MALT1 recruitment and signalosome formation

Marieke De BruyneLevi HosteDelfien BogaertLien Van den BosscheSimon TavernierEef ParthoensMélanie MigaudDeborah KonopnickiJean Cyr YombiBart Lambrecht et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Nonselective chemical inhibition of Sec7 domain-containing ARF GTPase exchange factors

Kiril MishevQing LuBram DenooFrancois PeuroisWim DejongheJan HullaertRiet De RyckeSjef BoerenMarine BretouSteven De Munck et al.

A1 Journal Article in PLANT CELL

Sensory-neuropathy-causing mutations in ATL3 cause aberrant ER membrane tethering

Michiel KrolsSammy DetryBob AsselberghLeonardo Almeida-SouzaAnna KremerSaskia LippensRiet De RyckeVicky De WinterFranz-Josef MüllerIngo Kurth et al.

A1 Journal Article in CELL REPORTS

Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha

Srinath GovindarajanDjoere GaublommeRenée Van der CruyssenEveline VerheugenSofie Van GassenYvan SaeysSimon TavernierTakao IwawakiYehudi BlochSavvas Savvides et al.

A1 Journal Article in NATURE COMMUNICATIONS

Structural activation of pro-inflammatory human cytokine IL-23 by cognate IL-23 receptor enables recruitment of the shared receptor IL-12Rβ1

Yehudi BlochLaura BouchareychasRomain MerceronKatarzyna SkladanowskaLien Van den BosscheSammy DetrySrinath GovindarajanDirk ElewautFilomeen HaerynckMelissa Dullaers et al.

A1 Journal Article in IMMUNITY

Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells

Stephanie LienartRomain MerceronChristophe VanderaaFanny LambertDidier ColauJulie StockisBas van der WoningHans De HaardMichael SaundersPierre G Coulie et al.

A1 Journal Article in SCIENCE

Structure and oligomerization of the periplasmic domain of GspL from the type II secretion system of Pseudomonas aeruginosa

Aleksandra FularaIsabel VandenbergheRandy J ReadBart DevreeseSavvas Savvides

A1 Journal Article in SCIENTIFIC REPORTS

Structure guided lead generation toward nonchiral M. tuberculosis thymidylate kinase inhibitors

Lijun SongRomain MerceronBegoña GraciaAinhoa Lucía QuintanaMartijn RisseeuwFabian HulpiaPaul CosJosé A AínsaHélène Munier-LehmannSavvas Savvides et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Structure, mechanism and antagonism of the pro-inflammatory receptor complex mediated by interleukin-23

Yehudi BlochSavvas SavvidesKenneth Verstraete

Study of the GspLM complex, an inner membrane component of the type II secretion system from Pseudomonas aeruginosa

Aleksandra FularaSavvas Savvides

2017

Alzheimer's-causing mutations shift Aβ length by destabilizing γ-secretase-Aβn interactions

Maria SzarugaBogdan MunteanuSam LismontSarah VeugelenKatrien HorreMarc MerckenTakaomi C SaidoNatalie S RyanTatjana De VosSavvas Savvides et al.

A1 Journal Article in CELL

Mechanisms of immunomodulation by mammalian and viral decoy receptors : insights from structures

Jan FélixSavvas Savvides

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

Membrane vesicle secretion and prophage induction in multidrug-resistant Stenotrophomonas maltophilia in response to ciprofloxacin stress

Simon DevosWouter Van PutteJolien VitseGonzalez Van DriesscheStephan StremerschWim Van Den BroeckKoen RaemdonckKevin BraeckmansHenning StahlbergMisha Kudryashev et al.

A1 Journal Article in ENVIRONMENTAL MICROBIOLOGY

Structural dissection of Shewanella oneidensis old yellow enzyme 4 bound to a Meisenheimer complex and (nitro)phenolic ligands

Jonathan ElegheertAnn BrigeJozef Van BeeumenSavvas Savvides

A1 Journal Article in FEBS LETTERS

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma

Kenneth VerstraeteFrank PeelmanHarald BraunJuan LopezDries Van RompaeyAnn DansercoerIsabel VandenbergheKris PauwelsJan TavernierBart Lambrecht et al.

A1 Journal Article in NATURE COMMUNICATIONS

Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10

Hamida HammadMatthias VanderkerkenPhilippe PouliotKim DeswarteWendy ToussaintKarl VergoteLana VandersarrenSophie JanssensIoanna RamouSavvas Savvides et al.

A1 Journal Article in NATURE IMMUNOLOGY

Virtual screening for inhibitors of the human TSLP:TSLPR interaction

Dries Van RompaeyKenneth VerstraeteFrank PeelmanSavvas SavvidesKoen AugustynsPieter Van Der VekenHans De Winter

A1 Journal Article in SCIENTIFIC REPORTS

2016

Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF

Jan FélixEaazhisai KandiahSteven De MunckYehudi BlochGydo CP van ZundertKris PauwelsAnn DansercoerKatka NovanskaRandy J ReadAlexandre MJJ Bonvin et al.

A1 Journal Article in NATURE COMMUNICATIONS

Structural principles of binding duality in cognate and viral cytokine receptors

Jan FélixSavvas SavvidesEwald Pauwels

The design and synthesis of inhibitors of Mycobacterium tuberculosis thymidylate kinase (MtTMPK)

Lijun SongMartijn RisseeuwFabian HulpiaRomain MerceronSavvas SavvidesHélène Munier-LehmannSerge Van Calenbergh

The type II secretion system and membrane vesiculation : bacterial secretion systems as a target for anti-virulence drug development

Wouter Van PutteSavvas Savvides

2015

Structure and assembly mechanism of the signaling complex mediated by human CSF-1

Jan FélixSteven De MunckKenneth VerstraeteLeander MeurisNico CallewaertJonathan ElegheertSavvas Savvides

A1 Journal Article in STRUCTURE

2014

20 Years of leptin: insights into signaling assemblies of the leptin receptor

Frank PeelmanLennart ZabeauKedar MoharanaSavvas SavvidesJan Tavernier

A1 Journal Article in JOURNAL OF ENDOCRINOLOGY

An integrative structural biology approach in the study of bacterial persistence and virulence

Yurong WenBart DevreeseSavvas Savvides

Characterization of a type D1A EUL-related lectin from rice expressed in Pichia pastoris

Bassam Al AtalahDieter VanderschaegheYehudi BlochPaul ProostKirsten PlasNico CallewaertSavvas SavvidesEls Van Damme

A1 Journal Article in BIOLOGICAL CHEMISTRY

MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates

Yves DondelingerWim DeclercqSylvie MontessuitRia RoelandtAmanda GonçalvesInge BruggemanPaco HulpiauKathrin WeberClark A SehonRobert W Marquis et al.

A1 Journal Article in CELL REPORTS

Mechanistic paradigm of leptin receptor activation revealed by complexes with wild type and antagonist leptins

Kedar MoharanaSavvas SavvidesJan Tavernier

Structural and biophysical characterization of inner and outer membrane components of the type II secretion system from the opportunistic pathogen Pseudomonas aeruginosa

Ruben Van der MeerenSavvas Savvides

Structural and mechanistic paradigm of leptin receptor activation revealed by complexes with wild-type and antagonist leptins

Kedar MoharanaLennart ZabeauFrank PeelmanPhilippe RinglerHenning StahlbergJan TavernierSavvas Savvides

A1 Journal Article in STRUCTURE

Structural basis of IL-23 antagonism by an Alphabody protein scaffold

Johan DesmetKenneth VerstraeteYehudi BlochEric LorentYurong WenBart DevreeseKaren VandenbrouckeStefan LoverixThore HettmannSabrina Deroo et al.

A1 Journal Article in NATURE COMMUNICATIONS

Structural basis of the proinflammatory signaling complex mediated by TSLP

Kenneth VerstraeteLoes van SchieLaurens VynckeYehudi BlochJan TavernierEwald PauwelsFrank PeelmanSavvas Savvides

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY

The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence

Yurong WenEster BehielsJan FélixJonathan ElegheertBjorn VergauwenBart DevreeseSavvas Savvides

A1 Journal Article in NUCLEIC ACIDS RESEARCH

2013

Human IL-34 and CSF-1 establish structurally similar extracellular assemblies with their common hematopoietic receptor

Jan FélixJonathan ElegheertIrina GutscheAlexander ShkumatovYurong WenNathalie BrackeErwin PannecouckeIsabel VandenbergheBart DevreeseDmitri Svergun et al.

A1 Journal Article in STRUCTURE

Molecular and structural basis of glutathione import in Gram-positive bacteria via GshT and the cystine ABC importer TcyBC of Streptococcus mutans

Bjorn VergauwenKenneth VerstraeteDilani B. SenadheeraAnn DansercoerDennis G. CvitkovitchEric GuedonSavvas Savvides

A1 Journal Article in MOLECULAR MICROBIOLOGY

New insights into the assembly of bacterial secretins: structural studies of the periplasmic domain of XcpQ from Pseudomonas aeruginosa

Ruben Van der MeerenYurong WenPatrick Van GelderJan TommassenBart DevreeseSavvas Savvides

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and biochemical characterization of an atypical short-chain dehydrogenase/reductase reveals an unusual cofactor preference

Géraldine BuysschaertKenneth VerstraeteSavvas SavvidesBjorn Vergauwen

A1 Journal Article in FEBS JOURNAL

2012

Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1

Jonathan ElegheertNathalie BrackePhilippe PouliotIrina GutscheAlexander V ShkumatovNicolas TarbouriechKenneth VerstraeteAnaïs BekaertWim P BurmeisterDmitri I Svergun et al.

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY

An REMD and QM/MM study into the sequence effect on asparagine deamidation

Ewald PauwelsSamuel MoorsJan FélixSavvas SavvidesMichel WaroquierVeronique Van SpeybroeckSaron Catak

Crystallization of an atypical short-chain dehydrogenase from Vibrio vulnificus lacking the conserved catalytic tetrad

Géraldine BuysschaertKenneth VerstraeteSavvas SavvidesBjorn Vergauwen

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS

Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinases

Kenneth VerstraeteSavvas Savvides

A1 Journal Article in NATURE REVIEWS CANCER

Glutathione biosynthesis in bacteria by bifunctional GshF is driven by a modular structure featuring a novel hybrid ATP-grasp fold

Jan StoutDirk De VosBjorn VergauwenSavvas Savvides

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Structural and biochemical analysis of an atypical short-chain dehydrogenase reveals an unusual cofactor preference : comparative kinetic study on classical and atypical glutaredoxins

Géraldine BuysschaertSavvas Savvides

Structural biology of Colony-Stimulating Factor 1 (CSF-1) signaling and decoy complexes

Jonathan ElegheertSavvas Savvides

2011

Delineation of the Pasteurellaceae-specific GbpA-family of glutathione-binding proteins

Bjorn VergauwenRuben Van der MeerenAnn DansercoerSavvas Savvides

A1 Journal Article in BMC BIOCHEMISTRY

Extracellular complexes of the hematopoietic human and mouse CSF-1 receptor are driven by common assembly principles

Jonathan ElegheertAmbroise DesfossesAlexander V ShkumatovXiongwu WuNathalie BrackeKenneth VerstraeteKathleen Van CraenenbroeckBernard R BrooksDmitri I SvergunBjorn Vergauwen et al.

A1 Journal Article in STRUCTURE

Inducible production of recombinant human Flt3 ectodomain variants in mammalian cells and preliminary crystallographic analysis of Flt3 ligand-receptor complexes

Kenneth VerstraeteBert RemmerieJonathan ElegheertBéatrice LintermansGuy HaegemanPeter VanhoenackerKathleen Van CraenenbroeckSavvas Savvides

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS

Peptide deamidation : effect of neighboring residues

Saron CatakJan FélixSavvas SavvidesVeronique Van SpeybroeckMichel WaroquierEwald Pauwels

Profiling the biofilm secretome of Burkholderia cenocpepacia in a context of type two secretion system

Agata GozaTom CoenyeSavvas SavvidesBart Devreese

Structural insights into the extracellular assembly of the hematopoietic Flt3 ligand-receptor complex

Kenneth VerstraeteSavvas SavvidesJozef Van Beeumen

Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex

Kenneth VerstraeteGonzalez VandriesscheMariska JanuarJonathan ElegheertAlexander V ShkumatovAmbroise DesfossesKathleen Van CraenenbroeckDmitri I SvergunIrina GutscheBjorn Vergauwen et al.

A1 Journal Article in BLOOD

2010

Construction of cellobiose phosphorylase variants with broadened acceptor specificity towards anomerically substituted glucosides

Manu De GroeveLaurens RemmeryAnnelies Van HoorebekeJan StoutTom DesmetSavvas SavvidesWim Soetaert

A1 Journal Article in BIOTECHNOLOGY AND BIOENGINEERING

Crystallization and X-ray diffraction studies of cellobiose phosphorylase from Cellulomonas uda

Annelies Van HoorebekeJan StoutJohn KyndtManu De GroeveIna DixTom DesmetWim SoetaertJozef Van BeeumenSavvas Savvides

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS

Crystallization and X-ray diffraction studies of inverting trehalose phosphorylase from Thermoanaerobacter sp.

Annelies Van HoorebekeJan StoutRuben Van der MeerenJohn KyndtJozef Van BeeumenSavvas Savvides

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS

Development and application of a screening assay for glycoside phosphorylases

Manu De GroeveHai Giang TranAnnelies Van HoorebekeJan StoutTom DesmetSavvas SavvidesWim Soetaert

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

Glutathione import in Haemophilus influenzae Rd is primed by the periplasmic heme-binding protein HbpA

Bjorn VergauwenJonathan ElegheertAnn DansercoerBart DevreeseSavvas Savvides

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrophobic surface patches on LolA of Pseudomonas aeruginosa are essential for lipoprotein binding

Kim RemansKris PauwelsPeter van UlsenLieven ButsPierre CornelisJan TommassenSavvas SavvidesKlaas DecannierePatrick Van Gelder

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Structure-functional studies of bacterial glycoside phosphorylases

Annelies Van HoorebekeSavvas Savvides

The 285 kDa Bap/RTX hybrid cell surface protein (SO4317) of Shewanella oneidensis MR-1 is a key mediator of biofilm formation

Sofie TheunissenLina De SmetAnn DansercoerBart MotteTom CoenyeJozef Van BeeumenBart DevreeseSavvas SavvidesBjorn Vergauwen

A1 Journal Article in RESEARCH IN MICROBIOLOGY

Towards structural studies of the old yellow enzyme homologue SYE4 from Shewanella oneidensis and its complexes at atomic resolution

Jonathan ElegheertDebbie van den HemelIna DixJan StoutJozef Van BeeumenAnn BrigéSavvas Savvides

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS

2009

Efficient production of bioactive recombinant human Flt3 ligand in E. coli

Kenneth VerstraeteSina KochSevgi ErtugrulIsabel VandenbergheMaarten AertsGonzalez VandriesscheChristian ThiedeSavvas Savvides

A1 Journal Article in PROTEIN JOURNAL

Myristoylated adenylate kinase-2 of Plasmodium falciparum forms a heterodimer with myristoyltransferase

Stefan RahlfsSasa KoncarevicRimma IozefBoniface Mwongela MailuSavvas SavvidesR. Heiner SchirmerKatja Becker

A1 Journal Article in MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Related lectins from snowdrop and maize differ in their carbohydrate-binding specificity.

Elke FouquaertDavid F SmithWilly J PeumansPaul ProostJan BalzariniSavvas SavvidesEls Van Damme

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The agglutination protein AggA from Shewanella oneidensis MR-1 is a TolC-like protein and forms active channels in vitro

Sofie TheunissenBjorn VergauwenLina De SmetJozef Van BeeumenPatrick Van GelderSavvas Savvides

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

2008

Catalytic cycle of human glutathione reductase near 1 Å resolution

Donald BerkholzlH. Richard FaberSavvas SavvidesP. Andrew Karplus

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Expression, purification, crystallization and structure determination of two glutathione S-transferase-like proteins from Shewanella oneidensis

Bert RemmerieKaren VandenbrouckeLina De SmetWesley CarpentierDirk De VosJan StoutJozef Van BeeumenSavvas Savvides

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS

Structural insights into component SoxY of the thiosulfate-oxidizing multienzyme system of Chlorobaculum thiosulfatiphilum

Jan StoutLina De SmetBjorn VergauwenSavvas SavvidesJozef Van Beeumen

The "Old'' Euonymus europaeus agglutinin represents a novel family of ubiquitous plant proteins

Elke FouquaertWJ PEUMANSDF SMITHP PROOSTSavvas SavvidesEls Van Damme

A1 Journal Article in PLANT PHYSIOLOGY

Towards a better understanding of extracellular cytokine receptor biology: the initial characterization of a lectin/R complex

Bert RemmerieKoenraad VerstraeteJonathan ElegheertBjorn VergauwenSavvas Savvides

2007

Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase

MN GRECOMJ HAWKINSET POWELLHR ALMONDL DE GARAVILLAJ HALLLK MINORYP WANGTW CORCORANE DI CERA et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Secretion superfamily ATPases swing big

Savvas Savvides

Editorial material

Structural role of tyrosine 98 in photoactive yellow protein: Effects on fluorescence, gateway, and photocycle recovery

JA KYNDTSavvas SavvidesSamy MemmiM KOHJC FITCHTE MEYERMP HEYNJozef Van BeeumenMA CUSANOVICH

A1 Journal Article in BIOCHEMISTRY

Understanding nicotinamide dinucleotide cofactor and substrate specificity in class I flavoprotein disulfide oxidoreductases: Crystallographic analysis of a glutathione amide reductase

Filip Van PetegemDirk De VosSavvas SavvidesBjorn VergauwenJ VAN BEELUMEN

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

X-ray crystallographic analysis of the sulfur carrier protein SoxY from Chlorobium limicola f. thiosulfatophilum reveals a tetrameric structure

Jan StoutGonzalez Van DriesscheSavvas SavvidesJozef Van Beeumen

A1 Journal Article in PROTEIN SCIENCE

2006

Crystallization, preliminary crystallographic analysis and phasing of the thiosulfate-binding protein SoxY from Chlorobium limicola f. thiosulfatophilum

Jan StoutLina De SmetS PANJIKARMS WEISSSavvas SavvidesJozef Van Beeumen

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS

Ligand-induced conformational changes in the capping subdomain of a bacterial old yellow enzyme homologue and conserved sequence fingerprints provide new insights into substrate binding

Debbie van den HemelAnn BrigeSavvas SavvidesJozef Van Beeumen

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Oligosaccharide binding in family 8 glycosidases: Crystal structures of active-site mutants of the beta-1,4-xylanase pXyl from Pseudoaltermonas haloplanktis TAH3a in complex with substrate and product

Dirk De VosT COLLINSWim NerinckxSavvas SavvidesMarc ClaeyssensC GERDAYG FELLERJozef Van Beeumen

A1 Journal Article in BIOCHEMISTRY

Structural and mutagenesis studies on the cytochrome c peroxidase from Rhodobacter capsulatus provide new insights into structure-function relationships of bacterial di-heme peroxidases

Lina De SmetSavvas SavvidesEllen Van HorenG PETTIGREWJozef Van Beeumen

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of a membrane-based steric chaperone in complex with its lipase substrate

K PAUWELSA LUSTIGL WYNSJ TOMMASSENSavvas SavvidesP VAN GELDER

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY

2005

Expression, purification, crystallization and preliminary X-ray crystallographic studies of a cold-adapted aspartate carbamoyltransferase from Moritella profunda

Dirk De VosPaco HulpiauBjorn VergauwenSavvas SavvidesJozef Van Beeumen

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS

Expression, purification, crystallization and preliminary crystallographic analysis of a stand-alone RAM domain with hydrolytic activity from the hyperthermophile Pyrococcus furiosus

RC AgapaySavvas SavvidesGonzalez Van DriesscheBart DevreeseJozef Van BeeumenJA JongejanWR Hagen

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS

Structure of hemocyanin subunit CaeSS2 of the crustacean Mediterranean crab Carcinus aestuarii

P DOLASHKA-ANGELOVAA DOLASHKISavvas SavvidesR HRISTOVAJozef Van BeeumenW VOELTERBart DevreeseU WESERP DI MUROB SALVATO et al.

A1 Journal Article in JOURNAL OF BIOCHEMISTRY

Study of the active site residues of a glycoside hydrolase family 8 xylanase

T COLLINSDirk De VosA HOYOUXSavvas SavvidesC GERDAYJozef Van BeeumenG FELLER

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

2004

Crystal structure of the thrombin mutant D221A/D222K: the Asp222: Arg187 ion-pair stabilizes the fast form

AO PINEDAE ZHANGER GUINTOSavvas SavvidesA TULINSKYE DI CERA

A1 Journal Article in BIOPHYSICAL CHEMISTRY

Getting the most out of a trip to the synchrotron: Structure of a putative bacterial dehalogenase

Savvas SavvidesKaren VandenbrouckeDirk De VosWesley CarpentierJozef Van Beeumen

The C-terminal domain of full-length E-coli SSB is disordered even when bound to DNA

Savvas SavvidesS RAGHUNATHANK FUTTERERAG KOZLOVTM LOHMANG WAKSMAN

A1 Journal Article in PROTEIN SCIENCE

The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket

AO PINEDAZW CHENS CACCIAAM CANTWELLSavvas SavvidesG WAKSMANFS MATHEWSE DI CERA

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2003

Glutathione reductase of the malarial parasite Plasmodium falciparum: Crystal structure and inhibitor development

GN SARMASavvas SavvidesK BECKERM SCHIRMERRH SCHIRMERPA KARPLUS

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

VirB11 ATPases are dynamic hexameric assemblies: new insights into bacterial type IV secretion

Savvas SavvidesHJ YEOMR BECKF BLAESINGR LURZE LANKAR BUHRDORFW FISCHERR HAASG WAKSMAN

A1 Journal Article in EMBO JOURNAL

2002

Crystal structure of the anticoagulant slow form of thrombin

AO PINEDASavvas SavvidesG WAKSMANE DI CERA

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the antioxidant enzyme glutathione reductase inactivated by peroxynitrite

Savvas SavvidesM SCHEIWEINCC BOHMEGE ARTEELPA KARPLUSK BECKERRH SCHIRMER

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2000

Crystal structure of the hexameric traffic ATPase of the Helicobacter pylori type IV secretion system

HJ YEOSavvas SavvidesAB HERRE LANKAG WAKSMAN

A1 Journal Article in MOLECULAR CELL

Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots

Savvas SavvidesT BOONEPA KARPLUS

A1 Journal Article in NATURE STRUCTURAL BIOLOGY

1998

Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers

K BECKERSavvas SavvidesM KEESERH SCHIRMERPA KARPLUS

A1 Journal Article in NATURE STRUCTURAL BIOLOGY

1996

Charge is the major discriminating factor for glutathione reductase versus trypanothione reductase inhibitors

CH FAERMANSavvas SavvidesC STRICKLANDMA BREIDENBACHJA PONASIKB GANEMD RIPOLLRL KRAUTHSIEGELPA KARPLUS

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Kinetics and crystallographic analysis of human glutathione reductase in complex with a xanthene inhibitor

Savvas SavvidesPA KARPLUS

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1995

KUKOAMINE-A AND OTHER HYDROPHOBIC ACYLPOLYAMINES - POTENT AND SELECTIVE INHIBITORS OF CRITHIDIA-FASCICULATA TRYPANOTHIONE REDUCTASE

JA PONASIKC STRICKLANDC FAERMANSavvas SavvidesPA KARPLUSB GANEM

A1 Journal Article in BIOCHEMICAL JOURNAL

OVEREXPRESSION OF CRITHIDIA-FASCICULATA TRYPANOTHIONE REDUCTASE AND CRYSTALLIZATION USING A NOVEL GEOMETRY

CL STRICKLANDR PUCHALSKISavvas SavvidesPA KARPLUS

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY